TY  - JOUR
AU  - Stanisavljević, Dragana
AU  - Đorđević, Sofija
AU  - Milenković, Marina
AU  - Lazić, Miodrag
AU  - Veličković, Dragan
AU  - Ranđelović, Novica
AU  - Zlatković, Branislav
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2145
AB  - The way of drying the fresh herbal material influences the chemical content and the biological activities of their essential oils. The influence of the different drying methods of the herb Mentha longifolia (L.) Hudson on the antioxidant and antimicrobial activity of the extracted essential oils has been analyzed in this study. Drying has been carried out in three ways: in the natural way, in the laboratory oven (45 degrees C) and in the absorptional low-temperature condensational drier (35 degrees C). The antioxidant activity of the essential oil has been estimated by FRAP and DPPH assays, while the antimicrobial activity has been estimated by the diffusible and micro-delusional method, testing on the nine types of bacteria and two types of fungi. The essential oil obtained from the herb dried in the natural way has shown the highest antioxidant activity and the lowest from the herb dried in the laboratory oven. Bacillus subtilis, Micrococcus luteus and Enterococcus faecalis have shown the highest sensitivity on the three samples. The oil obtained from the herb dried in the absorptional low-temperature drier has shown the strongest antimicrobial effect.
PB  - Acg Publications, Gebze-Kocaeli
T2  - Renal Failure
T1  - Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques
VL  - 8
IS  - 1
SP  - 61
EP  - 65
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2145
ER  - 

@article{
author = "Stanisavljević, Dragana and Đorđević, Sofija and Milenković, Marina and Lazić, Miodrag and Veličković, Dragan and Ranđelović, Novica and Zlatković, Branislav",
year = "2014",
abstract = "The way of drying the fresh herbal material influences the chemical content and the biological activities of their essential oils. The influence of the different drying methods of the herb Mentha longifolia (L.) Hudson on the antioxidant and antimicrobial activity of the extracted essential oils has been analyzed in this study. Drying has been carried out in three ways: in the natural way, in the laboratory oven (45 degrees C) and in the absorptional low-temperature condensational drier (35 degrees C). The antioxidant activity of the essential oil has been estimated by FRAP and DPPH assays, while the antimicrobial activity has been estimated by the diffusible and micro-delusional method, testing on the nine types of bacteria and two types of fungi. The essential oil obtained from the herb dried in the natural way has shown the highest antioxidant activity and the lowest from the herb dried in the laboratory oven. Bacillus subtilis, Micrococcus luteus and Enterococcus faecalis have shown the highest sensitivity on the three samples. The oil obtained from the herb dried in the absorptional low-temperature drier has shown the strongest antimicrobial effect.",
publisher = "Acg Publications, Gebze-Kocaeli",
journal = "Renal Failure",
title = "Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques",
volume = "8",
number = "1",
pages = "61-65",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2145"
}

Stanisavljević, D., Đorđević, S., Milenković, M., Lazić, M., Veličković, D., Ranđelović, N.,& Zlatković, B.. (2014). Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques. in Renal Failure
Acg Publications, Gebze-Kocaeli., 8(1), 61-65.
https://hdl.handle.net/21.15107/rcub_farfar_2145

Stanisavljević D, Đorđević S, Milenković M, Lazić M, Veličković D, Ranđelović N, Zlatković B. Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques. in Renal Failure. 2014;8(1):61-65.
https://hdl.handle.net/21.15107/rcub_farfar_2145 .

Stanisavljević, Dragana, Đorđević, Sofija, Milenković, Marina, Lazić, Miodrag, Veličković, Dragan, Ranđelović, Novica, Zlatković, Branislav, "Antimicrobial and Antioxidant Activity of the Essential Oils Obtained from Mentha longifolia L. Hudson, Dried by Three Different Techniques" in Renal Failure, 8, no. 1 (2014):61-65,
https://hdl.handle.net/21.15107/rcub_farfar_2145 .

TY  - JOUR
AU  - Đorđević, Sanela
AU  - Cekić, Nebojša
AU  - Isailović, Tanja
AU  - Milić, Jela
AU  - Vuleta, Gordana
AU  - Lazić, Miodrag
AU  - Savić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2064
AB  - The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80-based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40 mass% medium chain triglyceride as oil phase, and 4, 6 and 8 mass% lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The effects of emulsifier type, emulsifier concentration and oil content were investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All the produced formulations revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0.072-0.124). Zeta potentials were found to be about -20 and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained from the stability studies (6 months at 25 °C and 1 month at 40 °C) indicated that nanoemulsion stability was influenced by their composition. The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization.
AB  - Cilj ovog istraživanja bio je da se homogenizacijom pod visokim pritiskom izrade nanoemulzije stabilizovane alkil poliglukozidnim (APG) emulgatorom i da se njihove karakteristike i fizička stabilnost uporede sa nanoemulzijama stabilizovanim standardnom kombinacijom lecitina (L) i polisorbata 80 (P80). U istraživanju je praćen uticaj parametara formulacije, i to vrste i koncentracije emulgatora (smeša L/P80 vs. APG, u koncentraciji od 4, 6 i 8%) i koncentracije uljane faze (20, 30 i 40% trigliceridi srednje dužine lanca) na veličinu i raspodelu veličina kapi, zeta potencijal (ζ) i fizičku stabilnost nanoemulzija. Takođe je praćen uticaj procesnih parametara (postupak, pritisak i broj ciklusa homogenizacije) na veličinu kapi i indeks polidisperznosti (PdI), u cilju identifikovanja optimalnih uslova za izradu nanoemulzija. Dobijeni rezultati pokazuju da postoji uticaj sastava formulacije na karakteristike (L/P80 nanoemulzije: veličina kapi 147-156 nm, ζ oko -20 mV; APG nanoemulzije: veličina kapi 165-228 nm, ζ oko -50 mV) i fizičku stabilnost ispitivanih nanoemulzija, i da se diskontinualnim postupkom homogenizacije (9 ciklusa, 500 bar) mogu dobiti nanoemulzije optimalnih svojstava (veličina kapi, PdI).
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability
T1  - Nanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnost
VL  - 67
IS  - 5
SP  - 795
EP  - 809
DO  - 10.2298/HEMIND120905005D
ER  - 

@article{
author = "Đorđević, Sanela and Cekić, Nebojša and Isailović, Tanja and Milić, Jela and Vuleta, Gordana and Lazić, Miodrag and Savić, Snežana",
year = "2013",
abstract = "The aim of the present study was to prepare oil-in-water nanoemulsions stabilized with a novel natural alkyl polyglucoside surfactant and to compare them with corresponding lecithin/polysorbate 80-based nanoemulsions in terms of physicochemical properties and physical stability. Nanoemulsions were prepared by high pressure homogenization, using 20, 30 and 40 mass% medium chain triglyceride as oil phase, and 4, 6 and 8 mass% lecithin/polysorbate 80 mixture (1/1) or caprylyl/capryl glucoside as emulsifiers. The effects of emulsifier type, emulsifier concentration and oil content were investigated with respect to changes in particle size, particle size distribution, surface charge and physical stability. The influence of production parameters (number of homogenization cycles, type of homogenization process, homogenization pressure) on particle size was also investigated. Analysis was performed by photon correlation spectroscopy, laser diffraction, zeta potential, pH and electrical conductivity measurements. All the produced formulations revealed a small droplet size ranging from 147 to 228 nm and a very narrow size distribution (polydispersity index range 0.072-0.124). Zeta potentials were found to be about -20 and -50 mV for nanoemulsions stabilized with lecithin/polysorbate 80 and caprylyl/capryl glucoside, respectively. The results obtained from the stability studies (6 months at 25 °C and 1 month at 40 °C) indicated that nanoemulsion stability was influenced by their composition. The results also suggested the most appropriate production parameters: 9 homogenization cycles, homogenization pressure of 500 bar and discontinuous process of homogenization., Cilj ovog istraživanja bio je da se homogenizacijom pod visokim pritiskom izrade nanoemulzije stabilizovane alkil poliglukozidnim (APG) emulgatorom i da se njihove karakteristike i fizička stabilnost uporede sa nanoemulzijama stabilizovanim standardnom kombinacijom lecitina (L) i polisorbata 80 (P80). U istraživanju je praćen uticaj parametara formulacije, i to vrste i koncentracije emulgatora (smeša L/P80 vs. APG, u koncentraciji od 4, 6 i 8%) i koncentracije uljane faze (20, 30 i 40% trigliceridi srednje dužine lanca) na veličinu i raspodelu veličina kapi, zeta potencijal (ζ) i fizičku stabilnost nanoemulzija. Takođe je praćen uticaj procesnih parametara (postupak, pritisak i broj ciklusa homogenizacije) na veličinu kapi i indeks polidisperznosti (PdI), u cilju identifikovanja optimalnih uslova za izradu nanoemulzija. Dobijeni rezultati pokazuju da postoji uticaj sastava formulacije na karakteristike (L/P80 nanoemulzije: veličina kapi 147-156 nm, ζ oko -20 mV; APG nanoemulzije: veličina kapi 165-228 nm, ζ oko -50 mV) i fizičku stabilnost ispitivanih nanoemulzija, i da se diskontinualnim postupkom homogenizacije (9 ciklusa, 500 bar) mogu dobiti nanoemulzije optimalnih svojstava (veličina kapi, PdI).",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability, Nanoemulzije dobijene variranjem tipa emulgatora i udela masne faze - uticaj formulacije i procesnih parametara na karakteristike i fizičku stabilnost",
volume = "67",
number = "5",
pages = "795-809",
doi = "10.2298/HEMIND120905005D"
}

Đorđević, S., Cekić, N., Isailović, T., Milić, J., Vuleta, G., Lazić, M.,& Savić, S.. (2013). Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 67(5), 795-809.
https://doi.org/10.2298/HEMIND120905005D

Đorđević S, Cekić N, Isailović T, Milić J, Vuleta G, Lazić M, Savić S. Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability. in Hemijska industrija. 2013;67(5):795-809.
doi:10.2298/HEMIND120905005D .

Đorđević, Sanela, Cekić, Nebojša, Isailović, Tanja, Milić, Jela, Vuleta, Gordana, Lazić, Miodrag, Savić, Snežana, "Nanoemulsions produced by varying the type of emulsifier and oil content: Effect of formulation and process parameters on the characteristics and physical stability" in Hemijska industrija, 67, no. 5 (2013):795-809,
https://doi.org/10.2298/HEMIND120905005D . .

TY  - CONF
AU  - Todorović, Z.
AU  - Todorović, Vanja
AU  - Šobajić, Slađana
AU  - Stojičević, Saša S.
AU  - Marjanović, J.
AU  - Nikolić, N.
AU  - Lazić, Miodrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1479
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes
VL  - 77
IS  - 12
SP  - 1286
EP  - 1286
DO  - 10.1055/s-0031-1282298
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1479
ER  - 

@conference{
author = "Todorović, Z. and Todorović, Vanja and Šobajić, Slađana and Stojičević, Saša S. and Marjanović, J. and Nikolić, N. and Lazić, Miodrag",
year = "2011",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes",
volume = "77",
number = "12",
pages = "1286-1286",
doi = "10.1055/s-0031-1282298",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1479"
}

Todorović, Z., Todorović, V., Šobajić, S., Stojičević, S. S., Marjanović, J., Nikolić, N.,& Lazić, M.. (2011). Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 77(12), 1286-1286.
https://doi.org/10.1055/s-0031-1282298
https://hdl.handle.net/21.15107/rcub_farfar_1479

Todorović Z, Todorović V, Šobajić S, Stojičević SS, Marjanović J, Nikolić N, Lazić M. Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes. in Planta Medica. 2011;77(12):1286-1286.
doi:10.1055/s-0031-1282298
https://hdl.handle.net/21.15107/rcub_farfar_1479 .

Todorović, Z., Todorović, Vanja, Šobajić, Slađana, Stojičević, Saša S., Marjanović, J., Nikolić, N., Lazić, Miodrag, "Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes" in Planta Medica, 77, no. 12 (2011):1286-1286,
https://doi.org/10.1055/s-0031-1282298 .,
https://hdl.handle.net/21.15107/rcub_farfar_1479 .

TY  - JOUR
AU  - Veličković, Dragan
AU  - Karabegović, Ivana T.
AU  - Stojičević, Saša S.
AU  - Lazić, Miodrag
AU  - Marinković, Valentina
AU  - Veljković, Vlada B.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1586
AB  - Antioxidant and antimicrobial activities as well as total phenols and flavonoids contents of Salvia glutinosa L. (glutinous sage) and Salvia officinalis L. (sage) extracts were studied. Methanol and aqueous ethanol (70% v/v) were used for extraction of bioactive compounds, both in the presence and the absence of ultrasound, from herb and the spent plant material remaining after the essential oil hydrodistillation. The ratio of plant material to extracting solvent was 1:10 g/mL. Antioxidant and antimicrobial activities of the extracts were found to depend on the type of plant material and the extraction conditions. The plant materials from which essential oil had been recovered were proven to be valuable raw materials for making various herbal preparations.
AB  - Ispitivana je antioksidantna i antimikrobna aktivnost, kao i sadržaj ukupnih fenola i flavonoida, ekstrakta lepljive žalfije (Salvia glutinosa L.) i žalfije (kadulje) (Salvia officinalis L.). Ekstrakcija bioaktivnih komponenata je vršena ultrazvukom i klasičnom ekstrakcijom (maceracijom) iz suve herbe, kao i biljnog materijala koji je ostao nakon izolacije etarskih ulja postupkom hidrodestilacije. Za ekstrakciju su korišćeni rastvarači metanol i vodeni rastvor etanola (70% v/v) pri hidromodulu 1:10 (g/mL), pri čemu je upotrebom drugog rastvarača dobijen veći prinos ekstraktivnih supstanci. Antioksidantna aktivnost dobijenih ekstrakata ispitana je DPPH testom, dok je njihova antimikrobna aktivnost određena disk difuzionom metodom. Pokazalo se da navedene aktivnosti ekstrakata zavise od tipa biljnog materijala i uslova ekstrakcije. Nezavisno od tipa rastvarača, biljnog materijala i tehnike ekstrakcije, S. glutinosa je pokazala snažniju antioksidantnu aktivnost, dok je S. officinalis bila bogatija fenolnim komponentama. Takođe, ekstrakti herbe S. glutinosa sadržali su više flavonoida od ekstrakata S. officinalis. Svi etanolni ekstrakti pokazali su veću antioksidantnu aktivnost od metanolnih ekstrakata. Posebno se ističu ekstrakti herbe, koji su bogatiji fenolnim komponentama i flavonoidima od ekstrakata rezidualnog biljnog materijala. Za razliku od ekstrakata S. officinalis, ekstrakti S. glutinosa su pokazali bolji antioksidantni kapacitet. Generalno, ekstrakti S. glutinosa dobijeni iz rezidualnog biljnog materijala, pokazali su jaču antimikrobnu aktivnost protiv svih mikroorganizama u poređenju sa ekstraktima herbe. I u ovom slučaju, etanolni ekstrakti su pokazali jaču antimikrobnu aktivnost od metanolnih ekstrakata. Biljni materijal (SPM) iz kojeg je prethodno izolovano etarsko ulje sadrži i dalje komplekse aktivnih materija koje pokazuju značajne biološke aktivnosti, što ga svrstava u vrednu sirovinu za izradu raznovrsnih fitopreparata.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L.
T1  - Poređenje antioksidantne i antimikrobne aktivnost ekstrakta Salvia glutinosa L. i Salvia officinalis L.
VL  - 65
IS  - 5
SP  - 599
EP  - 605
DO  - 10.2298/HEMIND110412034V
ER  - 

@article{
author = "Veličković, Dragan and Karabegović, Ivana T. and Stojičević, Saša S. and Lazić, Miodrag and Marinković, Valentina and Veljković, Vlada B.",
year = "2011",
abstract = "Antioxidant and antimicrobial activities as well as total phenols and flavonoids contents of Salvia glutinosa L. (glutinous sage) and Salvia officinalis L. (sage) extracts were studied. Methanol and aqueous ethanol (70% v/v) were used for extraction of bioactive compounds, both in the presence and the absence of ultrasound, from herb and the spent plant material remaining after the essential oil hydrodistillation. The ratio of plant material to extracting solvent was 1:10 g/mL. Antioxidant and antimicrobial activities of the extracts were found to depend on the type of plant material and the extraction conditions. The plant materials from which essential oil had been recovered were proven to be valuable raw materials for making various herbal preparations., Ispitivana je antioksidantna i antimikrobna aktivnost, kao i sadržaj ukupnih fenola i flavonoida, ekstrakta lepljive žalfije (Salvia glutinosa L.) i žalfije (kadulje) (Salvia officinalis L.). Ekstrakcija bioaktivnih komponenata je vršena ultrazvukom i klasičnom ekstrakcijom (maceracijom) iz suve herbe, kao i biljnog materijala koji je ostao nakon izolacije etarskih ulja postupkom hidrodestilacije. Za ekstrakciju su korišćeni rastvarači metanol i vodeni rastvor etanola (70% v/v) pri hidromodulu 1:10 (g/mL), pri čemu je upotrebom drugog rastvarača dobijen veći prinos ekstraktivnih supstanci. Antioksidantna aktivnost dobijenih ekstrakata ispitana je DPPH testom, dok je njihova antimikrobna aktivnost određena disk difuzionom metodom. Pokazalo se da navedene aktivnosti ekstrakata zavise od tipa biljnog materijala i uslova ekstrakcije. Nezavisno od tipa rastvarača, biljnog materijala i tehnike ekstrakcije, S. glutinosa je pokazala snažniju antioksidantnu aktivnost, dok je S. officinalis bila bogatija fenolnim komponentama. Takođe, ekstrakti herbe S. glutinosa sadržali su više flavonoida od ekstrakata S. officinalis. Svi etanolni ekstrakti pokazali su veću antioksidantnu aktivnost od metanolnih ekstrakata. Posebno se ističu ekstrakti herbe, koji su bogatiji fenolnim komponentama i flavonoidima od ekstrakata rezidualnog biljnog materijala. Za razliku od ekstrakata S. officinalis, ekstrakti S. glutinosa su pokazali bolji antioksidantni kapacitet. Generalno, ekstrakti S. glutinosa dobijeni iz rezidualnog biljnog materijala, pokazali su jaču antimikrobnu aktivnost protiv svih mikroorganizama u poređenju sa ekstraktima herbe. I u ovom slučaju, etanolni ekstrakti su pokazali jaču antimikrobnu aktivnost od metanolnih ekstrakata. Biljni materijal (SPM) iz kojeg je prethodno izolovano etarsko ulje sadrži i dalje komplekse aktivnih materija koje pokazuju značajne biološke aktivnosti, što ga svrstava u vrednu sirovinu za izradu raznovrsnih fitopreparata.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L., Poređenje antioksidantne i antimikrobne aktivnost ekstrakta Salvia glutinosa L. i Salvia officinalis L.",
volume = "65",
number = "5",
pages = "599-605",
doi = "10.2298/HEMIND110412034V"
}

Veličković, D., Karabegović, I. T., Stojičević, S. S., Lazić, M., Marinković, V.,& Veljković, V. B.. (2011). Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L.. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 65(5), 599-605.
https://doi.org/10.2298/HEMIND110412034V

Veličković D, Karabegović IT, Stojičević SS, Lazić M, Marinković V, Veljković VB. Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L.. in Hemijska industrija. 2011;65(5):599-605.
doi:10.2298/HEMIND110412034V .

Veličković, Dragan, Karabegović, Ivana T., Stojičević, Saša S., Lazić, Miodrag, Marinković, Valentina, Veljković, Vlada B., "Comparison of antioxidant and antimicrobial activities of extracts obtained from Salvia glutinosa L. and Salvia officinalis L." in Hemijska industrija, 65, no. 5 (2011):599-605,
https://doi.org/10.2298/HEMIND110412034V . .