Vehicle-controlled effect of urea on normal and SLS-irritated skin
Samo za registrovane korisnike
2004
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that... barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin.
Ključne reči:
urea / moisturiser / skin hydration / TEWL / erythema index / emulsionIzvor:
International Journal of Pharmaceutics, 2004, 271, 1-2, 269-280Izdavač:
- Elsevier Science BV, Amsterdam
DOI: 10.1016/j.ijpharm.2003.11.033
ISSN: 0378-5173
PubMed: 15129994
WoS: 000189248000028
Scopus: 2-s2.0-1142279560
Institucija/grupa
PharmacyTY - JOUR AU - Savić, Snežana AU - Tamburić, Slobodanka AU - Savić, Miroslav AU - Cekić, Nebojša AU - Milić, J. AU - Vuleta, G PY - 2004 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/528 AB - It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - Vehicle-controlled effect of urea on normal and SLS-irritated skin VL - 271 IS - 1-2 SP - 269 EP - 280 DO - 10.1016/j.ijpharm.2003.11.033 ER -
@article{ author = "Savić, Snežana and Tamburić, Slobodanka and Savić, Miroslav and Cekić, Nebojša and Milić, J. and Vuleta, G", year = "2004", abstract = "It is known that, depending on the concentration, treatment with urea could improve skin barrier function, despite its penetration-enhancing properties. This controversial skin effect of urea has been explored systematically in this study in terms of the effect of vehicle on the performance of urea. In the first part, a series of four semi-solid emulsions with 5% (w/w) urea, varying in the type of emulsion, nature of emulsifier and polarity of oil ingredients, have been evaluated with regard to their skin hydrating and transepidermal water loss (TEWL)-modifying properties. Placebo samples were tested alongside the urea-containing ones. Two best performing moisturisers from the above were chosen for the second part of the study, in which sodium lauryl sulphate (SLS)-irritated skin was treated with both placebo and urea-containing samples. In addition to TEWL and skin hydration level, the erythema index (EI) was measured before, during and after the treatment. The results have shown that barrier-improving and hydrating abilities of urea are bi-directional and dependent on both the type of vehicle used for its delivery and the state of skin.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Vehicle-controlled effect of urea on normal and SLS-irritated skin", volume = "271", number = "1-2", pages = "269-280", doi = "10.1016/j.ijpharm.2003.11.033" }
Savić, S., Tamburić, S., Savić, M., Cekić, N., Milić, J.,& Vuleta, G.. (2004). Vehicle-controlled effect of urea on normal and SLS-irritated skin. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 271(1-2), 269-280. https://doi.org/10.1016/j.ijpharm.2003.11.033
Savić S, Tamburić S, Savić M, Cekić N, Milić J, Vuleta G. Vehicle-controlled effect of urea on normal and SLS-irritated skin. in International Journal of Pharmaceutics. 2004;271(1-2):269-280. doi:10.1016/j.ijpharm.2003.11.033 .
Savić, Snežana, Tamburić, Slobodanka, Savić, Miroslav, Cekić, Nebojša, Milić, J., Vuleta, G, "Vehicle-controlled effect of urea on normal and SLS-irritated skin" in International Journal of Pharmaceutics, 271, no. 1-2 (2004):269-280, https://doi.org/10.1016/j.ijpharm.2003.11.033 . .