TY  - JOUR
AU  - Suručić, Relja V.
AU  - Kundaković, Tatjana
AU  - Lakušić, Branislava
AU  - Drakul, Dragana
AU  - Milovanović, Slobodan R.
AU  - Kovačević, Nada
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3027
AB  - The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)
VL  - 14
IS  - 5
DO  - 10.1002/cbdv.201600407
ER  - 

@article{
author = "Suručić, Relja V. and Kundaković, Tatjana and Lakušić, Branislava and Drakul, Dragana and Milovanović, Slobodan R. and Kovačević, Nada",
year = "2017",
abstract = "The present paper describes environmental and seasonal-related chemical composition variations, vasorelaxant and angiotensin I-converting enzyme (ACE) activities of essential oil from aerial parts of Seseli pallasii BESSER. The composition was analyzed by GC and GC/MS. Monoterpenes were found to be the most abundant chemical class with alpha-pinene (42.7 - 48.2%) as the most prevalent component. Seseli pallasi essential oil relaxed isolated endothelium-intact mesenteric arteries rings precontracted with phenylephrine with IC50 = 3.10 nl/ml (IC50 = 2.70 mu g/ml). Also, S. pallasii essential oil was found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 0.33 mg/ml. In silico evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of -7.5 kcal/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed S. pallasii essential oil might have the potential therapeutic significance in hypertension.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)",
volume = "14",
number = "5",
doi = "10.1002/cbdv.201600407"
}

Suručić, R. V., Kundaković, T., Lakušić, B., Drakul, D., Milovanović, S. R.,& Kovačević, N.. (2017). Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae). in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 14(5).
https://doi.org/10.1002/cbdv.201600407

Suručić RV, Kundaković T, Lakušić B, Drakul D, Milovanović SR, Kovačević N. Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae). in Chemistry & Biodiversity. 2017;14(5).
doi:10.1002/cbdv.201600407 .

Suručić, Relja V., Kundaković, Tatjana, Lakušić, Branislava, Drakul, Dragana, Milovanović, Slobodan R., Kovačević, Nada, "Variations in Chemical Composition, Vasorelaxant and Angiotensin I-Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of Seseli pallasii Besser (Apiaceae)" in Chemistry & Biodiversity, 14, no. 5 (2017),
https://doi.org/10.1002/cbdv.201600407 . .