@article{
author = "Jovanović, MS and Brborić, Jasmina and Vladimirov, S and Zmbova, B and Vuksanović, LJ and Živanov-Stakić, Dobrila and Obradović, V",
year = "1999",
abstract = "A new diiodine substituted LDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with Tc-99m. It was established that Tc-99m-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on Tc-99m-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for Tc-99m-SOLCOIODIDA. Related to Tc-99m-SOLCOIODIDA, Tc-99m-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of Tc-99m-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of Tc-99m-SOLCOIODIDA has been reduced for about 60%. The protein binding of Tc-99m-DIIODIDA and Tc-99m-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that Tc-99m-DIIODIDA hepatobiliary imaging agent is superior to the presently used Tc-99m-monoiodine IDA derivatives.",
publisher = "Springer, Elsevier Science B. V., Amsterdam",
journal = "Journal of Radioanalytical and Nuclear Chemistry",
title = "New Tc-99m-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging",
volume = "240",
number = "1",
pages = "321-324",
doi = "10.1007/BF02349171"
}