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Prediction of aqueous solubility of drug-like molecules using a novel algorithm for automatic adjustment of relative importance of descriptors implemented in counter-propagation artificial neural networks
(Elsevier Science BV, Amsterdam, 2012)
In this work, we present a novel approach for the development of models for prediction of aqueous solubility, based on the implementation of an algorithm for the automatic adjustment of descriptor's relative importance ...
Two-step reduction of the O-methyloxime group in the antibiotic cefetamet
(Elsevier, 2001)
Abstract
Most oximes as well as their N-alkyl and O-alkyl derivatives are electrochemically reduced in a single four-electron step to the amine. Some exceptions have been reported, where the reduction occurs in two ...
Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cells
(Hindawi, 2019)
The health benefits of natural products have long been recognized. Consumption of dietary compounds such as supplements provides an alternative source of natural products to those obtained from the diet. There is a growing ...
Voltammetric behavior and square-wave voltammetric determination of cefotaxime in urine
(Elsevier, 2006)
Abstract
The voltammetric behavior of cefotaxime (CFX) is investigated by cyclic and square-wave voltammetry in BR buffers (pH 1.80–12.0).
Based on the cathodic reduction peak at approximately 0.5 V in BR buffer (pH 2.8 ...
Strain specificities in cellular and molecular immunopathogenic mechanisms underlying development of experimental autoimmune encephalomyelitis in aged rats
(Elsevier Ireland Ltd, Clare, 2017)
To understand strain-specificities of immune system in aged rats and their immunopathological implications, CD4+T lymphocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis (EAE) was studied in two ...
Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation
(Elsevier Science BV, Amsterdam, 2015)
This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble psychopharmacological drug. The nanoemulsions were prepared through ...