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Insight into the formation of glimepiride nanocrystals by wet media milling
(MDPI, 2020)
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted
by wet media milling. Di erent stabilizers were tested and the obtained nanosuspensions were
solidified by spray drying in presence of ...
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients
(John Wiley and Sons Inc, 2022)
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational ...
Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats
(Frontiers Media S.A., 2020)
Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim ...
Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
(MDPI, 2021)
The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to ...
Nano-and microcarriers as drug delivery systems for usnic acid: Review of literature
(MDPI, 2020)
Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed ...
In vitro - in vivo - in silico approach in the development of inhaled drug products: Nanocrystal-based formulations with budesonide as a model drug
(Elsevier B.V., 2021)
This study aims to understand the absorption patterns of three different kinds of inhaled formulations via in silico modeling using budesonide (BUD) as a model drug. The formulations investigated in this study are: (i) ...
Digital light processing (DLP) 3D printing of atomoxetine hydrochloride tablets using photoreactive suspensions
(MDPI AG, 2020)
Three-dimensional (3D) printing technologies are based on successive material printing layer-by-layer and are considered suitable for the production of dosage forms customized for a patient’s needs. In this study, tablets ...
CYP2C19 slow metabolizer phenotype is associated with lower antidepressant efficacy and tolerability
(Elsevier Ireland Ltd, 2022)
The inter-individual variability in CYP2C19-mediated metabolism may affect the antidepressant treatment. The aim of this study is to evaluate differences in antidepressant efficacy and tolerability between different CYP2C19 ...
Health Benefits and Applications of Goji Berries in Functional Food Products Development: A Review
(MDPI, 2022)
Goji berries have long been used for their nutritional value and medicinal purposes in Asian countries. In the last two decades, goji berries have become popular around the world and are consumed as a functional food due ...
The role of toxic metals and metalloids in nrf2 signaling
(MDPI AG, 2021)
Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resis-tance to oxidants, serves as one of the key defensive factors against a range of pathological processessuch as oxidative damage, ...