TY  - JOUR
AU  - Pejić, Nataša
AU  - Kolar-Anić, Ljiljana
AU  - Maksimović, Jelena
AU  - Janković, Marija
AU  - Vukojević, Vladana
AU  - Anić, Slobodan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2528
AB  - The temporal dynamics of the Bray-Liebhafsky reaction (iodate-based catalytic decomposition of hydrogen peroxide in an acidic aqueous solution) was experimentally characterized in a continuous stirred tank reactor by independently varying the temperature and the mixed inflow hydrogen peroxide concentration. When the temperature was the bifurcation parameter, the emergence/disappearance of oscillatory behavior via a supercritical Andronov-Hopf bifurcation was observed for different mixed inflow hydrogen peroxide concentrations. An increase in the mixed inflow hydrogen-peroxide concentration resulted in a shift of the bifurcation point towards higher values of temperature, but did not alter the bifurcation type.
PB  - Springer, Dordrecht
T2  - Records of Natural Products
T1  - Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation
VL  - 118
IS  - 1
SP  - 15
EP  - 26
DO  - 10.1007/s11144-016-0984-y
ER  - 

@article{
author = "Pejić, Nataša and Kolar-Anić, Ljiljana and Maksimović, Jelena and Janković, Marija and Vukojević, Vladana and Anić, Slobodan",
year = "2016",
abstract = "The temporal dynamics of the Bray-Liebhafsky reaction (iodate-based catalytic decomposition of hydrogen peroxide in an acidic aqueous solution) was experimentally characterized in a continuous stirred tank reactor by independently varying the temperature and the mixed inflow hydrogen peroxide concentration. When the temperature was the bifurcation parameter, the emergence/disappearance of oscillatory behavior via a supercritical Andronov-Hopf bifurcation was observed for different mixed inflow hydrogen peroxide concentrations. An increase in the mixed inflow hydrogen-peroxide concentration resulted in a shift of the bifurcation point towards higher values of temperature, but did not alter the bifurcation type.",
publisher = "Springer, Dordrecht",
journal = "Records of Natural Products",
title = "Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation",
volume = "118",
number = "1",
pages = "15-26",
doi = "10.1007/s11144-016-0984-y"
}

Pejić, N., Kolar-Anić, L., Maksimović, J., Janković, M., Vukojević, V.,& Anić, S.. (2016). Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation. in Records of Natural Products
Springer, Dordrecht., 118(1), 15-26.
https://doi.org/10.1007/s11144-016-0984-y

Pejić N, Kolar-Anić L, Maksimović J, Janković M, Vukojević V, Anić S. Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation. in Records of Natural Products. 2016;118(1):15-26.
doi:10.1007/s11144-016-0984-y .

Pejić, Nataša, Kolar-Anić, Ljiljana, Maksimović, Jelena, Janković, Marija, Vukojević, Vladana, Anić, Slobodan, "Dynamic transitions in the Bray-Liebhafsky oscillating reaction. Effect of hydrogen peroxide and temperature on bifurcation" in Records of Natural Products, 118, no. 1 (2016):15-26,
https://doi.org/10.1007/s11144-016-0984-y . .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Blagojević, Slavica
AU  - Anić, Slobodan
AU  - Vukojević, Vladana
AU  - Mijatović, Miroslav D.
AU  - Ćirić, Jasna S.
AU  - Marković, Zoran S.
AU  - Marković, Svetlana D.
AU  - Kolar-Anić, Ljiljana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/942
AB  - A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.
PB  - Elsevier Science BV, Amsterdam
T2  - Analytica Chimica Acta
T1  - Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique
VL  - 582
IS  - 2
SP  - 367
EP  - 374
DO  - 10.1016/j.aca.2006.09.026
ER  - 

@article{
author = "Pejić, Nataša and Blagojević, Slavica and Anić, Slobodan and Vukojević, Vladana and Mijatović, Miroslav D. and Ćirić, Jasna S. and Marković, Zoran S. and Marković, Svetlana D. and Kolar-Anić, Ljiljana",
year = "2007",
abstract = "A novel kinetic method for micro-quantitative determinations of morphine (MH) is proposed and validated. The method is based on the potentiometric monitoring of the concentration perturbations of the oscillatory reaction system being in a stable non-equilibrium stationary state close to the bifurcation point between stable and oscillatory state. The response of the Bray-Liebhafsky (BL) oscillatory reaction as a matrix system, to the perturbations by different concentrations of morphine, is followed by a Pt-electrode. The proposed method relies on the linear relationship between maximal potential shift, Delta E-m, and the logarithm of the added morphine amounts in the range of 0.004-0.18 mu mol. Under optimum conditions, the sensitivity of the proposed method (as the limit of detection) is 0.001 mu mol and the method is featured by good precision (R.S.D. = 1.6%) as well as the excellent sample throughput (45 samples h(-1)). In addition to standard solution analysis, this approach was successfully applied for quantitative determination of morphine in a typical pharmaceutical dosage form. Some aspects of the possible mechanism of morphine action on the BL oscillating chemical system are discussed in detail.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Analytica Chimica Acta",
title = "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique",
volume = "582",
number = "2",
pages = "367-374",
doi = "10.1016/j.aca.2006.09.026"
}

Pejić, N., Blagojević, S., Anić, S., Vukojević, V., Mijatović, M. D., Ćirić, J. S., Marković, Z. S., Marković, S. D.,& Kolar-Anić, L.. (2007). Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta
Elsevier Science BV, Amsterdam., 582(2), 367-374.
https://doi.org/10.1016/j.aca.2006.09.026

Pejić N, Blagojević S, Anić S, Vukojević V, Mijatović MD, Ćirić JS, Marković ZS, Marković SD, Kolar-Anić L. Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique. in Analytica Chimica Acta. 2007;582(2):367-374.
doi:10.1016/j.aca.2006.09.026 .

Pejić, Nataša, Blagojević, Slavica, Anić, Slobodan, Vukojević, Vladana, Mijatović, Miroslav D., Ćirić, Jasna S., Marković, Zoran S., Marković, Svetlana D., Kolar-Anić, Ljiljana, "Kinetic determination of morphine by means of Bray-Liebhafsky oscillatory reaction system using analyte pulse perturbation technique" in Analytica Chimica Acta, 582, no. 2 (2007):367-374,
https://doi.org/10.1016/j.aca.2006.09.026 . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Pejić, Nataša
AU  - Ivković, Branka
AU  - Vujić, Zorica
AU  - Ilić, Katarina
AU  - Micić, Svetlana
AU  - Vukojević, Vladana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/944
AB  - A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase analytical column, the following conditions were chosen as optimal: mobile phase methanol-water 1:1 (v/v), pH 2.8 (adjusted with phosphoric acid), flow rate = 1 mL min(-1) and temperature T = 40.0 degrees C. Linearity was observed in the concentration range 8-120 mu g mL(-1) with a correlation coefficient of 0.99982 and the limit of detection (LOD) = 2.6 mu g mL(-1), and limit of quantification (LOQ) = 8.0 mu g mL(-1). Intra- and inter-day precision were within acceptable limits. Robustness test indicated that the mobile phase composition and pH influence mainly the separation. The proposed method allowed direct determination of rutin in pharmaceutical dosage forms in the presence of excipients, but is not suitable for preparations where compounds structurally/chemically related to rutin may be present.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Isocratic RP-HPLC method for rutin determination in solid oral dosage forms
VL  - 43
IS  - 2
SP  - 718
EP  - 721
DO  - 10.1016/j.jpba.2006.07.019
ER  - 

@article{
author = "Kuntić, Vesna and Pejić, Nataša and Ivković, Branka and Vujić, Zorica and Ilić, Katarina and Micić, Svetlana and Vukojević, Vladana",
year = "2007",
abstract = "A rapid and sensitive assay for quantitative determination of rutin in oral dosage forms based on isocratic reversed phase high performance liquid chromatography (RP-HPLC) was developed and validated. Using a C-18 reverse-phase analytical column, the following conditions were chosen as optimal: mobile phase methanol-water 1:1 (v/v), pH 2.8 (adjusted with phosphoric acid), flow rate = 1 mL min(-1) and temperature T = 40.0 degrees C. Linearity was observed in the concentration range 8-120 mu g mL(-1) with a correlation coefficient of 0.99982 and the limit of detection (LOD) = 2.6 mu g mL(-1), and limit of quantification (LOQ) = 8.0 mu g mL(-1). Intra- and inter-day precision were within acceptable limits. Robustness test indicated that the mobile phase composition and pH influence mainly the separation. The proposed method allowed direct determination of rutin in pharmaceutical dosage forms in the presence of excipients, but is not suitable for preparations where compounds structurally/chemically related to rutin may be present.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Isocratic RP-HPLC method for rutin determination in solid oral dosage forms",
volume = "43",
number = "2",
pages = "718-721",
doi = "10.1016/j.jpba.2006.07.019"
}

Kuntić, V., Pejić, N., Ivković, B., Vujić, Z., Ilić, K., Micić, S.,& Vukojević, V.. (2007). Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 43(2), 718-721.
https://doi.org/10.1016/j.jpba.2006.07.019

Kuntić V, Pejić N, Ivković B, Vujić Z, Ilić K, Micić S, Vukojević V. Isocratic RP-HPLC method for rutin determination in solid oral dosage forms. in Journal of Pharmaceutical and Biomedical Analysis. 2007;43(2):718-721.
doi:10.1016/j.jpba.2006.07.019 .

Kuntić, Vesna, Pejić, Nataša, Ivković, Branka, Vujić, Zorica, Ilić, Katarina, Micić, Svetlana, Vukojević, Vladana, "Isocratic RP-HPLC method for rutin determination in solid oral dosage forms" in Journal of Pharmaceutical and Biomedical Analysis, 43, no. 2 (2007):718-721,
https://doi.org/10.1016/j.jpba.2006.07.019 . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Stanojević, Maja
AU  - Holclajtner-Antunović, Ivanka
AU  - Uskoković-Marković, Snežana
AU  - Mioč, Ubavka B.
AU  - Todorović, Marija R.
AU  - Jovanović, Tanja
AU  - Vukojević, Vladana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/837
AB  - Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.
PB  - Springer Wien, Wien
T2  - Monatshefte für Chemie Chemical Monthly
T1  - Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid
VL  - 137
IS  - 6
SP  - 803
EP  - 810
DO  - 10.1007/s00706-006-0467-3
ER  - 

@article{
author = "Kuntić, Vesna and Stanojević, Maja and Holclajtner-Antunović, Ivanka and Uskoković-Marković, Snežana and Mioč, Ubavka B. and Todorović, Marija R. and Jovanović, Tanja and Vukojević, Vladana",
year = "2006",
abstract = "Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid",
volume = "137",
number = "6",
pages = "803-810",
doi = "10.1007/s00706-006-0467-3"
}

Kuntić, V., Stanojević, M., Holclajtner-Antunović, I., Uskoković-Marković, S., Mioč, U. B., Todorović, M. R., Jovanović, T.,& Vukojević, V.. (2006). Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly
Springer Wien, Wien., 137(6), 803-810.
https://doi.org/10.1007/s00706-006-0467-3

Kuntić V, Stanojević M, Holclajtner-Antunović I, Uskoković-Marković S, Mioč UB, Todorović MR, Jovanović T, Vukojević V. Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid. in Monatshefte für Chemie Chemical Monthly. 2006;137(6):803-810.
doi:10.1007/s00706-006-0467-3 .

Kuntić, Vesna, Stanojević, Maja, Holclajtner-Antunović, Ivanka, Uskoković-Marković, Snežana, Mioč, Ubavka B., Todorović, Marija R., Jovanović, Tanja, Vukojević, Vladana, "Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid" in Monatshefte für Chemie Chemical Monthly, 137, no. 6 (2006):803-810,
https://doi.org/10.1007/s00706-006-0467-3 . .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Blagojević, Slavica
AU  - Anić, Slobodan
AU  - Vukojević, Vladana
AU  - Kolar-Anić, Ljiljana
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/639
AB  - A simple and reliable kinetic method for the determination of hesperidin (Hesp) is developed. It is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system which is in a stable non-equilibrium stationary state close to the bifurcation point. The Bray-Liebhafsky oscillatory reaction is used as the matrix system. The response of the matrix to perturbations by different concentrations of Hesp is followed by using a Pt electrode. A linear relationship between maximal potential shift and the logarithm of Hesp concentrations is obtained between 7.5 and 599.4 mu g mL(-1). The limit of detection is 0.65 mu g mL(-1). The described procedure has been successfully applied to the determination of Hesp from different sources (capsules, industrial and hand-squeezed orange juice, and white wine).
PB  - Springer Heidelberg, Heidelberg
T2  - Analytical and Bioanalytical Chemistry
T1  - Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system
VL  - 381
IS  - 3
SP  - 775
EP  - 780
DO  - 10.1007/s00216-004-2913-6
ER  - 

@article{
author = "Pejić, Nataša and Blagojević, Slavica and Anić, Slobodan and Vukojević, Vladana and Kolar-Anić, Ljiljana",
year = "2005",
abstract = "A simple and reliable kinetic method for the determination of hesperidin (Hesp) is developed. It is based on potentiometric monitoring of the concentration perturbations of the matrix reaction system which is in a stable non-equilibrium stationary state close to the bifurcation point. The Bray-Liebhafsky oscillatory reaction is used as the matrix system. The response of the matrix to perturbations by different concentrations of Hesp is followed by using a Pt electrode. A linear relationship between maximal potential shift and the logarithm of Hesp concentrations is obtained between 7.5 and 599.4 mu g mL(-1). The limit of detection is 0.65 mu g mL(-1). The described procedure has been successfully applied to the determination of Hesp from different sources (capsules, industrial and hand-squeezed orange juice, and white wine).",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Analytical and Bioanalytical Chemistry",
title = "Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system",
volume = "381",
number = "3",
pages = "775-780",
doi = "10.1007/s00216-004-2913-6"
}

Pejić, N., Blagojević, S., Anić, S., Vukojević, V.,& Kolar-Anić, L.. (2005). Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system. in Analytical and Bioanalytical Chemistry
Springer Heidelberg, Heidelberg., 381(3), 775-780.
https://doi.org/10.1007/s00216-004-2913-6

Pejić N, Blagojević S, Anić S, Vukojević V, Kolar-Anić L. Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system. in Analytical and Bioanalytical Chemistry. 2005;381(3):775-780.
doi:10.1007/s00216-004-2913-6 .

Pejić, Nataša, Blagojević, Slavica, Anić, Slobodan, Vukojević, Vladana, Kolar-Anić, Ljiljana, "Microquantitative determination of hesperidin by pulse perturbation of the oscillatory reaction system" in Analytical and Bioanalytical Chemistry, 381, no. 3 (2005):775-780,
https://doi.org/10.1007/s00216-004-2913-6 . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Pejić, Nataša
AU  - Mićić, Svetlana
AU  - Vukojević, Vladana
AU  - Vujić, Zorica
AU  - Malešev, Dušan
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/657
AB  - Asimple, rapid and accurate procedure for the quantitative determination of quercetin in its pure form and in formulations has been developed. The method is based on the spectrophotometric determination of a complex formed between quercetin and potassium titanyloxalate in 50 % ethanolic solutions. To characterize the quercetin titanyloxalato complex, the stability constants of the complex were determinated potentiometrically and spectrophotometrically at different temperatures (T = 26.0oC, 34oC and 39.0oC), as well as at different ionic strengths (I = 5.0x10-4 mol dm-3, 3.0x10-2 mol dm-3 and 6.0x10-2 mol dm-3) and the thermodynamic parameters were calculated. As quercetin is usually conjugated to vitamin C in pharmaceutical formulations, two procedures for the quantitative determination of quercetin by this complexing reaction were tested - both in the absence and presence of ascorbic acid. In both procedures, the Beer law was obeyed over the same concentration range of quercetin, i.e., 0.85 μg mL-1 - 16.9 μg mL-1. In the first procedure in the absence of ascorbic acid the molar absorptivity coefficient of the quercetin-titanyloxalate complex is a=2.49 x 104 mol-1 dm3 cm-1, Sandells sensitivity of the method is S = 1.35 x 10-2 μg cm-2 and the detection limit is d = 0.67 μg mL-1. Whereas, in the presence of ascorbic acid (second procedure) a = 3.04 x 104 mol-1 dm3 cm-1, S = 1.11 x 10-2 μg mL-1. The proposed method was verified for the determination of quercetin in pharmaceutical dosage forms.
AB  - Predložen je brz, jednostavan i tačan metod za određivanje kvercetina u farmaceutskim sirovinama i doziranim oblicima.Metod je baziran na spektrofotometrijskom određivanju kompleksa formiranog između kvercetina i kalijum-titaniloksalata u 50 % etanolu. Određene su konstante stabilnosti kvercetin titaniloksalatnog kompleksa potenciometrijski i spektrofotometrijski na različitim temperaturama (T = 26.0oC, 34oC and 39.0oC) i jonskim jačinama (I = 5.0x10-4 mol dm-3, 3.0x10-2 mol dm-3 and 6.0x10-2 mol dm-3) i izračunati su termodinamički parametri. Kako se kvercetin uobičajeno nalazi zajedno sa vitaminom C u doziranim oblicima, predložene su dve procedure za određivanje kvercetina: bez i u prisustvu askorbinske kiseline.U obe predložene procedure, Beer-ov zakon važi u oblasti 00.85 μg mL-1 - 16.9 μg mL-1 kvercetina. Prema prvoj proceduri, molarni apsorpcioni koeficijent kvercetin–titaniloksalatnog kompleksa je a=2.49 x 104 mol-1 dm3 cm-1, Sandelova osetljivost metode je S = 1.35 x 10-2 μg cm-2, a limit detekcije je d = 0.67 μg mL-1. Prema drugoj proceduri, a = 3.04 x 104 mol-1 dm3 cm-1, S = 1.11 x 10-2 μg mL-1. Predloženi metod je primenjen za određivanje kvercetina u doziranim oblicima.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Determination of quercetin in pharmaceutical formulations via its reaction with potassium-titanyloxalate: Determination of the stability constants of the quercetin-titanyloxalato complex
T1  - Određivanje kvercetina u farmaceutskim preparatima preko reakcije sa kalijum-titaniloksalatom - određivanje konstanti stabilnosti kvercetin-titaniloksalatnog kompleksa
VL  - 70
IS  - 5
SP  - 753
EP  - 763
DO  - 10.2298/JSC0505753K
ER  - 

@article{
author = "Kuntić, Vesna and Pejić, Nataša and Mićić, Svetlana and Vukojević, Vladana and Vujić, Zorica and Malešev, Dušan",
year = "2005",
abstract = "Asimple, rapid and accurate procedure for the quantitative determination of quercetin in its pure form and in formulations has been developed. The method is based on the spectrophotometric determination of a complex formed between quercetin and potassium titanyloxalate in 50 % ethanolic solutions. To characterize the quercetin titanyloxalato complex, the stability constants of the complex were determinated potentiometrically and spectrophotometrically at different temperatures (T = 26.0oC, 34oC and 39.0oC), as well as at different ionic strengths (I = 5.0x10-4 mol dm-3, 3.0x10-2 mol dm-3 and 6.0x10-2 mol dm-3) and the thermodynamic parameters were calculated. As quercetin is usually conjugated to vitamin C in pharmaceutical formulations, two procedures for the quantitative determination of quercetin by this complexing reaction were tested - both in the absence and presence of ascorbic acid. In both procedures, the Beer law was obeyed over the same concentration range of quercetin, i.e., 0.85 μg mL-1 - 16.9 μg mL-1. In the first procedure in the absence of ascorbic acid the molar absorptivity coefficient of the quercetin-titanyloxalate complex is a=2.49 x 104 mol-1 dm3 cm-1, Sandells sensitivity of the method is S = 1.35 x 10-2 μg cm-2 and the detection limit is d = 0.67 μg mL-1. Whereas, in the presence of ascorbic acid (second procedure) a = 3.04 x 104 mol-1 dm3 cm-1, S = 1.11 x 10-2 μg mL-1. The proposed method was verified for the determination of quercetin in pharmaceutical dosage forms., Predložen je brz, jednostavan i tačan metod za određivanje kvercetina u farmaceutskim sirovinama i doziranim oblicima.Metod je baziran na spektrofotometrijskom određivanju kompleksa formiranog između kvercetina i kalijum-titaniloksalata u 50 % etanolu. Određene su konstante stabilnosti kvercetin titaniloksalatnog kompleksa potenciometrijski i spektrofotometrijski na različitim temperaturama (T = 26.0oC, 34oC and 39.0oC) i jonskim jačinama (I = 5.0x10-4 mol dm-3, 3.0x10-2 mol dm-3 and 6.0x10-2 mol dm-3) i izračunati su termodinamički parametri. Kako se kvercetin uobičajeno nalazi zajedno sa vitaminom C u doziranim oblicima, predložene su dve procedure za određivanje kvercetina: bez i u prisustvu askorbinske kiseline.U obe predložene procedure, Beer-ov zakon važi u oblasti 00.85 μg mL-1 - 16.9 μg mL-1 kvercetina. Prema prvoj proceduri, molarni apsorpcioni koeficijent kvercetin–titaniloksalatnog kompleksa je a=2.49 x 104 mol-1 dm3 cm-1, Sandelova osetljivost metode je S = 1.35 x 10-2 μg cm-2, a limit detekcije je d = 0.67 μg mL-1. Prema drugoj proceduri, a = 3.04 x 104 mol-1 dm3 cm-1, S = 1.11 x 10-2 μg mL-1. Predloženi metod je primenjen za određivanje kvercetina u doziranim oblicima.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Determination of quercetin in pharmaceutical formulations via its reaction with potassium-titanyloxalate: Determination of the stability constants of the quercetin-titanyloxalato complex, Određivanje kvercetina u farmaceutskim preparatima preko reakcije sa kalijum-titaniloksalatom - određivanje konstanti stabilnosti kvercetin-titaniloksalatnog kompleksa",
volume = "70",
number = "5",
pages = "753-763",
doi = "10.2298/JSC0505753K"
}

Kuntić, V., Pejić, N., Mićić, S., Vukojević, V., Vujić, Z.,& Malešev, D.. (2005). Determination of quercetin in pharmaceutical formulations via its reaction with potassium-titanyloxalate: Determination of the stability constants of the quercetin-titanyloxalato complex. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 70(5), 753-763.
https://doi.org/10.2298/JSC0505753K

Kuntić V, Pejić N, Mićić S, Vukojević V, Vujić Z, Malešev D. Determination of quercetin in pharmaceutical formulations via its reaction with potassium-titanyloxalate: Determination of the stability constants of the quercetin-titanyloxalato complex. in Journal of the Serbian Chemical Society. 2005;70(5):753-763.
doi:10.2298/JSC0505753K .

Kuntić, Vesna, Pejić, Nataša, Mićić, Svetlana, Vukojević, Vladana, Vujić, Zorica, Malešev, Dušan, "Determination of quercetin in pharmaceutical formulations via its reaction with potassium-titanyloxalate: Determination of the stability constants of the quercetin-titanyloxalato complex" in Journal of the Serbian Chemical Society, 70, no. 5 (2005):753-763,
https://doi.org/10.2298/JSC0505753K . .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Anić, Slobodan
AU  - Kuntić, Vesna
AU  - Vukojević, Vladana
AU  - Kolar-Anić, Ljiljana
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/426
AB  - A kinetic method is described for the microquantitative (microconcentration/microvolume) determination of rutin based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky (BL) oscillatory reaction being in a non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor. The response of the matrix system to perturbations by different concentrations of rutin ethanolic solutions is followed by a Pt-electrode. In the concentration range between 7.8x10(-8) mol dm(-3) and 9.1x10(-6) mol dm(-3), we found a linear dependence of the maximal potential shift, DeltaE(m), on the logarithm of the rutin concentrations. The unknown concentrations can be determined from the calibration curve up to an accuracy of +/-5%. The detection limit is 3.6x10(-8) mol dm(-3). The amount of required sample can be as small as 10 muL.
PB  - Springer-Verlag Wien, Vienna
T2  - Microchimica Acta
T1  - Kinetic determination of microquantities of rutin by perturbation of the Bray-Liebhafsky oscillatory reaction in an open system
VL  - 143
IS  - 4
SP  - 261
EP  - 267
DO  - 10.1007/s00604-003-0071-8
ER  - 

@article{
author = "Pejić, Nataša and Anić, Slobodan and Kuntić, Vesna and Vukojević, Vladana and Kolar-Anić, Ljiljana",
year = "2003",
abstract = "A kinetic method is described for the microquantitative (microconcentration/microvolume) determination of rutin based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky (BL) oscillatory reaction being in a non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor. The response of the matrix system to perturbations by different concentrations of rutin ethanolic solutions is followed by a Pt-electrode. In the concentration range between 7.8x10(-8) mol dm(-3) and 9.1x10(-6) mol dm(-3), we found a linear dependence of the maximal potential shift, DeltaE(m), on the logarithm of the rutin concentrations. The unknown concentrations can be determined from the calibration curve up to an accuracy of +/-5%. The detection limit is 3.6x10(-8) mol dm(-3). The amount of required sample can be as small as 10 muL.",
publisher = "Springer-Verlag Wien, Vienna",
journal = "Microchimica Acta",
title = "Kinetic determination of microquantities of rutin by perturbation of the Bray-Liebhafsky oscillatory reaction in an open system",
volume = "143",
number = "4",
pages = "261-267",
doi = "10.1007/s00604-003-0071-8"
}

Pejić, N., Anić, S., Kuntić, V., Vukojević, V.,& Kolar-Anić, L.. (2003). Kinetic determination of microquantities of rutin by perturbation of the Bray-Liebhafsky oscillatory reaction in an open system. in Microchimica Acta
Springer-Verlag Wien, Vienna., 143(4), 261-267.
https://doi.org/10.1007/s00604-003-0071-8

Pejić N, Anić S, Kuntić V, Vukojević V, Kolar-Anić L. Kinetic determination of microquantities of rutin by perturbation of the Bray-Liebhafsky oscillatory reaction in an open system. in Microchimica Acta. 2003;143(4):261-267.
doi:10.1007/s00604-003-0071-8 .

Pejić, Nataša, Anić, Slobodan, Kuntić, Vesna, Vukojević, Vladana, Kolar-Anić, Ljiljana, "Kinetic determination of microquantities of rutin by perturbation of the Bray-Liebhafsky oscillatory reaction in an open system" in Microchimica Acta, 143, no. 4 (2003):261-267,
https://doi.org/10.1007/s00604-003-0071-8 . .

TY  - JOUR
AU  - Anić, Slobodan
AU  - Kolar-Anić, Ljiljana
AU  - Čupić, Željko
AU  - Pejić, Nataša
AU  - Vukojević, Vladana
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/307
AB  - The main kinetic characteristics of a catalyst could be obtained by examination of its behavior in some known reaction system, so-called model reaction system. The model reaction system is usually chosen to be as simple as possible. Therefore, for this purpose, the first or second order reaction with relatively simple mechanism and with only one reaction pathway is often selected. However, for the model reaction system one oscillatory chemical reaction, having the complex mechanism with the alternating reaction pathways, could be chosen. It can be expressed over the state far from equilibrium and the variety of kinetic characteristics, resulting from the properties of examined catalyst, can be found. The special attention is paid on Bray-Liebhafsky oscillatory chemical reaction, as well as on the comparative analysis of the iron based catalysts, whereby iron could be used either as peroxydazirene or supported on acidic polyvinylpyridine. .
AB  - Glavne kinetičke karakteristike katalizatora dobijaju se ispitivanjem njegovog ponašanja u nekom poznatom reakcionom sistemu, takozvanom modelnom reakcionom sistemu. Za modelni reakcioni sistem obično se bira što je moguće jednostavniji. Zbog toga se, u tu svrhu, najčešće koristi neka reakcija prvog ili drugog reda sa definisanim i jednostavnim mehanizmom i jasnom stehiometrijom ukupne reakcije, kao i samo jednim reakcionim putem. Međutim, za modelnu reakciju može se izabrati i neka složena hemijska reakcija, na primer, neka od oscilatornih hemijskih reakcija sa nizom alternativnih reakcionih puteva, a koji se ispoljavaju u nekim od njenih stanja daleko od ravnoteže. Kao takva, veoma je osetljiva na uvođenje katalizatora čija svojstva želimo ispitati. Ovom prilikom pažnja je posvećena modelnoj Bray-Liebhafsky (BL) oscilatornoj reakciji i uporednoj analizi katalizatora na bazi gvožda bilo da je u pitanju gvožđe u peroksidazi rena ili ono naneto na kiseli polivinilpiridin. .
PB  - Društvo inženjera plastičara i gumara, Beograd
T2  - Svet polimera
T1  - Oscillatory chemical reaction as model system for the catalysts characterization
T1  - Oscilatorna hemijska reakcija kao modelni sistem za karakterizaciju katalizatora
VL  - 4
IS  - 2
SP  - 55
EP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_cer_41
ER  - 

@article{
author = "Anić, Slobodan and Kolar-Anić, Ljiljana and Čupić, Željko and Pejić, Nataša and Vukojević, Vladana",
year = "2001",
abstract = "The main kinetic characteristics of a catalyst could be obtained by examination of its behavior in some known reaction system, so-called model reaction system. The model reaction system is usually chosen to be as simple as possible. Therefore, for this purpose, the first or second order reaction with relatively simple mechanism and with only one reaction pathway is often selected. However, for the model reaction system one oscillatory chemical reaction, having the complex mechanism with the alternating reaction pathways, could be chosen. It can be expressed over the state far from equilibrium and the variety of kinetic characteristics, resulting from the properties of examined catalyst, can be found. The special attention is paid on Bray-Liebhafsky oscillatory chemical reaction, as well as on the comparative analysis of the iron based catalysts, whereby iron could be used either as peroxydazirene or supported on acidic polyvinylpyridine. ., Glavne kinetičke karakteristike katalizatora dobijaju se ispitivanjem njegovog ponašanja u nekom poznatom reakcionom sistemu, takozvanom modelnom reakcionom sistemu. Za modelni reakcioni sistem obično se bira što je moguće jednostavniji. Zbog toga se, u tu svrhu, najčešće koristi neka reakcija prvog ili drugog reda sa definisanim i jednostavnim mehanizmom i jasnom stehiometrijom ukupne reakcije, kao i samo jednim reakcionim putem. Međutim, za modelnu reakciju može se izabrati i neka složena hemijska reakcija, na primer, neka od oscilatornih hemijskih reakcija sa nizom alternativnih reakcionih puteva, a koji se ispoljavaju u nekim od njenih stanja daleko od ravnoteže. Kao takva, veoma je osetljiva na uvođenje katalizatora čija svojstva želimo ispitati. Ovom prilikom pažnja je posvećena modelnoj Bray-Liebhafsky (BL) oscilatornoj reakciji i uporednoj analizi katalizatora na bazi gvožda bilo da je u pitanju gvožđe u peroksidazi rena ili ono naneto na kiseli polivinilpiridin. .",
publisher = "Društvo inženjera plastičara i gumara, Beograd",
journal = "Svet polimera",
title = "Oscillatory chemical reaction as model system for the catalysts characterization, Oscilatorna hemijska reakcija kao modelni sistem za karakterizaciju katalizatora",
volume = "4",
number = "2",
pages = "55-66",
url = "https://hdl.handle.net/21.15107/rcub_cer_41"
}

Anić, S., Kolar-Anić, L., Čupić, Ž., Pejić, N.,& Vukojević, V.. (2001). Oscillatory chemical reaction as model system for the catalysts characterization. in Svet polimera
Društvo inženjera plastičara i gumara, Beograd., 4(2), 55-66.
https://hdl.handle.net/21.15107/rcub_cer_41

Anić S, Kolar-Anić L, Čupić Ž, Pejić N, Vukojević V. Oscillatory chemical reaction as model system for the catalysts characterization. in Svet polimera. 2001;4(2):55-66.
https://hdl.handle.net/21.15107/rcub_cer_41 .

Anić, Slobodan, Kolar-Anić, Ljiljana, Čupić, Željko, Pejić, Nataša, Vukojević, Vladana, "Oscillatory chemical reaction as model system for the catalysts characterization" in Svet polimera, 4, no. 2 (2001):55-66,
https://hdl.handle.net/21.15107/rcub_cer_41 .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Čupić, Željko
AU  - Anić, Slobodan
AU  - Vukojević, Vladana
AU  - Kolar-Anić, Ljiljana
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/301
AB  - The Bray-Liebhafsky (BL) oscillatory reaction, as a reaction where hydrogen peroxide decomposes into the water and oxygen in the presence of iodate and hydrogen ions through a complex mechanism involving a number of intermediates, such as I-, I2, HIO and HIO2, was used as the matrix for analysis of kinetic properties of the catalysts for hydrogen peroxide decomposition. The examined catalysts were enzyme peroxidase (isolated from the horseradish root) and polymeric catalyst (acid form of poly-4-vynil-pyridine functionalized by fericsulfate). The change of kinetic state of the system caused by the presence of added catalyst is reflected in the form of oscillograms, in the time elapsed from the beginning of the reaction to the first oscillation, in the time elapsed from the beginning of the reaction to the end of oscillatory evolution, the number of oscillations, the average period between oscillations and its frequency. Since all these kinetic properties depend on the added amounts of both mentioned catalysts in a complex but analogous manner, a similar reaction mechanism could be expected in both cases.
AB  - Braj-Liebhafski (BL) oscilatorna reakcija, kao reakcija u kojoj se vodonik-peroksid, u prisustvu jodata i vodoničnih jona, razlaže na vodu i kiseonik, po kompleksnom mehanizmu koji uključuje nastanak brojnih intermedijera kao što su I-, I2, HIO i HIO2 je korišćena kao matrica za analizu kinetičkih osobina katalizatora za razlaganje vodonik-peroksida. Ispitivani katalizatori su peroksidaza izolovana iz korena rena i sintetički polimer (kiseli oblik poli-4-vinil-piridina funkcionalizovanog sa ferisulfatom). Promene kinetičkog stanja sistema izazvane prisustvom dodatih količina katalizatora se reflektuju na formu oscilograma, na vreme proteklo od početka reakcije do pojave prve oscilacije, na vreme proteklo od početka reakcije do kraja oscilatorne evolucije, broj oscilacija, srednjeg perioda oscilovanja i njihovu frekvenciju. Kako sva ova kinetička svojstva zavise od dodatih količina katalizatora na kompleksan ali analogan način, sličan reakcioni mehanizam se može očekivati u oba slučaja.
PB  - Međunarodni Institut za nauku o sinterovanju, Beograd
T2  - Science of Sintering
T1  - The oscillatory Bray-Liebhafsky reaction as a matrix for analyzing enzyme and polymeric catalysts for hydrogen peroxide
VL  - 33
IS  - 2
SP  - 107
EP  - 115
UR  - https://hdl.handle.net/21.15107/rcub_farfar_301
ER  - 

@article{
author = "Pejić, Nataša and Čupić, Željko and Anić, Slobodan and Vukojević, Vladana and Kolar-Anić, Ljiljana",
year = "2001",
abstract = "The Bray-Liebhafsky (BL) oscillatory reaction, as a reaction where hydrogen peroxide decomposes into the water and oxygen in the presence of iodate and hydrogen ions through a complex mechanism involving a number of intermediates, such as I-, I2, HIO and HIO2, was used as the matrix for analysis of kinetic properties of the catalysts for hydrogen peroxide decomposition. The examined catalysts were enzyme peroxidase (isolated from the horseradish root) and polymeric catalyst (acid form of poly-4-vynil-pyridine functionalized by fericsulfate). The change of kinetic state of the system caused by the presence of added catalyst is reflected in the form of oscillograms, in the time elapsed from the beginning of the reaction to the first oscillation, in the time elapsed from the beginning of the reaction to the end of oscillatory evolution, the number of oscillations, the average period between oscillations and its frequency. Since all these kinetic properties depend on the added amounts of both mentioned catalysts in a complex but analogous manner, a similar reaction mechanism could be expected in both cases., Braj-Liebhafski (BL) oscilatorna reakcija, kao reakcija u kojoj se vodonik-peroksid, u prisustvu jodata i vodoničnih jona, razlaže na vodu i kiseonik, po kompleksnom mehanizmu koji uključuje nastanak brojnih intermedijera kao što su I-, I2, HIO i HIO2 je korišćena kao matrica za analizu kinetičkih osobina katalizatora za razlaganje vodonik-peroksida. Ispitivani katalizatori su peroksidaza izolovana iz korena rena i sintetički polimer (kiseli oblik poli-4-vinil-piridina funkcionalizovanog sa ferisulfatom). Promene kinetičkog stanja sistema izazvane prisustvom dodatih količina katalizatora se reflektuju na formu oscilograma, na vreme proteklo od početka reakcije do pojave prve oscilacije, na vreme proteklo od početka reakcije do kraja oscilatorne evolucije, broj oscilacija, srednjeg perioda oscilovanja i njihovu frekvenciju. Kako sva ova kinetička svojstva zavise od dodatih količina katalizatora na kompleksan ali analogan način, sličan reakcioni mehanizam se može očekivati u oba slučaja.",
publisher = "Međunarodni Institut za nauku o sinterovanju, Beograd",
journal = "Science of Sintering",
title = "The oscillatory Bray-Liebhafsky reaction as a matrix for analyzing enzyme and polymeric catalysts for hydrogen peroxide",
volume = "33",
number = "2",
pages = "107-115",
url = "https://hdl.handle.net/21.15107/rcub_farfar_301"
}

Pejić, N., Čupić, Ž., Anić, S., Vukojević, V.,& Kolar-Anić, L.. (2001). The oscillatory Bray-Liebhafsky reaction as a matrix for analyzing enzyme and polymeric catalysts for hydrogen peroxide. in Science of Sintering
Međunarodni Institut za nauku o sinterovanju, Beograd., 33(2), 107-115.
https://hdl.handle.net/21.15107/rcub_farfar_301

Pejić N, Čupić Ž, Anić S, Vukojević V, Kolar-Anić L. The oscillatory Bray-Liebhafsky reaction as a matrix for analyzing enzyme and polymeric catalysts for hydrogen peroxide. in Science of Sintering. 2001;33(2):107-115.
https://hdl.handle.net/21.15107/rcub_farfar_301 .

Pejić, Nataša, Čupić, Željko, Anić, Slobodan, Vukojević, Vladana, Kolar-Anić, Ljiljana, "The oscillatory Bray-Liebhafsky reaction as a matrix for analyzing enzyme and polymeric catalysts for hydrogen peroxide" in Science of Sintering, 33, no. 2 (2001):107-115,
https://hdl.handle.net/21.15107/rcub_farfar_301 .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Malešev, Dušan
AU  - Radović, Z
AU  - Vukojević, Vladana
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/233
AB  - In the present work, rutin (3,3',4',5,7-pentahydrohyflavone-3-rhamnoglucoside) was determinated via a complexing reaction with a titanyloxalate anion. K-2[TiO(C2O4)(2)] and rutin react in 50% ethanol forming a 1:2 complex in a pH range from 4.00 to 11.50, in which the TiO(C2O4)(2)(2-) ion is linked to rutin through the 4-carbonyl and 5-hydroxyl group. The thermodynamic stability constant log beta(2)(0) of the complex is determined to 10.80 at pH = 6.50. The change of the standard Gibbs free energy Delta G(0) amounts to -61 kJ . mol(-1), indicating that the process of complex formation is spontaneous. The optimal conditions for the spectrophotometric determination of microconcentrations of rutin are at pH = 6.40 and lambda = 430 nm, where the complex shows an absorption maximum with a molar absorption coefficient a(430) = (60+/-2) . 10(3) dm(3) . mol(-1) . cm(-1). The method is applied rutin determination from tablets.
PB  - Springer-Verlag Wien, Vienna
T2  - Monatshefte für Chemie Chemical Monthly
T1  - Spectrophotometric investigation of the complexing reaction between rutin and titanyloxalate anion in 50% ethanol
VL  - 131
IS  - 7
SP  - 769
EP  - 777
DO  - 10.1007/s007060050024
ER  - 

@article{
author = "Kuntić, Vesna and Malešev, Dušan and Radović, Z and Vukojević, Vladana",
year = "2000",
abstract = "In the present work, rutin (3,3',4',5,7-pentahydrohyflavone-3-rhamnoglucoside) was determinated via a complexing reaction with a titanyloxalate anion. K-2[TiO(C2O4)(2)] and rutin react in 50% ethanol forming a 1:2 complex in a pH range from 4.00 to 11.50, in which the TiO(C2O4)(2)(2-) ion is linked to rutin through the 4-carbonyl and 5-hydroxyl group. The thermodynamic stability constant log beta(2)(0) of the complex is determined to 10.80 at pH = 6.50. The change of the standard Gibbs free energy Delta G(0) amounts to -61 kJ . mol(-1), indicating that the process of complex formation is spontaneous. The optimal conditions for the spectrophotometric determination of microconcentrations of rutin are at pH = 6.40 and lambda = 430 nm, where the complex shows an absorption maximum with a molar absorption coefficient a(430) = (60+/-2) . 10(3) dm(3) . mol(-1) . cm(-1). The method is applied rutin determination from tablets.",
publisher = "Springer-Verlag Wien, Vienna",
journal = "Monatshefte für Chemie Chemical Monthly",
title = "Spectrophotometric investigation of the complexing reaction between rutin and titanyloxalate anion in 50% ethanol",
volume = "131",
number = "7",
pages = "769-777",
doi = "10.1007/s007060050024"
}

Kuntić, V., Malešev, D., Radović, Z.,& Vukojević, V.. (2000). Spectrophotometric investigation of the complexing reaction between rutin and titanyloxalate anion in 50% ethanol. in Monatshefte für Chemie Chemical Monthly
Springer-Verlag Wien, Vienna., 131(7), 769-777.
https://doi.org/10.1007/s007060050024

Kuntić V, Malešev D, Radović Z, Vukojević V. Spectrophotometric investigation of the complexing reaction between rutin and titanyloxalate anion in 50% ethanol. in Monatshefte für Chemie Chemical Monthly. 2000;131(7):769-777.
doi:10.1007/s007060050024 .

Kuntić, Vesna, Malešev, Dušan, Radović, Z, Vukojević, Vladana, "Spectrophotometric investigation of the complexing reaction between rutin and titanyloxalate anion in 50% ethanol" in Monatshefte für Chemie Chemical Monthly, 131, no. 7 (2000):769-777,
https://doi.org/10.1007/s007060050024 . .

TY  - JOUR
AU  - Kuntić, Vesna
AU  - Malešev, Dušan
AU  - Radović, ZV
AU  - Kosanić, MM
AU  - Mioč, Ubavka B.
AU  - Vukojević, Vladana
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/189
AB  - The composition and stability constant of a UO2(II)-rutin complex in 70% ethanol were determined by suitable spectrophotometric methods and pH measurement. UO2(II) ion and rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) form a 1:1 complex in which the UO2(II) ion is linked to rutin through the carbonyl and 5-hydroxyl group. The concentration stability constant of the complex, log beta(1), ranged from 6.57 at pH 4.00 to 4.72 at pH 7.00. Conditions for spectrophotometric determination of rutin, by complex formation with UO2(II) ion, were investigated. Beer's law was obeyed in the concentration range from 1.0 x 10(-5) to 2.0 x 10(-4) M for rutin. Determination of rutin in Rutinion forte tablets was demonstrated.
PB  - Amer Chemical Soc, Washington
T2  - Journal of Agricultural and Food Chemistry
T1  - Spectrophotometric investigation of uranil(II)-rutin complex in 70% ethanol
VL  - 46
IS  - 12
SP  - 5139
EP  - 5142
DO  - 10.1021/jf980376k
ER  - 

@article{
author = "Kuntić, Vesna and Malešev, Dušan and Radović, ZV and Kosanić, MM and Mioč, Ubavka B. and Vukojević, Vladana",
year = "1998",
abstract = "The composition and stability constant of a UO2(II)-rutin complex in 70% ethanol were determined by suitable spectrophotometric methods and pH measurement. UO2(II) ion and rutin (3,3',4',5,7-pentahydroxyflavone-3-rhamnoglucoside) form a 1:1 complex in which the UO2(II) ion is linked to rutin through the carbonyl and 5-hydroxyl group. The concentration stability constant of the complex, log beta(1), ranged from 6.57 at pH 4.00 to 4.72 at pH 7.00. Conditions for spectrophotometric determination of rutin, by complex formation with UO2(II) ion, were investigated. Beer's law was obeyed in the concentration range from 1.0 x 10(-5) to 2.0 x 10(-4) M for rutin. Determination of rutin in Rutinion forte tablets was demonstrated.",
publisher = "Amer Chemical Soc, Washington",
journal = "Journal of Agricultural and Food Chemistry",
title = "Spectrophotometric investigation of uranil(II)-rutin complex in 70% ethanol",
volume = "46",
number = "12",
pages = "5139-5142",
doi = "10.1021/jf980376k"
}

Kuntić, V., Malešev, D., Radović, Z., Kosanić, M., Mioč, U. B.,& Vukojević, V.. (1998). Spectrophotometric investigation of uranil(II)-rutin complex in 70% ethanol. in Journal of Agricultural and Food Chemistry
Amer Chemical Soc, Washington., 46(12), 5139-5142.
https://doi.org/10.1021/jf980376k

Kuntić V, Malešev D, Radović Z, Kosanić M, Mioč UB, Vukojević V. Spectrophotometric investigation of uranil(II)-rutin complex in 70% ethanol. in Journal of Agricultural and Food Chemistry. 1998;46(12):5139-5142.
doi:10.1021/jf980376k .

Kuntić, Vesna, Malešev, Dušan, Radović, ZV, Kosanić, MM, Mioč, Ubavka B., Vukojević, Vladana, "Spectrophotometric investigation of uranil(II)-rutin complex in 70% ethanol" in Journal of Agricultural and Food Chemistry, 46, no. 12 (1998):5139-5142,
https://doi.org/10.1021/jf980376k . .