Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus
Апстракт
Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds r...educed the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.
Кључне речи:
chalcones / glycocalyx / biofilms / MRSAИзвор:
Brazilian Journal of Microbiology, 2014, 45, 1, 263-270Издавач:
- Soc Brasileira Microbiologia, Sao Paulo
Финансирање / пројекти:
- Бактерије резистентне на антибиотике у Србији: фенотипска и генотипска карактеризација (RS-MESTD-Basic Research (BR or ON)-175039)
DOI: 10.1590/S1517-83822014000100038
ISSN: 1517-8382
PubMed: 24948943
WoS: 000338109800038
Scopus: 2-s2.0-84901921016
Институција/група
PharmacyTY - JOUR AU - Božić, Dragana AU - Milenković, Marina AU - Ivković, Branka AU - Cirković, Ivana PY - 2014 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2209 AB - Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds reduced the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy. PB - Soc Brasileira Microbiologia, Sao Paulo T2 - Brazilian Journal of Microbiology T1 - Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus VL - 45 IS - 1 SP - 263 EP - 270 DO - 10.1590/S1517-83822014000100038 ER -
@article{ author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Cirković, Ivana", year = "2014", abstract = "Biofilm formation and adherence of bacteria to host tissue are one of the most important virulence factors of methicillin-resistant strains of Staphylococcus aureus (MRSA). The number of resistant strains is seriously increasing during the past years and bacteria have become resistant, not only to methicillin, but also to other commonly used antistaphylococcal antibiotics. There is a great need for discovering a novel antimicrobial agent for the treatment of staphylococcal infections. One of the most promising groups of compounds appears to be chalcones. In present study we evaluated the in vitro effect of three newly synthesized chalcones: 1,3-Bis-(2-hydroxy-phenyl)-propenone, 3-(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxyphenyl)-propenone on glycocalyx production, biofilm formation and adherence to human fibronectin of clinical isolates and laboratory control strain of MRSA (ATCC 43300). Subinhibitory concentrations of the tested compounds reduced the production of glycocalyx, biofilm formation and adherence to human fibronectin of all MRSA strains. Inhibition of biofilm formation was dose dependent and the most effective was 1,3-Bis-(2-hydroxy-phenyl)-propenone. In our study we demonstrated that three newly-synthesized chalcones exhibited significant effect on adherence and biofilm formation of MRSA strains. Chalcones may be considered as promising new antimicrobial agents that can be used for prevention of staphylococcal infections or as adjunct to antibiotics in conventional therapy.", publisher = "Soc Brasileira Microbiologia, Sao Paulo", journal = "Brazilian Journal of Microbiology", title = "Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus", volume = "45", number = "1", pages = "263-270", doi = "10.1590/S1517-83822014000100038" }
Božić, D., Milenković, M., Ivković, B.,& Cirković, I.. (2014). Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus. in Brazilian Journal of Microbiology Soc Brasileira Microbiologia, Sao Paulo., 45(1), 263-270. https://doi.org/10.1590/S1517-83822014000100038
Božić D, Milenković M, Ivković B, Cirković I. Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus. in Brazilian Journal of Microbiology. 2014;45(1):263-270. doi:10.1590/S1517-83822014000100038 .
Božić, Dragana, Milenković, Marina, Ivković, Branka, Cirković, Ivana, "Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus" in Brazilian Journal of Microbiology, 45, no. 1 (2014):263-270, https://doi.org/10.1590/S1517-83822014000100038 . .