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Development of level a in vitro - in vivo correlation for carbamazepine immediate release tablets
(Elsevier Science BV, 2005)
Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis
(Elsevier Science BV, Amsterdam, 2005)
An alkylpolyglucoside surfactant as a prospective pharmaceutical excipient for topical formulations: The influence of oil polarity on the colloidal structure and hydrocortisone in vitro/in vivo permeation
(Elsevier Science BV, Amsterdam, 2007)
There is a growing need for research into new skin- and environment-friendly surfactants. This paper focuses on a natural surfactant of an alkylpolyglucoside type, which can form both thermotropic and lyotropic liquid-crystalline ...
The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling
(Elsevier Science BV, Amsterdam, 2009)
Monitoring valproic acid (VPA) concentrations is especially challenging due to its highly variable pharmacokinetics (PK) and complex interactions with other antiepileptic drugs. We used sparse routine therapeutic drug ...
Application of dynamic neural networks in the modeling of drug release from polyethylene oxide matrix tablets
(Elsevier Science BV, Amsterdam, 2009)
The main objective of this study was to demonstrate the possible use of dynamic neural networks to model diclofenac sodium release from polyethylene oxide hydrophilic matrix tablets. High and low molecular weight polymers ...
An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
(Elsevier Science BV, Amsterdam, 2007)
Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. ...
The role of therapeutic drug monitoring in optimazing pharmacotherapy of selected antiepileptics
(Elsevier Science BV, Amsterdam, 2009)