Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis
Apstrakt
Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selectio...n of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions.
Ključne reči:
poloxamer / neusilin / diatomite / solid surfactant drug delivery systems / polymorphous transitionIzvor:
Journal of the Serbian Chemical Society, 2015, 80, 2, 209-222Izdavač:
- Srpsko hemijsko društvo, Beograd
Finansiranje / projekti:
- Razvoj proizvoda i tehnologija koje obezbeđuju željeno oslobađanje lekovitih supstanci iz čvrstih farmaceutskih oblika (RS-MESTD-Technological Development (TD or TR)-34007)
DOI: 10.2298/JSC030814114K
ISSN: 0352-5139
WoS: 000351326300009
Scopus: 2-s2.0-84914671083
Institucija/grupa
PharmacyTY - JOUR AU - Krstić, Marko AU - Ražić, Slavica AU - Vasiljević, Dragana AU - Spasojević, Durdija AU - Ibrić, Svetlana PY - 2015 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2406 AB - Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selection of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions. PB - Srpsko hemijsko društvo, Beograd T2 - Journal of the Serbian Chemical Society T1 - Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis VL - 80 IS - 2 SP - 209 EP - 222 DO - 10.2298/JSC030814114K ER -
@article{ author = "Krstić, Marko and Ražić, Slavica and Vasiljević, Dragana and Spasojević, Durdija and Ibrić, Svetlana", year = "2015", abstract = "Poor solubility is one of the key reasons for the poor bioavailability of carbamazepine drugs. This study considers formulation of solid surfactant systems with carbamazepine, in order to increase its dissolution rate. Solid-state surfactant systems were formed by application of fractional experimental design. Poloxamer 237 and Poloxamer 338 were used as the surfactants and Brij (R) 35 was used as the co-surfactant. The ratios of the excipients and carbamazepine were varied and their effects on the dissolution rate of carbamazepine were examined. Moreover, the effects of the addition of natural (diatomite) and a synthetic adsorbent carrier (Neusilin (R) UFL2) on the dissolution rate of carbamazepine were also tested. The prepared surfactant systems were characterized and the influences of the excipients on possible changes of the polymorphous form of carbamazepine examined by application of analytical techniques (DSC, TGA, FT-IR and PXRD). It was determined that an appropriate selection of the excipient type and ratio could provide a significant increase in the carbamazepine dissolution rate. By application of analytical techniques, it was found that the employed excipients induce a transition of carbamazepine into the amorphous form and that the selected sample was stable for three months, when kept under ambient conditions.", publisher = "Srpsko hemijsko društvo, Beograd", journal = "Journal of the Serbian Chemical Society", title = "Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis", volume = "80", number = "2", pages = "209-222", doi = "10.2298/JSC030814114K" }
Krstić, M., Ražić, S., Vasiljević, D., Spasojević, D.,& Ibrić, S.. (2015). Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis. in Journal of the Serbian Chemical Society Srpsko hemijsko društvo, Beograd., 80(2), 209-222. https://doi.org/10.2298/JSC030814114K
Krstić M, Ražić S, Vasiljević D, Spasojević D, Ibrić S. Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis. in Journal of the Serbian Chemical Society. 2015;80(2):209-222. doi:10.2298/JSC030814114K .
Krstić, Marko, Ražić, Slavica, Vasiljević, Dragana, Spasojević, Durdija, Ibrić, Svetlana, "Application of experimental design in the examination of the dissolution rate of carbamazepine from formulations. Characterization of the optimal formulation by DSC, TGA, FT-IR and PXRD analysis" in Journal of the Serbian Chemical Society, 80, no. 2 (2015):209-222, https://doi.org/10.2298/JSC030814114K . .