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Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.)
(Elsevier, 2019)
Sweet flag rhizome (Acorus calamus L., Araceae) exhibits various biological activities such as sedative, anticonvulsant,
immunosuppressant, antidiabetic, and anti-inflammatory. This plant is protected in Serbia, but due ...
CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability
(Elsevier Ireland Ltd, 2022)
The inter-individual variability in CYP2C19-mediated metabolism may affect the antidepressant treatment. The aim of this study is to evaluate differences in antidepressant efficacy and tolerability between different CYP2C19 ...
Quantitative structure retention relationship modeling in liquid chromatography method for separation of candesartan cilexetil and its degradation products
(Elsevier Science BV, Amsterdam, 2015)
Artificial neural network (ANN) is a learning system based on a computation technique, which was employed for building of the quantitative structure-retention relationship (QSRR) model for candesartan cilexetil and its ...
Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain
(John Wiley and Sons Inc., 2020)
Background and Purpose: Neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile (3β-OH) is a novel hypnotic and voltage-dependent blocker of T-type calcium channels. Here, we examine its potential analgesic ...
Multifunctional jute fabrics obtained by different chemical modifications
(Springer Nature B.V., 2020)
Abstract: The aim of the present research is first to reduce the jute fabric non-cellulosic components by using different chemical modifications (i.e. alkali and oxidative) and then to analyze their influence on the jute ...
Influence of surface coverage of kaolin with surfactant ions on adsorption of ochratoxin A and zearalenone
(Elsevier Ltd, 2021)
A natural kaolin from Serbia was modified with different amounts of octadecyldimethylbenzyl ammonium (ODMBA) - (25, 50 and 90% of kaolin cation exchange capacity). Samples were denoted as OKR-25, OKR-50 and OKR-90. Several ...
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients
(John Wiley and Sons Inc, 2022)
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational ...
Insight into the formation of glimepiride nanocrystals by wet media milling
(MDPI, 2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted
by wet media milling. Di erent stabilizers were tested and the obtained nanosuspensions were
solidified by spray drying in presence of ...
Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats
(Frontiers Media S.A., 2020)
Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim ...
Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
(MDPI, 2021)
The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to ...