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Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test / Ispitivanje stepena oštećenja DNK leukocita periferne krvi pacijenata sa Alchajmerovom bolešću primenom Komet testa
(Savez farmaceutskih udruženja Srbije, Beograd, 2011)
DNA damage is a powerful trigger of apoptosis in neurons and is present in patients with Alzheimer's disease (AB). Also, DNA damage is registered in cells that are not neurons, such as peripheral blood leukocytes and ...
Maternal deprivation causes CaMKII downregulation and modulates glutamate, norepinephrine and serotonin in limbic brain areas in a rat model of single prolonged stress
(Elsevier B.V., 2024)
Background: Early life stress is a major risk factor for later development of psychiatric disorders, including post-traumatic stress disorder (PTSD). An intricate relationship exists between various neurotransmitters (such ...
Development of Hydrophilic Interaction Liquid Chromatography Method for the Analysis of Moxonidine and Its Impurities
(Hindawi Publishing Corp, New York, 2016)
Fast and simple hydrophilic interaction liquid chromatography (HILIC) method was developed and validated for the analysis of moxonidine and its four impurities (A, B, C, and D) in pharmaceutical dosage form. All experiments ...
Oculometric determination of cupric salts / Kulometrijsko odredivanje kupri soli
(Vojnomedicinska akademija - Institut za naučne informacije, Beograd, 1973)
Antioxidative Effects of Black Currant and Cornelian Cherry Juices in Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
(MDPI, 2023)
A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms ...
Current level of evidence for improvement of antidepressant efficacy and tolerability by pharmacogenomic-guided treatment: A Systematic review and meta-analysis of randomized controlled clinical trials
(Elsevier B.V., 2024)
The aim of the study was to assess the clinical utility of currently available pharmacogenomic (PGx) tools compared with treatment as usual (TAU), using a meta-analysis of dichotomous and continuous antidepressant efficacy ...
High-performance liquid chromatography evaluation of lipophilicity and QSRR modeling of a series of dual DNA gyrase and topoisomerase IV inhibitors
(Akadémiai Kiadó, 2024)
Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during replication
and represent important antibacterial drug targets. To be successful as drug candidates, newly synthesized compounds must ...
Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus
(MDPI, 2023)
Zaleplon is a positive allosteric modulator of the γ-aminobutyric acid (GABA)A receptor approved for the short-term treatment of insomnia. Previous publications on zaleplon have not addressed the proteins involved in its ...
Baseline Correction for HPLC Chromatograms by Using Free Open-Source Software
(MDPI, 2023)
Chromatograms with overlapping peaks and a baseline rise or upset constitute a great challenge for analysts. Such a case regarding the analysis of bupropion hydrochloride and its 5 impurities in a tablet formulation was ...
Natural and natural-like polyphenol compounds: in vitro antioxidant activity and potential for therapeutic application
(Termedia Publishing House, 2023)
Introduction: Phenols are a large family of natural and synthetic compounds with known antioxidant activity. The aim of this study was to perform in vitro screening of natural and natural-like phenol monomers and their ...