TY  - JOUR
AU  - Ravnikar, Matjaž
AU  - Štrukelj, Borut
AU  - Otašević, Biljana
AU  - Sirše, Mateja
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5641
AB  - The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.
PB  - MDPI
T2  - Nutraceuticals
T1  - Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis
VL  - 4
IS  - 2
SP  - 273
EP  - 282
DO  - 10.3390/nutraceuticals4020017
ER  - 

@article{
author = "Ravnikar, Matjaž and Štrukelj, Borut and Otašević, Biljana and Sirše, Mateja",
year = "2024",
abstract = "The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans.",
publisher = "MDPI",
journal = "Nutraceuticals",
title = "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis",
volume = "4",
number = "2",
pages = "273-282",
doi = "10.3390/nutraceuticals4020017"
}

Ravnikar, M., Štrukelj, B., Otašević, B.,& Sirše, M.. (2024). Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals
MDPI., 4(2), 273-282.
https://doi.org/10.3390/nutraceuticals4020017

Ravnikar M, Štrukelj B, Otašević B, Sirše M. Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis. in Nutraceuticals. 2024;4(2):273-282.
doi:10.3390/nutraceuticals4020017 .

Ravnikar, Matjaž, Štrukelj, Borut, Otašević, Biljana, Sirše, Mateja, "Fomentariol, a Fomes fomentarius Compound, Exhibits Anti-Diabetic Effects in Fungal Material: An In Vitro Analysis" in Nutraceuticals, 4, no. 2 (2024):273-282,
https://doi.org/10.3390/nutraceuticals4020017 . .

TY  - JOUR
AU  - Ignjatović, Janko
AU  - Maljurić, Nevena
AU  - Golubović, Jelena
AU  - Ravnikar, Matjaž
AU  - Petković, Miloš
AU  - Savodnik, Nika
AU  - Štrukelj, Borut
AU  - Otašević, Biljana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3661
AB  - Recently, growing interest is devoted to investigation of bioactive secondary metabolites of endophytic fungi. Thus, as an extension to our previous achievements related to antimicrobial potential of endophytic fungi, Phomopsis species isolated from  conifer  needles  was  selected  as  appropriately  promising  natural  source  for  drug  discovery.  Its  dichloromethane  and  ethanol  extracts  considerably  inhibited  growth  of  Escherichia  coli  and  Staphylococcus  aureus.  Moreover,  the  indi-vidual compounds of dichloromethane extract have been separated, collected and purified using semi preparative liquid chromatographic analysis and comprehensively characterized using mass spectrometry (MS) and nuclear magnetic res-onance spectroscopy (NMR). Based on their antimicrobial activity and unique structural characteristics in comparison with  well-established  drugs  from  the  same  therapeutic  category,  two  dominant  compounds  (Z)-(Z)-2-acetoxyprop-1-en-1-yl-3-(3-((E)-3,4-dihydroxypent-1-en-1-yl)oxiran-2-yl)acrylate  (denoted  as  325-3)  and  (Z)-(Z)-2-acetoxyprop-1-en-1-yl  3-(3-((E)-4-hydroxy-3-oxopent-1-en-1-yl)oxiran-2-yl)acrylate  (denoted  as  325-5)  were  recognized  as  valuable  leading structures for future discovery of novel antibiotics.
PB  - Slovenian Chemical Society
T2  - Acta Chimica Slovenica
T1  - Characterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species
VL  - 67
IS  - 2
SP  - 445
EP  - 461
DO  - 10.17344/acsi.2019.5389
ER  - 

@article{
author = "Ignjatović, Janko and Maljurić, Nevena and Golubović, Jelena and Ravnikar, Matjaž and Petković, Miloš and Savodnik, Nika and Štrukelj, Borut and Otašević, Biljana",
year = "2020",
abstract = "Recently, growing interest is devoted to investigation of bioactive secondary metabolites of endophytic fungi. Thus, as an extension to our previous achievements related to antimicrobial potential of endophytic fungi, Phomopsis species isolated from  conifer  needles  was  selected  as  appropriately  promising  natural  source  for  drug  discovery.  Its  dichloromethane  and  ethanol  extracts  considerably  inhibited  growth  of  Escherichia  coli  and  Staphylococcus  aureus.  Moreover,  the  indi-vidual compounds of dichloromethane extract have been separated, collected and purified using semi preparative liquid chromatographic analysis and comprehensively characterized using mass spectrometry (MS) and nuclear magnetic res-onance spectroscopy (NMR). Based on their antimicrobial activity and unique structural characteristics in comparison with  well-established  drugs  from  the  same  therapeutic  category,  two  dominant  compounds  (Z)-(Z)-2-acetoxyprop-1-en-1-yl-3-(3-((E)-3,4-dihydroxypent-1-en-1-yl)oxiran-2-yl)acrylate  (denoted  as  325-3)  and  (Z)-(Z)-2-acetoxyprop-1-en-1-yl  3-(3-((E)-4-hydroxy-3-oxopent-1-en-1-yl)oxiran-2-yl)acrylate  (denoted  as  325-5)  were  recognized  as  valuable  leading structures for future discovery of novel antibiotics.",
publisher = "Slovenian Chemical Society",
journal = "Acta Chimica Slovenica",
title = "Characterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species",
volume = "67",
number = "2",
pages = "445-461",
doi = "10.17344/acsi.2019.5389"
}

Ignjatović, J., Maljurić, N., Golubović, J., Ravnikar, M., Petković, M., Savodnik, N., Štrukelj, B.,& Otašević, B.. (2020). Characterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species. in Acta Chimica Slovenica
Slovenian Chemical Society., 67(2), 445-461.
https://doi.org/10.17344/acsi.2019.5389

Ignjatović J, Maljurić N, Golubović J, Ravnikar M, Petković M, Savodnik N, Štrukelj B, Otašević B. Characterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species. in Acta Chimica Slovenica. 2020;67(2):445-461.
doi:10.17344/acsi.2019.5389 .

Ignjatović, Janko, Maljurić, Nevena, Golubović, Jelena, Ravnikar, Matjaž, Petković, Miloš, Savodnik, Nika, Štrukelj, Borut, Otašević, Biljana, "Characterization of biomolecules with antibiotic activity from endophytic fungi phomopsis species" in Acta Chimica Slovenica, 67, no. 2 (2020):445-461,
https://doi.org/10.17344/acsi.2019.5389 . .