TY  - JOUR
AU  - Račić, Anđelka
AU  - Jurišić-Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Vučen, Sonja
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Pecikoza, Uroš
AU  - Bajac, Jelena
AU  - Krajišnik, Danina
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5610
AB  - The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the
residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The
main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient,
containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone
and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between
ketotifen and polymers. Physicochemical and rheological analysis at ambient and simulated physiological conditions, as well as the evaluation of mucoadhesive properties showed that vehicles containing combinations of
polymers have suitable physicochemical and functional properties with demonstrated synergism between
combined polymers (MCH and HPG i.e. SH and HPG). The drug permeability was successfully estimated in vitro
using HCE-T cell-based models. MTT cytotoxicity assay demonstrates that the tested formulations were non-toxic
and well tolerated. In vivo preclinical study on mice revealed that both vehicles containing mixed polymers
enhanced and prolonged the antipruritic/analgesic-like effect of ophthalmic ketotifen. Based on these results,
both combinations of polysaccharide polymers, especially SH-HPG, could be considered as potential new carriers
for ketotifen for ophthalmic use.
PB  - Elsevier
T2  - International Journal of Pharmaceutics
T1  - Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy
VL  - 655
SP  - 124033
DO  - 10.1016/j.ijpharm.2024.124033
ER  - 

@article{
author = "Račić, Anđelka and Jurišić-Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Vučen, Sonja and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Pecikoza, Uroš and Bajac, Jelena and Krajišnik, Danina",
year = "2024",
abstract = "The incorporation of polymers into drug delivery vehicles has been shown to be a useful approach to prolong the
residence time of drugs in the precorneal tear film and to improve penetration into biological membranes. The
main objective of this research was to formulate novel viscous eye drops with ketotifen as the active ingredient,
containing the polysaccharides: chitosan (MCH), hydroxypropyl guar gum (HPG) and hyaluronic acid (SH) alone
and in combination as functional polymers. DSC and FT-IR techniques showed the compatibility between
ketotifen and polymers. Physicochemical and rheological analysis at ambient and simulated physiological conditions, as well as the evaluation of mucoadhesive properties showed that vehicles containing combinations of
polymers have suitable physicochemical and functional properties with demonstrated synergism between
combined polymers (MCH and HPG i.e. SH and HPG). The drug permeability was successfully estimated in vitro
using HCE-T cell-based models. MTT cytotoxicity assay demonstrates that the tested formulations were non-toxic
and well tolerated. In vivo preclinical study on mice revealed that both vehicles containing mixed polymers
enhanced and prolonged the antipruritic/analgesic-like effect of ophthalmic ketotifen. Based on these results,
both combinations of polysaccharide polymers, especially SH-HPG, could be considered as potential new carriers
for ketotifen for ophthalmic use.",
publisher = "Elsevier",
journal = "International Journal of Pharmaceutics",
title = "Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy",
volume = "655",
pages = "124033",
doi = "10.1016/j.ijpharm.2024.124033"
}

Račić, A., Jurišić-Dukovski, B., Lovrić, J., Dobričić, V., Vučen, S., Micov, A., Stepanović-Petrović, R., Tomić, M., Pecikoza, U., Bajac, J.,& Krajišnik, D.. (2024). Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy. in International Journal of Pharmaceutics
Elsevier., 655, 124033.
https://doi.org/10.1016/j.ijpharm.2024.124033

Račić A, Jurišić-Dukovski B, Lovrić J, Dobričić V, Vučen S, Micov A, Stepanović-Petrović R, Tomić M, Pecikoza U, Bajac J, Krajišnik D. Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy. in International Journal of Pharmaceutics. 2024;655:124033.
doi:10.1016/j.ijpharm.2024.124033 .

Račić, Anđelka, Jurišić-Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Vučen, Sonja, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Pecikoza, Uroš, Bajac, Jelena, Krajišnik, Danina, "Synergism of polysaccharide polymers in antihistamine eye drops: Influence on physicochemical properties and in vivo efficacy" in International Journal of Pharmaceutics, 655 (2024):124033,
https://doi.org/10.1016/j.ijpharm.2024.124033 . .

TY  - CONF
AU  - Račić, Anđelka
AU  - Čalija, Bojan
AU  - Dobričić, Vladimir
AU  - Jurišić Dukovsk, Bisera
AU  - Lovrić, Jasmina
AU  - Krajišnik, Danina
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4566
AB  - To improve ocular bioavailability of eye drops, viscosity-increasing polymers with improved
functional properties have been used (1,2). The aim of this study was formulation and evaluation of
viscous eye drops using vehicles containing hydroxypropyl guar gum (HPG) (0.25% w/v), sodium
hyaluronate (SH) (0.4% w/v), and their combination (HPG-SH) as carriers for olopatadine (0.1% w/v).
Physicochemical properties (appearance, clarity, pH, osmolality, viscosity) of the prepared
formulations were tested. The drug permeability was estimated in vitro using HCE-T cell-based models
and the parallel artificial membrane permeability assay (PAMPA). MTT cytotoxicity assay was
performed at the end of the permeability study. Physicochemical stability of the formulated eye drops
was tested during 12 months. An accelerated stability study was performed using the heating/cooling
cycles test. The clarity, pH and osmolality of all formulations were in acceptable range for ophthalmic
preparations. Formulation HPG-SH showed significantly higher viscosity (73.1 mPa·s) than
formulations with single polymer (7.4 mPa·s for HPG i.e 3.7 mPa·s for SH) pointing to synergistic effect
of polymers. The addition of polymers led to a decrease in transcorneal permeability and lower
permeability coefficients with prolonged residence of drug at the ocular surface. The results of MTT
assay demonstrated that the tested formulations were biocompatible and well tolerated. Formulated
eye drops showed satisfactory physicochemical stability under all storage conditions.
Olopatadine was successfully formulated in biocompatible viscous ophthalmic solutions. The
combination of viscosity enhancer HPG with mucoadhesive polymer SH has a potential to improve
precorneal residence time and therapeutic effect of olopatadine.
AB  - Polimeri poboljšanih funkcionalnih karakteristika koji povećavaju viskozitet koriste se u
kapima za oči kako bi se povećala okularna raspoloživost (1,2). Cilj ove studije bio je formulacija i
ispitivanje viskoznih kapi za oči korišćenjem vehikuluma koji sadrže hidroksipropil guar gumu (HPG)
(0,25% v/v), natrijum hijaluronat (SH) (0,4% v/v) i njihovu kombinaciju (HPG-SH) kao nosača za
olopatadin (0,1% v/v). Ispitivane su fizičkohemijske osobine (izgled, bistrina, pH, osmolalnost,
viskozitet) pripremljenih formulacija. Permeabilnost leka je procenjena in vitro korišćenjem modela
zasnovanih na HCE-T ćelijama i testa permeabilnosti na paralelnim veštačkim membranama (PAMPA).
MTT citotoksični test sproveden je na kraju studije permeabilnosti. Fizičkohemijska stabilnost
formulisanih kapi za oči ispitivana je tokom 12 meseci. Sprovedena je ubrzana studija stabilnosti
korišćenjem cikličnog testa grejanja/hlađenja. Bistrina, pH i osmolalnost svih formulacija bili su u
prihvatljivom opsegu za oftalmološke preparate. Formulacija HPG-SH je pokazala značajno viši
viskozitet (73,1 mPa·s) od formulacija sa pojedinačnim polimerom (7,4 mPa·s za HPG, tj. 3,7 mPa·s za
SH) ukazujući na sinergistički efekat polimera. Dodatak polimera je doveo do smanjenja
transkornealne permeabilnosti i nižih koeficijenata permeabilnosti uz produženo zadržavanje leka na
površini oka. Rezultati MTT testa su pokazali da su testirane formulacije biokompatibilne i dobro
podnošljive. Formulisane kapi za oči imale su zadovoljavajuću fizičkohemijsku stabilnost pri svim
uslovima čuvanja. Uspešno su formulisani biokompatibilni viskozni rastvori za oftalmološku primenu
sa olopatadinom. Kombinacija HPG kao sredstva za povećanje viskoziteta sa mukoadhezivnim
polimerom SH ima potencijal da poboljša prekornealno vreme zadržavanja i terapijski efekat
olopatadina.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Evaluation of the influence of hydroxypropylguar gum and hyaluronic acid on physicochemical and functional characteristics of ophthalmic vehicles for olopatadine
T1  - Procena uticaja hidroksipropil guar gume i hijaluronske kiseline na fizičkohemijske i funkcionalne karakteristike oftalmoloških vehikuluma za olopatadin
VL  - 72
IS  - 4 suplement
SP  - S388
EP  - S389
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4566
ER  - 

@conference{
author = "Račić, Anđelka and Čalija, Bojan and Dobričić, Vladimir and Jurišić Dukovsk, Bisera and Lovrić, Jasmina and Krajišnik, Danina",
year = "2022",
abstract = "To improve ocular bioavailability of eye drops, viscosity-increasing polymers with improved
functional properties have been used (1,2). The aim of this study was formulation and evaluation of
viscous eye drops using vehicles containing hydroxypropyl guar gum (HPG) (0.25% w/v), sodium
hyaluronate (SH) (0.4% w/v), and their combination (HPG-SH) as carriers for olopatadine (0.1% w/v).
Physicochemical properties (appearance, clarity, pH, osmolality, viscosity) of the prepared
formulations were tested. The drug permeability was estimated in vitro using HCE-T cell-based models
and the parallel artificial membrane permeability assay (PAMPA). MTT cytotoxicity assay was
performed at the end of the permeability study. Physicochemical stability of the formulated eye drops
was tested during 12 months. An accelerated stability study was performed using the heating/cooling
cycles test. The clarity, pH and osmolality of all formulations were in acceptable range for ophthalmic
preparations. Formulation HPG-SH showed significantly higher viscosity (73.1 mPa·s) than
formulations with single polymer (7.4 mPa·s for HPG i.e 3.7 mPa·s for SH) pointing to synergistic effect
of polymers. The addition of polymers led to a decrease in transcorneal permeability and lower
permeability coefficients with prolonged residence of drug at the ocular surface. The results of MTT
assay demonstrated that the tested formulations were biocompatible and well tolerated. Formulated
eye drops showed satisfactory physicochemical stability under all storage conditions.
Olopatadine was successfully formulated in biocompatible viscous ophthalmic solutions. The
combination of viscosity enhancer HPG with mucoadhesive polymer SH has a potential to improve
precorneal residence time and therapeutic effect of olopatadine., Polimeri poboljšanih funkcionalnih karakteristika koji povećavaju viskozitet koriste se u
kapima za oči kako bi se povećala okularna raspoloživost (1,2). Cilj ove studije bio je formulacija i
ispitivanje viskoznih kapi za oči korišćenjem vehikuluma koji sadrže hidroksipropil guar gumu (HPG)
(0,25% v/v), natrijum hijaluronat (SH) (0,4% v/v) i njihovu kombinaciju (HPG-SH) kao nosača za
olopatadin (0,1% v/v). Ispitivane su fizičkohemijske osobine (izgled, bistrina, pH, osmolalnost,
viskozitet) pripremljenih formulacija. Permeabilnost leka je procenjena in vitro korišćenjem modela
zasnovanih na HCE-T ćelijama i testa permeabilnosti na paralelnim veštačkim membranama (PAMPA).
MTT citotoksični test sproveden je na kraju studije permeabilnosti. Fizičkohemijska stabilnost
formulisanih kapi za oči ispitivana je tokom 12 meseci. Sprovedena je ubrzana studija stabilnosti
korišćenjem cikličnog testa grejanja/hlađenja. Bistrina, pH i osmolalnost svih formulacija bili su u
prihvatljivom opsegu za oftalmološke preparate. Formulacija HPG-SH je pokazala značajno viši
viskozitet (73,1 mPa·s) od formulacija sa pojedinačnim polimerom (7,4 mPa·s za HPG, tj. 3,7 mPa·s za
SH) ukazujući na sinergistički efekat polimera. Dodatak polimera je doveo do smanjenja
transkornealne permeabilnosti i nižih koeficijenata permeabilnosti uz produženo zadržavanje leka na
površini oka. Rezultati MTT testa su pokazali da su testirane formulacije biokompatibilne i dobro
podnošljive. Formulisane kapi za oči imale su zadovoljavajuću fizičkohemijsku stabilnost pri svim
uslovima čuvanja. Uspešno su formulisani biokompatibilni viskozni rastvori za oftalmološku primenu
sa olopatadinom. Kombinacija HPG kao sredstva za povećanje viskoziteta sa mukoadhezivnim
polimerom SH ima potencijal da poboljša prekornealno vreme zadržavanja i terapijski efekat
olopatadina.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Evaluation of the influence of hydroxypropylguar gum and hyaluronic acid on physicochemical and functional characteristics of ophthalmic vehicles for olopatadine, Procena uticaja hidroksipropil guar gume i hijaluronske kiseline na fizičkohemijske i funkcionalne karakteristike oftalmoloških vehikuluma za olopatadin",
volume = "72",
number = "4 suplement",
pages = "S388-S389",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4566"
}

Račić, A., Čalija, B., Dobričić, V., Jurišić Dukovsk, B., Lovrić, J.,& Krajišnik, D.. (2022). Evaluation of the influence of hydroxypropylguar gum and hyaluronic acid on physicochemical and functional characteristics of ophthalmic vehicles for olopatadine. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S388-S389.
https://hdl.handle.net/21.15107/rcub_farfar_4566

Račić A, Čalija B, Dobričić V, Jurišić Dukovsk B, Lovrić J, Krajišnik D. Evaluation of the influence of hydroxypropylguar gum and hyaluronic acid on physicochemical and functional characteristics of ophthalmic vehicles for olopatadine. in Arhiv za farmaciju. 2022;72(4 suplement):S388-S389.
https://hdl.handle.net/21.15107/rcub_farfar_4566 .

Račić, Anđelka, Čalija, Bojan, Dobričić, Vladimir, Jurišić Dukovsk, Bisera, Lovrić, Jasmina, Krajišnik, Danina, "Evaluation of the influence of hydroxypropylguar gum and hyaluronic acid on physicochemical and functional characteristics of ophthalmic vehicles for olopatadine" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S388-S389,
https://hdl.handle.net/21.15107/rcub_farfar_4566 .

TY  - JOUR
AU  - Račić, Andjelka
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Jurišić Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Micov, Ana
AU  - Vuković, Milja
AU  - Stepanović-Petrović, Radica
AU  - Krajišnik, Danina
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3938
AB  - The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) and their com-bination as carriers for olopatadine (0.1% w/v). Physicochemical properties (appearance, clarity, pH, osmolality, viscosity and drug content) of the tested formulations were within acceptable ranges for the ophthalmic prep-arations, while DSC and FT-IR techniques demonstrated the compatibility between olopatadine and polymers. The drug permeability was successfully estimated in vitro using both HCE-T cell-based models (Model I and Model II) and the parallel artificial membrane permeability assay (PAMPA), considering the impact of chitosan as a permeation enhancer. The MTT cytotoxicity assay demonstrates that the tested formulations (diluted 10-fold in HBSS pH 5.5) were non-toxic and well tolerated. An ocular itch test on mice was carried out with the formulation containing the combination of polymers comparable with a commercially available olopatadine eye drops without viscosity enhancers. The tested eye drops produced a slightly higher anti-pruritic/analgesic-like effect than the commercial preparation. It could be assumed that the use of this viscous ophthalmic vehicle due to its advanced mucoadhesive properties and good safety profile is a feasible strategy to improve the efficacy of olopatadine.
PB  - Elsevier B.V.
T2  - European Journal of Pharmaceutical Sciences
T1  - Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches
VL  - 166
DO  - 10.1016/j.ejps.2021.105906
ER  - 

@article{
author = "Račić, Andjelka and Čalija, Bojan and Milić, Jela and Jurišić Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Micov, Ana and Vuković, Milja and Stepanović-Petrović, Radica and Krajišnik, Danina",
year = "2021",
abstract = "The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) and their com-bination as carriers for olopatadine (0.1% w/v). Physicochemical properties (appearance, clarity, pH, osmolality, viscosity and drug content) of the tested formulations were within acceptable ranges for the ophthalmic prep-arations, while DSC and FT-IR techniques demonstrated the compatibility between olopatadine and polymers. The drug permeability was successfully estimated in vitro using both HCE-T cell-based models (Model I and Model II) and the parallel artificial membrane permeability assay (PAMPA), considering the impact of chitosan as a permeation enhancer. The MTT cytotoxicity assay demonstrates that the tested formulations (diluted 10-fold in HBSS pH 5.5) were non-toxic and well tolerated. An ocular itch test on mice was carried out with the formulation containing the combination of polymers comparable with a commercially available olopatadine eye drops without viscosity enhancers. The tested eye drops produced a slightly higher anti-pruritic/analgesic-like effect than the commercial preparation. It could be assumed that the use of this viscous ophthalmic vehicle due to its advanced mucoadhesive properties and good safety profile is a feasible strategy to improve the efficacy of olopatadine.",
publisher = "Elsevier B.V.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches",
volume = "166",
doi = "10.1016/j.ejps.2021.105906"
}

Račić, A., Čalija, B., Milić, J., Jurišić Dukovski, B., Lovrić, J., Dobričić, V., Micov, A., Vuković, M., Stepanović-Petrović, R.,& Krajišnik, D.. (2021). Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches. in European Journal of Pharmaceutical Sciences
Elsevier B.V.., 166.
https://doi.org/10.1016/j.ejps.2021.105906

Račić A, Čalija B, Milić J, Jurišić Dukovski B, Lovrić J, Dobričić V, Micov A, Vuković M, Stepanović-Petrović R, Krajišnik D. Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches. in European Journal of Pharmaceutical Sciences. 2021;166.
doi:10.1016/j.ejps.2021.105906 .

Račić, Andjelka, Čalija, Bojan, Milić, Jela, Jurišić Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Micov, Ana, Vuković, Milja, Stepanović-Petrović, Radica, Krajišnik, Danina, "Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches" in European Journal of Pharmaceutical Sciences, 166 (2021),
https://doi.org/10.1016/j.ejps.2021.105906 . .

TY  - CONF
AU  - Račić, Anđelka
AU  - Jurišić Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Krajišnik, Danina
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5481
AB  - Olopatadine is a selective H1-receptore antagonist that
inhibits release of histamine and proinflammatory
mediators [1]. The poor ocular bioavailability, as the main
limitation of efficient ocular therapy, could be overcome by
increasing residence time and enhancing corneal
penetration. ...
PB  - International Association for Pharmaceutical Technology, Mainz, Germany
C3  - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting
T1  - Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5481
ER  - 

@conference{
author = "Račić, Anđelka and Jurišić Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Čalija, Bojan and Milić, Jela and Krajišnik, Danina",
year = "2021",
abstract = "Olopatadine is a selective H1-receptore antagonist that
inhibits release of histamine and proinflammatory
mediators [1]. The poor ocular bioavailability, as the main
limitation of efficient ocular therapy, could be overcome by
increasing residence time and enhancing corneal
penetration. ...",
publisher = "International Association for Pharmaceutical Technology, Mainz, Germany",
journal = "12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting",
title = "Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5481"
}

Račić, A., Jurišić Dukovski, B., Lovrić, J., Dobričić, V., Čalija, B., Milić, J.,& Krajišnik, D.. (2021). Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting
International Association for Pharmaceutical Technology, Mainz, Germany..
https://hdl.handle.net/21.15107/rcub_farfar_5481

Račić A, Jurišić Dukovski B, Lovrić J, Dobričić V, Čalija B, Milić J, Krajišnik D. Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_5481 .

Račić, Anđelka, Jurišić Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Čalija, Bojan, Milić, Jela, Krajišnik, Danina, "Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model" in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting (2021),
https://hdl.handle.net/21.15107/rcub_farfar_5481 .