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Application of Artificial Neural Networks in Prediction of Diclofenac Sodium Release From Drug-Modified Zeolites Physical Mixtures and Antiedematous Activity Assessment
(Wiley-Blackwell, Hoboken, 2014)
In this study, utilization of artificial neural network (ANN) models [staticmultilayer perceptron (MLP) and generalized regression neural networks and dynamicgamma one-layer network and recurrent one-layer network] for ...
Structural insights into binding of small molecule inhibitors to Enhancer of Zeste Homolog 2
(Springer, Dordrecht, 2014)
Enhancer of Zeste Homolog 2 (EZH2) is a SET domain protein lysine methyltransferase (PKMT) which has recently emerged as a chemically tractable and therapeutically promising epigenetic target, evidenced by the discovery ...
Age-associated changes in rat immune system: Lessons learned from experimental autoimmune encephalomyelitis
(Pergamon-Elsevier Science Ltd, Oxford, 2014)
Aging is associated with the decline in immune response to infectious agents and tumors and increasing risk of autoimmunity, but the incidence of autoimmune diseases does not increase in the elderly. To elucidate the ...
Antinociceptive and Anti-edematous Activities of the Essential Oils of Two Balkan Endemic Laserpitium Species
(Natural Products Inc, Westerville, 2014)
In this paper antinociceptive and anti-edematous effects are examined of the essential oils of the underground parts of two Balkan endemic Laserpitium species (Apiaceae), L. zernyi and L. ochridanum. Furthermore, the ...
Computational classification models for predicting the interaction of drugs with P-glycoprotein and breast cancer resistance protein
(Taylor & Francis Ltd, Abingdon, 2014)
P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) are two members of the adenosine triphosphate (ATP) binding cassette (ABC) family of transporters which function as membrane efflux transporters ...
Effect of Long-term Topiramate Therapy on Serum Bicarbonate and Potassium Levels in Adult Epileptic Patients
(Sage Publications Inc, Thousand Oaks, 2014)
Background: Topiramate (TPM) is a sulfamate-substituted monosaccharide that is structurally different from other antiepileptic drugs. TPM inhibits carbonic anhydrase activity, which is associated with loss of bicarbonate ...
Synthesis, QSAR analysis and mechanism of antybacterial activity of simple 2 '-hydroxy chalcones
(Inst Materials Physics, Bucharest, 2014)
Twelve 2'-hydroxy chalcones were synthesized and their in vitro antibacterial activity was tested using eight standard strains of bacteria: S. aureus (ATCC 25923), S. epidermidis (ATCC 12228), B. subtilis (ATCC 6633), M. ...
Analysis of antibiotic consumption for treating respiratory tract infections in children and compliance with the national clinical guidelines / Analiza potrošnje antibiotika za lečenje infekcija respiratornog trakta u dečjoj populaciji i usklađenosti sa nacionalnim vodičima dobre kliničke prakse
(Društvo lekara Vojvodine Srpskog lekarskog društva, Novi Sad, 2014)
Introduction. Respiratory infections are the most common infections in children. The aims of the study were to analyze the use of antibiotics for respiratory infections in the period 2008 - 2010 in children's population ...
Evaluation of Competences at the Community Pharmacy Settings
(Indian Journal of Pharmaceutical Education and Research, 2014)
The General Level Framework (GLF) document provides a model to be used in evaluating
and upgrading of pharmacists’ competences currently used in many countries. This
study has several Objectives: To show the adaptation ...
Insights into mechanism of anticancer activity of pentacyclic oxindole alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach
(Springer Wien, Wien, 2014)
Alkaloid-rich extract from Uncaria tomentosa (cat's claw) has been reported to cause apoptosis in cancer lines. Oxindole pentacyclic alkaloids of the plant are responsible for this effect, yet their biological mechanism ...