Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis
2013
Аутори
Vekić, JelenaZeljković, Aleksandra
Jelić-Ivanović, Zorana
Spasojević-Kalimanovska, Vesna
Spasić, Slavica
Videnović-Ivanov, Jelica
Ivanišević, Jasmina
Vučinić-Mihailović, Violeta
Gojković, Tamara
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P lt .001), but more LDL II and III (P lt .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size... (P lt .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.
Извор:
Archives of Pathology & Laboratory Medicine, 2013, 137, 12, 1780-1787Издавач:
- Coll Amer Pathologists, Northfield
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.5858/arpa.2012-0299-OA
ISSN: 0003-9985
PubMed: 24283859
WoS: 000328263900011
Scopus: 2-s2.0-84892742319
Институција/група
PharmacyTY - JOUR AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Jelić-Ivanović, Zorana AU - Spasojević-Kalimanovska, Vesna AU - Spasić, Slavica AU - Videnović-Ivanov, Jelica AU - Ivanišević, Jasmina AU - Vučinić-Mihailović, Violeta AU - Gojković, Tamara PY - 2013 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1912 AB - Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P lt .001), but more LDL II and III (P lt .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P lt .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course. PB - Coll Amer Pathologists, Northfield T2 - Archives of Pathology & Laboratory Medicine T1 - Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis VL - 137 IS - 12 SP - 1780 EP - 1787 DO - 10.5858/arpa.2012-0299-OA ER -
@article{ author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Videnović-Ivanov, Jelica and Ivanišević, Jasmina and Vučinić-Mihailović, Violeta and Gojković, Tamara", year = "2013", abstract = "Context.-Systemic inflammatory diseases are associated with proatherogenic lipoprotein profile, but there is a lack of information regarding overall distributions of lipoprotein subclasses in sarcoidosis. Objective.-To investigate whether patients with sarcoidosis have altered distributions of plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Design.-Seventy-seven patients with biopsy-proven sarcoidosis (29 with acute and 48 with chronic sarcoidosis) treated with corticosteroids and 77 age-and sex-matched controls were included in the study. Low-density lipoprotein and HDL subclasses were determined by gradient gel electrophoresis, while inflammatory markers and lipid parameters were measured by standard laboratory methods. Results.-Compared to controls, patients had fewer LDL I subclasses (P lt .001), but more LDL II and III (P lt .001) subclasses. This pattern was evident in both acute and chronic disease groups. Patients also had smaller HDL size (P lt .001) and higher proportions of HDL 2a (P = .006) and 3a particles (P = .004). Patients with chronic sarcoidosis had smaller LDL size than those with acute disease (P = .02) and higher proportions of HDL 3a subclasses (P = .04) than controls. In acute sarcoidosis, relative proportions of LDL and HDL particles were associated with levels of inflammatory markers, whereas in chronic disease an association with concentrations of serum lipid parameters was found. Conclusions.-The obtained results demonstrate adverse lipoprotein subfraction profile in sarcoidosis with sustained alterations during disease course. Evaluation of LDL and HDL particles may be helpful in identifying patients with higher cardiovascular risk, at least for prolonged corticosteroid therapy due to chronic disease course.", publisher = "Coll Amer Pathologists, Northfield", journal = "Archives of Pathology & Laboratory Medicine", title = "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis", volume = "137", number = "12", pages = "1780-1787", doi = "10.5858/arpa.2012-0299-OA" }
Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S., Videnović-Ivanov, J., Ivanišević, J., Vučinić-Mihailović, V.,& Gojković, T.. (2013). Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine Coll Amer Pathologists, Northfield., 137(12), 1780-1787. https://doi.org/10.5858/arpa.2012-0299-OA
Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Videnović-Ivanov J, Ivanišević J, Vučinić-Mihailović V, Gojković T. Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis. in Archives of Pathology & Laboratory Medicine. 2013;137(12):1780-1787. doi:10.5858/arpa.2012-0299-OA .
Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Videnović-Ivanov, Jelica, Ivanišević, Jasmina, Vučinić-Mihailović, Violeta, Gojković, Tamara, "Distribution of Low-Density Lipoprotein and High-Density Lipoprotein Subclasses in Patients With Sarcoidosis" in Archives of Pathology & Laboratory Medicine, 137, no. 12 (2013):1780-1787, https://doi.org/10.5858/arpa.2012-0299-OA . .