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N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a New Cholinesterase and Monoamine Oxidase Dual
(Amer Chemical Soc, Washington, 2014)
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of ...
A Multimarker Approach for the Prediction of Coronary Artery Disease: Cost-Effectiveness Analysis
(Elsevier Science Inc, 2010)
Objectives: Coronary artery disease (CAD), as the leading cause of death, poses a huge economic burden on health-care systems. We used a multi-marker approach to explore discriminative abilities of several lipid, inflammatory, ...
Abnormal development of monoaminergic neurons is implicated in mood fluctuations and bipolar disorder
(Nature Publishing Group, 2015)
Subtle mood fluctuations are normal emotional experiences, whereas drastic mood swings can be a manifestation of bipolar disorder (BPD). Despite their importance for normal and pathological behavior, the mechanisms underlying ...
Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures
(Springer Verlag, 2019)
Humans are exposed to multiple chemicals on a daily basis instead of to just a single chemical, yet the majority of existing toxicity data comes from single-chemical exposure. Multiple factors must be considered such as ...
Premature Centromere Division of Metaphase Chromosomes in Peripheral Blood Lymphocytes of Alzheimer's Disease Patients: Relation to Gender and Age
(Oxford Univ Press Inc, Cary, 2010)
Chromosomal alterations are a feature of both aging and Alzheimer's disease (AD). This study examined if premature centromere division (PCD), a chromosomal instability indicator increased in AD, is correlated with aging ...
Triggered dynamics in a model of different fault creep regimes
(Nature Publishing Group, London, 2014)
The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is represented by the movement of a spring-block ...
Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies
(Pergamon-Elsevier Science Ltd, Oxford, 2019)
Although profoundly studied, etiology of pancreatic cancer (PC) is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd) body burden. Hence, the aim of this study was to ...
Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen)
(Frontiers Media Sa, Lausanne, 2015)
The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio, and temperature on ...
Regulatory and general epidemiological knowledge about rare diseases and access to treatment for rare diseases: health professionals' view in Serbia
(Elsevier Inc., 2013)
Objectives: To assess the knowledge of health professionals about epidemiological
and national regulatory issues concerning rare diseases (RD) and access to orphan
drugs. MethOds: This paper reports some of the results ...
Optimization and prediction of ibuprofen release from 3D DLP printlets using artificial neural networks
(MDPI, 2019)
The aim of this work was to investigate eects of the formulation factors on tablet printability as well as to optimize and predict extended drug release from cross-linked polymeric ibuprofen printlets using an artificial ...