TY  - JOUR
AU  - Stojković, Aleksandra
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Corrigan, Owen I.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2162
AB  - With the development of physiologically based absorption models, there is an increased scientific and regulatory interest in in silico modelling and simulation of drug-drug and drug-food interactions. Clinically significant interactions between ciprofloxacin and metallic compounds are widely documented. In the current study, a previously developed ciprofloxacin-specific in silico absorption model was employed in order to simulate ciprofloxacin/metallic compound interaction observed in vivo. Commercially available software GastroPlus (TM) (Simulations Plus Inc., USA) based on the ACAT model was used for gastrointestinal (GI) simulations. The required input parameters, relating to ciprofloxacin hydrochloride physicochemical and pharmacokinetic characteristics, were experimentally determined, taken from the literature or estimated by GastroPlus (TM). Parameter sensitivity analysis (PSA) was used to assess the importance of selected input parameters (solubility, permeability, stomach and small intestine transit time) in predicting percent drug absorbed. PSA identified solubility and permeability as critical parameters affecting the rate and extent of ciprofloxacin absorption. Using the selected input parameters, it was possible to generate a ciprofloxacin absorption model, without/with metal cation containing preparations co-administration, which matched well the in vivo data available. It was found that reduced ciprofloxacin absorption in the presence of aluminium hydroxide, calcium carbonate or multivitamins/zinc was accounted for by reduced drug solubility. The impact of solubility-permeability interplay on ciprofloxacin absorption can be observed in the ciprofloxacin-aluminium interaction, while in ciprofloxacin-calcium and ciprofloxacin-zinc interactions, effect of solubility was more pronounced. The results obtained indicate that in silico model developed can be successfully used to complement relevant in vitro studies in the simulation of physicochemical ciprofloxacin/metallic compound interactions.
PB  - Springer, New York
T2  - AAPS PharmSciTech
T1  - A Case Study of In Silico Modelling of Ciprofloxacin Hydrochloride/Metallic Compound Interactions
VL  - 15
IS  - 2
SP  - 270
EP  - 278
DO  - 10.1208/s12249-013-0055-x
ER  - 

@article{
author = "Stojković, Aleksandra and Parojčić, Jelena and Đurić, Zorica and Corrigan, Owen I.",
year = "2014",
abstract = "With the development of physiologically based absorption models, there is an increased scientific and regulatory interest in in silico modelling and simulation of drug-drug and drug-food interactions. Clinically significant interactions between ciprofloxacin and metallic compounds are widely documented. In the current study, a previously developed ciprofloxacin-specific in silico absorption model was employed in order to simulate ciprofloxacin/metallic compound interaction observed in vivo. Commercially available software GastroPlus (TM) (Simulations Plus Inc., USA) based on the ACAT model was used for gastrointestinal (GI) simulations. The required input parameters, relating to ciprofloxacin hydrochloride physicochemical and pharmacokinetic characteristics, were experimentally determined, taken from the literature or estimated by GastroPlus (TM). Parameter sensitivity analysis (PSA) was used to assess the importance of selected input parameters (solubility, permeability, stomach and small intestine transit time) in predicting percent drug absorbed. PSA identified solubility and permeability as critical parameters affecting the rate and extent of ciprofloxacin absorption. Using the selected input parameters, it was possible to generate a ciprofloxacin absorption model, without/with metal cation containing preparations co-administration, which matched well the in vivo data available. It was found that reduced ciprofloxacin absorption in the presence of aluminium hydroxide, calcium carbonate or multivitamins/zinc was accounted for by reduced drug solubility. The impact of solubility-permeability interplay on ciprofloxacin absorption can be observed in the ciprofloxacin-aluminium interaction, while in ciprofloxacin-calcium and ciprofloxacin-zinc interactions, effect of solubility was more pronounced. The results obtained indicate that in silico model developed can be successfully used to complement relevant in vitro studies in the simulation of physicochemical ciprofloxacin/metallic compound interactions.",
publisher = "Springer, New York",
journal = "AAPS PharmSciTech",
title = "A Case Study of In Silico Modelling of Ciprofloxacin Hydrochloride/Metallic Compound Interactions",
volume = "15",
number = "2",
pages = "270-278",
doi = "10.1208/s12249-013-0055-x"
}

Stojković, A., Parojčić, J., Đurić, Z.,& Corrigan, O. I.. (2014). A Case Study of In Silico Modelling of Ciprofloxacin Hydrochloride/Metallic Compound Interactions. in AAPS PharmSciTech
Springer, New York., 15(2), 270-278.
https://doi.org/10.1208/s12249-013-0055-x

Stojković A, Parojčić J, Đurić Z, Corrigan OI. A Case Study of In Silico Modelling of Ciprofloxacin Hydrochloride/Metallic Compound Interactions. in AAPS PharmSciTech. 2014;15(2):270-278.
doi:10.1208/s12249-013-0055-x .

Stojković, Aleksandra, Parojčić, Jelena, Đurić, Zorica, Corrigan, Owen I., "A Case Study of In Silico Modelling of Ciprofloxacin Hydrochloride/Metallic Compound Interactions" in AAPS PharmSciTech, 15, no. 2 (2014):270-278,
https://doi.org/10.1208/s12249-013-0055-x . .

TY  - JOUR
AU  - Stojković, Aleksandra
AU  - Tajber, Lidia
AU  - Paluch, Krzysztof J.
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Corrigan, Owen I.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2161
AB  - Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)(2)(Cl)(2)(ciprofloxacin)(2) x nH(2)O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.
PB  - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
T2  - Acta Pharmaceutica
T1  - Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution
VL  - 64
IS  - 1
SP  - 77
EP  - 88
DO  - 10.2478/acph-2014-0007
ER  - 

@article{
author = "Stojković, Aleksandra and Tajber, Lidia and Paluch, Krzysztof J. and Đurić, Zorica and Parojčić, Jelena and Corrigan, Owen I.",
year = "2014",
abstract = "Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)(2)(Cl)(2)(ciprofloxacin)(2) x nH(2)O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.",
publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb",
journal = "Acta Pharmaceutica",
title = "Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution",
volume = "64",
number = "1",
pages = "77-88",
doi = "10.2478/acph-2014-0007"
}

Stojković, A., Tajber, L., Paluch, K. J., Đurić, Z., Parojčić, J.,& Corrigan, O. I.. (2014). Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. in Acta Pharmaceutica
Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 64(1), 77-88.
https://doi.org/10.2478/acph-2014-0007

Stojković A, Tajber L, Paluch KJ, Đurić Z, Parojčić J, Corrigan OI. Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution. in Acta Pharmaceutica. 2014;64(1):77-88.
doi:10.2478/acph-2014-0007 .

Stojković, Aleksandra, Tajber, Lidia, Paluch, Krzysztof J., Đurić, Zorica, Parojčić, Jelena, Corrigan, Owen I., "Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution" in Acta Pharmaceutica, 64, no. 1 (2014):77-88,
https://doi.org/10.2478/acph-2014-0007 . .

TY  - JOUR
AU  - Stojković, Aleksandra
AU  - Tajber, Lidia
AU  - Đurić, Zorica
AU  - Corrigan, Owen I.
AU  - Parojčić, Jelena
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2097
AB  - In vitro dissolution testing has long been used as a tool in drug product development and quality control, however, its potential for drug/food and drug/drug interactions has not yet been filly exploited. Ciprofloxacin absorption in vivo may be reduced when co-administered with different metallic compounds. In the present study, in vitro ciprofloxacin solubility and drug dissolution from tablets were performed in the reactive media containing zinc chloride in order to simulate ciprofloxacin/zinc interaction observed in vivo. The precipitates collected from dissolution vessel and from mixture containing ciprofloxacin-hydrochloride and zinc-chloride were investigated using XRPD, TGA, DCS, FTIR. Ciprofloxacin-hydrochloride solubility and drug dissolution from tablet were reduced in aqueous media containing increasing amounts of zinc-chloride. Complex with probable chemical structure kin [cfH(2)](2)center dot[ZnCl4]center dot 2H(2)O was generated in the presence of high concentrations of ciprofloxacin-hydrochloride and zinc-chloride, indicating that small volume dissolution experiments can be useful in biopharmaceutical characterisation of drug interaction studies.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - In vitro simulation of drug interaction: ciprofloxacin/zinc chloride
VL  - 24
IS  - 2
SP  - 229
EP  - 233
DO  - 10.1016/S1773-2247(14)50037-8
ER  - 

@article{
author = "Stojković, Aleksandra and Tajber, Lidia and Đurić, Zorica and Corrigan, Owen I. and Parojčić, Jelena",
year = "2014",
abstract = "In vitro dissolution testing has long been used as a tool in drug product development and quality control, however, its potential for drug/food and drug/drug interactions has not yet been filly exploited. Ciprofloxacin absorption in vivo may be reduced when co-administered with different metallic compounds. In the present study, in vitro ciprofloxacin solubility and drug dissolution from tablets were performed in the reactive media containing zinc chloride in order to simulate ciprofloxacin/zinc interaction observed in vivo. The precipitates collected from dissolution vessel and from mixture containing ciprofloxacin-hydrochloride and zinc-chloride were investigated using XRPD, TGA, DCS, FTIR. Ciprofloxacin-hydrochloride solubility and drug dissolution from tablet were reduced in aqueous media containing increasing amounts of zinc-chloride. Complex with probable chemical structure kin [cfH(2)](2)center dot[ZnCl4]center dot 2H(2)O was generated in the presence of high concentrations of ciprofloxacin-hydrochloride and zinc-chloride, indicating that small volume dissolution experiments can be useful in biopharmaceutical characterisation of drug interaction studies.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "In vitro simulation of drug interaction: ciprofloxacin/zinc chloride",
volume = "24",
number = "2",
pages = "229-233",
doi = "10.1016/S1773-2247(14)50037-8"
}

Stojković, A., Tajber, L., Đurić, Z., Corrigan, O. I.,& Parojčić, J.. (2014). In vitro simulation of drug interaction: ciprofloxacin/zinc chloride. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 24(2), 229-233.
https://doi.org/10.1016/S1773-2247(14)50037-8

Stojković A, Tajber L, Đurić Z, Corrigan OI, Parojčić J. In vitro simulation of drug interaction: ciprofloxacin/zinc chloride. in Journal of Drug Delivery Science and Technology. 2014;24(2):229-233.
doi:10.1016/S1773-2247(14)50037-8 .

Stojković, Aleksandra, Tajber, Lidia, Đurić, Zorica, Corrigan, Owen I., Parojčić, Jelena, "In vitro simulation of drug interaction: ciprofloxacin/zinc chloride" in Journal of Drug Delivery Science and Technology, 24, no. 2 (2014):229-233,
https://doi.org/10.1016/S1773-2247(14)50037-8 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Stojković, Aleksandra
AU  - Tajber, Lidia
AU  - Cvijić, Sandra
AU  - Paluch, Krzysztof J.
AU  - Đurić, Zorica
AU  - Corrigan, Owen I.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1512
AB  - The ciprofloxacin-iron interaction, resulting in a lower bioavailability, is well documented in vivo; however, a mechanistic explanation supported by experimental data of this interaction is missing. In the present study, ciprofloxacin hydrochloride (HCl) and ferrous sulfate interaction was simulated in vitro by performing solubility and dissolution studies in the reactive media containing ferrous sulfate. Characterization of the precipitate formed indicated its probable chemical structure as Fe(SO(4)(2-))(2)(Cl(-))(2)(ciprofloxacin)(2) x (H(2)O)(n), where n is up to 12 molecules of water. The solubility of this complex in water was estimated to be approximately 2mg/mL, being about 20-fold lower than the solubility of ciprofloxacin HCl. The solubility of the complex was used as input parameter for an in silico modeling by GastroPlus (TM) and the resulting predicted plasma time curves were in good agreement with the in vivo data. These results strongly indicate that ciprofloxacin-iron interaction in vivo is caused by the formation of a low soluble complex. This interaction was also simulated by in vitro dissolution, in which a mini scale apparatus provided more biorelevant results than the standard dissolution apparatus, probably because the drug concentrations in the mini apparatus were higher and, thus, closer to the conditions encountered in vivo.
PB  - Wiley-Blackwell, Malden
T2  - Journal of Pharmaceutical Sciences
T1  - Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction
VL  - 100
IS  - 12
SP  - 5174
EP  - 5184
DO  - 10.1002/jps.22707
ER  - 

@article{
author = "Parojčić, Jelena and Stojković, Aleksandra and Tajber, Lidia and Cvijić, Sandra and Paluch, Krzysztof J. and Đurić, Zorica and Corrigan, Owen I.",
year = "2011",
abstract = "The ciprofloxacin-iron interaction, resulting in a lower bioavailability, is well documented in vivo; however, a mechanistic explanation supported by experimental data of this interaction is missing. In the present study, ciprofloxacin hydrochloride (HCl) and ferrous sulfate interaction was simulated in vitro by performing solubility and dissolution studies in the reactive media containing ferrous sulfate. Characterization of the precipitate formed indicated its probable chemical structure as Fe(SO(4)(2-))(2)(Cl(-))(2)(ciprofloxacin)(2) x (H(2)O)(n), where n is up to 12 molecules of water. The solubility of this complex in water was estimated to be approximately 2mg/mL, being about 20-fold lower than the solubility of ciprofloxacin HCl. The solubility of the complex was used as input parameter for an in silico modeling by GastroPlus (TM) and the resulting predicted plasma time curves were in good agreement with the in vivo data. These results strongly indicate that ciprofloxacin-iron interaction in vivo is caused by the formation of a low soluble complex. This interaction was also simulated by in vitro dissolution, in which a mini scale apparatus provided more biorelevant results than the standard dissolution apparatus, probably because the drug concentrations in the mini apparatus were higher and, thus, closer to the conditions encountered in vivo.",
publisher = "Wiley-Blackwell, Malden",
journal = "Journal of Pharmaceutical Sciences",
title = "Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction",
volume = "100",
number = "12",
pages = "5174-5184",
doi = "10.1002/jps.22707"
}

Parojčić, J., Stojković, A., Tajber, L., Cvijić, S., Paluch, K. J., Đurić, Z.,& Corrigan, O. I.. (2011). Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction. in Journal of Pharmaceutical Sciences
Wiley-Blackwell, Malden., 100(12), 5174-5184.
https://doi.org/10.1002/jps.22707

Parojčić J, Stojković A, Tajber L, Cvijić S, Paluch KJ, Đurić Z, Corrigan OI. Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction. in Journal of Pharmaceutical Sciences. 2011;100(12):5174-5184.
doi:10.1002/jps.22707 .

Parojčić, Jelena, Stojković, Aleksandra, Tajber, Lidia, Cvijić, Sandra, Paluch, Krzysztof J., Đurić, Zorica, Corrigan, Owen I., "Biopharmaceutical Characterization of Ciprofloxacin HCl-Ferrous Sulfate Interaction" in Journal of Pharmaceutical Sciences, 100, no. 12 (2011):5174-5184,
https://doi.org/10.1002/jps.22707 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Corrigan, Owen I.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1076
AB  - Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introduction of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutics and Biopharmaceutics
T1  - Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption
VL  - 69
IS  - 2
SP  - 640
EP  - 647
DO  - 10.1016/j.ejpb.2008.01.001
ER  - 

@article{
author = "Parojčić, Jelena and Corrigan, Owen I.",
year = "2008",
abstract = "Ibuprofen is a widely used NSAID which is often co-administered with antacids because of its gastro-irritant effects. Literature data suggest that antacid interactions may increase or decrease the drug's absorption rate and onset of action and that the interaction may be formulation specific. In the present study, literature data on ibuprofen absorption were evaluated in order to gain insight into the nature of the in vivo effect. Solubility determinations in reactive media containing magnesium or aluminium and dissolution studies in the presence of antacid suspension were performed in an attempt to simulate in vitro the effects observed in vivo. The results obtained indicate that magnesium hydroxide enhances ibuprofen solubility, dissolution and bioavailability, while aluminium hydroxide has a retarding effect. Solubility studies indicated formation of a soluble solid ibuprofen phase in the presence of Mg2+, in contrast, an insoluble ibuprofen salt was formed with Al3+. The introduction of magnesium based antacid suspension into the dissolution media resulted in a formulation specific increase in drug dissolution rate with the most pronounced effect observed for the slowest release tablet formulation. The results obtained indicate the potential for in vitro studies to predict physicochemical interactions that are likely to influence drug absorption rate in vivo.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
title = "Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption",
volume = "69",
number = "2",
pages = "640-647",
doi = "10.1016/j.ejpb.2008.01.001"
}

Parojčić, J.,& Corrigan, O. I.. (2008). Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption. in European Journal of Pharmaceutics and Biopharmaceutics
Elsevier Science BV, Amsterdam., 69(2), 640-647.
https://doi.org/10.1016/j.ejpb.2008.01.001

Parojčić J, Corrigan OI. Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption. in European Journal of Pharmaceutics and Biopharmaceutics. 2008;69(2):640-647.
doi:10.1016/j.ejpb.2008.01.001 .

Parojčić, Jelena, Corrigan, Owen I., "Rationale for ibuprofen co-administration with antacids: Potential interaction mechanisms affecting drug absorption" in European Journal of Pharmaceutics and Biopharmaceutics, 69, no. 2 (2008):640-647,
https://doi.org/10.1016/j.ejpb.2008.01.001 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
AU  - Jovanović, Milica
AU  - Corrigan, Owen I.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/960
AB  - Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. Although linear regression analysis represents the simplest relationship, it is recognized that IVIVC should not be limited to linear relationship. With regards to the implementation of non-linear IVIVC models and the ability of artificial neural network (ANN) computing to cope with non-linear relationships, the usefulness of ANN analysis in the development of IVIVC merits further evaluation. The present paper is an attempt to develop an IVIVC for model sustained release paracetamol matrix tablet formulations employing various correlation approaches based on linear and non-linear modeling of in vitro and in vivo data. Currently accepted compendial methodology was compared with the alternative approaches, involving general mixed effects model and generalized regression neural network (GRNN) analysis, in order to evaluate their usefulness for predicting the in vivo behavior of drug products. Although based on analogous approaches, data generated by GRNN were closer to those observed in vivo, leading to the higher level of IVIVC than obtained by convolution. It can be assumed that GRNN analysis was able to generalize complex relations between the output and input parameters and could account for the differences in drug release kinetics observed under various conditions in vitro, thus offering potential as a reliable and robust estimate of drug products in vivo behavior.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
VL  - 30
IS  - 3-4
SP  - 264
EP  - 272
DO  - 10.1016/j.ejps.2006.11.010
ER  - 

@article{
author = "Parojčić, Jelena and Ibrić, Svetlana and Đurić, Zorica and Jovanović, Milica and Corrigan, Owen I.",
year = "2007",
abstract = "Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. Although linear regression analysis represents the simplest relationship, it is recognized that IVIVC should not be limited to linear relationship. With regards to the implementation of non-linear IVIVC models and the ability of artificial neural network (ANN) computing to cope with non-linear relationships, the usefulness of ANN analysis in the development of IVIVC merits further evaluation. The present paper is an attempt to develop an IVIVC for model sustained release paracetamol matrix tablet formulations employing various correlation approaches based on linear and non-linear modeling of in vitro and in vivo data. Currently accepted compendial methodology was compared with the alternative approaches, involving general mixed effects model and generalized regression neural network (GRNN) analysis, in order to evaluate their usefulness for predicting the in vivo behavior of drug products. Although based on analogous approaches, data generated by GRNN were closer to those observed in vivo, leading to the higher level of IVIVC than obtained by convolution. It can be assumed that GRNN analysis was able to generalize complex relations between the output and input parameters and could account for the differences in drug release kinetics observed under various conditions in vitro, thus offering potential as a reliable and robust estimate of drug products in vivo behavior.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation",
volume = "30",
number = "3-4",
pages = "264-272",
doi = "10.1016/j.ejps.2006.11.010"
}

Parojčić, J., Ibrić, S., Đurić, Z., Jovanović, M.,& Corrigan, O. I.. (2007). An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 30(3-4), 264-272.
https://doi.org/10.1016/j.ejps.2006.11.010

Parojčić J, Ibrić S, Đurić Z, Jovanović M, Corrigan OI. An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation. in European Journal of Pharmaceutical Sciences. 2007;30(3-4):264-272.
doi:10.1016/j.ejps.2006.11.010 .

Parojčić, Jelena, Ibrić, Svetlana, Đurić, Zorica, Jovanović, Milica, Corrigan, Owen I., "An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation" in European Journal of Pharmaceutical Sciences, 30, no. 3-4 (2007):264-272,
https://doi.org/10.1016/j.ejps.2006.11.010 . .

TY  - CONF
AU  - Parojčić, Jelena
AU  - Lane, M.E.
AU  - Corrigan, Owen I.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/768
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Development of biorelevant dissolution media for a BCS group II model drug: Mefenamic acid
T1  - Razvoj biorelevantnog in vitro testa za ispitivanje brzine rastvaranja - mefenaminska kiselina kao model supstanca
VL  - 56
IS  - 4
SP  - 482
EP  - 483
UR  - https://hdl.handle.net/21.15107/rcub_farfar_768
ER  - 

@conference{
author = "Parojčić, Jelena and Lane, M.E. and Corrigan, Owen I.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Development of biorelevant dissolution media for a BCS group II model drug: Mefenamic acid, Razvoj biorelevantnog in vitro testa za ispitivanje brzine rastvaranja - mefenaminska kiselina kao model supstanca",
volume = "56",
number = "4",
pages = "482-483",
url = "https://hdl.handle.net/21.15107/rcub_farfar_768"
}

Parojčić, J., Lane, M.E.,& Corrigan, O. I.. (2006). Development of biorelevant dissolution media for a BCS group II model drug: Mefenamic acid. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 482-483.
https://hdl.handle.net/21.15107/rcub_farfar_768

Parojčić J, Lane M, Corrigan OI. Development of biorelevant dissolution media for a BCS group II model drug: Mefenamic acid. in Arhiv za farmaciju. 2006;56(4):482-483.
https://hdl.handle.net/21.15107/rcub_farfar_768 .

Parojčić, Jelena, Lane, M.E., Corrigan, Owen I., "Development of biorelevant dissolution media for a BCS group II model drug: Mefenamic acid" in Arhiv za farmaciju, 56, no. 4 (2006):482-483,
https://hdl.handle.net/21.15107/rcub_farfar_768 .