The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?
2009
Autori
Bajić, VladanPotparević, Biljana
Živković, Lada
Bonda, David J.
Siedlak, Sandra L.
Casadesus, Gemma
Lee, Hyoung-Gon
Smith, Mark A.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression... of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.
Izvor:
Medical Hypotheses, 2009, 73, 6, 917-920Izdavač:
- Churchill Livingstone, Edinburgh
Finansiranje / projekti:
- Evaluacija dejstva hormona i citostatika prmenom citogenetičkih analiza i Komet testa (RS-MESTD-MPN2006-2010-143018)
DOI: 10.1016/j.mehy.2009.06.046
ISSN: 0306-9877
PubMed: 19647374
WoS: 000272923000011
Scopus: 2-s2.0-70450248506
Institucija/grupa
PharmacyTY - JOUR AU - Bajić, Vladan AU - Potparević, Biljana AU - Živković, Lada AU - Bonda, David J. AU - Siedlak, Sandra L. AU - Casadesus, Gemma AU - Lee, Hyoung-Gon AU - Smith, Mark A. PY - 2009 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1212 AB - Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain. PB - Churchill Livingstone, Edinburgh T2 - Medical Hypotheses T1 - The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging? VL - 73 IS - 6 SP - 917 EP - 920 DO - 10.1016/j.mehy.2009.06.046 ER -
@article{ author = "Bajić, Vladan and Potparević, Biljana and Živković, Lada and Bonda, David J. and Siedlak, Sandra L. and Casadesus, Gemma and Lee, Hyoung-Gon and Smith, Mark A.", year = "2009", abstract = "Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.", publisher = "Churchill Livingstone, Edinburgh", journal = "Medical Hypotheses", title = "The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?", volume = "73", number = "6", pages = "917-920", doi = "10.1016/j.mehy.2009.06.046" }
Bajić, V., Potparević, B., Živković, L., Bonda, D. J., Siedlak, S. L., Casadesus, G., Lee, H.,& Smith, M. A.. (2009). The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?. in Medical Hypotheses Churchill Livingstone, Edinburgh., 73(6), 917-920. https://doi.org/10.1016/j.mehy.2009.06.046
Bajić V, Potparević B, Živković L, Bonda DJ, Siedlak SL, Casadesus G, Lee H, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?. in Medical Hypotheses. 2009;73(6):917-920. doi:10.1016/j.mehy.2009.06.046 .
Bajić, Vladan, Potparević, Biljana, Živković, Lada, Bonda, David J., Siedlak, Sandra L., Casadesus, Gemma, Lee, Hyoung-Gon, Smith, Mark A., "The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?" in Medical Hypotheses, 73, no. 6 (2009):917-920, https://doi.org/10.1016/j.mehy.2009.06.046 . .