Приказ основних података о документу
New trends in design and development of topical anti-inflammatory steroids
Novine u dizajniranju i razvoju lokalnih antiinflamatornih steroida
dc.creator | Marković, Bojan | |
dc.creator | Vladimirov, Sote | |
dc.date.accessioned | 2019-09-02T11:15:17Z | |
dc.date.available | 2019-09-02T11:15:17Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0004-1963 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1142 | |
dc.description.abstract | Topical anti-inflammatory corticosteroids are "drug of choice" in treatment of many inflammatory and allergic diseases in dermatology, pulmology, ophthalmology rheumatology and gastroenterology. Their using is limited because some serious systematic effects have been noted by longtime using of these drugs. In this manuscript, it was made a review of the relationship of structural changes on molecules of corticosteroids and intensity and specificity of their activity. Some of recently trends in design of newly anti-inflammatory steroids are based on retrometabolic design of "soft drugs", which are biotransformed to the inactive metabolits in body of patient after their applications. In manuscript, design and synthesis of new diastereoisomeric esters of steroid, as potentional antiinflammatory agents, was shown. | en |
dc.description.abstract | Lokalni antiinflamatorni steroidi su "lekovi izbora" u lečenju raznih inflamatornih i alergijskih oboljenja u dermatologiji, pulmologiji, oftalmologiji, reumatologiji, gastroenterologiji. Dugotrajnom primenom ovih lekova mogu nastati veoma ozbiljni sistemski neželjeni efekti koji ograničavaju njihovu upotrebu. U ovom radu, dat je pregled uticaja strukturnih promena, u molekulama lokalnih antiinflamatornih steroida, na jačinu i specifičnost antiinflamatornog dejstva, a sve u cilju dobijanja novih bezbednijih lekova. Jedan od savremenih trendova u dizajnu antiinflamatornih steroida zasniva se na retrometaboličkom pristupu "soft" lekova, koji se nakon ispoljavanja dejstva, u organizmu pacijenta biotransformišu do neaktivnih i netoksičnih metabolita. U radu je prikazan dizajn i sinteza novih diastereoizomernih estara antiinflamatornih steroida kao potencijalnih lekova u lokalnoj terapiji. | sr |
dc.publisher | Savez farmaceutskih udruženja Srbije, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142072/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-sa/4.0/ | |
dc.source | Arhiv za farmaciju | |
dc.subject | anti-inflammatory steroids | en |
dc.subject | topical activity | en |
dc.subject | 'soft drugs' | en |
dc.subject | diastereoisomeric esters | en |
dc.subject | antiinflamatorni steroidi | sr |
dc.subject | lokalna primena | sr |
dc.subject | "soft" lekovi | sr |
dc.subject | diastereoizomerni estri | sr |
dc.title | New trends in design and development of topical anti-inflammatory steroids | en |
dc.title | Novine u dizajniranju i razvoju lokalnih antiinflamatornih steroida | sr |
dc.type | article | |
dc.rights.license | BY-SA | |
dcterms.abstract | Владимиров, Соте; Марковић, Бојан; Новине у дизајнирању и развоју локалних антиинфламаторних стероида; Новине у дизајнирању и развоју локалних антиинфламаторних стероида; | |
dc.citation.volume | 58 | |
dc.citation.issue | 2-3 | |
dc.citation.spage | 137 | |
dc.citation.epage | 152 | |
dc.citation.other | 58(2-3): 137-152 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/111/1140.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1142 | |
dc.type.version | publishedVersion |