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Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine
dc.creator | Vladimirov, S | |
dc.creator | Čudina, Olivera | |
dc.creator | Agbaba, Danica | |
dc.creator | Jovanović, M | |
dc.creator | Živanov-Stakić, Dobrila | |
dc.date.accessioned | 2019-09-02T10:49:21Z | |
dc.date.available | 2019-09-02T10:49:21Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0731-7085 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/136 | |
dc.description.abstract | The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product has an absorption maximum at 380 nm. A linear relationship between absorbance and concentration was established in the concentration range 3.19 x 10(-6)-3.19 x 10(-5) mol l(-1) (the regression equation was y = 0.013 167 3 + 0.019 025 9x; correlation coefficient r = 0.9991; n = 6). The detection limit was 1.2 mu g ml(-1) (molar absorptivity found was 1.97 x 10(4) l mol(-1) cm(-1)). The reliability of the proposed method was checked at three different concentrations; the relative standard deviation (RSD) varied from 1.03 to 2.01%. The described method applied to the determination of desoximetasone in ointment gave precise and reproducible results; the recovery was 98.55% with RSD = 2.40% (n = 10). | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Journal of Pharmaceutical and Biomedical Analysis | |
dc.title | Spectrophotometric determination of desoximetasone in ointment using 1,4-dihydrazinophthalazine | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Чудина, Оливера; Владимиров, С; Aгбаба, Даница; Живанов-Стакић, Добрила; Јовановић, М; | |
dc.citation.volume | 14 | |
dc.citation.issue | 8-10 | |
dc.citation.spage | 947 | |
dc.citation.epage | 950 | |
dc.citation.other | 14(8-10): 947-950 | |
dc.identifier.wos | A1996UY34400011 | |
dc.identifier.doi | 10.1016/0731-7085(95)01681-3 | |
dc.identifier.pmid | 8817999 | |
dc.identifier.scopus | 2-s2.0-0030176421 | |
dc.type.version | publishedVersion |