@article{
author = "Ravnikar, Matjaž and Štrukelj, Borut and Otašević, Biljana and Sirše, Mateja",
year = "2024",
abstract = "The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.",
publisher = "MDPI",
journal = "Nutraceuticals",
title = "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis",
volume = "4",
number = "2",
pages = "273-282",
doi = "10.3390/nutraceuticals4020017"
}