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In silico assessment of intestinal precipitation: Case study of a poorly soluble, weakly basic compound
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Precipitation of a drug substance in the small intestine
is a phenomenon relevant to weak bases due to their pH-
dependent solubility. Because of the low solubility at
higher pH, upon entry in the small intestine, a ...
Application of the Gradient boosted tree approach for thin film classification based on disintegration time
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Thin films are polymeric strips that disintegrate in the
oral cavity and consist of a film-forming agent and an
active pharmaceutical ingredient (API). Generally, thin
films disintegrate within seconds, but their ...
The influence of preparation conditions on the formation and extent of interactions in chitosan/xanthan gum polyelectrolyte complexes as potential drug delivery carriers
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
The formation and properties of polyelectrolyte
complexes (PECs) based on chitosan (CH) and xanthan
gum (XG) depend on various preparation parameters (pH
value, ionic strength, mixing order of polyelectrolytes,
etc.). ...
An investigation into applicability of sodium carboxymethylcellulose and sodium alginate as film-forming agents for semi-solid 3D printing
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Semi-solid 3D printing technology has gained
increased interest in the pharmaceutical field as it enables
on-demand fabrication of personalized dosage forms.
Orodispersible films (ODFs) are good candidates for 3D
printing ...
Preformulation and development of preliminary nanoemulsion carrier for patent protected compound GL-II-73
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Nanopharmaceuticals offer a good option to avoid
some of the difficulties that novel drug candidates
confront. They can be tailored to adjust their water
solubility, half-life, biodistribution, and govern the release
of ...
Data mining implementation in multiparticulate unit systems characterization
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Multiparticulate unit systems (MPUs) represent
versatile drug delivery systems which provide flexible
dosing and reproducible drug release profile (Al-Hashimi
et al., 2018). They are usually filled in capsules/sachets ...
Selective laser sintering (SLS) 3D printing process: Influence of model design on the properties of zolpidem tartrate tablets
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Three-dimensional printing (3DP) is an innovative
additive manufacturing technology in the field of
pharmaceuticals that has the potential to provide small
batches of patient-tailored medicines (Wang et al., 2021).
One ...
Assessment of mucoadhesive buccal tablets with propranolol hydrochloride using principal component analysis
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Multivariate analysis methods are a set of statistical
techniques that allow multiple variables to be tested
simultaneously. This makes them ideal for studying
relationships in large complex datasets. Pharmaceutical
products ...
3D printing of carvedilol oral dosage forms using selective laser sintering technique
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
The adjustment of the dose according to the individual
needs of the patient is a unique advantage of 3D printing
technology, which is of particular importance for the
pediatric and geriatric population, due to the diverse ...
From co-processing by melt granulation towards direct compression of high ibuprofen loaded formulations
(Macedonian Pharmaceutical AssociationSs. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2023)
Direct compression, as the simplest and therefore
preferable method of tableting, is often hindered by poor
flow and compaction properties of the active
pharmaceutical ingredient (API). Tableting by direct
compression ...