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Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: The approximated activation of receptor subtypes may explain behavioral effects
(Elsevier Science BV, Amsterdam, 2014)
Enormous progress in understanding the role of four populations of benzodiazepine-sensitive GABA(A) receptors was paralleled by the puzzling findings suggesting that substantial separation of behavioral effects may be ...
The role of alpha(1) and alpha(5) subunit-containing GABA(A) receptors in motor impairment induced by benzodiazepines in rats
(Lippincott Williams & Wilkins, Philadelphia, 2012)
Benzodiazepines negatively affect motor coordination and balance and produce myorelaxation. The aim of the present study was to examine the extent to which populations of gamma-aminobutyric acid A (GABA(A)) receptors ...
Structure-retention relationships of diuretics in reversed-phase liquid chromatography
(John Wiley and Sons Ltd, 2000)
Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent
(Wiley-VCH Verlag GMBH, Weinheim, 2004)
A novel and unique approach was used for retention modelling in the separation of simvastatin and six impurities by liquid chromatographic using a microemulsion as mobile phase. A microemulsion is a modification of a ...
Chronic alpha(1)-adrenoreceptor blockade produces age-dependent changes in rat thymus structure and thymocyte differentiation
(F Hernandez, Murcia, 2005)
In order to examine the influence of chronic alpha(1)-adrenergic receptor (alpha(1)-AR) blockade on the thymus structure and T-cell maturation, peripubertal and adult male rats were treated with urapidil (0.20 mg/kg BW/d; ...
Study of acid hydrolysis of bromazepam
(Canadian Science Publishing, Nrc Research Press, Ottawa, 2004)
Quantitative study of an acid hydrolysis of bromazepam, which in acidic solution simultaneously undergoes reversible 4,5-azomethine bond cleavage and protolytic reactions, was performed (t = 25degreesC). When an equilibrium ...
Placenta-specific plasma miR518b is a potential biomarker for preeclampsia
(Elsevier, 2020)
Introduction: MicroRNAs have a significant role in the pathogenesis of preeclampsia. Circulating microRNAs could represent a potential biomarker for preeclampsia. The aim of this study was to evaluate plasma miR210-3p and ...
Direct Spectrophotometric Determination of Hesperidin in Pharmaceutical Preparations
(Slovensko Kemijsko Drustvo, Ljubljana, 2012)
A simple, rapid and reliable direct spectrophotometric method for the determination of hesperidin is proposed and validated. The influence of wavelength, solvent, the ionic strength, pH and temperature on hesperidin ...
Triterpenic derivatives of Achillea alexandri-regis Bornm. & Rudski
(Pharmaceutical Soc Japan, Tokyo, 2004)
Investigation of the aerial parts of Achillea alexandri-regis led to the identification of 19 chemical constituents: twelve 3-O-fatty acid esters of triterpene alcohols arnidiol (1-4), maniladiol (5-8) and 16beta-hydroxy-lupeol ...
Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients
(Sage Publications Inc, Thousand Oaks, 2014)
Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without ...