TY  - JOUR
AU  - Peruničić-Peković, Gordana
AU  - Rasić, Zorica
AU  - Plješa, Steva
AU  - Šobajić, Slađana
AU  - Đuričić, Ivana
AU  - Maletić, Radojka
AU  - Ristić-Medić, Danijela K.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/990
AB  - Aims: Nutrition as an aetiological factor participates a great deal in premature atherosclerosis in haemodialysis (HD) patients. The basic mechanisms of end-stage renal disease and premature atherosclerosis are connected with changes in cell functions at the membrane level. We investigated the red cell membrane fatty acids and the effects of fish oil supplements on nutritional status and inflammatory markers in HD patients. Methods: We examined 42 HD patients (mean age 55 +/- 8 years). The control group consisted of 16 healthy subjects of similar age and sex to the tested group. HD patients were administered supplements with 2.4 g of n-3 polyunsaturated fatty acids per day for 2 months. Before and after supplementation, we examined plasma lipids, cell membrane erythrocyte phospholipids content, serum albumin, haemoglobin, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). Results: Baseline values in the tested group confirmed the presence of essential fatty acids deficiency. A statistically significant negative correlation between TNF-alpha and eicosapentaenoic acid (EPA) (r=-0.497; P  lt  0.05) and IL-6 and EPA (r=-468; P=0.03) was found in HD patients before supplementation. There was a significant increase in docosahexaenoic acids, high density lipoprotein cholesterol, plasma albumin, haemoglobin levels in HD patients after supplementation (P=0.0001). There was a significant increase in EPA (P=0.01) after treatment, and there was a significant decrease in inflammatory markers (IL-6 and TNF-alpha, P=0.0001) after supplementation in the tested group. Conclusion: A dietary regime with fish oil could be used in dialysis patients to slow down the development of atherosclerosis and improve nutritional parameters.
PB  - Wiley, Hoboken
T2  - Nephrology
T1  - Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients
VL  - 12
IS  - 4
SP  - 331
EP  - 336
DO  - 10.1111/j.1440-1797.2007.00777.x
ER  - 

@article{
author = "Peruničić-Peković, Gordana and Rasić, Zorica and Plješa, Steva and Šobajić, Slađana and Đuričić, Ivana and Maletić, Radojka and Ristić-Medić, Danijela K.",
year = "2007",
abstract = "Aims: Nutrition as an aetiological factor participates a great deal in premature atherosclerosis in haemodialysis (HD) patients. The basic mechanisms of end-stage renal disease and premature atherosclerosis are connected with changes in cell functions at the membrane level. We investigated the red cell membrane fatty acids and the effects of fish oil supplements on nutritional status and inflammatory markers in HD patients. Methods: We examined 42 HD patients (mean age 55 +/- 8 years). The control group consisted of 16 healthy subjects of similar age and sex to the tested group. HD patients were administered supplements with 2.4 g of n-3 polyunsaturated fatty acids per day for 2 months. Before and after supplementation, we examined plasma lipids, cell membrane erythrocyte phospholipids content, serum albumin, haemoglobin, interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). Results: Baseline values in the tested group confirmed the presence of essential fatty acids deficiency. A statistically significant negative correlation between TNF-alpha and eicosapentaenoic acid (EPA) (r=-0.497; P  lt  0.05) and IL-6 and EPA (r=-468; P=0.03) was found in HD patients before supplementation. There was a significant increase in docosahexaenoic acids, high density lipoprotein cholesterol, plasma albumin, haemoglobin levels in HD patients after supplementation (P=0.0001). There was a significant increase in EPA (P=0.01) after treatment, and there was a significant decrease in inflammatory markers (IL-6 and TNF-alpha, P=0.0001) after supplementation in the tested group. Conclusion: A dietary regime with fish oil could be used in dialysis patients to slow down the development of atherosclerosis and improve nutritional parameters.",
publisher = "Wiley, Hoboken",
journal = "Nephrology",
title = "Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients",
volume = "12",
number = "4",
pages = "331-336",
doi = "10.1111/j.1440-1797.2007.00777.x"
}

Peruničić-Peković, G., Rasić, Z., Plješa, S., Šobajić, S., Đuričić, I., Maletić, R.,& Ristić-Medić, D. K.. (2007). Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients. in Nephrology
Wiley, Hoboken., 12(4), 331-336.
https://doi.org/10.1111/j.1440-1797.2007.00777.x

Peruničić-Peković G, Rasić Z, Plješa S, Šobajić S, Đuričić I, Maletić R, Ristić-Medić DK. Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients. in Nephrology. 2007;12(4):331-336.
doi:10.1111/j.1440-1797.2007.00777.x .

Peruničić-Peković, Gordana, Rasić, Zorica, Plješa, Steva, Šobajić, Slađana, Đuričić, Ivana, Maletić, Radojka, Ristić-Medić, Danijela K., "Effect of n-3 fatty acids on nutritional status and inflammatory markers in haemodialysis patients" in Nephrology, 12, no. 4 (2007):331-336,
https://doi.org/10.1111/j.1440-1797.2007.00777.x . .

TY  - JOUR
AU  - Rasić-Milutinović, Z.
AU  - Perunicić, G.
AU  - Plješa, Steva
AU  - Gluvić, Z.
AU  - Šobajić, Slađana
AU  - Đurić, I.
AU  - Ristić, D.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/935
AB  - Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Reproductive Toxicology
T1  - Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients
VL  - 29
IS  - 3
SP  - 321
EP  - 329
DO  - 10.1080/08860220601184092
ER  - 

@article{
author = "Rasić-Milutinović, Z. and Perunicić, G. and Plješa, Steva and Gluvić, Z. and Šobajić, Slađana and Đurić, I. and Ristić, D.",
year = "2007",
abstract = "Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Reproductive Toxicology",
title = "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients",
volume = "29",
number = "3",
pages = "321-329",
doi = "10.1080/08860220601184092"
}

Rasić-Milutinović, Z., Perunicić, G., Plješa, S., Gluvić, Z., Šobajić, S., Đurić, I.,& Ristić, D.. (2007). Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology
Taylor & Francis Ltd, Abingdon., 29(3), 321-329.
https://doi.org/10.1080/08860220601184092

Rasić-Milutinović Z, Perunicić G, Plješa S, Gluvić Z, Šobajić S, Đurić I, Ristić D. Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology. 2007;29(3):321-329.
doi:10.1080/08860220601184092 .

Rasić-Milutinović, Z., Perunicić, G., Plješa, Steva, Gluvić, Z., Šobajić, Slađana, Đurić, I., Ristić, D., "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients" in Reproductive Toxicology, 29, no. 3 (2007):321-329,
https://doi.org/10.1080/08860220601184092 . .