TY  - JOUR
AU  - Prekrat, Dragan
AU  - Todorović-Vasović, Kristina Neli
AU  - Vasović, Nebojša
AU  - Kostić, Srđan
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5561
AB  - In the present paper, we investigate the effect of the initial conditions on the dynamics of the spring-block landslide model. The time evolution of the studied model, which is governed by a system of stochastic delay differential equations, is analyzed in the mean-field approximation, which qualitatively exhibits the same dynamics as the initial model. The results of the numerical analysis show that changing the initial conditions has different effects in different parts of the parameter space of the model. Namely, moving away from the fixed-point initial conditions has a stabilizing effect on the dynamics when the noise, the friction parameters a (higher values) and c as well as the spring stiffness k are taken into account. The stabilization manifests itself in a complete suppression of the unstable dynamics or a partial limitation of the effect of some friction parameters. On the other hand, the destabilizing effect of changing the initial conditions occurs for the lower values of the friction parameters a and for b. The main feature of destabilization is the complete suppression of the sliding regime or a larger parameter range with a transient oscillatory regime. Our approach underlines the importance of analyzing the influence of initial conditions on landslide dynamics.
PB  - Frontiers Media
T2  - Frontiers in Earth Science
T1  - Complex global dynamics of conditionally stable slopes: effect of initial conditions
VL  - 12
DO  - 10.3389/feart.2024.1374942
ER  - 

@article{
author = "Prekrat, Dragan and Todorović-Vasović, Kristina Neli and Vasović, Nebojša and Kostić, Srđan",
year = "2024",
abstract = "In the present paper, we investigate the effect of the initial conditions on the dynamics of the spring-block landslide model. The time evolution of the studied model, which is governed by a system of stochastic delay differential equations, is analyzed in the mean-field approximation, which qualitatively exhibits the same dynamics as the initial model. The results of the numerical analysis show that changing the initial conditions has different effects in different parts of the parameter space of the model. Namely, moving away from the fixed-point initial conditions has a stabilizing effect on the dynamics when the noise, the friction parameters a (higher values) and c as well as the spring stiffness k are taken into account. The stabilization manifests itself in a complete suppression of the unstable dynamics or a partial limitation of the effect of some friction parameters. On the other hand, the destabilizing effect of changing the initial conditions occurs for the lower values of the friction parameters a and for b. The main feature of destabilization is the complete suppression of the sliding regime or a larger parameter range with a transient oscillatory regime. Our approach underlines the importance of analyzing the influence of initial conditions on landslide dynamics.",
publisher = "Frontiers Media",
journal = "Frontiers in Earth Science",
title = "Complex global dynamics of conditionally stable slopes: effect of initial conditions",
volume = "12",
doi = "10.3389/feart.2024.1374942"
}

Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12.
https://doi.org/10.3389/feart.2024.1374942

Prekrat D, Todorović-Vasović KN, Vasović N, Kostić S. Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science. 2024;12.
doi:10.3389/feart.2024.1374942 .

Prekrat, Dragan, Todorović-Vasović, Kristina Neli, Vasović, Nebojša, Kostić, Srđan, "Complex global dynamics of conditionally stable slopes: effect of initial conditions" in Frontiers in Earth Science, 12 (2024),
https://doi.org/10.3389/feart.2024.1374942 . .

TY  - DATA
AU  - Prekrat, Dragan
AU  - Todorović-Vasović, Kristina Neli
AU  - Vasović, Nebojša
AU  - Kostić, Srđan
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5562
AB  - In the present paper, we investigate the effect of the initial conditions on the dynamics of the spring-block landslide model. The time evolution of the studied model, which is governed by a system of stochastic delay differential equations, is analyzed in the mean-field approximation, which qualitatively exhibits the same dynamics as the initial model. The results of the numerical analysis show that changing the initial conditions has different effects in different parts of the parameter space of the model. Namely, moving away from the fixed-point initial conditions has a stabilizing effect on the dynamics when the noise, the friction parameters a (higher values) and c as well as the spring stiffness k are taken into account. The stabilization manifests itself in a complete suppression of the unstable dynamics or a partial limitation of the effect of some friction parameters. On the other hand, the destabilizing effect of changing the initial conditions occurs for the lower values of the friction parameters a and for b. The main feature of destabilization is the complete suppression of the sliding regime or a larger parameter range with a transient oscillatory regime. Our approach underlines the importance of analyzing the influence of initial conditions on landslide dynamics.
PB  - Frontiers Media
T2  - Frontiers in Earth Science
T1  - Supplementary material for: Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12 - 2024 https://doi.org/10.3389/feart.2024.1374942
VL  - 12
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5562
ER  - 

@misc{
author = "Prekrat, Dragan and Todorović-Vasović, Kristina Neli and Vasović, Nebojša and Kostić, Srđan",
year = "2024",
abstract = "In the present paper, we investigate the effect of the initial conditions on the dynamics of the spring-block landslide model. The time evolution of the studied model, which is governed by a system of stochastic delay differential equations, is analyzed in the mean-field approximation, which qualitatively exhibits the same dynamics as the initial model. The results of the numerical analysis show that changing the initial conditions has different effects in different parts of the parameter space of the model. Namely, moving away from the fixed-point initial conditions has a stabilizing effect on the dynamics when the noise, the friction parameters a (higher values) and c as well as the spring stiffness k are taken into account. The stabilization manifests itself in a complete suppression of the unstable dynamics or a partial limitation of the effect of some friction parameters. On the other hand, the destabilizing effect of changing the initial conditions occurs for the lower values of the friction parameters a and for b. The main feature of destabilization is the complete suppression of the sliding regime or a larger parameter range with a transient oscillatory regime. Our approach underlines the importance of analyzing the influence of initial conditions on landslide dynamics.",
publisher = "Frontiers Media",
journal = "Frontiers in Earth Science",
title = "Supplementary material for: Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12 - 2024 https://doi.org/10.3389/feart.2024.1374942",
volume = "12",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5562"
}

Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Supplementary material for: Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12 - 2024 https://doi.org/10.3389/feart.2024.1374942. in Frontiers in Earth Science
Frontiers Media., 12.
https://hdl.handle.net/21.15107/rcub_farfar_5562

Prekrat D, Todorović-Vasović KN, Vasović N, Kostić S. Supplementary material for: Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12 - 2024 https://doi.org/10.3389/feart.2024.1374942. in Frontiers in Earth Science. 2024;12.
https://hdl.handle.net/21.15107/rcub_farfar_5562 .

Prekrat, Dragan, Todorović-Vasović, Kristina Neli, Vasović, Nebojša, Kostić, Srđan, "Supplementary material for: Prekrat, D., Todorović-Vasović, K. N., Vasović, N.,& Kostić, S.. (2024). Complex global dynamics of conditionally stable slopes: effect of initial conditions. in Frontiers in Earth Science
Frontiers Media., 12 - 2024 https://doi.org/10.3389/feart.2024.1374942" in Frontiers in Earth Science, 12 (2024),
https://hdl.handle.net/21.15107/rcub_farfar_5562 .

TY  - JOUR
AU  - Kulizić, Mihajlo
AU  - Stanković, Milan
AU  - Rašić, Marija
AU  - Mijatović, Aleksandar
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5406
AB  - In this paper, a simple, sensitive, and precise flow injection system was optimized and applied to ascorbic acid determination with a carbon paste electrode modified with the Schiff base copper complex. The modified sensor showed increased sensitivity toward ascorbic acid oxidation with a decrease of oxidation potential by 200 mV. Under optimized flow parameters, working potential, gasket thickness, sample and reaction coil volumes, and flow rate, the developed flow system gave a linear response from 5 to 75 μmol/L of ascorbic acid. The calculated limit of detection was 4.5 μmol/L, calculated as 3σ/s which corresponds to the absolute value of 40 ng for the 50 μL sample coil. The precision for six consecutive injections of 5 and 75 μmol/L ascorbic acid solutions was determined as a relative standard deviation of 5.8 % and 1.5 %, respectively. The flow injection system enabled up to 120 analyses per hour. An optimized flow system was applied to the determination of ascorbic acid in dietary supplements, after simple preparation.
PB  - John Wiley and Sons Inc
T2  - ChemistrySelect
T1  - A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode
VL  - 8
IS  - 48
DO  - 10.1002/slct.202304631
ER  - 

@article{
author = "Kulizić, Mihajlo and Stanković, Milan and Rašić, Marija and Mijatović, Aleksandar and Baošić, Rada and Lolić, Aleksandar",
year = "2023",
abstract = "In this paper, a simple, sensitive, and precise flow injection system was optimized and applied to ascorbic acid determination with a carbon paste electrode modified with the Schiff base copper complex. The modified sensor showed increased sensitivity toward ascorbic acid oxidation with a decrease of oxidation potential by 200 mV. Under optimized flow parameters, working potential, gasket thickness, sample and reaction coil volumes, and flow rate, the developed flow system gave a linear response from 5 to 75 μmol/L of ascorbic acid. The calculated limit of detection was 4.5 μmol/L, calculated as 3σ/s which corresponds to the absolute value of 40 ng for the 50 μL sample coil. The precision for six consecutive injections of 5 and 75 μmol/L ascorbic acid solutions was determined as a relative standard deviation of 5.8 % and 1.5 %, respectively. The flow injection system enabled up to 120 analyses per hour. An optimized flow system was applied to the determination of ascorbic acid in dietary supplements, after simple preparation.",
publisher = "John Wiley and Sons Inc",
journal = "ChemistrySelect",
title = "A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode",
volume = "8",
number = "48",
doi = "10.1002/slct.202304631"
}

Kulizić, M., Stanković, M., Rašić, M., Mijatović, A., Baošić, R.,& Lolić, A.. (2023). A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode. in ChemistrySelect
John Wiley and Sons Inc., 8(48).
https://doi.org/10.1002/slct.202304631

Kulizić M, Stanković M, Rašić M, Mijatović A, Baošić R, Lolić A. A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode. in ChemistrySelect. 2023;8(48).
doi:10.1002/slct.202304631 .

Kulizić, Mihajlo, Stanković, Milan, Rašić, Marija, Mijatović, Aleksandar, Baošić, Rada, Lolić, Aleksandar, "A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid Using Carbon Paste/Copper Schiff Base Composite Electrode" in ChemistrySelect, 8, no. 48 (2023),
https://doi.org/10.1002/slct.202304631 . .

TY  - JOUR
AU  - Mitrović, Jelena
AU  - Divović-Matović, Branka
AU  - Knutson, Daniel
AU  - Đoković, Jelena
AU  - Kremenović, Aleksandar
AU  - Dobričić, Vladimir
AU  - Ranđelović, Danijela
AU  - Pantelić, Ivana
AU  - Cook, James
AU  - Savić, Miroslav
AU  - Savić, Snežana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3934
AB  - Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric disorders. In this research, based on preformulation studies, nanocrystal technology was chosen to improve the oral bioavailability of DK-I-60-3. Nanocrystal dispersions stabilized by sodium lauryl sulfate and polyvinylpyrrolidone were prepared by modified wet media milling technique, with the selection of appropriate process and formulation parameters. The nanoparticles characterization included particle size and zeta potential measurements, differential scanning calorimetry, X-ray powder diffraction, dissolution and solubility study, and in vivo pharmacokinetic experiments. Developed formulations had small uniform particle sizes and were stable for three months. Nanonization caused decreased crystallite size and induced crystal defects formation, as well as a DK-I-60-3 solubility increase. Furthermore, after oral administration of the developed formulations in rats, two to three-fold bioavailability enhancement was observed in plasma and investigated organs, including the brain.
PB  - MDPI AG
T2  - Pharmaceutics
T1  - Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach
VL  - 13
IS  - 8
DO  - 10.3390/pharmaceutics13081188
ER  - 

@article{
author = "Mitrović, Jelena and Divović-Matović, Branka and Knutson, Daniel and Đoković, Jelena and Kremenović, Aleksandar and Dobričić, Vladimir and Ranđelović, Danijela and Pantelić, Ivana and Cook, James and Savić, Miroslav and Savić, Snežana",
year = "2021",
abstract = "Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical properties of the drug and introduced in the early stages of drug research. One example of the new potential drug substance with poor solubility is DK-I-60-3, deuterated pyrazoloquinolinone, designed for the treatment of various neuropsychiatric disorders. In this research, based on preformulation studies, nanocrystal technology was chosen to improve the oral bioavailability of DK-I-60-3. Nanocrystal dispersions stabilized by sodium lauryl sulfate and polyvinylpyrrolidone were prepared by modified wet media milling technique, with the selection of appropriate process and formulation parameters. The nanoparticles characterization included particle size and zeta potential measurements, differential scanning calorimetry, X-ray powder diffraction, dissolution and solubility study, and in vivo pharmacokinetic experiments. Developed formulations had small uniform particle sizes and were stable for three months. Nanonization caused decreased crystallite size and induced crystal defects formation, as well as a DK-I-60-3 solubility increase. Furthermore, after oral administration of the developed formulations in rats, two to three-fold bioavailability enhancement was observed in plasma and investigated organs, including the brain.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach",
volume = "13",
number = "8",
doi = "10.3390/pharmaceutics13081188"
}

Mitrović, J., Divović-Matović, B., Knutson, D., Đoković, J., Kremenović, A., Dobričić, V., Ranđelović, D., Pantelić, I., Cook, J., Savić, M.,& Savić, S.. (2021). Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach. in Pharmaceutics
MDPI AG., 13(8).
https://doi.org/10.3390/pharmaceutics13081188

Mitrović J, Divović-Matović B, Knutson D, Đoković J, Kremenović A, Dobričić V, Ranđelović D, Pantelić I, Cook J, Savić M, Savić S. Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach. in Pharmaceutics. 2021;13(8).
doi:10.3390/pharmaceutics13081188 .

Mitrović, Jelena, Divović-Matović, Branka, Knutson, Daniel, Đoković, Jelena, Kremenović, Aleksandar, Dobričić, Vladimir, Ranđelović, Danijela, Pantelić, Ivana, Cook, James, Savić, Miroslav, Savić, Snežana, "Overcoming the low oral bioavailability of deuterated pyrazoloquinolinone ligand dk-i-60-3 by nanonization: A knowledge-based approach" in Pharmaceutics, 13, no. 8 (2021),
https://doi.org/10.3390/pharmaceutics13081188 . .