Претраживање
Приказ резултата 1-10 од 27
Chemometrically Assisted Development and Validation of LC for Simultaneous Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form
(Springer Heidelberg, Heidelberg, 2009)
A chemometrical approach was applied to develop a reversed-phase liquid chromatographic method for simultaneous determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form. According ...
LC determination of lercanidipine and its impurities using DryLab software and experimental design procedures
(Vieweg, Wiesbaden, 2008)
The main objective in all optimization procedures is to define the most appropriate conditions for rapid, sensitive, precise, and reproducible analysis, as economically as possible. Experimental design and DryLab optimization ...
Robust Optimization of Chaotropic Chromatography Assay for Lamotrigine and its Two Impurities in Tablets
(Springer Heidelberg, Heidelberg, 2019)
In this study robust optimization was applied for the development of a reliable analytical assay for lamotrigine, its impurity A, and impurity G in tablets by chaotropic chromatography. The influence of the critical method ...
Simultaneous Determination of Hydrochlorothiazide, Cilazapril and Its Active Metabolite Cilazaprilat in Urine by Gradient RP-LC
(Springer Heidelberg, Heidelberg, 2009)
A rapid and simple liquid chromatographic method with UV detection has been developed for the determination of hydrochlorothiazide (HCTZ), cilazapril (CL) and its active metabolite cilazaprilat (CLT) in urine. Sample ...
Factorial Design in Optimization of Chromatographic Separation of Ramipril and Its Impurities
(Springer Heidelberg, Heidelberg, 2010)
In this paper optimization of chromatographic retention of ramipril and its five impurities employing factorial design is presented. On the basis of preliminary experiments three factors were chosen as inputs (acetonitrile ...
Monitoring of Simvastatin impurities by HPLC with microemulsion eluents
(Springer Heidelberg, Heidelberg, 2006)
The use of microemulsions as eluents in HPLC has shown excellent potential. We have developed a novel approach for the analysis of Simvastatin and its six impurities, applying microemulsions as mobile phase. The method was ...
Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong
(Springer Heidelberg, Heidelberg, 2013)
This paper proposes an innovative concept for robustness evaluation guided by two crucial aims: indubitable identification of the factors that significantly affect the LC method and avoidance of unnecessary time and money ...
AQbD-Oriented Development of a New LC Method for Simultaneous Determination of Telmisartan and Its Impurities
(Springer Heidelberg, Heidelberg, 2017)
Analytical quality by design (AQbD)-oriented liquid chromatographic method development for determination of telmisartan and its impurities A, C, and 1 is determination is presented. Step-by-step process was conducted in ...
An Improved HPLC Method for Simultaneous Analysis of Losartan Potassium and Hydrochlorothiazide with the Aid of a Chemometric Protocol
(Springer Heidelberg, Heidelberg, 2013)
An experimental design method was used for fast, simple, and accurate high-performance-pressure liquid chromatograpy (HPLC) determination of losartan and hydrochlorothiazide in combined dosage forms. This method avoids the ...
Optimization of Artificial Neural Networks for Modeling of Atorvastatin and Its Impurities Retention in Micellar Liquid Chromatography
(Springer Heidelberg, Heidelberg, 2011)
Artificial Neural Networks (ANNs) present a powerful tool for the modeling of chromatographic retention. In this paper, the main objective was to use ANNs as a tool in modeling of atorvastatin and its impurities' retention ...