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Development of Hydrophilic Interaction Liquid Chromatography Method for the Analysis of Moxonidine and Its Impurities
(Hindawi Publishing Corp, New York, 2016)
Fast and simple hydrophilic interaction liquid chromatography (HILIC) method was developed and validated for the analysis of moxonidine and its four impurities (A, B, C, and D) in pharmaceutical dosage form. All experiments ...
Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
(MDPI, 2023)
A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms ...
High-performance liquid chromatography evaluation of lipophilicity and QSRR modeling of a series of dual DNA gyrase and topoisomerase IV inhibitors
(Akadémiai Kiadó, 2024)
Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during replication
and represent important antibacterial drug targets. To be successful as drug candidates, newly synthesized compounds must ...
Antioxidant potential and polyphenolic content of three medicinal wild-growing species from Kopaonik mountain
(Institute of Botany and Botanical Garden Jevremovac, Belgrade, 2018)
Wild-growing plants are good potential sources of natural substances useful for preventing diseases related to oxidative stress. Th e food industry is becoming increasingly interested
in plants, because of their anti-infl ...
Preformulation and development of preliminary nanoemulsion carrier for patent protected compound GL-II-73
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Introduction Nanopharmaceuticals offer a good method to avoid some of the difficulties that novel drug candidates confront. They can be tailored to adjust their water solubility, half-life, biodistribution, and govern the ...
The influence of directly compressible fillers/diluents on selected compact properties and drug dissolution: a case study of rivaroxaban
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression represents a favorable tablet
manufacturing method. However, obtaining satisfactory
mechanical properties of the compacts and drug dissolution
remains a challenge in formulation development,
particularly ...
Targeting noncoding RNAs to treat atherosclerosis
(John Wiley and Sons Inc, 2024)
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential for leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of ...
Current level of evidence for improvement of antidepressant efficacy and tolerability by pharmacogenomic-guided treatment: A Systematic review and meta-analysis of randomized controlled clinical trials
(Elsevier B.V., 2024)
The aim of the study was to assess the clinical utility of currently available pharmacogenomic (PGx) tools compared with treatment as usual (TAU), using a meta-analysis of dichotomous and continuous antidepressant efficacy ...
Baseline Correction for HPLC Chromatograms by Using Free Open-Source Software
(MDPI, 2023)
Chromatograms with overlapping peaks and a baseline rise or upset constitute a great challenge for analysts. Such a case regarding the analysis of bupropion hydrochloride and its 5 impurities in a tablet formulation was ...
Chemical composition and antimicrobial activity of volatile fraction of Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae)
(Faculty o f Biology, University of Belgrade, 2009)
Anthriscus nemorosa (Bieb.) Sprengel (Umbelliferae) is a nitrophile pererurial with a long, stout root. This plant occurs in the temperate area of Eurasia [l], from ltaly on the west to Japan on the East. The species is a ...