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The Expression of Major Facilitator Superfamily Domain-Containing Protein2a (Mfsd2a) and Aquaporin 4 Is Altered in the Retinas of a 5xFAD Mouse Model of Alzheimer’s Disease
(MDPI, 2023)
Cerebral amyloid angiopathy (CAA) is characterized by amyloid β (Aβ) accumulation in the blood vessels and is associated with cognitive impairment in Alzheimer’s disease (AD). The increased accumulation of Aβ is also present ...
Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?
(MDPI, 2023)
Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed ...
Predictors of Inadequate Health Literacy among Patients with Type 2 Diabetes Mellitus: Assessment with Different Self-Reported Instruments
(MDPI, 2023)
INTRODUCTION: Obtaining, understanding, interpreting, and acting on health information enables people with diabetes to engage and make health decisions in various contexts. Hence, inadequate health literacy (HL) could pose ...
LncRNAs as Regulators of Atherosclerotic Plaque Stability
(MDPI, 2023)
Current clinical data show that, despite constant efforts to develop novel therapies and clinical approaches, atherosclerotic cardiovascular diseases (ASCVD) are still one of the leading causes of death worldwide. Advanced ...
Approximate treatment of noncommutative curvature in quartic matrix model
(Springer Science and Business Media Deutschland GmbH, 2023)
We study a Hermitian matrix model with the standard quartic potential amended by a tr(RΦ2) term for fixed external matrix R. This is motivated by a curvature term in the truncated Heisenberg algebra formulation of the ...
Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor
(Oxford University Press ( Oxford Academic), 2023)
People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other
neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive ...
The phenotype of Graves’ orbitopathy is associated with thyrotropin receptor antibody levels
(Springer Science and Business Media, 2023)
Purpose: Graves’ orbitopathy (GO) is a specific inflammatory disorder of the orbit characterized by a highly heterogeneous clinical phenotype. The role of thyrotropin receptor antibodies (TSH-R-Ab) has been widely researched, ...
The secret of reversed-phase/weak cation exchange retention mechanisms in mixed-mode liquid chromatography applied for small drug molecule analysis
(Elsevier B.V., 2023)
Resolving complex sample mixtures by liquid chromatography in a single run is challenging. The so-called mixed-mode liquid chromatography (MMLC) which combines several retention mechanisms within a single column, can provide ...
Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA
(Elsevier B.V., 2023)
Electrochemical oxidation of newly synthesized acridine derivatives (ADs): PG, PA, EG and EA was studied using square wave voltammetry at a glassy carbon electrode. Oxidation occurs as an irreversible process for all ADs. ...
Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge
(Elsevier Ltd, 2023)
Environmentally relevant toxic substances may affect human health, provoking numerous harmful effects on central nervous, respiratory, cardiovascular, endocrine and reproductive system, and even cause various types of ...