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COVID-19 signalome: Potential therapeutic interventions
(Elsevier Inc., 2023)
The COVID-19 pandemic has triggered intensive research and development of drugs and vaccines against SARS-CoV-2 during the last two years. The major success was especially observed with development of vaccines based on ...
Analytical method development supported by DoE-DS approach for enantioseparation of (S,S)- and (R,R)-moxifloxacin
(Elsevier B.V., 2023)
In this paper, method for enantiomeric purity testing of fourth-generation fluoroquinolone, moxifloxacin hydrochloride, was developed and validated. Exceptional enantioselectivity for this assay was achieved using cyclodextrin ...
Iron deficiency in nonanaemic COPD patients—Could Low haemoglobin density and Microcytic anaemia factor be usefull?
(John Wiley and Sons Inc, 2023)
Introduction: Erythrocyte indices LHD and Maf are complementary parameters to complete blood count and have been shown as reliable iron deficiency markers in different clinical settings. The aim of the study was to assess ...
HPTLC-based metabolomics approach for the detection of chokeberry (Aronia melanocarpa (Michx.) Elliott) adulteration
(Elsevier GmbH, 2023)
Introduction: Chokeberry is a plant belonging to the family Rosaceae which has a long history of edible and medicinal use. The aims of this study are: i) to investigate of HPTLC profile of the berry samples using HPTLC ...
Electrochemical and theoretical study on interaction between erlotinib and DNA
(Elsevier B.V., 2023)
A comprehensive investigation of tyrosine kinase inhibitor erlotinib (ERL) electrochemical behavior and interaction with DNA was performed with the aim to clarify its redox mechanism and to determine the mode of binding. ...
Influence of UV/H2O2 processes on C- and N-disinfection by-products formation in different water matrices
(Institute for Ionics, 2023)
The aim of this study was to investigate the influence of UV/H2O2 advanced oxidation process on the natural organic matter content and disinfection by-products formation potential of different water matrices. Three water ...
Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution
(Georg Thieme Verlag, 2023)
A cascade, metal promoted transformations utilizing chloro allenylamide, primary amine and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as one-pot process ...
Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites
(John Wiley and Sons Inc, 2023)
The composition and anticholinesterase activity of the dried MeOH extracts of Hieracium scheppigianum and H. naegelianum underground parts (rhizomes and roots), as well as the anticholinesterase activity of the dried, ...
Predicting liquid chromatography−electrospray ionization/mass spectrometry signal from the structure of model compounds and experimental factors; case study of aripiprazole and its impurities
(Elsevier Inc., 2023)
A priori estimation of analyte response is crucial for the efficient development of liquid chromatography–electrospray ionization/mass spectrometry (LC–ESI/MS) methods, but remains a demanding task given the lack of knowledge ...
Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson's Disease
(Elsevier Ltd, 2023)
Background: Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease (PD). We aimed to clarify the relationship between hypovitaminosis ...