@conference{
author = "Aleksić, Ivana and Ćirin-Varađan, Slobodanka and Glišić, Teodora and Petrović, Nađa and Đuriš, Jelena and Parojčić, Jelena",
year = "2023",
abstract = "Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression is particularly challenging when high API
loading is required. The use of co-processed excipients can
result in a robust directly compressible formulation, while
melt granulation has emerged as an environmentally
friendly co-processing method that can result in highly
functional co-processed excipients (Ćirin-Varađan et al,
2022).
The aim of the present study was to investigate the
suitability of lactose co-processed with glyceryl
palmitostearate for the preparation of a directly
compressible formulation of ibuprofen, a challenging high-
dose API. The influence of initial particle size of glyceryl
palmitostearate, ibuprofen content and compression
parameters on compaction behavior of tableting mixtures
was investigated.",
publisher = "Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy",
journal = "Macedonian Pharmaceutical Bulletin",
title = "From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations",
volume = "69",
number = "Suppl 1",
pages = "139-140",
doi = "10.33320/maced.pharm.bull.2023.69.03.068"
}