Претраживање
Приказ резултата 1-10 од 13
In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems
(Taylor & Francis Ltd, Abingdon, 2018)
Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also ...
Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements
(Taylor & Francis Ltd, Abingdon, 2019)
Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared ...
Spray coating as a powerful technique in preparation of solid dispersions with enhanced desloratadine dissolution rate
(Taylor & Francis Ltd, Abingdon, 2013)
Solid dispersion systems have been widely used to enhance dissolution rate and oral bioavailability of poorly water-soluble drugs. However, the formulation process development and scale-up present a number of difficulties ...
In vitro/in silico approach in the development of simvastatin-loaded self-microemulsifying drug delivery systems
(Taylor & Francis Ltd, Abingdon, 2018)
Objective: The aims of this study were to formulate simvastatin (SV)-loaded self-microemulsifying drug delivery systems (SMEDDS), and explore the potential of these drug delivery systems to improve SV solubility, and also ...
Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance
(Informa Healthcare, London, 2014)
Context: Approaching of pharmaceutical and cosmetic industries in some aspects inevitably influence formulation of topical pharmaceuticals, urging researchers to introduce novel excipients with proven benefits over traditional ...
Chitosan oligosaccharide as prospective cross-linking agent for naproxen-loaded Ca-alginate microparticles with improved pH sensitivity
(Informa Healthcare, London, 2013)
Objectives: The aim of the presented work was to develop Ca-alginate microparticles for oral administration of naproxen reinforced with chitosan oligosaccharide (COS) with a special interest to examine the potential of COS ...
Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements
(Taylor & Francis Ltd, Abingdon, 2019)
Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared ...
The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations
(Informa Healthcare, London, 2015)
Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well as for the assessment ...
Combined application of mixture experimental design and artificial neural networks in the solid dispersion development
(Taylor & Francis Ltd, Abingdon, 2016)
This study for the first time demonstrates combined application of mixture experimental design and artificial neural networks (ANNs) in the solid dispersions (SDs) development. Ternary carbamazepine-Soluplus (R)-poloxamer ...
The influence of bile salts on the distribution of simvastatin in the octanol/buffer system
(Taylor & Francis Ltd, Abingdon, 2016)
Introduction: Distribution coefficient (D) is useful parameter for evaluating drugs permeability properties across biological membranes, which are of importance for drugs bioavailability. Given that bile acids are intensively ...