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Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin
(MDPI AG, 2020)
In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased ...
Placenta-specific plasma miR518b is a potential biomarker for preeclampsia
(Elsevier, 2020)
Introduction: MicroRNAs have a significant role in the pathogenesis of preeclampsia. Circulating microRNAs could represent a potential biomarker for preeclampsia. The aim of this study was to evaluate plasma miR210-3p and ...
Biological evaluation of oil-in-water microemulsions as carriers of benzothiophene analogues for dermal applications
(MDPI AG, 2021)
During the last decade, many studies have been reported on the design and formulation of novel drug delivery systems proposed for dermal or transdermal administration. The efforts focus on the development of biocompatible ...
Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction
(Elsevier, 2020)
Objectives: The goal of this study was to investigate metabolic changes in lipids and oxidative stress parameters in the first trimester of pregnancy with the more specific aim of estimating the significance and strength ...
Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein
(Blackwell Publishing Ltd, 2021)
Hydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S-induced relaxation in human ...
Preparation and characterisation of amino-functionalized pore-expanded mesoporous silica for carbon dioxide capture
(Springer Nature, 2021)
In this study, the preparation of some large-pore ordered mesoporous silicas using a proper surfactant with different swelling agents was carried out. The synthesis of conventional SBA-15 was modified to obtain pore-expanded ...
N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction
(Elsevier, 2020)
Ischemic heart disease leading to heart failure (HF) portends a high overall morbidity and mortality. A higher N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) at rest reflects HF severity and impaired cardiac output, ...
Healthcare associated Clostridioides difficile infection in adult surgical and medical patients hospitalized in tertiary hospital in Belgrade, Serbia: a seven years prospective cohort study
(Taylor & Francis, 2020)
Introduction: Clostridioides difficile (C. difficile) infection (CDI) is one of the most common healthcare-associated (HA) infections in contemporary medicine. The risk factors (RFs) for HA CDI in medical and surgical ...
Optimization of extraction yield and chemical characterization of optimal extract from Juglans nigra L. leaves
(Elsevier, 2020)
The extraction yield of Juglans nigra L. leaves was assessed at different ethanol concen-trations (0–96% (v/v)) and solvent-to-solid ratios (5–20 kg kg−1). The response surfacemethodology (RSM) and artificial neural network ...
A Mechanistic In Vivo/Ex Vivo Pharmacokinetic-Pharmacodynamic Model of Tenofovir for HIV Prevention
(American Society for Clinical Pharmacology and Therapeutics, 2021)
Defining tissue and plasma-specific prophylactic drug concentrations is central to pre-exposure prophylaxis product development for sexual transmission of HIV-1. Pharmacokinetic (PK) data from study RMP-02/MTN-006 comparing ...