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Are moclobemide trough concentrations an adequate predictor of the systemic drug exposure
(Elsevier Science BV, Amsterdam, 2008)
Експресија α2 адренергичких рецептора у мозгу пацова у моделу депресивног понашања резистентног на примену трицикличних антидепресива / The expression of α2-adrenergic receptor in rats' brain in a model of depressive-like behavior resistant to tricyclic antidepressants
(2022)
Једно од најважнијих открића у неуробиологији депресије везује се за поремећај серотонергичке, норадренергичке и допаминергичке трансмисије. Депресивни фенотип одликују промене у експресији и активности α2 адренергичких ...
Вортиоксетин ублажава болно понашање у моделу акутне мигренозне главобоље: улога серотонергичких 5-HT1B/1D рецептора / Vortioxetine alleviates pain-like behavior in the model of acute migraine attack: involvement of serotonergic 5-HT1B/1D receptors
(2022)
Мигрена је водећи узрок онеспособљености и нарушеног квалитета живота, посебно у млађих жена. Постојеће терапијске опције за лечење мигрене имају ограничену ефикасност/безбедност. Вортиоксетин, нови мултимодални антидепресив, ...
Design and characterization of a novel structural class of Kv1.3 inhibitors
(Elsevier, 2020)
The voltage-gated potassium channel Kv1.3 is involved in multiple autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, diabetes mellitus type 1 and psoriasis. In many auto-immune diseases better treatment ...
Discovery of membrane permeability, pharmacokinetics properties and mechanism of action for analogs of ethylenediamine-n,n′-di-2-(3-cyclohexyl)propionic acid and 1,3-propandiamine-n,n′-di-2-(3-cyclohexyl)propionic acid with antiproliferative activity using In Vitro and In Silico Methods
(Springer Verlag, 2020)
In previously in vitro studies on different cell lines and in vivo on melanoma and 4T1 murine breast cancer and metastasis it was shown antiproliferative activity for ester derivatives of (S,S)-ethylenediamine-N,N′-di-2- ...
Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy
(Elsevier Ltd, 2021)
Intranasal treatment with oxytocin showed beneficial effects in post-traumatic stress disorder and autism spectrum disorders; however, it was not investigated as much in depression. Keeping in mind the favorable effects ...
From experimental design to quality by design in pharmaceutical legislation
(Springer, New York, 2012)
Quality by design (QbD) is a concept first outlined by Juran, who believed that quality could be planned and that most quality crises and problems relate to the way in which quality was planned in the first place. Experimental ...
Effect of supplemental magnesium on the kidney levels of cadmium, zinc, and copper of mice exposed to toxic levels of cadmium
(Humana Press Inc, Totowa, 2006)
In this report, we present the results of our investigations on the effect of Mg pretreatment on Cd and bioelements (Cu and Zn) contents in kidney of mice exposed to acute and subacute Cd intoxication. Acute intoxication ...
Apoptotic versus genotoxic potential of antiotumor agents: a concept of duality in unity (vol 61, pg 131, 2003)
(Churchill Livingstone, Edinburgh, 2003)
Involvement of toxic metals and PCBs mixture in the thyroid and male reproductive toxicity: In silico toxicogenomic data mining
(Elsevier, 2023)
Toxicological research is mostly limited to considering the effects of a single substance, even though the real exposure of people is reflected in their daily exposure to many different chemical substances in low-doses. ...