TY  - JOUR
AU  - Boškov, Ivana A.
AU  - Savić, Ivan M.
AU  - Grozdanić Stanisavljević, Nađa Ð.
AU  - Kundaković-Vasović, Tatjana
AU  - Radović-Selgrad, Jelena
AU  - Savić Gajić, Ivana M.
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5573
AB  - Black locust flower extract contains various polyphenols and their glucosides contribute to the potential health benefits. After intake of these bioactive compounds and passage through the gastrointestinal tract, their degradation can occur and lead to a loss of biological activity. To overcome this problem, the bioactive compounds should be protected from environmental conditions. This study aimed to encapsulate the black flower extract in the microparticles based on biodegradable polysaccharides, alginate, and chitosan. In the extract, the total antioxidant content was found to be 3.18 ± 0.01 g gallic acid equivalent per 100 g of dry weight. Also, the presence of lipids (16), phenolics (27), organic acids (4), L-aspartic acid derivative, questinol, gibberellic acid, sterol, and saponins (2) was confirmed using the UHPLC–ESI–MS analysis. In vitro assays showed that the extract has weak anti-α-glucosidase activity and moderate antioxidant and cytotoxic activity against the HeLa cell line. The extrusion method with secondary air flow enabled the preparation of microparticles (about 270 μm) encapsulated with extract. An encapsulation efficiency of over 92% was achieved in the alginate and alginate–chitosan microparticles. The swelling study confirmed a lower permeability of alginate–chitosan microparticles compared with alginate microparticles. For both types of microparticles, the release profile of antioxidants in the simulated gastrointestinal fluids at 37 °C followed the Korsmeyer–Peppas model. A lower diffusion coefficient than 0.5 indicated the simple Fick diffusion of antioxidants. The alginate–chitosan microparticles enabled a more sustained release of antioxidants from extract compared to the alginate microparticles. The obtained results indicated an improvement in the antioxidant activity of bioactive compounds from the extract and their protection from degradation in the simulated gastric conditions via encapsulation in the polymer matrixes. Alginate–chitosan showed slightly slower cumulative antioxidant release from microparticles and better antioxidant activity of the extract compared to the alginate system. According to these results, alginate–chitosan microparticles are more suitable for further application in the encapsulation of black locust flower extract. Also, the proposed polymer matrix as a drug delivery system is safe for human use due to its biodegradability and non-toxicity.
PB  - MDPI
T2  - Polymers
T1  - Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate–Chitosan Microparticles
VL  - 16
IS  - 5
DO  - 10.3390/polym16050688
ER  - 

@article{
author = "Boškov, Ivana A. and Savić, Ivan M. and Grozdanić Stanisavljević, Nađa Ð. and Kundaković-Vasović, Tatjana and Radović-Selgrad, Jelena and Savić Gajić, Ivana M.",
year = "2024",
abstract = "Black locust flower extract contains various polyphenols and their glucosides contribute to the potential health benefits. After intake of these bioactive compounds and passage through the gastrointestinal tract, their degradation can occur and lead to a loss of biological activity. To overcome this problem, the bioactive compounds should be protected from environmental conditions. This study aimed to encapsulate the black flower extract in the microparticles based on biodegradable polysaccharides, alginate, and chitosan. In the extract, the total antioxidant content was found to be 3.18 ± 0.01 g gallic acid equivalent per 100 g of dry weight. Also, the presence of lipids (16), phenolics (27), organic acids (4), L-aspartic acid derivative, questinol, gibberellic acid, sterol, and saponins (2) was confirmed using the UHPLC–ESI–MS analysis. In vitro assays showed that the extract has weak anti-α-glucosidase activity and moderate antioxidant and cytotoxic activity against the HeLa cell line. The extrusion method with secondary air flow enabled the preparation of microparticles (about 270 μm) encapsulated with extract. An encapsulation efficiency of over 92% was achieved in the alginate and alginate–chitosan microparticles. The swelling study confirmed a lower permeability of alginate–chitosan microparticles compared with alginate microparticles. For both types of microparticles, the release profile of antioxidants in the simulated gastrointestinal fluids at 37 °C followed the Korsmeyer–Peppas model. A lower diffusion coefficient than 0.5 indicated the simple Fick diffusion of antioxidants. The alginate–chitosan microparticles enabled a more sustained release of antioxidants from extract compared to the alginate microparticles. The obtained results indicated an improvement in the antioxidant activity of bioactive compounds from the extract and their protection from degradation in the simulated gastric conditions via encapsulation in the polymer matrixes. Alginate–chitosan showed slightly slower cumulative antioxidant release from microparticles and better antioxidant activity of the extract compared to the alginate system. According to these results, alginate–chitosan microparticles are more suitable for further application in the encapsulation of black locust flower extract. Also, the proposed polymer matrix as a drug delivery system is safe for human use due to its biodegradability and non-toxicity.",
publisher = "MDPI",
journal = "Polymers",
title = "Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate–Chitosan Microparticles",
volume = "16",
number = "5",
doi = "10.3390/polym16050688"
}

Boškov, I. A., Savić, I. M., Grozdanić Stanisavljević, N. Ð., Kundaković-Vasović, T., Radović-Selgrad, J.,& Savić Gajić, I. M.. (2024). Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate–Chitosan Microparticles. in Polymers
MDPI., 16(5).
https://doi.org/10.3390/polym16050688

Boškov IA, Savić IM, Grozdanić Stanisavljević NÐ, Kundaković-Vasović T, Radović-Selgrad J, Savić Gajić IM. Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate–Chitosan Microparticles. in Polymers. 2024;16(5).
doi:10.3390/polym16050688 .

Boškov, Ivana A., Savić, Ivan M., Grozdanić Stanisavljević, Nađa Ð., Kundaković-Vasović, Tatjana, Radović-Selgrad, Jelena, Savić Gajić, Ivana M., "Stabilization of Black Locust Flower Extract via Encapsulation Using Alginate and Alginate–Chitosan Microparticles" in Polymers, 16, no. 5 (2024),
https://doi.org/10.3390/polym16050688 . .

TY  - CONF
AU  - Radović-Selgrad, Jelena
AU  - Milutinović, Violeta
AU  - Dragićević-Sudimac, Katarina
AU  - Vićentijević, Lazar
AU  - Kopanja, Đurđica
AU  - Kundaković-Vasović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5149
AB  - Sorbus torminalis (L.) Crantz (Rosaceae), брекиња, је листопадно дрво средње величине које потиче из централне и јужне Европе, северозападне Африке, Балканског полуострва и Мале Азије. Разни делови биљке, укључујући плод, лист, цваст и кору брекиње, традиционално се користе као диуретици, антид ијароици, антиинфламатори, антидијабетици и антиатерогена средства, вазопротективи и вазорелаксанси, али и као добри антиоксиданси. ...
AB  - Sorbus torminalis (L.) Crantz (Rosaceae) is a medium-sized deciduous tree native to central and southern Europe, northwestern Africa, the Balkan Peninsula, and western Asia. Various parts of the plant, including the fruit, leaf, inflorescence, and bark are traditionally used as diuretics, antidiarrheals, anti-inflammatory, antidiabetic and antiatherogenic agents, vasoprotective and vasorelaxants, but also as potent antioxidants. ...
PB  - Ботаничко друштво „Андреас Волни”, Нови Сад
PB  - Матица српска, Одељење за природне науке, Нови Сад
C3  - 2. Симпозијум "Трећи век ботанике у Војводини", Књига сажетака
T1  - Ензимска инхибиторна својства метанолног екстракта коре стабла брекиње, Sorbus torminalis (L.) Crantz
T1  - Enzyme inhibitory properties of the methanol extract of the tree bark of Sorbus torminalis (L.) Crantz
SP  - 39
EP  - 41
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5149
ER  - 

@conference{
author = "Radović-Selgrad, Jelena and Milutinović, Violeta and Dragićević-Sudimac, Katarina and Vićentijević, Lazar and Kopanja, Đurđica and Kundaković-Vasović, Tatjana",
year = "2023",
abstract = "Sorbus torminalis (L.) Crantz (Rosaceae), брекиња, је листопадно дрво средње величине које потиче из централне и јужне Европе, северозападне Африке, Балканског полуострва и Мале Азије. Разни делови биљке, укључујући плод, лист, цваст и кору брекиње, традиционално се користе као диуретици, антид ијароици, антиинфламатори, антидијабетици и антиатерогена средства, вазопротективи и вазорелаксанси, али и као добри антиоксиданси. ..., Sorbus torminalis (L.) Crantz (Rosaceae) is a medium-sized deciduous tree native to central and southern Europe, northwestern Africa, the Balkan Peninsula, and western Asia. Various parts of the plant, including the fruit, leaf, inflorescence, and bark are traditionally used as diuretics, antidiarrheals, anti-inflammatory, antidiabetic and antiatherogenic agents, vasoprotective and vasorelaxants, but also as potent antioxidants. ...",
publisher = "Ботаничко друштво „Андреас Волни”, Нови Сад, Матица српска, Одељење за природне науке, Нови Сад",
journal = "2. Симпозијум "Трећи век ботанике у Војводини", Књига сажетака",
title = "Ензимска инхибиторна својства метанолног екстракта коре стабла брекиње, Sorbus torminalis (L.) Crantz, Enzyme inhibitory properties of the methanol extract of the tree bark of Sorbus torminalis (L.) Crantz",
pages = "39-41",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5149"
}

Radović-Selgrad, J., Milutinović, V., Dragićević-Sudimac, K., Vićentijević, L., Kopanja, Đ.,& Kundaković-Vasović, T.. (2023). Ензимска инхибиторна својства метанолног екстракта коре стабла брекиње, Sorbus torminalis (L.) Crantz. in 2. Симпозијум "Трећи век ботанике у Војводини", Књига сажетака
Ботаничко друштво „Андреас Волни”, Нови Сад., 39-41.
https://hdl.handle.net/21.15107/rcub_farfar_5149

Radović-Selgrad J, Milutinović V, Dragićević-Sudimac K, Vićentijević L, Kopanja Đ, Kundaković-Vasović T. Ензимска инхибиторна својства метанолног екстракта коре стабла брекиње, Sorbus torminalis (L.) Crantz. in 2. Симпозијум "Трећи век ботанике у Војводини", Књига сажетака. 2023;:39-41.
https://hdl.handle.net/21.15107/rcub_farfar_5149 .

Radović-Selgrad, Jelena, Milutinović, Violeta, Dragićević-Sudimac, Katarina, Vićentijević, Lazar, Kopanja, Đurđica, Kundaković-Vasović, Tatjana, "Ензимска инхибиторна својства метанолног екстракта коре стабла брекиње, Sorbus torminalis (L.) Crantz" in 2. Симпозијум "Трећи век ботанике у Војводини", Књига сажетака (2023):39-41,
https://hdl.handle.net/21.15107/rcub_farfar_5149 .

TY  - CONF
AU  - Leković, Aleksandra
AU  - Samardžić, Stevan
AU  - Radović-Selgrad, Jelena
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4584
AB  - Sorbus torminalis (L.) Crantz (Rosaceae), also known as wild service tree, is a
deciduous tree widespread in central and southern Europe, north-western Africa, western
Asia, the Balkan Peninsula and the Caucasus (1, 2). Species of the genus Sorbus represent a
rich source of polyphenols that are responsible for their numerous proven effects, including
anti-diarrhoeal, anti-inflammatory, antidiabetic, antioxidant and anti-atherogenic effect.
Accordingly, the bark of S. torminalis could have interesting composition and effects,
however, data about this herbal drug is insufficient (1). Bark dry methanol extract (DER
9.74:1), obtained after successive extraction with cyclohexane and dichloromethane, was
analyzed for antioxidant potential using DPPH and FRAP assay. Contents of total
polyphenols, flavonoids and tannins were determined using spectrophotometric methods
based on reaction with Folin-Ciocalteu reagent (FC), reaction with aluminum-chloride and
adsorption by hide powder in combination with reaction with FC, respectively. LC-DAD-ESI-
MS analysis was used for identification of main extract constituents. In DPPH test IC50 value
8.66±0.07 μg/mL was shown, while result of FRAP test was 3.01±0.11 μmol Fe 2+ /mg of dry
extract. Contents of total polyphenols, flavonoids and tannins were 0.39±0.06 mg GA/mg of
dry extract, 0.035±0.019% and 1.3±0.08%, respectively. By LC-DAD-ESI-MS analysis 25
compounds were detected among which procyanidins (dimers, trimers and tetramers) are
dominant. The results of this study showed that dry methanol extract of S. torminalis bark is
rich in procyanidins which potentially contribute to its antioxidant activity. Additional
significant effects of this herbal drug and its isolated compounds should be investigated in
future studies.
AB  - Sorbus torminalis (L.) Crantz (Rosaceae) je listopadno drvo, u narodu poznato pod
nazivom brekinja. Rasprostranjeno je širom centralne i južne Evrope, severozapadne Afrike,
zapadne Azije, Balkanskog poluostrva i Kavkaza (1, 2). Vrste roda Sorbus predstavljaju bogat
izvor polifenola koji su odgovorni za njihove brojne dokazane efekte, uključuju antidijaroični,
antiinflamatorni, antidijabetski, antioksidantni i antiaterogeni efekat. U skladu sa tim, kora S.
torminalis mogla bi imati interesantan sastav i efekte, međutim, o ovoj biljnoj drogi nema
dovoljno podataka (1). Antioksidantna aktivnost suvog metanolnog ekstrakta kore stabla
(DER 9,74:1), dobijenog nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
analizirana je DPPH i FRAP testom. Sadržaji ukupnih polifenola, flavonoida i tanina određeni
su spektrofotometrijskim metodama koje se zasnivaju na reakciji sa Folin‐Ciocalteu
reagensom (FC), reakciji sa aluminijum-hloridom i na adsorpciji na kožni prah u kombinaciji
sa reakcijom sa FC reagensom, redom. LC‐DAD‐ESI‐MS analiza korišćena je za identifikaciju
glavnih sastojaka ekstrakta. U DPPH testu dobijena je IC50 vrednost 8,66±0,07 μg/mL, a
rezultat FRAP testa bio je 3,01±0,11 μmol Fe 2+ /mg suvog ekstrakta. Sadžaj ukupnih
polifenola bio je 0,39±0,06 mg GA/mg suvog ekstrakta, flavonoida 0,035±0,019%, a tanina
1,3±0,08%. LC‐DAD‐ESI‐MS analizom detektovano je 25 jedinjenja od kojih su dominantni
procijanidini (dimeri, trimeri i tetrameri). Rezultati ovog istraživanja pokazali su da je suvi
metanolni ekstrakt kore stabla S. torminalis bogat procijanidinima koji potencijalno
doprinose njegovoj antioksidantnoj aktivnosti. Dodatne značajne efekte ove biljne droge i
njenih izolovanih jedinjenja trebalo bi ispitati u budućim istraživanjima.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract
T1  - Hemijski sastav i antioksidantna aktivnost metanolnog ekstrakta kore stabla Sorbus torminalis
VL  - 72
IS  - 4 suplement
SP  - S467
EP  - S468
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4584
ER  - 

@conference{
author = "Leković, Aleksandra and Samardžić, Stevan and Radović-Selgrad, Jelena and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Sorbus torminalis (L.) Crantz (Rosaceae), also known as wild service tree, is a
deciduous tree widespread in central and southern Europe, north-western Africa, western
Asia, the Balkan Peninsula and the Caucasus (1, 2). Species of the genus Sorbus represent a
rich source of polyphenols that are responsible for their numerous proven effects, including
anti-diarrhoeal, anti-inflammatory, antidiabetic, antioxidant and anti-atherogenic effect.
Accordingly, the bark of S. torminalis could have interesting composition and effects,
however, data about this herbal drug is insufficient (1). Bark dry methanol extract (DER
9.74:1), obtained after successive extraction with cyclohexane and dichloromethane, was
analyzed for antioxidant potential using DPPH and FRAP assay. Contents of total
polyphenols, flavonoids and tannins were determined using spectrophotometric methods
based on reaction with Folin-Ciocalteu reagent (FC), reaction with aluminum-chloride and
adsorption by hide powder in combination with reaction with FC, respectively. LC-DAD-ESI-
MS analysis was used for identification of main extract constituents. In DPPH test IC50 value
8.66±0.07 μg/mL was shown, while result of FRAP test was 3.01±0.11 μmol Fe 2+ /mg of dry
extract. Contents of total polyphenols, flavonoids and tannins were 0.39±0.06 mg GA/mg of
dry extract, 0.035±0.019% and 1.3±0.08%, respectively. By LC-DAD-ESI-MS analysis 25
compounds were detected among which procyanidins (dimers, trimers and tetramers) are
dominant. The results of this study showed that dry methanol extract of S. torminalis bark is
rich in procyanidins which potentially contribute to its antioxidant activity. Additional
significant effects of this herbal drug and its isolated compounds should be investigated in
future studies., Sorbus torminalis (L.) Crantz (Rosaceae) je listopadno drvo, u narodu poznato pod
nazivom brekinja. Rasprostranjeno je širom centralne i južne Evrope, severozapadne Afrike,
zapadne Azije, Balkanskog poluostrva i Kavkaza (1, 2). Vrste roda Sorbus predstavljaju bogat
izvor polifenola koji su odgovorni za njihove brojne dokazane efekte, uključuju antidijaroični,
antiinflamatorni, antidijabetski, antioksidantni i antiaterogeni efekat. U skladu sa tim, kora S.
torminalis mogla bi imati interesantan sastav i efekte, međutim, o ovoj biljnoj drogi nema
dovoljno podataka (1). Antioksidantna aktivnost suvog metanolnog ekstrakta kore stabla
(DER 9,74:1), dobijenog nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
analizirana je DPPH i FRAP testom. Sadržaji ukupnih polifenola, flavonoida i tanina određeni
su spektrofotometrijskim metodama koje se zasnivaju na reakciji sa Folin‐Ciocalteu
reagensom (FC), reakciji sa aluminijum-hloridom i na adsorpciji na kožni prah u kombinaciji
sa reakcijom sa FC reagensom, redom. LC‐DAD‐ESI‐MS analiza korišćena je za identifikaciju
glavnih sastojaka ekstrakta. U DPPH testu dobijena je IC50 vrednost 8,66±0,07 μg/mL, a
rezultat FRAP testa bio je 3,01±0,11 μmol Fe 2+ /mg suvog ekstrakta. Sadžaj ukupnih
polifenola bio je 0,39±0,06 mg GA/mg suvog ekstrakta, flavonoida 0,035±0,019%, a tanina
1,3±0,08%. LC‐DAD‐ESI‐MS analizom detektovano je 25 jedinjenja od kojih su dominantni
procijanidini (dimeri, trimeri i tetrameri). Rezultati ovog istraživanja pokazali su da je suvi
metanolni ekstrakt kore stabla S. torminalis bogat procijanidinima koji potencijalno
doprinose njegovoj antioksidantnoj aktivnosti. Dodatne značajne efekte ove biljne droge i
njenih izolovanih jedinjenja trebalo bi ispitati u budućim istraživanjima.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract, Hemijski sastav i antioksidantna aktivnost metanolnog ekstrakta kore stabla Sorbus torminalis",
volume = "72",
number = "4 suplement",
pages = "S467-S468",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4584"
}

Leković, A., Samardžić, S., Radović-Selgrad, J.,& Kundaković-Vasović, T.. (2022). Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S467-S468.
https://hdl.handle.net/21.15107/rcub_farfar_4584

Leković A, Samardžić S, Radović-Selgrad J, Kundaković-Vasović T. Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract. in Arhiv za farmaciju. 2022;72(4 suplement):S467-S468.
https://hdl.handle.net/21.15107/rcub_farfar_4584 .

Leković, Aleksandra, Samardžić, Stevan, Radović-Selgrad, Jelena, Kundaković-Vasović, Tatjana, "Chemical composition and antioxidant activity of Sorbus torminalis bark methanol extract" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S467-S468,
https://hdl.handle.net/21.15107/rcub_farfar_4584 .

TY  - CONF
AU  - Radović-Selgrad, Jelena
AU  - Ušjak, Dušan
AU  - Milenković, Marina
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4580
AB  - Dry methanol extract (DER 3.95:1) of aerial flowering parts of Alchemilla viridiflora
Rothm., Rosaceae, obtained after successive extraction with cyclohexane and
dichloromethane, predominantly contains polyphenols, tannins (3.74%), mostly ellagic, and
flavonoids (0.30%), hexosides of quercetin and kaempferol. It shows ACE inhibitory and
anti-Helicobacter pylori activity in vitro (1). Based on the traditional use of the common A.
vulgaris in the treatment of diabetes (2), the effect of this A. viridiflora extract on α-amylase
activity in vitro and lowering blood glucose in rats were investigated. α-Amylase inhibitory
activity was assessed using the 3,5-dinitrosalicylic acid method. Extract in doses of 50, 100
and 200 mg/kg, p.o., was administered to streptozotocin-induced diabetic rats for 20 days,
and blood glucose level and weight of rats were monitored during treatment. Extract
inhibited α-amylase activity at IC 50 5.47 ± 0.30 mg/mL. A dose of 200 mg/kg significantly
decreased blood glucose level after 10 (32.2%) and 20 days of treatment (38.3%). The effect
of this dose was similar to the effect of the reference drug, glibenclamide. A dose of 100
mg/kg significantly increased glucose level by day 10 (50.5%) and a reduction in blood sugar
level of 51.2% was observed only after 10 days. Body weight was correlated with changes in
blood sugar levels. A dose of 50 mg/kg had no statistically significant effect. Results indicate
a significant potential of A. viridiflora aerial parts in the treatment of diabetes, which must be
confirmed by additional studies, and active ingredients need to be identified.
AB  - Suvi metanolni ekstrakt (DER 3,95:1) nadzemnih delova u cvetu Alchemilla viridiflora
Rothm., Rosaceae, dobijen nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
sadrži visok nivo polifenola, tanina (3,74%), uglavnom elagnih, i flavonoida (0,30%),
heksozida kvercetina i kemferola. Pokazuje ACE inhibitornu i anti-Helicobacter pylori
aktivnost in vitro (1). Na osnovu podataka o tradicionalnoj upotrebi herbe A. vulgaris,
najčešće korišćene Alchemilla vrste, u lečenju dijabetesa (2), ispitivan je uticaj navedenog
ekstrakta A. viridiflora na aktivnost α-amilaze in vitro i na snižavanje nivoa glukoze u krvi
kod pacova. Uticaj na aktivnost α-amilaze procenjen je primenom metode sa 3,5-
dinitrosalicilnom kiselinom. Ekstrakt A. viridiflora u dozama od 50, 100 i 200 mg/kg, p.o.,
aplikovan je pacovima sa dijabetesom izazvanim streptozotocinom tokom 20 dana, a nivoi
glukoze u krvi i težina pacova su praćeni u određenim vremenskim intervalima tokom
trajanja tretmana. Ekstrakt je inhibirao aktivnost α-amilaze, a vrednost IC 50 iznosila je
5,47±0,30 mg/mL. Doza od 200 mg/kg značajno je smanjila nivo glukoze u krvi nakon 10
(32,2%) i 20 dana tretmana (38,3%). Efekat ove doze bio je sličan efektu referentnog leka,
glibenklamida. S druge strane, doza od 100 mg/kg značajno je povećala nivo glukoze do 10.
dana (50,5%) a do značajnog poboljšanja, tj. sniženja nivoa šećera od 51,2% dovela je tek
nakon 10 dana. Telesna težina bila je u korelaciji sa promenama nivoa šećera u krvi. Doza od
50 mg/kg nije imala statistički značajan efekat. Rezultati ukazuju na značajan potencijal
herbe A. viridiflora u lečenju dijabetesa, što mora biti potvrđeno dodatnim studijama, a
aktivni sastojci identifikovani.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Inhibition of A-amylase in vitro and in vivo hypoglycemic effect of methanol extract of Alchemilla viridiflora Rothm
T1  - Inhibicija Α‐amilaze in vitro i in vivo hipoglikemijski efekat metanolnog ekstrakta herbe Alchemilla viridiflora Rothm
VL  - 72
IS  - 4 suplement
SP  - S461
EP  - S462
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4580
ER  - 

@conference{
author = "Radović-Selgrad, Jelena and Ušjak, Dušan and Milenković, Marina and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Dry methanol extract (DER 3.95:1) of aerial flowering parts of Alchemilla viridiflora
Rothm., Rosaceae, obtained after successive extraction with cyclohexane and
dichloromethane, predominantly contains polyphenols, tannins (3.74%), mostly ellagic, and
flavonoids (0.30%), hexosides of quercetin and kaempferol. It shows ACE inhibitory and
anti-Helicobacter pylori activity in vitro (1). Based on the traditional use of the common A.
vulgaris in the treatment of diabetes (2), the effect of this A. viridiflora extract on α-amylase
activity in vitro and lowering blood glucose in rats were investigated. α-Amylase inhibitory
activity was assessed using the 3,5-dinitrosalicylic acid method. Extract in doses of 50, 100
and 200 mg/kg, p.o., was administered to streptozotocin-induced diabetic rats for 20 days,
and blood glucose level and weight of rats were monitored during treatment. Extract
inhibited α-amylase activity at IC 50 5.47 ± 0.30 mg/mL. A dose of 200 mg/kg significantly
decreased blood glucose level after 10 (32.2%) and 20 days of treatment (38.3%). The effect
of this dose was similar to the effect of the reference drug, glibenclamide. A dose of 100
mg/kg significantly increased glucose level by day 10 (50.5%) and a reduction in blood sugar
level of 51.2% was observed only after 10 days. Body weight was correlated with changes in
blood sugar levels. A dose of 50 mg/kg had no statistically significant effect. Results indicate
a significant potential of A. viridiflora aerial parts in the treatment of diabetes, which must be
confirmed by additional studies, and active ingredients need to be identified., Suvi metanolni ekstrakt (DER 3,95:1) nadzemnih delova u cvetu Alchemilla viridiflora
Rothm., Rosaceae, dobijen nakon sukcesivne ekstrakcije cikloheksanom i dihlormetanom,
sadrži visok nivo polifenola, tanina (3,74%), uglavnom elagnih, i flavonoida (0,30%),
heksozida kvercetina i kemferola. Pokazuje ACE inhibitornu i anti-Helicobacter pylori
aktivnost in vitro (1). Na osnovu podataka o tradicionalnoj upotrebi herbe A. vulgaris,
najčešće korišćene Alchemilla vrste, u lečenju dijabetesa (2), ispitivan je uticaj navedenog
ekstrakta A. viridiflora na aktivnost α-amilaze in vitro i na snižavanje nivoa glukoze u krvi
kod pacova. Uticaj na aktivnost α-amilaze procenjen je primenom metode sa 3,5-
dinitrosalicilnom kiselinom. Ekstrakt A. viridiflora u dozama od 50, 100 i 200 mg/kg, p.o.,
aplikovan je pacovima sa dijabetesom izazvanim streptozotocinom tokom 20 dana, a nivoi
glukoze u krvi i težina pacova su praćeni u određenim vremenskim intervalima tokom
trajanja tretmana. Ekstrakt je inhibirao aktivnost α-amilaze, a vrednost IC 50 iznosila je
5,47±0,30 mg/mL. Doza od 200 mg/kg značajno je smanjila nivo glukoze u krvi nakon 10
(32,2%) i 20 dana tretmana (38,3%). Efekat ove doze bio je sličan efektu referentnog leka,
glibenklamida. S druge strane, doza od 100 mg/kg značajno je povećala nivo glukoze do 10.
dana (50,5%) a do značajnog poboljšanja, tj. sniženja nivoa šećera od 51,2% dovela je tek
nakon 10 dana. Telesna težina bila je u korelaciji sa promenama nivoa šećera u krvi. Doza od
50 mg/kg nije imala statistički značajan efekat. Rezultati ukazuju na značajan potencijal
herbe A. viridiflora u lečenju dijabetesa, što mora biti potvrđeno dodatnim studijama, a
aktivni sastojci identifikovani.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Inhibition of A-amylase in vitro and in vivo hypoglycemic effect of methanol extract of Alchemilla viridiflora Rothm, Inhibicija Α‐amilaze in vitro i in vivo hipoglikemijski efekat metanolnog ekstrakta herbe Alchemilla viridiflora Rothm",
volume = "72",
number = "4 suplement",
pages = "S461-S462",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4580"
}

Radović-Selgrad, J., Ušjak, D., Milenković, M.,& Kundaković-Vasović, T.. (2022). Inhibition of A-amylase in vitro and in vivo hypoglycemic effect of methanol extract of Alchemilla viridiflora Rothm. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S461-S462.
https://hdl.handle.net/21.15107/rcub_farfar_4580

Radović-Selgrad J, Ušjak D, Milenković M, Kundaković-Vasović T. Inhibition of A-amylase in vitro and in vivo hypoglycemic effect of methanol extract of Alchemilla viridiflora Rothm. in Arhiv za farmaciju. 2022;72(4 suplement):S461-S462.
https://hdl.handle.net/21.15107/rcub_farfar_4580 .

Radović-Selgrad, Jelena, Ušjak, Dušan, Milenković, Marina, Kundaković-Vasović, Tatjana, "Inhibition of A-amylase in vitro and in vivo hypoglycemic effect of methanol extract of Alchemilla viridiflora Rothm" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S461-S462,
https://hdl.handle.net/21.15107/rcub_farfar_4580 .

TY  - JOUR
AU  - Suručić, Relja
AU  - Radović-Selgrad, Jelena
AU  - Kundaković-Vasović, Tatjana
AU  - Lazović, Vesna
AU  - Travar, Maja
AU  - Suručić, Ljiljana
AU  - Škrbić, Ranko
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4261
AB  - Since the outbreak of the COVID-19 pandemic, it has been obvious that virus infection poses
a serious threat to human health on a global scale. Certain plants, particularly those rich in polyphe-
nols, have been found to be effective antiviral agents. The effectiveness of Alchemilla viridiflora Rothm.
(Rosaceae) methanol extract to prevent contact between virus spike (S)-glycoprotein and angiotensin-
converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors was investigated. In vitro results
revealed that the tested samples inhibited 50% of virus-receptor binding interactions in doses of
0.18 and 0.22 mg/mL for NRP1 and ACE2, respectively. Molecular docking studies revealed that the
compounds from A. viridiflora ellagitannins class had a higher affinity for binding with S-glycoprotein
whilst flavonoid compounds more significantly interacted with the NRP1 receptor. Quercetin
3-(6”-ferulylglucoside) and pentagalloylglucose were two compounds with the highest exhibited
interfering potential for selected target receptors, with binding energies of −8.035 (S-glycoprotein)
and −7.685 kcal/mol (NRP1), respectively. Furthermore, computational studies on other SARS-CoV-2
strains resulting from mutations in the original wild strain (V483A, N501Y-K417N-E484K, N501Y,
N439K, L452R-T478K, K417N, G476S, F456L, E484K) revealed that virus internalization activity was
maintained, but with different single compound contributions.
PB  - MDPI
T2  - Molecules
T1  - In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization
VL  - 27
IS  - 16
DO  - 10.3390/molecules27165174
ER  - 

@article{
author = "Suručić, Relja and Radović-Selgrad, Jelena and Kundaković-Vasović, Tatjana and Lazović, Vesna and Travar, Maja and Suručić, Ljiljana and Škrbić, Ranko",
year = "2022",
abstract = "Since the outbreak of the COVID-19 pandemic, it has been obvious that virus infection poses
a serious threat to human health on a global scale. Certain plants, particularly those rich in polyphe-
nols, have been found to be effective antiviral agents. The effectiveness of Alchemilla viridiflora Rothm.
(Rosaceae) methanol extract to prevent contact between virus spike (S)-glycoprotein and angiotensin-
converting enzyme 2 (ACE2) and neuropilin-1 (NRP1) receptors was investigated. In vitro results
revealed that the tested samples inhibited 50% of virus-receptor binding interactions in doses of
0.18 and 0.22 mg/mL for NRP1 and ACE2, respectively. Molecular docking studies revealed that the
compounds from A. viridiflora ellagitannins class had a higher affinity for binding with S-glycoprotein
whilst flavonoid compounds more significantly interacted with the NRP1 receptor. Quercetin
3-(6”-ferulylglucoside) and pentagalloylglucose were two compounds with the highest exhibited
interfering potential for selected target receptors, with binding energies of −8.035 (S-glycoprotein)
and −7.685 kcal/mol (NRP1), respectively. Furthermore, computational studies on other SARS-CoV-2
strains resulting from mutations in the original wild strain (V483A, N501Y-K417N-E484K, N501Y,
N439K, L452R-T478K, K417N, G476S, F456L, E484K) revealed that virus internalization activity was
maintained, but with different single compound contributions.",
publisher = "MDPI",
journal = "Molecules",
title = "In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization",
volume = "27",
number = "16",
doi = "10.3390/molecules27165174"
}

Suručić, R., Radović-Selgrad, J., Kundaković-Vasović, T., Lazović, V., Travar, M., Suručić, L.,& Škrbić, R.. (2022). In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization. in Molecules
MDPI., 27(16).
https://doi.org/10.3390/molecules27165174

Suručić R, Radović-Selgrad J, Kundaković-Vasović T, Lazović V, Travar M, Suručić L, Škrbić R. In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization. in Molecules. 2022;27(16).
doi:10.3390/molecules27165174 .

Suručić, Relja, Radović-Selgrad, Jelena, Kundaković-Vasović, Tatjana, Lazović, Vesna, Travar, Maja, Suručić, Ljiljana, Škrbić, Ranko, "In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols' Potential for Inhibition of SARS-CoV-2 Internalization" in Molecules, 27, no. 16 (2022),
https://doi.org/10.3390/molecules27165174 . .

TY  - CONF
AU  - Georgijev, Dejan
AU  - Kopanja, Đurđica
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5507
AB  - In the pharmacies of Republic of Serbia, three dietary products and food supplements with blueberry fruit preparations intended to improve eyesight were found and the content of anthocyanins in them was analyzed. According to Ph. Eur. 10, colorimetric method was used for determination of anthocyanins, which was given in the monograph of Myrthilli fructus recens. For compairing, the content of anthocyanins in two juices with blueberry fruit and other fruits with anthocyanins (aronia, grape) was analysed using an AOAC colorimetric method given by Lee et al. (2005).
Retin activ (ESI srl, Italy) a dietary product with a special medical purpose, contains vitamins A, C, E, 15 mg of dry blueberry extract standardized at 25% anthocyanosides, lutein and zeaxanthin. The advice of the manufacturer for use is one capsule a day. Our analysis have shown that Retin activ in one capsule contain 8.35 ±0,17 mg of anthocyanins, calculated as cyanidin 3-O-glucoside chloride. 
Pro-Visio tablets (United Pharma, Bratislava, Slovakia), a food supplement with lutein, zeaxanthin, 20 mg of blueberry extract, vitamin E and selenium, contained 5.14±0.18 mg of anthocyanins, calculated as cyanidin 3-O-glucoside chloride in one tablet. The advice of the manufacturer for use is one capsule a day.  
Visionace Original tablets (Vitabiotics, London, UK) contain 23 components including blueberry extract (60 mg) and 0.02±0.0089 mg of anthocyanins per tablets.
The juices, Bravo - blueberry (RAUCH SERBIA DOO) and Nectar - apple, aronia, blueberry and grape (Nectar DOO, Serbia), contained 42.57±2.66 mg/L and 31.80±0.01 mg/L of anthocyanins, respectively. 
According to the literature, blueberry anthocyanins has been reported to enhance night visual acuity and contrast sensitivity and are used in the supplements to improve vision health. Older studies (Vannini et al., 1986) have shown significant improvement of the pupillary muscle contraction in reduced light conditions in healthy young subjects after administration of 240 mg of blueberry extract containing 36% anthocyanins.  The claimed effect refers to an improvement of visual adaptation to the dark.  Newer studies were contradictory.
JECFA has established an Acceptable Daily Intake (ADI) of 2.5 mg/kg bw/day for anthocyanins from grape skin. The dose of 50 mg of anthocyanins of black current concentrate have shown positive effect after 30 min of dark adaptation compared before and 2 h after intake of test drink in 12 healthy subjects (Nomi et al., 2019). 
In conclusion, our results suggest that the best option for better eye health is to use products with concentrated blueberry fruit extracts instead of juices, but the intake of at least 50 mg of anthocyanins per day should be ensured.
References
1. Lee J., Durst RW, Wrolstad E., Journal of AOAC International, 88:5, 1269-1278, 2005
2. Vannini L., Samuelly R., Coffano M., Tibaldi L. Bollett Ocul, 65 (6):569-577, 1986
3. Nomi Y, Iwasaki-Kurashige K., Matsumoto H., Molecules, 24(18): 3311, 2019
PB  - The International Pharmaceutical Federation (FIP)
C3  - 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain
T1  - The quantity of anthocyanins in blueberry fruit based dietary products and juices
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5507
ER  - 

@conference{
author = "Georgijev, Dejan and Kopanja, Đurđica and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "In the pharmacies of Republic of Serbia, three dietary products and food supplements with blueberry fruit preparations intended to improve eyesight were found and the content of anthocyanins in them was analyzed. According to Ph. Eur. 10, colorimetric method was used for determination of anthocyanins, which was given in the monograph of Myrthilli fructus recens. For compairing, the content of anthocyanins in two juices with blueberry fruit and other fruits with anthocyanins (aronia, grape) was analysed using an AOAC colorimetric method given by Lee et al. (2005).
Retin activ (ESI srl, Italy) a dietary product with a special medical purpose, contains vitamins A, C, E, 15 mg of dry blueberry extract standardized at 25% anthocyanosides, lutein and zeaxanthin. The advice of the manufacturer for use is one capsule a day. Our analysis have shown that Retin activ in one capsule contain 8.35 ±0,17 mg of anthocyanins, calculated as cyanidin 3-O-glucoside chloride. 
Pro-Visio tablets (United Pharma, Bratislava, Slovakia), a food supplement with lutein, zeaxanthin, 20 mg of blueberry extract, vitamin E and selenium, contained 5.14±0.18 mg of anthocyanins, calculated as cyanidin 3-O-glucoside chloride in one tablet. The advice of the manufacturer for use is one capsule a day.  
Visionace Original tablets (Vitabiotics, London, UK) contain 23 components including blueberry extract (60 mg) and 0.02±0.0089 mg of anthocyanins per tablets.
The juices, Bravo - blueberry (RAUCH SERBIA DOO) and Nectar - apple, aronia, blueberry and grape (Nectar DOO, Serbia), contained 42.57±2.66 mg/L and 31.80±0.01 mg/L of anthocyanins, respectively. 
According to the literature, blueberry anthocyanins has been reported to enhance night visual acuity and contrast sensitivity and are used in the supplements to improve vision health. Older studies (Vannini et al., 1986) have shown significant improvement of the pupillary muscle contraction in reduced light conditions in healthy young subjects after administration of 240 mg of blueberry extract containing 36% anthocyanins.  The claimed effect refers to an improvement of visual adaptation to the dark.  Newer studies were contradictory.
JECFA has established an Acceptable Daily Intake (ADI) of 2.5 mg/kg bw/day for anthocyanins from grape skin. The dose of 50 mg of anthocyanins of black current concentrate have shown positive effect after 30 min of dark adaptation compared before and 2 h after intake of test drink in 12 healthy subjects (Nomi et al., 2019). 
In conclusion, our results suggest that the best option for better eye health is to use products with concentrated blueberry fruit extracts instead of juices, but the intake of at least 50 mg of anthocyanins per day should be ensured.
References
1. Lee J., Durst RW, Wrolstad E., Journal of AOAC International, 88:5, 1269-1278, 2005
2. Vannini L., Samuelly R., Coffano M., Tibaldi L. Bollett Ocul, 65 (6):569-577, 1986
3. Nomi Y, Iwasaki-Kurashige K., Matsumoto H., Molecules, 24(18): 3311, 2019",
publisher = "The International Pharmaceutical Federation (FIP)",
journal = "80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain",
title = "The quantity of anthocyanins in blueberry fruit based dietary products and juices",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5507"
}

Georgijev, D., Kopanja, Đ.,& Kundaković-Vasović, T.. (2022). The quantity of anthocyanins in blueberry fruit based dietary products and juices. in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain
The International Pharmaceutical Federation (FIP)..
https://hdl.handle.net/21.15107/rcub_farfar_5507

Georgijev D, Kopanja Đ, Kundaković-Vasović T. The quantity of anthocyanins in blueberry fruit based dietary products and juices. in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_5507 .

Georgijev, Dejan, Kopanja, Đurđica, Kundaković-Vasović, Tatjana, "The quantity of anthocyanins in blueberry fruit based dietary products and juices" in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain (2022),
https://hdl.handle.net/21.15107/rcub_farfar_5507 .

TY  - CONF
AU  - Georgijev, Dejan
AU  - Kopanja, Đurđica
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5506
AB  - The attitudes of pharmacists about anthocyanin-based products from blueberry in the pharmacies were tested with electronic based questionnaire. In the study, 107 pharmacists from the Republic of Serbia and the Republic of Srpska participated, mostly females (84.1%), over 30 years of age who work in pharmacy chains (3 or more pharmacies) (79.4%). When asked if they have any of the anthocyanin-based products from blueberry fruit in the pharmacy, the majority answered in affirmative (72.0%) and that these are dietary supplements for maintaining eye health (76.9%). Half of the surveyed pharmacists (50.5%) answered that they only sometimes recommend these products. More than 50% were familiar with the pharmacological action of anthocyanins, and as many as 64% that anthocyanins achieve their positive effect on vision in low light by regenerating visible purple, rhodopsin. Also, the pharmacist knew other pharmacological activities of anthocyannins, as vasoprotective (52.3%), antioxidant (83.2%) and anti-inflammatory (44.9%). A large number of respondents knew that carotenoids (lutein and zeaxanthin), in addition to anthocyanins, also show a beneficial effect on vision.
Finally, it can be concluded that pharmacists in pharmacies lack knowledge about the pharmacological effect of anthocyanins and that we need to work on educating pharmacists about the effects of these herbal pigments and herbal ingredients in general.
PB  - International Pharmaceutical Federation (FIP)
C3  - 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain
T1  - Attitudes of pharmacists about anthocyanin-based products from blueberry fruit in the pharmacies
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5506
ER  - 

@conference{
author = "Georgijev, Dejan and Kopanja, Đurđica and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "The attitudes of pharmacists about anthocyanin-based products from blueberry in the pharmacies were tested with electronic based questionnaire. In the study, 107 pharmacists from the Republic of Serbia and the Republic of Srpska participated, mostly females (84.1%), over 30 years of age who work in pharmacy chains (3 or more pharmacies) (79.4%). When asked if they have any of the anthocyanin-based products from blueberry fruit in the pharmacy, the majority answered in affirmative (72.0%) and that these are dietary supplements for maintaining eye health (76.9%). Half of the surveyed pharmacists (50.5%) answered that they only sometimes recommend these products. More than 50% were familiar with the pharmacological action of anthocyanins, and as many as 64% that anthocyanins achieve their positive effect on vision in low light by regenerating visible purple, rhodopsin. Also, the pharmacist knew other pharmacological activities of anthocyannins, as vasoprotective (52.3%), antioxidant (83.2%) and anti-inflammatory (44.9%). A large number of respondents knew that carotenoids (lutein and zeaxanthin), in addition to anthocyanins, also show a beneficial effect on vision.
Finally, it can be concluded that pharmacists in pharmacies lack knowledge about the pharmacological effect of anthocyanins and that we need to work on educating pharmacists about the effects of these herbal pigments and herbal ingredients in general.",
publisher = "International Pharmaceutical Federation (FIP)",
journal = "80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain",
title = "Attitudes of pharmacists about anthocyanin-based products from blueberry fruit in the pharmacies",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5506"
}

Georgijev, D., Kopanja, Đ.,& Kundaković-Vasović, T.. (2022). Attitudes of pharmacists about anthocyanin-based products from blueberry fruit in the pharmacies. in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain
International Pharmaceutical Federation (FIP)..
https://hdl.handle.net/21.15107/rcub_farfar_5506

Georgijev D, Kopanja Đ, Kundaković-Vasović T. Attitudes of pharmacists about anthocyanin-based products from blueberry fruit in the pharmacies. in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain. 2022;.
https://hdl.handle.net/21.15107/rcub_farfar_5506 .

Georgijev, Dejan, Kopanja, Đurđica, Kundaković-Vasović, Tatjana, "Attitudes of pharmacists about anthocyanin-based products from blueberry fruit in the pharmacies" in 80th FIP World Congress of Pharmacy and Pharmaceutical Sciences, September 18-22, 2022. Seville, Spain (2022),
https://hdl.handle.net/21.15107/rcub_farfar_5506 .

TY  - JOUR
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Damjanović, Ana B.
AU  - Kopanja, Đurđica
AU  - Dodevska, Margarita
AU  - Stanojković, Tatjana
AU  - Marinković, Tijana
AU  - Jelić, Čedomir
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5057
AB  - The composition of biologically active compounds of Calocybe gambosa (Lyophyllaceae) was analysed, and
the antioxidant and cytotoxic activities were tested in vitro. C. gambosa was low in energy, fat, and car-
bohydrates, but rich in proteins and fibres. The total polyphenol content in the extracts was low (23.08 ±
0.67 in aqueous and 24.99 ± 4.25 mg GA mg 1 of extract in methanolic extract). The methanolic extract
showed anti-DPPH radical activity with an IC 50 of 626.10 ± 25.20 mg mL 1 . The sample of C. gambosa is
rich in nucleotides and amino acids responsible for its pleasant taste. The nucleoside and 50-mono-
phosphates contents were 0.97 mg g 1 and 2.32 mg g 1 of dry mushroom, respectively. The contents of
essential and non-essential amino acids were 18.41 ± 0.06 and 41.75 ± 0.30 mg g 1 d.w., respectively. The
percentages of saturated and unsaturated fatty acids were 42.6% and 57.4%, respectively. The most
abundant water-soluble and fat-soluble vitamins were B1 and E, respectively. Cytotoxic effect of the extracts was examined against different cancer cell lines, and the best cytotoxicity was showed by the
peptide extract against colon cancer cell line LS174.
T2  - Acta Alimentaria
T1  - St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds
VL  - 51
IS  - 1
SP  - 134
EP  - 144
DO  - 10.1556/066.2021.00227
ER  - 

@article{
author = "Radović, Jelena and Leković, Aleksandra and Damjanović, Ana B. and Kopanja, Đurđica and Dodevska, Margarita and Stanojković, Tatjana and Marinković, Tijana and Jelić, Čedomir and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "The composition of biologically active compounds of Calocybe gambosa (Lyophyllaceae) was analysed, and
the antioxidant and cytotoxic activities were tested in vitro. C. gambosa was low in energy, fat, and car-
bohydrates, but rich in proteins and fibres. The total polyphenol content in the extracts was low (23.08 ±
0.67 in aqueous and 24.99 ± 4.25 mg GA mg 1 of extract in methanolic extract). The methanolic extract
showed anti-DPPH radical activity with an IC 50 of 626.10 ± 25.20 mg mL 1 . The sample of C. gambosa is
rich in nucleotides and amino acids responsible for its pleasant taste. The nucleoside and 50-mono-
phosphates contents were 0.97 mg g 1 and 2.32 mg g 1 of dry mushroom, respectively. The contents of
essential and non-essential amino acids were 18.41 ± 0.06 and 41.75 ± 0.30 mg g 1 d.w., respectively. The
percentages of saturated and unsaturated fatty acids were 42.6% and 57.4%, respectively. The most
abundant water-soluble and fat-soluble vitamins were B1 and E, respectively. Cytotoxic effect of the extracts was examined against different cancer cell lines, and the best cytotoxicity was showed by the
peptide extract against colon cancer cell line LS174.",
journal = "Acta Alimentaria",
title = "St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds",
volume = "51",
number = "1",
pages = "134-144",
doi = "10.1556/066.2021.00227"
}

Radović, J., Leković, A., Damjanović, A. B., Kopanja, Đ., Dodevska, M., Stanojković, T., Marinković, T., Jelić, Č.,& Kundaković-Vasović, T.. (2022). St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds. in Acta Alimentaria, 51(1), 134-144.
https://doi.org/10.1556/066.2021.00227

Radović J, Leković A, Damjanović AB, Kopanja Đ, Dodevska M, Stanojković T, Marinković T, Jelić Č, Kundaković-Vasović T. St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds. in Acta Alimentaria. 2022;51(1):134-144.
doi:10.1556/066.2021.00227 .

Radović, Jelena, Leković, Aleksandra, Damjanović, Ana B., Kopanja, Đurđica, Dodevska, Margarita, Stanojković, Tatjana, Marinković, Tijana, Jelić, Čedomir, Kundaković-Vasović, Tatjana, "St. George’s mushroom, Calocybe gambosa (Fr.) Donk: A promising source of nutrients and biologically active compounds" in Acta Alimentaria, 51, no. 1 (2022):134-144,
https://doi.org/10.1556/066.2021.00227 . .

TY  - CONF
AU  - Radović, Jelena
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4619
AB  - The parasol mushroom Macrolepiota procera (Scop.:Fr.) Sing, Lepiotaceae, is a highly valued edible type of fungi. Its top is an egg-shaped, gray to brown hat, covered in peal-like marks. This mushroom resides on a layer of decomposing leaves in all types of the forests, appearing solitary or in small groups from late summer to autumn. Besides good taste, it has good nutritional and medicinal value. So far, scientific studies on M. procera have shown its antihypertensive, antioxidative, antiproliferative and cytotoxic abilities. Inhibitory effect against alpha-amylase, total polyphenolic content and antiradical scavenging activity of methanol extracts prepared from dry mushroom from local market in Belgrade was the main goal of this study. Alpha-amylase inhibitory assay was assessed spectrophotometrically with 3,5-dinitrosalicylic acid reagent. Total polyphenolic content and antiradical activity in methanolic extract was determined using common Folin-Ciocalteu method and DPPH assay. Concentration of methanolic extract that inhibited 50% alpha-amylase (IC50) was 0.66 mg/mL. The content of polyphenols in methanolic extract was 13.07±0.24 mg of gallic acid/g dry extract. The concentration that neutralizes 50% DPPH radicals was 466.45±5.52 μg/mL, which was weaker antiradical activity than standard antioxidants vitamin C (IC50 3.8 μg/ mL) and quercetin (IC50 2.75 μg/mL).
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia, Belgrade
C3  - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
T1  - Anti-alpha amylase activity of Macrolepiota procera (Scop.: Fr.) Sing.
SP  - 146
EP  - 147
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4619
ER  - 

@conference{
author = "Radović, Jelena and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "The parasol mushroom Macrolepiota procera (Scop.:Fr.) Sing, Lepiotaceae, is a highly valued edible type of fungi. Its top is an egg-shaped, gray to brown hat, covered in peal-like marks. This mushroom resides on a layer of decomposing leaves in all types of the forests, appearing solitary or in small groups from late summer to autumn. Besides good taste, it has good nutritional and medicinal value. So far, scientific studies on M. procera have shown its antihypertensive, antioxidative, antiproliferative and cytotoxic abilities. Inhibitory effect against alpha-amylase, total polyphenolic content and antiradical scavenging activity of methanol extracts prepared from dry mushroom from local market in Belgrade was the main goal of this study. Alpha-amylase inhibitory assay was assessed spectrophotometrically with 3,5-dinitrosalicylic acid reagent. Total polyphenolic content and antiradical activity in methanolic extract was determined using common Folin-Ciocalteu method and DPPH assay. Concentration of methanolic extract that inhibited 50% alpha-amylase (IC50) was 0.66 mg/mL. The content of polyphenols in methanolic extract was 13.07±0.24 mg of gallic acid/g dry extract. The concentration that neutralizes 50% DPPH radicals was 466.45±5.52 μg/mL, which was weaker antiradical activity than standard antioxidants vitamin C (IC50 3.8 μg/ mL) and quercetin (IC50 2.75 μg/mL).",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade",
journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts",
title = "Anti-alpha amylase activity of Macrolepiota procera (Scop.: Fr.) Sing.",
pages = "146-147",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4619"
}

Radović, J.,& Kundaković-Vasović, T.. (2022). Anti-alpha amylase activity of Macrolepiota procera (Scop.: Fr.) Sing.. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4619

Radović J, Kundaković-Vasović T. Anti-alpha amylase activity of Macrolepiota procera (Scop.: Fr.) Sing.. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:146-147.
https://hdl.handle.net/21.15107/rcub_farfar_4619 .

Radović, Jelena, Kundaković-Vasović, Tatjana, "Anti-alpha amylase activity of Macrolepiota procera (Scop.: Fr.) Sing." in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):146-147,
https://hdl.handle.net/21.15107/rcub_farfar_4619 .

TY  - CONF
AU  - Radović, Jelena
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4620
AB  - Tinder fungus, Fomes fomentarius (L.) Fr. (Polyporaceae), is a large, woody, perennial fungus. It is a plant pathogen which grows on the beech and other deciduous species as a parasite or saprophyte causing a heart rot of the wood. Some studies have shown that F. fomentarius has hypoglycemic, anti-nociceptive, anti-inflammatory, anti-infective and anti-tumor effect. Several classes of metabolites were identified: primary metabolites i.e., proteins, polysaccharides (β-glucans), polysaccharide-protein complexes, and secondary metabolites such as triterpenes and sterols, organic acids, benzofurans, coumarins, volatile components. GC/MS analysis of cyclohexane extract of fungus collected on mountain Avala in 2017 have shown the presence of sterols: ergosta-5,7,22-trien-3-ol (46.8%); ergosta-7,22-dien-3-ol (25.4%); ergosta-7,22-dien-3-on (15.9%); ergost-7-en-3-ol (fungisterol, kampesterol) (4.3%); 5,6-dihidro-3-ergosterol (5.5%). Fatty acids were also determined, including palmitic acid (C16:0) 34.0%, stearic acid (C18:0) 18.0%, linoleic acid (C18:2n6c) 10.8%, heneicosanoic acid (C21:0) (5.6%), behenic acid (C22:0) (10.9%), tricosanoic acid (C23:0) (18.4%) and lignoceric acid (C24:0) (2.3%). Cyclohexane extract has shown antibacterial activity against several bacterial strains including Helicobacter pylori and significant cytotoxic activity against HeLa cell line with an IC50 25.10±7.16 (μg/mL). These activities could be due to the presence of cytotoxic fatty acids.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia, Belgrade
C3  - 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
T1  - Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae
SP  - 140
EP  - 140
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4620
ER  - 

@conference{
author = "Radović, Jelena and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Tinder fungus, Fomes fomentarius (L.) Fr. (Polyporaceae), is a large, woody, perennial fungus. It is a plant pathogen which grows on the beech and other deciduous species as a parasite or saprophyte causing a heart rot of the wood. Some studies have shown that F. fomentarius has hypoglycemic, anti-nociceptive, anti-inflammatory, anti-infective and anti-tumor effect. Several classes of metabolites were identified: primary metabolites i.e., proteins, polysaccharides (β-glucans), polysaccharide-protein complexes, and secondary metabolites such as triterpenes and sterols, organic acids, benzofurans, coumarins, volatile components. GC/MS analysis of cyclohexane extract of fungus collected on mountain Avala in 2017 have shown the presence of sterols: ergosta-5,7,22-trien-3-ol (46.8%); ergosta-7,22-dien-3-ol (25.4%); ergosta-7,22-dien-3-on (15.9%); ergost-7-en-3-ol (fungisterol, kampesterol) (4.3%); 5,6-dihidro-3-ergosterol (5.5%). Fatty acids were also determined, including palmitic acid (C16:0) 34.0%, stearic acid (C18:0) 18.0%, linoleic acid (C18:2n6c) 10.8%, heneicosanoic acid (C21:0) (5.6%), behenic acid (C22:0) (10.9%), tricosanoic acid (C23:0) (18.4%) and lignoceric acid (C24:0) (2.3%). Cyclohexane extract has shown antibacterial activity against several bacterial strains including Helicobacter pylori and significant cytotoxic activity against HeLa cell line with an IC50 25.10±7.16 (μg/mL). These activities could be due to the presence of cytotoxic fatty acids.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia, Belgrade",
journal = "14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts",
title = "Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae",
pages = "140-140",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4620"
}

Radović, J.,& Kundaković-Vasović, T.. (2022). Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 140-140.
https://hdl.handle.net/21.15107/rcub_farfar_4620

Radović J, Kundaković-Vasović T. Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae. in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts. 2022;:140-140.
https://hdl.handle.net/21.15107/rcub_farfar_4620 .

Radović, Jelena, Kundaković-Vasović, Tatjana, "Lipids in tinder fungus, Fomes fometarius (L.) Fr., Polyporaceae" in 14th Symposium on the Flora of Southeastern Serbia and Neighboring Regions - Book of Abstracts (2022):140-140,
https://hdl.handle.net/21.15107/rcub_farfar_4620 .

TY  - JOUR
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Tačić, Ana
AU  - Dodevska, Margarita
AU  - Stanojković, Tatjana
AU  - Marinković, Tijana
AU  - Jelić, Čedomir
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4324
AB  - Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.
PB  - Polish Academy Sciences. Institute of Animal Reproduction and Food Research
T2  - Polish Journal of Food and Nutrition Sciences
T1  - Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity
VL  - 72
IS  - 2
SP  - 171
EP  - 181
DO  - 10.31883/pjfns/149914
ER  - 

@article{
author = "Radović, Jelena and Leković, Aleksandra and Tačić, Ana and Dodevska, Margarita and Stanojković, Tatjana and Marinković, Tijana and Jelić, Čedomir and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Nutritional value and chemical composition, including the content of vitamins, fatty acids, 5'-nucleotides and nucleosides and amino acids, as well as biological activities, including antioxidant, angiotensin converting enzyme (ACE) inhibitory and cytotoxic activity of black trumpet (Craterellus cornucopioides (L.) Pers.) were tested in vitro. C. cornucopioides was low in energy, fat and carbohydrate contents, but rich in dietary fibre, especially β-glucan as well as niacin and α-tocopherol. The content of essential and non-essential free amino acids was 1.49 and 5.48 mg/g dry weight (dw). The nucleosides and 5'-nucleotides were determined at 1.84 and 3.99 mg/g dw, respectively. The share of unsaturated fatty acids (UFAs) was 75.92% with oleic acid as the major UFA. Cyclohexane and dichloromethane extracts expressed significant cytotoxic activity against selected cell lines, human epithelial cervical cancer cells (HeLa), adenocarcinomic human alveolar basal epithelial cells (A549), colorectal cancer cells (LS174) and normal MRC-5 human embryonic lung fibroblast cells (IC50 of 78.3-155.6 μg/mL). ACE inhibitory activity of the aqueous extract was strong with an IC50 of 0.74 μg/mL. It can be concluded that black trumpet is a good source of nutrients, such as vitamins, dietary fibres, amino acids, nucleotides and fatty acids, which contribute to the overall nutritional value of this fungus with potential for ACE inhibitory activity and use in anti-hypertensive diet.",
publisher = "Polish Academy Sciences. Institute of Animal Reproduction and Food Research",
journal = "Polish Journal of Food and Nutrition Sciences",
title = "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity",
volume = "72",
number = "2",
pages = "171-181",
doi = "10.31883/pjfns/149914"
}

Radović, J., Leković, A., Tačić, A., Dodevska, M., Stanojković, T., Marinković, T., Jelić, Č.,& Kundaković-Vasović, T.. (2022). Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences
Polish Academy Sciences. Institute of Animal Reproduction and Food Research., 72(2), 171-181.
https://doi.org/10.31883/pjfns/149914

Radović J, Leković A, Tačić A, Dodevska M, Stanojković T, Marinković T, Jelić Č, Kundaković-Vasović T. Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity. in Polish Journal of Food and Nutrition Sciences. 2022;72(2):171-181.
doi:10.31883/pjfns/149914 .

Radović, Jelena, Leković, Aleksandra, Tačić, Ana, Dodevska, Margarita, Stanojković, Tatjana, Marinković, Tijana, Jelić, Čedomir, Kundaković-Vasović, Tatjana, "Black Trumpet, Craterellus cornucopioides (L.) Pers.: Culinary Mushroom with Angiotensin Converting Enzyme Inhibitory and Cytotoxic Activity" in Polish Journal of Food and Nutrition Sciences, 72, no. 2 (2022):171-181,
https://doi.org/10.31883/pjfns/149914 . .

TY  - JOUR
AU  - Radović, Jelena
AU  - Suručić, Relja
AU  - Niketić, Marjan
AU  - Kundaković-Vasović, Tatjana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4114
AB  - Alchemilla viridiflora Rothm., Rosaceae is a herbaceous plant widespread in central Greece, Bulgaria, North Macedonia and Serbia with Kosovo. Liquid chromatography-mass spectrometry analysis leads to the identification of 20 compounds in methanol extract, mainly ellagitannins and flavonoid glycosides. Given that various plant extracts have traditionally been used to treat hypertension and that some of the analyzed methanol extract constituents have beneficial cardiovascular effects, we hypothesized that some of these effects are achieved by inhibiting angiotensin I-converting enzyme (ACE). The dose- dependent ACE inhibitory activities of A. viridiflora and miquelianin were observed with an IC 50 of 2.51 ± 0.00 μg/mL of A. viridiflora extract compared to the IC 50 of 5.4139 ± 0.00 μM for miquelianin. The contribution of the single compounds to the tested activity was further analyzed through the in silico experimental approach. Computational docking results showed that tiliroside, ellagic acid pentose and galloyl-hexahydroxydiphenoyl-glucose exhibited even better binding affinity for the ACE active site than miquelianin, for which ACE activity was confirmed by an in vitro assay.
PB  - Springer
T2  - Molecular and Cellular Biochemistry
T1  - Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme
VL  - 477
SP  - 1893
EP  - 1903
DO  - 10.1007/s11010-022-04410-7
ER  - 

@article{
author = "Radović, Jelena and Suručić, Relja and Niketić, Marjan and Kundaković-Vasović, Tatjana",
year = "2022",
abstract = "Alchemilla viridiflora Rothm., Rosaceae is a herbaceous plant widespread in central Greece, Bulgaria, North Macedonia and Serbia with Kosovo. Liquid chromatography-mass spectrometry analysis leads to the identification of 20 compounds in methanol extract, mainly ellagitannins and flavonoid glycosides. Given that various plant extracts have traditionally been used to treat hypertension and that some of the analyzed methanol extract constituents have beneficial cardiovascular effects, we hypothesized that some of these effects are achieved by inhibiting angiotensin I-converting enzyme (ACE). The dose- dependent ACE inhibitory activities of A. viridiflora and miquelianin were observed with an IC 50 of 2.51 ± 0.00 μg/mL of A. viridiflora extract compared to the IC 50 of 5.4139 ± 0.00 μM for miquelianin. The contribution of the single compounds to the tested activity was further analyzed through the in silico experimental approach. Computational docking results showed that tiliroside, ellagic acid pentose and galloyl-hexahydroxydiphenoyl-glucose exhibited even better binding affinity for the ACE active site than miquelianin, for which ACE activity was confirmed by an in vitro assay.",
publisher = "Springer",
journal = "Molecular and Cellular Biochemistry",
title = "Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme",
volume = "477",
pages = "1893-1903",
doi = "10.1007/s11010-022-04410-7"
}

Radović, J., Suručić, R., Niketić, M.,& Kundaković-Vasović, T.. (2022). Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme. in Molecular and Cellular Biochemistry
Springer., 477, 1893-1903.
https://doi.org/10.1007/s11010-022-04410-7

Radović J, Suručić R, Niketić M, Kundaković-Vasović T. Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme. in Molecular and Cellular Biochemistry. 2022;477:1893-1903.
doi:10.1007/s11010-022-04410-7 .

Radović, Jelena, Suručić, Relja, Niketić, Marjan, Kundaković-Vasović, Tatjana, "Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme" in Molecular and Cellular Biochemistry, 477 (2022):1893-1903,
https://doi.org/10.1007/s11010-022-04410-7 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Maksimović, Zoran
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4304
AB  - Acute upper respiratory tract infections (URIs) are the most common infections in the population, especially in children. URIs are mostly of viral origin and tend to resolve spontaneously in approximately one week. Bacterial URIs are less common, and come mostly as superinfections of acute viral diseases. The therapy is symptomatic and aimed at alleviating cough, maintaining the patency of airways and preventing disease progression. If there are no reasons to see a doctor, parents should be advised to apply general measures and give herbal medicinal products to their children, in an attempt to relieve cough, sore throat and nasal symptoms. In productive cough, herbal expectorants, such as, for example, Hederae helicis folium extracts, are used to facilitate the elimination of mucus. On the other hand, demulcents (Althaeae radix, Plantaginis lanceolatae folium) alleviate dry cough by reducing local irritation. Honey also significantly reduces the frequency and severity of acute cough episodes. Extracts of Sisymbrii officinalis herba and Pelargonii radix are useful for the alleviation of nasal symptoms and sore throat. If the application of the proposed herbal products does not resolve the symptoms within a week, advice of a medical doctor should be sought. © 2022, Pharmaceutical Association of Serbia. All rights reserved.
AB  - Akutne infekcije gornjeg respiratornog trakta (IGRT) su najrasprostranjenije infekcije u populaciji, a posebno kod dece. Najčešće su virusnog porekla i spontano se povlače nakon približno nedelju dana. Bakterijske IGRT su ređe i uglavnom je reč o superinfekcijama akutnih virusnih infekcija. Terapija IGRT je simptomatska i usmerena ka ublažavanju kašlja, održavanju prohodnosti disajnih puteva i sprečavanju progresije oboljenja. Ukoliko nisu prisutni razlozi za upućivanje lekaru, roditelji treba da primenjuju opšte mere i pokušaju da ublaže simptome kašlja, bola u grlu i nazalne simptome primenom biljnih lekovitih proizvoda. Kod produktivnog kašlja, koriste se biljni ekspektoransi kao što su, na primer, ekstrakti Hederae helicis folium, u cilju olakšanja eliminacije mukusa. S druge strane, demulcentna sredstva (Althaeae radix, Plantaginis lanceolatae folium) ublažavaju suv kašalj smanjenjem lokalne iritacije. Med značajno smanjuje učestalost i težinu epizoda akutnog kašlja. Nazalni simptomi i bol u grlu se mogu ublažiti primenom biljnih lekovitih proizvoda na bazi ekstrakata Sisymbrii officinalis herba, Pelargonii radix i Origani majoranae herba. Ukoliko tokom nedelju dana primene ne dođe do poboljšanja stanja, potrebno je potražiti savet lekara.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Phytotherapy of acute upper respiratory tract infections in children
T1  - Fitoterapija akutnih infekcija gornjih respiratornih puteva kod dece
VL  - 72
IS  - 3
SP  - 320
EP  - 339
DO  - 10.5937/arhfarm72-37803
ER  - 

@article{
author = "Kundaković, Tatjana and Maksimović, Zoran",
year = "2022",
abstract = "Acute upper respiratory tract infections (URIs) are the most common infections in the population, especially in children. URIs are mostly of viral origin and tend to resolve spontaneously in approximately one week. Bacterial URIs are less common, and come mostly as superinfections of acute viral diseases. The therapy is symptomatic and aimed at alleviating cough, maintaining the patency of airways and preventing disease progression. If there are no reasons to see a doctor, parents should be advised to apply general measures and give herbal medicinal products to their children, in an attempt to relieve cough, sore throat and nasal symptoms. In productive cough, herbal expectorants, such as, for example, Hederae helicis folium extracts, are used to facilitate the elimination of mucus. On the other hand, demulcents (Althaeae radix, Plantaginis lanceolatae folium) alleviate dry cough by reducing local irritation. Honey also significantly reduces the frequency and severity of acute cough episodes. Extracts of Sisymbrii officinalis herba and Pelargonii radix are useful for the alleviation of nasal symptoms and sore throat. If the application of the proposed herbal products does not resolve the symptoms within a week, advice of a medical doctor should be sought. © 2022, Pharmaceutical Association of Serbia. All rights reserved., Akutne infekcije gornjeg respiratornog trakta (IGRT) su najrasprostranjenije infekcije u populaciji, a posebno kod dece. Najčešće su virusnog porekla i spontano se povlače nakon približno nedelju dana. Bakterijske IGRT su ređe i uglavnom je reč o superinfekcijama akutnih virusnih infekcija. Terapija IGRT je simptomatska i usmerena ka ublažavanju kašlja, održavanju prohodnosti disajnih puteva i sprečavanju progresije oboljenja. Ukoliko nisu prisutni razlozi za upućivanje lekaru, roditelji treba da primenjuju opšte mere i pokušaju da ublaže simptome kašlja, bola u grlu i nazalne simptome primenom biljnih lekovitih proizvoda. Kod produktivnog kašlja, koriste se biljni ekspektoransi kao što su, na primer, ekstrakti Hederae helicis folium, u cilju olakšanja eliminacije mukusa. S druge strane, demulcentna sredstva (Althaeae radix, Plantaginis lanceolatae folium) ublažavaju suv kašalj smanjenjem lokalne iritacije. Med značajno smanjuje učestalost i težinu epizoda akutnog kašlja. Nazalni simptomi i bol u grlu se mogu ublažiti primenom biljnih lekovitih proizvoda na bazi ekstrakata Sisymbrii officinalis herba, Pelargonii radix i Origani majoranae herba. Ukoliko tokom nedelju dana primene ne dođe do poboljšanja stanja, potrebno je potražiti savet lekara.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Phytotherapy of acute upper respiratory tract infections in children, Fitoterapija akutnih infekcija gornjih respiratornih puteva kod dece",
volume = "72",
number = "3",
pages = "320-339",
doi = "10.5937/arhfarm72-37803"
}

Kundaković, T.,& Maksimović, Z.. (2022). Phytotherapy of acute upper respiratory tract infections in children. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(3), 320-339.
https://doi.org/10.5937/arhfarm72-37803

Kundaković T, Maksimović Z. Phytotherapy of acute upper respiratory tract infections in children. in Arhiv za farmaciju. 2022;72(3):320-339.
doi:10.5937/arhfarm72-37803 .

Kundaković, Tatjana, Maksimović, Zoran, "Phytotherapy of acute upper respiratory tract infections in children" in Arhiv za farmaciju, 72, no. 3 (2022):320-339,
https://doi.org/10.5937/arhfarm72-37803 . .

TY  - JOUR
AU  - Suručić, Relja
AU  - Kundaković-Vasović, Tatjana
AU  - Marčetić, Mirjana
AU  - Drakul, Dragana
AU  - Milenković, Marina
AU  - Kovačević, Nada
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4002
AB  - Phytochemical and pharmacological in-vestigations of essential oils isolated from plant species of the genus Seseli have been intensified recently. These plant species have long-term use in nutrition and traditional medicine in the treatment of various disorders. Volatile secondary metabolites of Seseli gracile Waldst. & Kit (Apiaceae) have not been pharma-cologically examined so far. The aim of the conducted research was to assess the antiradical, antimicrobial and spasmolytic ac-tivities of S. gracile essential oil isolated from the aerial parts of the plant. Methods. The antiradical activity was determined us-ing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scaveng-ing test, antimicrobial activity using broth microdilution meth-od with standard strains of Gram (+), Gram (-) bacteria and yeast, while spasmolytic activity was evaluated on isolated rat il-eum, pre-contracted with a high concentration of potassium. Results. The results showed moderate antiradical (SC50 = 78.60 μg/mL) and good spasmolytic activity (IC50 = 271.4 nL/mL) of S. gracile essential oil. In the range of tested concen-trations, minimal inhibitory concentration (MIC) was deter-mined only for the strain of Escherichia coli (500 μg/mL). Con-clusion. Results obtained in this study justify the need for fur-ther studies to elucidate exact molecular mechanism underlay this spasmolytic effect of S. gracile herb essential oil.
AB  - Etarska ulja izolovana iz vrsta roda Seseli su u poslednje vreme intenzivno farmakološki i fitohemijski proučavana. Biljke iz ovog roda se koriste već duži niz godina u ishrani i tradicionalnoj terapiji različitih oboljenja. Farmakološka aktivnost etarskog ulja izolovanog iz Seseli gracile do sada nije ispitivana. Stoga je cilj ovog istraživanja bio da se ispita antiradikalska, antimikrobna i spazmolitična aktivnost etarskog ulja izolovanog iz nadzemnih delova biljne vrste S. gracile. Metode. Antiradikalska aktivnost je utvrđena testom neutralizacije 2.2-difenil-1-pikrilhidrazil (DPPH) radikala, antimikrobna, bujon-mikrodilucionom metodom uz upotrebu standardnih sojeva Gram (+), Gram (-) bakterija i gljivica, a spazmolitična na izolovanom ileumu pacova, prethodno kontrahovanom visokom koncentarcijom kalijuma. Rezultati. Rezultati pokazuju umerenu antiradikalsku (SC50 = 78.60 μg/mL) i dobru spazmolitičnu aktivnost (IC50 = 271.4 nL/mL) etarskog ulja S. gracile. U opsegu testiranih koncentracija utvrđena je minimalna inhibitorna koncentracija (MIC) samo za soj Escherichia coli (500 μg/mL). Zaključak. Dobijeni rezultati opravdavaju potrebu za budućim istraživanjima koja bi razjasnila tačne mehanizme kojima se ostvaruje spazmolitički efekat etarskog ulja nadzemnog dela S. gracile.
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Pharmacological characterisation of Seseli gracile Waldst. & Kit. (Apiaceae) essential oil
T1  - Farmakološka karakterizacija etarskog ulja Seseli gracile Waldst. & Kit. (Apiaceae)
VL  - 78
IS  - 10
SP  - 1065
EP  - 1071
DO  - 10.2298/VSP190320028S
ER  - 

@article{
author = "Suručić, Relja and Kundaković-Vasović, Tatjana and Marčetić, Mirjana and Drakul, Dragana and Milenković, Marina and Kovačević, Nada",
year = "2021",
abstract = "Phytochemical and pharmacological in-vestigations of essential oils isolated from plant species of the genus Seseli have been intensified recently. These plant species have long-term use in nutrition and traditional medicine in the treatment of various disorders. Volatile secondary metabolites of Seseli gracile Waldst. & Kit (Apiaceae) have not been pharma-cologically examined so far. The aim of the conducted research was to assess the antiradical, antimicrobial and spasmolytic ac-tivities of S. gracile essential oil isolated from the aerial parts of the plant. Methods. The antiradical activity was determined us-ing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scaveng-ing test, antimicrobial activity using broth microdilution meth-od with standard strains of Gram (+), Gram (-) bacteria and yeast, while spasmolytic activity was evaluated on isolated rat il-eum, pre-contracted with a high concentration of potassium. Results. The results showed moderate antiradical (SC50 = 78.60 μg/mL) and good spasmolytic activity (IC50 = 271.4 nL/mL) of S. gracile essential oil. In the range of tested concen-trations, minimal inhibitory concentration (MIC) was deter-mined only for the strain of Escherichia coli (500 μg/mL). Con-clusion. Results obtained in this study justify the need for fur-ther studies to elucidate exact molecular mechanism underlay this spasmolytic effect of S. gracile herb essential oil., Etarska ulja izolovana iz vrsta roda Seseli su u poslednje vreme intenzivno farmakološki i fitohemijski proučavana. Biljke iz ovog roda se koriste već duži niz godina u ishrani i tradicionalnoj terapiji različitih oboljenja. Farmakološka aktivnost etarskog ulja izolovanog iz Seseli gracile do sada nije ispitivana. Stoga je cilj ovog istraživanja bio da se ispita antiradikalska, antimikrobna i spazmolitična aktivnost etarskog ulja izolovanog iz nadzemnih delova biljne vrste S. gracile. Metode. Antiradikalska aktivnost je utvrđena testom neutralizacije 2.2-difenil-1-pikrilhidrazil (DPPH) radikala, antimikrobna, bujon-mikrodilucionom metodom uz upotrebu standardnih sojeva Gram (+), Gram (-) bakterija i gljivica, a spazmolitična na izolovanom ileumu pacova, prethodno kontrahovanom visokom koncentarcijom kalijuma. Rezultati. Rezultati pokazuju umerenu antiradikalsku (SC50 = 78.60 μg/mL) i dobru spazmolitičnu aktivnost (IC50 = 271.4 nL/mL) etarskog ulja S. gracile. U opsegu testiranih koncentracija utvrđena je minimalna inhibitorna koncentracija (MIC) samo za soj Escherichia coli (500 μg/mL). Zaključak. Dobijeni rezultati opravdavaju potrebu za budućim istraživanjima koja bi razjasnila tačne mehanizme kojima se ostvaruje spazmolitički efekat etarskog ulja nadzemnog dela S. gracile.",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Pharmacological characterisation of Seseli gracile Waldst. & Kit. (Apiaceae) essential oil, Farmakološka karakterizacija etarskog ulja Seseli gracile Waldst. & Kit. (Apiaceae)",
volume = "78",
number = "10",
pages = "1065-1071",
doi = "10.2298/VSP190320028S"
}

Suručić, R., Kundaković-Vasović, T., Marčetić, M., Drakul, D., Milenković, M.,& Kovačević, N.. (2021). Pharmacological characterisation of Seseli gracile Waldst. & Kit. (Apiaceae) essential oil. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 78(10), 1065-1071.
https://doi.org/10.2298/VSP190320028S

Suručić R, Kundaković-Vasović T, Marčetić M, Drakul D, Milenković M, Kovačević N. Pharmacological characterisation of Seseli gracile Waldst. & Kit. (Apiaceae) essential oil. in Vojnosanitetski pregled. 2021;78(10):1065-1071.
doi:10.2298/VSP190320028S .

Suručić, Relja, Kundaković-Vasović, Tatjana, Marčetić, Mirjana, Drakul, Dragana, Milenković, Marina, Kovačević, Nada, "Pharmacological characterisation of Seseli gracile Waldst. & Kit. (Apiaceae) essential oil" in Vojnosanitetski pregled, 78, no. 10 (2021):1065-1071,
https://doi.org/10.2298/VSP190320028S . .

TY  - JOUR
AU  - Punoševac, Milka
AU  - Radović, Jelena
AU  - Leković, Aleksandra
AU  - Kundaković-Vasović, Tatjana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3919
AB  - Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant, but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin,  apiol,  1-allyl-2,3,4,5-tetramethoxybenzene,  β-phellandrene,  1,3,8-p-menthatriene,                 β-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects  of  various  parsley  preparations  such  as  diuretic,  antiurolithiasis,  hypouricemic, hypolipidemic,  hypoglycemic,  hypotensive,  antioxidant,  anti-inflammatory  and  antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs.
AB  - Peršun je dvogodišnja aromatična biljka iz familije Apiaceae koju karakterišu nerazgranat koren, perasto deljeni listovi, štitaste cvasti i plod šizokarpijum. U svim delovima sadrži etarsko ulje, čije su glavne komponente fenilpropanska i terpenska jedinjenja. Bogat je flavonoidima i drugim polifenolnim jedinjenjima, sadrži furanokumarine, karotenoide, poliacetilene, a listovi su izvor vitamina i minerala. Hemijski sastav peršuna zavisi od brojnih faktora, pa tako postoje razlike u sastavu između ne samo različitih delova i varijeteta biljke, već i različitih uzoraka istih delova jednog varijeteta. Najzastupljenija jedinjenja peršuna su miristicin, apiol, 1-alil-2,3,4,5tetrametoksibenzen, b-felandren, 1,3,8-p-mentatrien, b-pinen, terpinolen, apiin, oksipeucedanin i falkarinol. Peršun ima dugu tradiciju upotrebe u tretmanu poremećaja funkcije urinarnog trakta, a savremena in vitro i in vivo ispitivanja otkrivaju i brojne efekte koje poseduju različiti preparati peršuna kao što su diuretički, antiurolitijazni, hipourikemijski, hipolipidemijski, hipoglikemijski, hipotenzivni, antioksidativni, antiinflamatorni, antimikrobni i antiagregacioni. Danas, pored medicinske primene, peršun je jedna od najkorišćenijih začinskih biljaka.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley
T1  - Pregled botaničkih karakteristika, hemijskog sastava, farmakološke aktivnosti i primene peršuna
VL  - 71
IS  - 3
SP  - 177
EP  - 196
DO  - 10.5937/arhfarm71‐30800
ER  - 

@article{
author = "Punoševac, Milka and Radović, Jelena and Leković, Aleksandra and Kundaković-Vasović, Tatjana",
year = "2021",
abstract = "Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant, but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin,  apiol,  1-allyl-2,3,4,5-tetramethoxybenzene,  β-phellandrene,  1,3,8-p-menthatriene,                 β-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects  of  various  parsley  preparations  such  as  diuretic,  antiurolithiasis,  hypouricemic, hypolipidemic,  hypoglycemic,  hypotensive,  antioxidant,  anti-inflammatory  and  antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs., Peršun je dvogodišnja aromatična biljka iz familije Apiaceae koju karakterišu nerazgranat koren, perasto deljeni listovi, štitaste cvasti i plod šizokarpijum. U svim delovima sadrži etarsko ulje, čije su glavne komponente fenilpropanska i terpenska jedinjenja. Bogat je flavonoidima i drugim polifenolnim jedinjenjima, sadrži furanokumarine, karotenoide, poliacetilene, a listovi su izvor vitamina i minerala. Hemijski sastav peršuna zavisi od brojnih faktora, pa tako postoje razlike u sastavu između ne samo različitih delova i varijeteta biljke, već i različitih uzoraka istih delova jednog varijeteta. Najzastupljenija jedinjenja peršuna su miristicin, apiol, 1-alil-2,3,4,5tetrametoksibenzen, b-felandren, 1,3,8-p-mentatrien, b-pinen, terpinolen, apiin, oksipeucedanin i falkarinol. Peršun ima dugu tradiciju upotrebe u tretmanu poremećaja funkcije urinarnog trakta, a savremena in vitro i in vivo ispitivanja otkrivaju i brojne efekte koje poseduju različiti preparati peršuna kao što su diuretički, antiurolitijazni, hipourikemijski, hipolipidemijski, hipoglikemijski, hipotenzivni, antioksidativni, antiinflamatorni, antimikrobni i antiagregacioni. Danas, pored medicinske primene, peršun je jedna od najkorišćenijih začinskih biljaka.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley, Pregled botaničkih karakteristika, hemijskog sastava, farmakološke aktivnosti i primene peršuna",
volume = "71",
number = "3",
pages = "177-196",
doi = "10.5937/arhfarm71‐30800"
}

Punoševac, M., Radović, J., Leković, A.,& Kundaković-Vasović, T.. (2021). A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(3), 177-196.
https://doi.org/10.5937/arhfarm71‐30800

Punoševac M, Radović J, Leković A, Kundaković-Vasović T. A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley. in Arhiv za farmaciju. 2021;71(3):177-196.
doi:10.5937/arhfarm71‐30800 .

Punoševac, Milka, Radović, Jelena, Leković, Aleksandra, Kundaković-Vasović, Tatjana, "A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley" in Arhiv za farmaciju, 71, no. 3 (2021):177-196,
https://doi.org/10.5937/arhfarm71‐30800 . .

TY  - CONF
AU  - Kundaković-Vasović, Tatjana
AU  - Radović, Jelena
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5058
AB  - UVOD I CILJ Jestive gljive su važan izvor hranljivih i bioaktivnih jedinjenja sa različitim farmakološkim aktivnostima. Ekstrakti gljiva Fomes fomentarius-FF, Laetiporus sulphureus-LS, Cantarellus cibarius-CC, Cratherellus cornucopioides-CrC i Calocibe gambosa-CG bile su predmet hemijske analize i in vitro ispitivanja nekoliko aktivnosti: antioksidantne, citotoksične, antibakterijske i ACE inhibitorne aktivnosti. ...
AB  - INTRODUCTION AND OBJECTIVE The edible mushrooms are important source of nutritive and bioactive compounds with different pharmacological activities. Extracts of fungi Fomes fomentarius-FF, Laetiporus sulphureus-LS, Cantarellus cibarius-CC, Cratherellus cornucopioides-CrC and Calocybe gambosa-CG, were the subject of chemical analysis and in vitro testing of several activities: antioxidant, cytotoxic, antibacterial activity, ACE inhibitory activity. ...
PB  - Komora magistara farmacije Federacije Bosne i Hercegovine
PB  - Farmaceutsko društvo Republike Srpske
C3  - 4. kongres farmaceuta u Bosni i Hercegovini sa međunarodnim učešćem, "Novi trendovi u farmaciji", 10-13.10.2019., Sarajevo, Knjiga sažetaka
T1  - Nutritivni i bioaktivni sastojci odabranih gljiva iz familija Polyporaceae, Cantharellaceae i Lyophyllaceae
SP  - 196
EP  - 197
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5058
ER  - 

@conference{
author = "Kundaković-Vasović, Tatjana and Radović, Jelena",
year = "2019",
abstract = "UVOD I CILJ Jestive gljive su važan izvor hranljivih i bioaktivnih jedinjenja sa različitim farmakološkim aktivnostima. Ekstrakti gljiva Fomes fomentarius-FF, Laetiporus sulphureus-LS, Cantarellus cibarius-CC, Cratherellus cornucopioides-CrC i Calocibe gambosa-CG bile su predmet hemijske analize i in vitro ispitivanja nekoliko aktivnosti: antioksidantne, citotoksične, antibakterijske i ACE inhibitorne aktivnosti. ..., INTRODUCTION AND OBJECTIVE The edible mushrooms are important source of nutritive and bioactive compounds with different pharmacological activities. Extracts of fungi Fomes fomentarius-FF, Laetiporus sulphureus-LS, Cantarellus cibarius-CC, Cratherellus cornucopioides-CrC and Calocybe gambosa-CG, were the subject of chemical analysis and in vitro testing of several activities: antioxidant, cytotoxic, antibacterial activity, ACE inhibitory activity. ...",
publisher = "Komora magistara farmacije Federacije Bosne i Hercegovine, Farmaceutsko društvo Republike Srpske",
journal = "4. kongres farmaceuta u Bosni i Hercegovini sa međunarodnim učešćem, "Novi trendovi u farmaciji", 10-13.10.2019., Sarajevo, Knjiga sažetaka",
title = "Nutritivni i bioaktivni sastojci odabranih gljiva iz familija Polyporaceae, Cantharellaceae i Lyophyllaceae",
pages = "196-197",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5058"
}

Kundaković-Vasović, T.,& Radović, J.. (2019). Nutritivni i bioaktivni sastojci odabranih gljiva iz familija Polyporaceae, Cantharellaceae i Lyophyllaceae. in 4. kongres farmaceuta u Bosni i Hercegovini sa međunarodnim učešćem, "Novi trendovi u farmaciji", 10-13.10.2019., Sarajevo, Knjiga sažetaka
Komora magistara farmacije Federacije Bosne i Hercegovine., 196-197.
https://hdl.handle.net/21.15107/rcub_farfar_5058

Kundaković-Vasović T, Radović J. Nutritivni i bioaktivni sastojci odabranih gljiva iz familija Polyporaceae, Cantharellaceae i Lyophyllaceae. in 4. kongres farmaceuta u Bosni i Hercegovini sa međunarodnim učešćem, "Novi trendovi u farmaciji", 10-13.10.2019., Sarajevo, Knjiga sažetaka. 2019;:196-197.
https://hdl.handle.net/21.15107/rcub_farfar_5058 .

Kundaković-Vasović, Tatjana, Radović, Jelena, "Nutritivni i bioaktivni sastojci odabranih gljiva iz familija Polyporaceae, Cantharellaceae i Lyophyllaceae" in 4. kongres farmaceuta u Bosni i Hercegovini sa međunarodnim učešćem, "Novi trendovi u farmaciji", 10-13.10.2019., Sarajevo, Knjiga sažetaka (2019):196-197,
https://hdl.handle.net/21.15107/rcub_farfar_5058 .

TY  - CONF
AU  - Kopanja, Đurđica
AU  - Zrilić, Mira
AU  - Kundaković, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5499
AB  - In 2017, there were 36 543 patients with cancer
in the hospitals in Republic of Srpska (RS). The trend for the growth of diseased patients of
younger age is evident.The costs for cytostatics in 2017 year amounted
to 14,31millions EUR. Procurement of cytostatics at the tertiary level of
healthcare is provided through the Health
Insurance Fund of Republic of Srpska and has
been conducted through public procurement. Very often there are the shortages of cytostatics
in the hospitals. The patients are forced to take over the
procurement of these drugs themselves. Patients are forced to buy drugs in other
countries.
PB  - International Pharmaceutical Federation (FIP)
C3  - 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 22-26 September, 2019. Abu Dhabi, United Arab Emirates
T1  - Procurement of Cytostatics in the Republic of Srpska
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5499
ER  - 

@conference{
author = "Kopanja, Đurđica and Zrilić, Mira and Kundaković, Tatjana",
year = "2019",
abstract = "In 2017, there were 36 543 patients with cancer
in the hospitals in Republic of Srpska (RS). The trend for the growth of diseased patients of
younger age is evident.The costs for cytostatics in 2017 year amounted
to 14,31millions EUR. Procurement of cytostatics at the tertiary level of
healthcare is provided through the Health
Insurance Fund of Republic of Srpska and has
been conducted through public procurement. Very often there are the shortages of cytostatics
in the hospitals. The patients are forced to take over the
procurement of these drugs themselves. Patients are forced to buy drugs in other
countries.",
publisher = "International Pharmaceutical Federation (FIP)",
journal = "79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 22-26 September, 2019. Abu Dhabi, United Arab Emirates",
title = "Procurement of Cytostatics in the Republic of Srpska",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5499"
}

Kopanja, Đ., Zrilić, M.,& Kundaković, T.. (2019). Procurement of Cytostatics in the Republic of Srpska. in 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 22-26 September, 2019. Abu Dhabi, United Arab Emirates
International Pharmaceutical Federation (FIP)..
https://hdl.handle.net/21.15107/rcub_farfar_5499

Kopanja Đ, Zrilić M, Kundaković T. Procurement of Cytostatics in the Republic of Srpska. in 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 22-26 September, 2019. Abu Dhabi, United Arab Emirates. 2019;.
https://hdl.handle.net/21.15107/rcub_farfar_5499 .

Kopanja, Đurđica, Zrilić, Mira, Kundaković, Tatjana, "Procurement of Cytostatics in the Republic of Srpska" in 79th FIP World Congress of Pharmacy and Pharmaceutical Sciences, 22-26 September, 2019. Abu Dhabi, United Arab Emirates (2019),
https://hdl.handle.net/21.15107/rcub_farfar_5499 .

TY  - CONF
AU  - Radović, Jelena
AU  - Dodevska, Margarita
AU  - Kopanja, Đurđica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5309
AB  - St. George's mushroom, Calocybe gambosa, is an edible mushroom from the family Lyophyllaceae. It is widespread in Europe. The colour of the mushroom varies from white, yellow to greyish-brown. ...
PB  - Phytochemical Society of Europe
PB  - Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
C3  - Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts
T1  - Chemical and nutritive composition of St. George’mushroom, Calocybe gambosa (Fr.) Donk
SP  - 212
EP  - 212
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5309
ER  - 

@conference{
author = "Radović, Jelena and Dodevska, Margarita and Kopanja, Đurđica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "St. George's mushroom, Calocybe gambosa, is an edible mushroom from the family Lyophyllaceae. It is widespread in Europe. The colour of the mushroom varies from white, yellow to greyish-brown. ...",
publisher = "Phytochemical Society of Europe, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal",
journal = "Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts",
title = "Chemical and nutritive composition of St. George’mushroom, Calocybe gambosa (Fr.) Donk",
pages = "212-212",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5309"
}

Radović, J., Dodevska, M., Kopanja, Đ.,& Kundaković-Vasović, T.. (2019). Chemical and nutritive composition of St. George’mushroom, Calocybe gambosa (Fr.) Donk. in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts
Phytochemical Society of Europe., 212-212.
https://hdl.handle.net/21.15107/rcub_farfar_5309

Radović J, Dodevska M, Kopanja Đ, Kundaković-Vasović T. Chemical and nutritive composition of St. George’mushroom, Calocybe gambosa (Fr.) Donk. in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts. 2019;:212-212.
https://hdl.handle.net/21.15107/rcub_farfar_5309 .

Radović, Jelena, Dodevska, Margarita, Kopanja, Đurđica, Kundaković-Vasović, Tatjana, "Chemical and nutritive composition of St. George’mushroom, Calocybe gambosa (Fr.) Donk" in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts (2019):212-212,
https://hdl.handle.net/21.15107/rcub_farfar_5309 .

TY  - CONF
AU  - Arsenijević, Jelena
AU  - Radović, Jelena
AU  - Stanojković, Tatjana
AU  - Ranđelović, Vladimir
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5308
AB  - Rumex balcanicus Rech.f. (Polygonaceae) is an endemic species that inhabits central parts of Serbia and Kosovo. Recent studies have demonstrated that the isolates of some Rumex species exhibited anti-inflammatory, antioxidant, anticancer, antidiabetic and antimicrobial activities, and aerial parts of some species are used as food. ...
PB  - Phytochemical Society of Europe
PB  - Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
C3  - Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts
T1  - Chemical analysis and cytotoxicity of Rumex balcanicus Rech. f. (Polygonaceae)
SP  - 169
EP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5308
ER  - 

@conference{
author = "Arsenijević, Jelena and Radović, Jelena and Stanojković, Tatjana and Ranđelović, Vladimir and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Rumex balcanicus Rech.f. (Polygonaceae) is an endemic species that inhabits central parts of Serbia and Kosovo. Recent studies have demonstrated that the isolates of some Rumex species exhibited anti-inflammatory, antioxidant, anticancer, antidiabetic and antimicrobial activities, and aerial parts of some species are used as food. ...",
publisher = "Phytochemical Society of Europe, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal",
journal = "Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts",
title = "Chemical analysis and cytotoxicity of Rumex balcanicus Rech. f. (Polygonaceae)",
pages = "169-169",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5308"
}

Arsenijević, J., Radović, J., Stanojković, T., Ranđelović, V.,& Kundaković-Vasović, T.. (2019). Chemical analysis and cytotoxicity of Rumex balcanicus Rech. f. (Polygonaceae). in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts
Phytochemical Society of Europe., 169-169.
https://hdl.handle.net/21.15107/rcub_farfar_5308

Arsenijević J, Radović J, Stanojković T, Ranđelović V, Kundaković-Vasović T. Chemical analysis and cytotoxicity of Rumex balcanicus Rech. f. (Polygonaceae). in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts. 2019;:169-169.
https://hdl.handle.net/21.15107/rcub_farfar_5308 .

Arsenijević, Jelena, Radović, Jelena, Stanojković, Tatjana, Ranđelović, Vladimir, Kundaković-Vasović, Tatjana, "Chemical analysis and cytotoxicity of Rumex balcanicus Rech. f. (Polygonaceae)" in Natural Products in Drug Discovery and Human Health (NatProdDDH) conference Lisbon, Portugal, 2019, Book of abstracts (2019):169-169,
https://hdl.handle.net/21.15107/rcub_farfar_5308 .

TY  - CONF
AU  - Radović, Jelena
AU  - Milenković, Marina
AU  - Ranđelović, Vladimir
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5295
AB  - Recent studies demonstrated that Rumex species exhibit various
pharmacological activities, such as antiinflamatory, antioxidant, anticancer,
antimicrobial, but there are almost no data on pharmacological activities of Balcan
endemic species Rumex balcanicus. Thus, the aim was to examine antioxidant
activity, using DPPH and FRAP method, antimicrobial activity via broth
microdilution method and α-amylase inhibitory activity using DNS reagent of
aqueous and methanol extracts of roots and aerial parts of R. balcanicus, collected on
Vlasina Lake in 2014. All tested extracts exhibited high antioxidant activity which
has been correlated with the high content of polyphenols. Aqueous extracts exhibited
lower activity compared to methanol extracts. Methanol extract ofR. balcanicus roots
showed the highest activity, both in DPPH (IC50= 9.57 μg/mL) and FRAP test
(IC50=3.98 μmol Fe/mg of extract), while aqueous extract of aerial parts showed the
lowest activity (IC50= 24.73 μg/mL; IC50=2.11 μmol Fe/mg). Only methanol extract
of aerial parts showed α-amylase inhibitory activity with IC50=252 μg/mL. All
extracts had low antimicrobial activity against almost all tested bacterial strains except
against Bacillus subtilis. Positive results obtained in this study show that R. balcanisus
contains potential as a new raw material and for the development of drugs efficient in
treating diabetes.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia
C3  - 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
T1  - Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)
SP  - 159
EP  - 159
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5295
ER  - 

@conference{
author = "Radović, Jelena and Milenković, Marina and Ranđelović, Vladimir and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Recent studies demonstrated that Rumex species exhibit various
pharmacological activities, such as antiinflamatory, antioxidant, anticancer,
antimicrobial, but there are almost no data on pharmacological activities of Balcan
endemic species Rumex balcanicus. Thus, the aim was to examine antioxidant
activity, using DPPH and FRAP method, antimicrobial activity via broth
microdilution method and α-amylase inhibitory activity using DNS reagent of
aqueous and methanol extracts of roots and aerial parts of R. balcanicus, collected on
Vlasina Lake in 2014. All tested extracts exhibited high antioxidant activity which
has been correlated with the high content of polyphenols. Aqueous extracts exhibited
lower activity compared to methanol extracts. Methanol extract ofR. balcanicus roots
showed the highest activity, both in DPPH (IC50= 9.57 μg/mL) and FRAP test
(IC50=3.98 μmol Fe/mg of extract), while aqueous extract of aerial parts showed the
lowest activity (IC50= 24.73 μg/mL; IC50=2.11 μmol Fe/mg). Only methanol extract
of aerial parts showed α-amylase inhibitory activity with IC50=252 μg/mL. All
extracts had low antimicrobial activity against almost all tested bacterial strains except
against Bacillus subtilis. Positive results obtained in this study show that R. balcanisus
contains potential as a new raw material and for the development of drugs efficient in
treating diabetes.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia",
journal = "13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts",
title = "Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)",
pages = "159-159",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5295"
}

Radović, J., Milenković, M., Ranđelović, V.,& Kundaković-Vasović, T.. (2019). Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 159-159.
https://hdl.handle.net/21.15107/rcub_farfar_5295

Radović J, Milenković M, Ranđelović V, Kundaković-Vasović T. Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts. 2019;:159-159.
https://hdl.handle.net/21.15107/rcub_farfar_5295 .

Radović, Jelena, Milenković, Marina, Ranđelović, Vladimir, Kundaković-Vasović, Tatjana, "Pharmacological activity of Rumex balcanicus Rech. F. (Polygonaceae)" in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts (2019):159-159,
https://hdl.handle.net/21.15107/rcub_farfar_5295 .

TY  - CONF
AU  - Arsenijević, Jelena
AU  - Stanojković, Tatjana
AU  - Ranđelović, Vladimir
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5294
AB  - Rumex balcanicus Rech.f. (Polygonaceae) is an endemic species that inhabits
central parts of Serbia and Kosovo. The genus Rumex is characterizied by the
accumulation of anthraquinones, naphthalene-1,8-diols, flavonoids and stilbenoids.
Aerial parts of R. balcanicus, collected on Vlasina Lake (Serbia) in 2014, were used
to determine the chemical composition and cytotoxic activity. Cyclohexane,
dichloromethane, methanol and aqueous extracts were prepared and tested using
MTT-test, against human epithelial cervical cancer cells (HeLa), human colon
carcinoma cell line (LS174), human non-small cell lung cancer cells (A549) and
healthy MRC-5 human embryonic lung fibroblast cell line. Methanol and aqueous
extracts were analyzed using LC-MS. In tested extracts, caffeic acid derivates and
flavonol derivatives were identified. The main components in both extracts were rutin,
miquelianin, quercitrin and quercetin 3-O-acetyl-rhamnoside. Caffeic acid and its
glycosides were also present in analyzed extracts. Aqueous extracts had no
cytotoxicity against tested cell lines, while cyclohexane, dichlormethane and
methanol extracts were active against all tested cell lines with IC50 ranged from
116.48±3.26 μg/mL to 178.21±1.30 μg/mL. Due to the presence of flavonoids and
exhibited cytotoxic effect, R. balcanicus herba could be interesting as a plant material
for further pharmacological analysis and isolation of the anti-tumor compounds.
PB  - Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš
PB  - Institute for Nature Conservation of Serbia
C3  - 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
T1  - Chemical analysis and cytotoxity of Rumex balcanicus Rech.F. (Polygonaceae)
SP  - 158
EP  - 158
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5294
ER  - 

@conference{
author = "Arsenijević, Jelena and Stanojković, Tatjana and Ranđelović, Vladimir and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Rumex balcanicus Rech.f. (Polygonaceae) is an endemic species that inhabits
central parts of Serbia and Kosovo. The genus Rumex is characterizied by the
accumulation of anthraquinones, naphthalene-1,8-diols, flavonoids and stilbenoids.
Aerial parts of R. balcanicus, collected on Vlasina Lake (Serbia) in 2014, were used
to determine the chemical composition and cytotoxic activity. Cyclohexane,
dichloromethane, methanol and aqueous extracts were prepared and tested using
MTT-test, against human epithelial cervical cancer cells (HeLa), human colon
carcinoma cell line (LS174), human non-small cell lung cancer cells (A549) and
healthy MRC-5 human embryonic lung fibroblast cell line. Methanol and aqueous
extracts were analyzed using LC-MS. In tested extracts, caffeic acid derivates and
flavonol derivatives were identified. The main components in both extracts were rutin,
miquelianin, quercitrin and quercetin 3-O-acetyl-rhamnoside. Caffeic acid and its
glycosides were also present in analyzed extracts. Aqueous extracts had no
cytotoxicity against tested cell lines, while cyclohexane, dichlormethane and
methanol extracts were active against all tested cell lines with IC50 ranged from
116.48±3.26 μg/mL to 178.21±1.30 μg/mL. Due to the presence of flavonoids and
exhibited cytotoxic effect, R. balcanicus herba could be interesting as a plant material
for further pharmacological analysis and isolation of the anti-tumor compounds.",
publisher = "Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Institute for Nature Conservation of Serbia",
journal = "13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts",
title = "Chemical analysis and cytotoxity of Rumex balcanicus Rech.F. (Polygonaceae)",
pages = "158-158",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5294"
}

Arsenijević, J., Stanojković, T., Ranđelović, V.,& Kundaković-Vasović, T.. (2019). Chemical analysis and cytotoxity of Rumex balcanicus Rech.F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts
Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš., 158-158.
https://hdl.handle.net/21.15107/rcub_farfar_5294

Arsenijević J, Stanojković T, Ranđelović V, Kundaković-Vasović T. Chemical analysis and cytotoxity of Rumex balcanicus Rech.F. (Polygonaceae). in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts. 2019;:158-158.
https://hdl.handle.net/21.15107/rcub_farfar_5294 .

Arsenijević, Jelena, Stanojković, Tatjana, Ranđelović, Vladimir, Kundaković-Vasović, Tatjana, "Chemical analysis and cytotoxity of Rumex balcanicus Rech.F. (Polygonaceae)" in 13th Symposium on the Flora of Southeastern Serbia and Neighboring Regions, 20th to 23th June, 2019 - Book of Abstracts (2019):158-158,
https://hdl.handle.net/21.15107/rcub_farfar_5294 .

TY  - CONF
AU  - Opačić-Galić, Vanja
AU  - Pavlica, Dušan
AU  - Kundaković-Vasović, Tatjana
AU  - Radović, Jelena
AU  - Popović Bajić, Marijana
AU  - Mitić-Ćulafić, Dragana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5222
PB  - European Society of Endodontology (ESE)
C3  - 19th Biennial ESE Congress, “Vienna calling – experience the sound of Endodontology”, September 12 - 14, 2019, Vienna, Austria
T1  - Antimicrobial potential of herbal tinctures on Enterococcus faecalis
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5222
ER  - 

@conference{
author = "Opačić-Galić, Vanja and Pavlica, Dušan and Kundaković-Vasović, Tatjana and Radović, Jelena and Popović Bajić, Marijana and Mitić-Ćulafić, Dragana",
year = "2019",
publisher = "European Society of Endodontology (ESE)",
journal = "19th Biennial ESE Congress, “Vienna calling – experience the sound of Endodontology”, September 12 - 14, 2019, Vienna, Austria",
title = "Antimicrobial potential of herbal tinctures on Enterococcus faecalis",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5222"
}

Opačić-Galić, V., Pavlica, D., Kundaković-Vasović, T., Radović, J., Popović Bajić, M.,& Mitić-Ćulafić, D.. (2019). Antimicrobial potential of herbal tinctures on Enterococcus faecalis. in 19th Biennial ESE Congress, “Vienna calling – experience the sound of Endodontology”, September 12 - 14, 2019, Vienna, Austria
European Society of Endodontology (ESE)..
https://hdl.handle.net/21.15107/rcub_farfar_5222

Opačić-Galić V, Pavlica D, Kundaković-Vasović T, Radović J, Popović Bajić M, Mitić-Ćulafić D. Antimicrobial potential of herbal tinctures on Enterococcus faecalis. in 19th Biennial ESE Congress, “Vienna calling – experience the sound of Endodontology”, September 12 - 14, 2019, Vienna, Austria. 2019;.
https://hdl.handle.net/21.15107/rcub_farfar_5222 .

Opačić-Galić, Vanja, Pavlica, Dušan, Kundaković-Vasović, Tatjana, Radović, Jelena, Popović Bajić, Marijana, Mitić-Ćulafić, Dragana, "Antimicrobial potential of herbal tinctures on Enterococcus faecalis" in 19th Biennial ESE Congress, “Vienna calling – experience the sound of Endodontology”, September 12 - 14, 2019, Vienna, Austria (2019),
https://hdl.handle.net/21.15107/rcub_farfar_5222 .

TY  - JOUR
AU  - Kundaković-Vasović, Tatjana
AU  - Radović, Jelena
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3487
AB  - Herbal medicinal products are very important for cough therapy and commonly used in both self-medication and doctor's recommendation. Herbal drugs used in cough therapy can be divided into expectorant and demulcent herbal drugs (drugs containing heteropolysaccharides, most commonly mucilages). Clinical studies have confirmed the efficacy of ivy leaf extracts and fixed combinations of thyme herb and primrose roots extracts as expectorants in productive cough, while for the most other herbal drugs and their preparations used in cough therapy only traditional use is documented. Each herbal drug used in cough therapy has its specific application restrictions (contraindications, special warnings, precautions, interactions, and adverse effects).
AB  - Biljni lekoviti proizvodi su veoma značajni za terapiju kašlja i često se koriste, kako u samomedikaciji, tako i po preporuci lekara. Biljne droge koje se koriste u terapiji kašlja se mogu podeliti na droge ekspektorantnog delovanja i demulcentna sredstva, odnosno droge koje sadrže heteropolisaharide, najčešće sluzi. Kliničke studije su potvrdile efikasnost primene ekstrakata herbe bršljana i fiksnih kombinacija herbe timijana i korena jagorčevine kao ekspektoranasa kod produktivnog kašlja, dok je za veći broj drugih biljnih droga i njihovih preparata koji se koriste u terapiji kašlja, dokumentovana samo tradicionalna primena. Svaka biljna droga koja se koristi u terapiji kašlja ima svoja specifična ograničenja za primenu (kontraindikacije, specijalna upozorenja, mere opreza, interakcije i neželjena dejstva).
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Biljni lekoviti proizvodi u terapiji kašlja povezanog sa prehladom
T1  - Herbal medicinal products in the treatment of cough associated with colds
VL  - 69
IS  - 4
SP  - 270
EP  - 285
DO  - 10.5937/arhfarm1904270K
ER  - 

@article{
author = "Kundaković-Vasović, Tatjana and Radović, Jelena",
year = "2019",
abstract = "Herbal medicinal products are very important for cough therapy and commonly used in both self-medication and doctor's recommendation. Herbal drugs used in cough therapy can be divided into expectorant and demulcent herbal drugs (drugs containing heteropolysaccharides, most commonly mucilages). Clinical studies have confirmed the efficacy of ivy leaf extracts and fixed combinations of thyme herb and primrose roots extracts as expectorants in productive cough, while for the most other herbal drugs and their preparations used in cough therapy only traditional use is documented. Each herbal drug used in cough therapy has its specific application restrictions (contraindications, special warnings, precautions, interactions, and adverse effects)., Biljni lekoviti proizvodi su veoma značajni za terapiju kašlja i često se koriste, kako u samomedikaciji, tako i po preporuci lekara. Biljne droge koje se koriste u terapiji kašlja se mogu podeliti na droge ekspektorantnog delovanja i demulcentna sredstva, odnosno droge koje sadrže heteropolisaharide, najčešće sluzi. Kliničke studije su potvrdile efikasnost primene ekstrakata herbe bršljana i fiksnih kombinacija herbe timijana i korena jagorčevine kao ekspektoranasa kod produktivnog kašlja, dok je za veći broj drugih biljnih droga i njihovih preparata koji se koriste u terapiji kašlja, dokumentovana samo tradicionalna primena. Svaka biljna droga koja se koristi u terapiji kašlja ima svoja specifična ograničenja za primenu (kontraindikacije, specijalna upozorenja, mere opreza, interakcije i neželjena dejstva).",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Biljni lekoviti proizvodi u terapiji kašlja povezanog sa prehladom, Herbal medicinal products in the treatment of cough associated with colds",
volume = "69",
number = "4",
pages = "270-285",
doi = "10.5937/arhfarm1904270K"
}

Kundaković-Vasović, T.,& Radović, J.. (2019). Biljni lekoviti proizvodi u terapiji kašlja povezanog sa prehladom. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(4), 270-285.
https://doi.org/10.5937/arhfarm1904270K

Kundaković-Vasović T, Radović J. Biljni lekoviti proizvodi u terapiji kašlja povezanog sa prehladom. in Arhiv za farmaciju. 2019;69(4):270-285.
doi:10.5937/arhfarm1904270K .

Kundaković-Vasović, Tatjana, Radović, Jelena, "Biljni lekoviti proizvodi u terapiji kašlja povezanog sa prehladom" in Arhiv za farmaciju, 69, no. 4 (2019):270-285,
https://doi.org/10.5937/arhfarm1904270K . .

TY  - JOUR
AU  - Milović, Sanja
AU  - Stanković, Ivan
AU  - Nikolić, Dejan
AU  - Radović, Jelena
AU  - Kolundžić, Marina
AU  - Nikolić, Vesna
AU  - Stanojković, Tatjana
AU  - Petović, Slavica
AU  - Kundaković-Vasović, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3468
AB  - Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).
PB  - Wiley
T2  - Chemistry and Biodiversity
T1  - Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro
VL  - 16
IS  - 10
SP  - 1
EP  - 11
DO  - 10.1002/cbdv.201900327
ER  - 

@article{
author = "Milović, Sanja and Stanković, Ivan and Nikolić, Dejan and Radović, Jelena and Kolundžić, Marina and Nikolić, Vesna and Stanojković, Tatjana and Petović, Slavica and Kundaković-Vasović, Tatjana",
year = "2019",
abstract = "Three seaweeds (Halimeda tuna, Codium bursa and Cystoseira barbata) and one seagrass (Cymodocea nodosa) were collected from the Coast of Montenegro, Gulf of Boka Kotorska and their chemical analysis was performed. In seagrass C. nodosa, three phenolic compounds were identified (diosmetin 7-sulfate, caftaric and coutaric acid). The content of β-glucan, fatty acids, sterols and micro- and macro-elements were investigated among all samples. The highest content of β-glucan was detected in C. nodosa seagrass (13.04±0.42 g/100 g). The highest polyunsaturated fatty acids (PUFAs) level was reported in C. barbata, the brown alga (7.157 mg/g), which also had the significant sterol content (fucosterol, 21.76±0.1 μg/g). Green algae, C. bursa and H. tuna, showed the highest level of sterols (β-sitosterol, 95.21±0.16 μg/g and 73.90±0.08 μg/g, respectively). H. tuna had the highest content of calcium (Ca) in amount of 55125 μg/g. In C. bursa, C. barbata and C. nodosa, the Na/K ratio was low (0.43, 0.46 and 0.69, respectively).",
publisher = "Wiley",
journal = "Chemistry and Biodiversity",
title = "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro",
volume = "16",
number = "10",
pages = "1-11",
doi = "10.1002/cbdv.201900327"
}

Milović, S., Stanković, I., Nikolić, D., Radović, J., Kolundžić, M., Nikolić, V., Stanojković, T., Petović, S.,& Kundaković-Vasović, T.. (2019). Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity
Wiley., 16(10), 1-11.
https://doi.org/10.1002/cbdv.201900327

Milović S, Stanković I, Nikolić D, Radović J, Kolundžić M, Nikolić V, Stanojković T, Petović S, Kundaković-Vasović T. Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro. in Chemistry and Biodiversity. 2019;16(10):1-11.
doi:10.1002/cbdv.201900327 .

Milović, Sanja, Stanković, Ivan, Nikolić, Dejan, Radović, Jelena, Kolundžić, Marina, Nikolić, Vesna, Stanojković, Tatjana, Petović, Slavica, Kundaković-Vasović, Tatjana, "Chemical Analysis of Selected Seaweeds and Seagrass from the Adriatic Coast of Montenegro" in Chemistry and Biodiversity, 16, no. 10 (2019):1-11,
https://doi.org/10.1002/cbdv.201900327 . .

TY  - JOUR
AU  - Škobić, Slađana
AU  - Marčetić, Mirjana
AU  - Kundaković-Vasović, Tatjana
AU  - Crnobarac, Jovan
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3465
AB  - Sweet flag rhizome (Acorus calamus L., Araceae) exhibits various biological activities such as sedative, anticonvulsant,
immunosuppressant, antidiabetic, and anti-inflammatory. This plant is protected in Serbia, but due to
its high market requirements, the cultivation of this species could be the final solution. The content and composition
of essential oils from 24 cultivated samples and five samples of sweet flag from natural populations, as
well as the influence of nitrogen fertilization on the composition of essential oils were studied. Essential oils were
analysed using GC and GC/MS. Statistical analysis included the ANOVA and PCA analysis. The total content of
essential oil was not significantly different between the natural (0.80–1.10%) and cultivated samples
(1.15–1.30%). In all essential oils main compounds were β-asarone (4.82–17.98%), cadinadienol
(10.14–13.95%), camphor (3.55–13.20%), and acorenone (9.68–12.64%). The cultivation of sweet flag showed
significant (p < 0.05) impact on the composition of essential oil and the content of β-asarone (4.82–17.07%,
mean 11.95±4.76 vs. 17.51–17.98%, mean 17.71 ± 2.23). The PCA analysis also separated the essential oils
from natural and cultivated conditions based on the content of β-asarone. On the other hand, the amount of the
fertilizer did not show any effect (p > 0.05) on the composition of investigated samples. The process of cultivation
increased the level of active, but potentially genotoxic and carcinogenic compound β-asarone. It would be
significant to determine the content of β-asarone routinely in the sweet flag rhizome, especially in the cultivated
plants.
PB  - Elsevier
T2  - Industrial Crops & Products
T1  - Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.)
VL  - 142
SP  - 1
EP  - 5
DO  - 10.1016/j.indcrop.2019.111871
ER  - 

@article{
author = "Škobić, Slađana and Marčetić, Mirjana and Kundaković-Vasović, Tatjana and Crnobarac, Jovan",
year = "2019",
abstract = "Sweet flag rhizome (Acorus calamus L., Araceae) exhibits various biological activities such as sedative, anticonvulsant,
immunosuppressant, antidiabetic, and anti-inflammatory. This plant is protected in Serbia, but due to
its high market requirements, the cultivation of this species could be the final solution. The content and composition
of essential oils from 24 cultivated samples and five samples of sweet flag from natural populations, as
well as the influence of nitrogen fertilization on the composition of essential oils were studied. Essential oils were
analysed using GC and GC/MS. Statistical analysis included the ANOVA and PCA analysis. The total content of
essential oil was not significantly different between the natural (0.80–1.10%) and cultivated samples
(1.15–1.30%). In all essential oils main compounds were β-asarone (4.82–17.98%), cadinadienol
(10.14–13.95%), camphor (3.55–13.20%), and acorenone (9.68–12.64%). The cultivation of sweet flag showed
significant (p < 0.05) impact on the composition of essential oil and the content of β-asarone (4.82–17.07%,
mean 11.95±4.76 vs. 17.51–17.98%, mean 17.71 ± 2.23). The PCA analysis also separated the essential oils
from natural and cultivated conditions based on the content of β-asarone. On the other hand, the amount of the
fertilizer did not show any effect (p > 0.05) on the composition of investigated samples. The process of cultivation
increased the level of active, but potentially genotoxic and carcinogenic compound β-asarone. It would be
significant to determine the content of β-asarone routinely in the sweet flag rhizome, especially in the cultivated
plants.",
publisher = "Elsevier",
journal = "Industrial Crops & Products",
title = "Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.)",
volume = "142",
pages = "1-5",
doi = "10.1016/j.indcrop.2019.111871"
}

Škobić, S., Marčetić, M., Kundaković-Vasović, T.,& Crnobarac, J.. (2019). Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.). in Industrial Crops & Products
Elsevier., 142, 1-5.
https://doi.org/10.1016/j.indcrop.2019.111871

Škobić S, Marčetić M, Kundaković-Vasović T, Crnobarac J. Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.). in Industrial Crops & Products. 2019;142:1-5.
doi:10.1016/j.indcrop.2019.111871 .

Škobić, Slađana, Marčetić, Mirjana, Kundaković-Vasović, Tatjana, Crnobarac, Jovan, "Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.)" in Industrial Crops & Products, 142 (2019):1-5,
https://doi.org/10.1016/j.indcrop.2019.111871 . .