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Factorial Design in Optimization of Chromatographic Separation of Ramipril and Its Impurities
(Springer Heidelberg, Heidelberg, 2010)
In this paper optimization of chromatographic retention of ramipril and its five impurities employing factorial design is presented. On the basis of preliminary experiments three factors were chosen as inputs (acetonitrile ...
Robust Optimization of Chaotropic Chromatography Assay for Lamotrigine and its Two Impurities in Tablets
(Springer Heidelberg, Heidelberg, 2019)
In this study robust optimization was applied for the development of a reliable analytical assay for lamotrigine, its impurity A, and impurity G in tablets by chaotropic chromatography. The influence of the critical method ...
Multiobjective Optimization Approach in Evaluation of Chromatographic Behaviour of Zolpidem Tartrate and Its Degradation Products
(Springer Heidelberg, Heidelberg, 2011)
Multiresponse optimization methodology in combination with experimental design was employed as a powerful technique for simultaneous optimization of input variables significant for evaluation of chromatographic behaviour ...
GC-ECD Determination of Lindane and Its Impurity alpha-HCH in Pharmaceutical Products
(Springer Heidelberg, Heidelberg, 2010)
A method was developed to determine lindane (gamma-HCH), the widely used organochlorine pesticide, and its impurity alpha-HCH in bulk and pharmaceutical products (shampoo, gel and emulsion). The system was able to successfully ...
Optimization of Artificial Neural Networks for Modeling of Atorvastatin and Its Impurities Retention in Micellar Liquid Chromatography
(Springer Heidelberg, Heidelberg, 2011)
Artificial Neural Networks (ANNs) present a powerful tool for the modeling of chromatographic retention. In this paper, the main objective was to use ANNs as a tool in modeling of atorvastatin and its impurities' retention ...
UPLC Method for Determination of Moxonidine and Its Degradation Products in Active Pharmaceutical Ingredient and Pharmaceutical Dosage Form
(Springer Heidelberg, Heidelberg, 2014)
A simple, rapid, isocratic, stability-indicating reverse phase ultra-performance liquid chromatographic (RP-UPLC) method was developed and validated for the routine analysis of moxonidine in the presence of its degradation ...
Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach
(Springer Heidelberg, Heidelberg, 2012)
The algorithm of Dong and error estimation based on a priori declared negligible effects (dummy factor effects approach) were evaluated for testing robustness, in case they provide contradictory results. Robustness of LC ...
Desirability Based Optimization and Validation of New RP-HPLC Method for Simultaneous Determination of Bisoprolol Fumarate, Hydrochlorothiazide and Their Impurities
(Springer Heidelberg, Heidelberg, 2016)
In this paper optimization and validation of a new RP-HPLC method for simultaneous determination of bisoprolol fumarate, hydrochlorothiazide and impurities A, L, K and B are presented. Factors which could have significant ...
Multi-Level Robustness Evaluation Approach: From Robustness Criterion to Adapted Algorithm of Dong
(Springer Heidelberg, Heidelberg, 2013)
This paper proposes an innovative concept for robustness evaluation guided by two crucial aims: indubitable identification of the factors that significantly affect the LC method and avoidance of unnecessary time and money ...
Evaluation of RP-HPLC Method Intended for the Analysis of Cefuroxime Axetil and ITS Impurities Supported by Experimental Design
(Springer Heidelberg, Heidelberg, 2013)
In this paper, a chemometrically assisted validation of RP-HPLC method, intended for the quantitative analysis of cefuroxime axetil (A and B), cefuroxime acid, cefuroxime lactone, cefuroxime axetil sulfoxide (A and B), a ...