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High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals
dc.creator | Letica, Jelena | |
dc.creator | Marković, Slavko | |
dc.creator | Zirojević, Jelena | |
dc.creator | Nikolić, Katarina | |
dc.creator | Agbaba, Danica | |
dc.date.accessioned | 2019-09-02T11:20:09Z | |
dc.date.available | 2019-09-02T11:20:09Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1060-3271 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/1334 | |
dc.description.abstract | An RP-HPLC method for simultaneous separation and quantification of pantoprazole and its five main impurities in pharmaceutical formulations was developed and validated. The separation was accomplished on a Zorbax Eclipse XDB C18 column (5 mu m particle size, 150 x 4.6 mm id) using a gradient with mobile phase A [buffer-acetonitrile (70 + 30, v/v)], and mobile phase B [buffer-acetonitrile (30 + 70, v/v)]. The buffer was 0.01 M ammonium acetate solution with addition of 1 mL triethylamine/L of the solution, adjusted to pH 4.5 with orthophosphoric acid. The eluent flow rate was 1 mL/min, the temperature of the column was 30 C, and the eluate was monitored at 290 nm. Linearity (r = 0.999), recovery (97.6-105.8%), RSD (0.55-1.90%), and LOQ (0.099-1.48 mu g/mL) were evaluated and found to be satisfactory. The proposed method can be used for simultaneous identification and quantification of the analyzed compounds in pharmaceutical formulations. | en |
dc.publisher | AOAC Int, Gaithersburg | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142071/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of AOAC International | |
dc.title | High-Performance Liquid Chromatographic Determination of Pantoprazole and Its Main Impurities in Pharmaceuticals | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aгбаба, Даница; Летица, Јелена; Марковић, Славко; Николић, Катарина; Зиројевић, Јелена; | |
dc.citation.volume | 93 | |
dc.citation.issue | 4 | |
dc.citation.spage | 1121 | |
dc.citation.epage | 1128 | |
dc.citation.other | 93(4): 1121-1128 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000281492100009 | |
dc.identifier.doi | 10.1093/jaoac/93.4.1121 | |
dc.identifier.pmid | 20922942 | |
dc.identifier.scopus | 2-s2.0-77956162993 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_1334 | |
dc.type.version | publishedVersion |