TY  - JOUR
AU  - Brborić, Jasmina
AU  - Vladimirov, S
AU  - Jovanović, MS
AU  - Dogović, N
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/523
AB  - The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.
PB  - Springer Wien, Vienna
T2  - Monatshefte für Chemie Chemical Monthly
T1  - The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents
VL  - 135
IS  - 8
SP  - 1009
EP  - 1014
DO  - 10.1007/s00706-004-0174-x
ER  - 

@article{
author = "Brborić, Jasmina and Vladimirov, S and Jovanović, MS and Dogović, N",
year = "2004",
abstract = "The synthesis and characterization of N-[2-[[4-iodo-2,6-bis(1-methylethyl)phenyl]amino]-2-oxoethyl]-N-(carboxymethyl)glycine and N-[2-[(4-iodo-2,6-diethylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine is presented, as well as a modified and improved synthesis of N-[2-[(2,4-diiodo-6-methylphenyl)amino]-2-oxoethyl]-N-(carboxymethyl)glycine. These compounds are new agents for hepatobiliary imaging.",
publisher = "Springer Wien, Vienna",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents",
volume = "135",
number = "8",
pages = "1009-1014",
doi = "10.1007/s00706-004-0174-x"
}

Brborić, J., Vladimirov, S., Jovanović, M.,& Dogović, N.. (2004). The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte für Chemie Chemical Monthly
Springer Wien, Vienna., 135(8), 1009-1014.
https://doi.org/10.1007/s00706-004-0174-x

Brborić J, Vladimirov S, Jovanović M, Dogović N. The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents. in Monatshefte für Chemie Chemical Monthly. 2004;135(8):1009-1014.
doi:10.1007/s00706-004-0174-x .

Brborić, Jasmina, Vladimirov, S, Jovanović, MS, Dogović, N, "The synthesis of novel iodinated iminodiacetic acid analogues as hepatobiliary imaging agents" in Monatshefte für Chemie Chemical Monthly, 135, no. 8 (2004):1009-1014,
https://doi.org/10.1007/s00706-004-0174-x . .

TY  - JOUR
AU  - Jovanović, MS
AU  - Popović, Gordana
AU  - Kapetanović, Vera
AU  - Orlić, M
AU  - Vladimirov, S
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/516
AB  - In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid
VL  - 35
IS  - 5
SP  - 1257
EP  - 1261
DO  - 10.1016/j.jpba.2004.03.009
ER  - 

@article{
author = "Jovanović, MS and Popović, Gordana and Kapetanović, Vera and Orlić, M and Vladimirov, S",
year = "2004",
abstract = "In order to develop a radiopharmaceutical for hepatobiliary scintigraphy with better hepatobiliary properties new ligand for complexation of Tc-99m, 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid (METHYLIODIDA), was synthesized. Acid-base equilibria of METHYLIODIDA were studied potentiometrically, because these data are important for determination of complex formation conditions. It was established that METHYLIODIDA undergoes a complex acid-base equilibrium due to its zwitterionic nature and four proton-binding sites. The stoichiometric ionization constants were determined at 25 degreesC and constant ionic strength 0.1 M (NaClO4): pK(1) = 1.7 +/- 0.1; pK(2) = 2.44 +/- 0.07; pK(3) = 6.29 +/- 0.02 and pK(4) = 10.91 +/- 0.06, respectively.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid",
volume = "35",
number = "5",
pages = "1257-1261",
doi = "10.1016/j.jpba.2004.03.009"
}

Jovanović, M., Popović, G., Kapetanović, V., Orlić, M.,& Vladimirov, S.. (2004). Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 35(5), 1257-1261.
https://doi.org/10.1016/j.jpba.2004.03.009

Jovanović M, Popović G, Kapetanović V, Orlić M, Vladimirov S. Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid. in Journal of Pharmaceutical and Biomedical Analysis. 2004;35(5):1257-1261.
doi:10.1016/j.jpba.2004.03.009 .

Jovanović, MS, Popović, Gordana, Kapetanović, Vera, Orlić, M, Vladimirov, S, "Determination of the ionization constants of 4-iodo-2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid" in Journal of Pharmaceutical and Biomedical Analysis, 35, no. 5 (2004):1257-1261,
https://doi.org/10.1016/j.jpba.2004.03.009 . .

TY  - JOUR
AU  - Jovanović, MS
AU  - Brborić, Jasmina
AU  - Vladimirov, S
AU  - Suturkova, L
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/236
AB  - The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.
PB  - Kluwer Academic Publ, Dordrecht
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives
VL  - 245
IS  - 3
SP  - 555
EP  - 560
DO  - 10.1023/A:1006709310527
ER  - 

@article{
author = "Jovanović, MS and Brborić, Jasmina and Vladimirov, S and Suturkova, L",
year = "2000",
abstract = "The partition coefficient (log P) for n-octanol/water system was calculated applying PACO program for various theoretically possible mono and dihalogenated IDA derivatives. Some of the synthesized ligands (SOLCOIODIDA, IODIDA and DIIODIDA) were labeled with the technetium-99m. The biodistribution and influence of bilirubin on their biokinetics were investigated in rats. The correlation between partition coefficients of ligands increase (log P) and better hepatobiliary properties of Tc-99m-IDA derivatives was determined. The values of log P increase from 1.16 for SOLCOIODIDA, 3.11 for IODIDA to 3.47 for DIIODIDA. In correlation with these results, biliary excretion decreased for 59% for Tc-99m-SOLCOIODIDA and 11% for Tc-99m-IODIDA and Tc-99m-DIIODIDA under hyperbilirubinemia (3.5 min after injection) and 45%, 11% and 0.38% respectively (15 min after injection). The highest biliary excretion had Tc-99m-DIIODIDA (55.4% for 3.5 min). Considering the correlation between hepatobiliary properties and log P, the evaluation of biological properties for various trifluoromethyl mono and dihalogenated IDA derivatives was performed on the basis of the calculated log P in order to synthetize a new radiopharmaceutical for hepatobiliary scintigraphy.",
publisher = "Kluwer Academic Publ, Dordrecht",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives",
volume = "245",
number = "3",
pages = "555-560",
doi = "10.1023/A:1006709310527"
}

Jovanović, M., Brborić, J., Vladimirov, S.,& Suturkova, L.. (2000). Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry
Kluwer Academic Publ, Dordrecht., 245(3), 555-560.
https://doi.org/10.1023/A:1006709310527

Jovanović M, Brborić J, Vladimirov S, Suturkova L. Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives. in Journal of Radioanalytical and Nuclear Chemistry. 2000;245(3):555-560.
doi:10.1023/A:1006709310527 .

Jovanović, MS, Brborić, Jasmina, Vladimirov, S, Suturkova, L, "Correlation between lipophilicity of the ligands and the hepatobiliary properties of the radiopharmaceuticals: Approach to the development of new IDA derivatives" in Journal of Radioanalytical and Nuclear Chemistry, 245, no. 3 (2000):555-560,
https://doi.org/10.1023/A:1006709310527 . .

TY  - JOUR
AU  - Jovanović, MS
AU  - Brborić, Jasmina
AU  - Vladimirov, S
AU  - Zmbova, B
AU  - Vuksanović, LJ
AU  - Živanov-Stakić, Dobrila
AU  - Obradović, V
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/219
AB  - A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.
PB  - Springer
PB  - Elsevier Science B. V., Amsterdam
T2  - Journal of Radioanalytical and Nuclear Chemistry
T1  - New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
VL  - 240
IS  - 1
SP  - 321
EP  - 324
DO  - 10.1007/BF02349171
ER  - 

@article{
author = "Jovanović, MS and Brborić, Jasmina and Vladimirov, S and Zmbova, B and Vuksanović, LJ and Živanov-Stakić, Dobrila and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
publisher = "Springer, Elsevier Science B. V., Amsterdam",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}

Jovanović, M., Brborić, J., Vladimirov, S., Zmbova, B., Vuksanović, L., Živanov-Stakić, D.,& Obradović, V.. (1999). New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry
Springer., 240(1), 321-324.
https://doi.org/10.1007/BF02349171

Jovanović M, Brborić J, Vladimirov S, Zmbova B, Vuksanović L, Živanov-Stakić D, Obradović V. New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging. in Journal of Radioanalytical and Nuclear Chemistry. 1999;240(1):321-324.
doi:10.1007/BF02349171 .

Jovanović, MS, Brborić, Jasmina, Vladimirov, S, Zmbova, B, Vuksanović, LJ, Živanov-Stakić, Dobrila, Obradović, V, "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging" in Journal of Radioanalytical and Nuclear Chemistry, 240, no. 1 (1999):321-324,
https://doi.org/10.1007/BF02349171 . .

TY  - JOUR
AU  - Jovanović, MS
AU  - Vuksanović, L
AU  - Brborić, Jasmina
AU  - Vladimirov, S
AU  - Živanov-Stakić, Dobrila
PY  - 1996
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/133
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA
VL  - 15
IS  - 4
SP  - 266
EP  - 266
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2027
ER  - 

@article{
author = "Jovanović, MS and Vuksanović, L and Brborić, Jasmina and Vladimirov, S and Živanov-Stakić, Dobrila",
year = "1996",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA",
volume = "15",
number = "4",
pages = "266-266",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2027"
}

Jovanović, M., Vuksanović, L., Brborić, J., Vladimirov, S.,& Živanov-Stakić, D.. (1996). Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 15(4), 266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027

Jovanović M, Vuksanović L, Brborić J, Vladimirov S, Živanov-Stakić D. Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA. in Jugoslovenska medicinska biohemija. 1996;15(4):266-266.
https://hdl.handle.net/21.15107/rcub_vinar_2027 .

Jovanović, MS, Vuksanović, L, Brborić, Jasmina, Vladimirov, S, Živanov-Stakić, Dobrila, "Interaction of Tc-99m-IODIDE IDA derivatives substituted with HSA" in Jugoslovenska medicinska biohemija, 15, no. 4 (1996):266-266,
https://hdl.handle.net/21.15107/rcub_vinar_2027 .