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Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms
dc.creator | Vujić, Zorica | |
dc.creator | Radulović, Dušanka | |
dc.creator | Živanović, Ljiljana | |
dc.date.accessioned | 2019-09-02T10:48:56Z | |
dc.date.available | 2019-09-02T10:48:56Z | |
dc.date.issued | 1995 | |
dc.identifier.issn | 0014-827X | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/119 | |
dc.description.abstract | A sensitive spectrophotometric method for the determination of metoprolol tartrate in tablets and ampoules is presented. Using spectrophotometric measurements, it was found that metoprolol tartrate and benzyl orange form a chloroform soluble ion-pair complex with an absorption maximum at 401 nm. The composition of the ion-pair complex was determined by applying Job's method to equimolar solutions of metoprolol tartrate: benzyl orange (1:2); molar absorptivity 7.39 x 103 mol-1 cm-1. Extraction of the ion-pair complex in chloroform was accomplished easily at a Britton-Robinson's buffered optimum pH = 5.2, μ = 0.1 mol/dm3. The relative stability constant, calculated according to the method of Sommer and Job's non-equimolar solutions, was log K = 9.72 (avg. value). Beer's law was obeyed up to 3.42 μg/ml of metoprolol tartrate (the detection limit was also 3.42 μg/ml). The precision of the method was checked at three different concentrations. The RSD (n = 7) varied from 0.51 to 2.03%. Reproducibility was examined by analysing Lopresor® tablets and ampoules. Recoveries varied from 99-101%. The reported method, applied to the assay of metoprolol tartrate in tablets and ampoules, gives precise and reproducible results. | en |
dc.rights | restrictedAccess | |
dc.source | Farmaco | |
dc.title | Spectrophotometric investigation of metopropol-benzyl orange reaction and its application to the assay in pharmaceutical dosage forms | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Вујић, Зорица; Живановић, Љиљана; Радуловић, Душанка; | |
dc.citation.volume | 50 | |
dc.citation.issue | 4 | |
dc.citation.spage | 281 | |
dc.citation.epage | 284 | |
dc.citation.other | 50(4): 281-284 | |
dc.identifier.scopus | 2-s2.0-0028990058 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_119 | |
dc.type.version | publishedVersion |
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