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Combined application of mixture experimental design and artificial neural networks in the solid dispersion development
(Taylor & Francis Ltd, Abingdon, 2016)
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus (R)-poloxamer ...
The influence of bile salts on the distribution of simvastatin in the octanol/buffer system
(Taylor & Francis Ltd, Abingdon, 2016)
Introduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance for drugs bioavailability. Given that bile acids are intensively ...
Preliminary evaluation of the in vitro release and in vivo absorption in rabbits of the modified-release dosage forms
(Informa Healthcare, London, 2013)
Objective: The suitability of the rabbit as an animal model for the primary screening and selection of the pilot scale batches during the early stages of the formulation development was studied. Materials and methods: Three ...