TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Vekić, Jelena
AU  - Stefanović, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Ninić, Ana
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Mihajlović, Marija
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3615
AB  - A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology
PB  - Blackwell Publishing Inc.
T2  - BioFactors
T1  - Paraoxonase 1 and atherosclerosis-related diseases
VL  - 46
IS  - 2
SP  - 193
EP  - 205
DO  - 10.1002/biof.1549
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Vekić, Jelena and Stefanović, Aleksandra and Zeljković, Aleksandra and Ninić, Ana and Ivanišević, Jasmina and Miljković, Milica and Sopić, Miron and Munjas, Jelena and Mihajlović, Marija and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna",
year = "2020",
abstract = "A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high-density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti-inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis-related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end-stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features. © 2019 International Union of Biochemistry and Molecular Biology",
publisher = "Blackwell Publishing Inc.",
journal = "BioFactors",
title = "Paraoxonase 1 and atherosclerosis-related diseases",
volume = "46",
number = "2",
pages = "193-205",
doi = "10.1002/biof.1549"
}

Kotur-Stevuljević, J., Vekić, J., Stefanović, A., Zeljković, A., Ninić, A., Ivanišević, J., Miljković, M., Sopić, M., Munjas, J., Mihajlović, M., Spasić, S., Jelić-Ivanović, Z.,& Spasojević-Kalimanovska, V.. (2020). Paraoxonase 1 and atherosclerosis-related diseases. in BioFactors
Blackwell Publishing Inc.., 46(2), 193-205.
https://doi.org/10.1002/biof.1549

Kotur-Stevuljević J, Vekić J, Stefanović A, Zeljković A, Ninić A, Ivanišević J, Miljković M, Sopić M, Munjas J, Mihajlović M, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V. Paraoxonase 1 and atherosclerosis-related diseases. in BioFactors. 2020;46(2):193-205.
doi:10.1002/biof.1549 .

Kotur-Stevuljević, Jelena, Vekić, Jelena, Stefanović, Aleksandra, Zeljković, Aleksandra, Ninić, Ana, Ivanišević, Jasmina, Miljković, Milica, Sopić, Miron, Munjas, Jelena, Mihajlović, Marija, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, "Paraoxonase 1 and atherosclerosis-related diseases" in BioFactors, 46, no. 2 (2020):193-205,
https://doi.org/10.1002/biof.1549 . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Ninić, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Miković, Željko
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3370
AB  - Background: Specific metabolic changes during physiological pregnancy are characterized by hyperlipidemia and increased oxidative stress. However, these specific changes raise the question of their pro-atherogenic potential during pregnancy and their influence on the risk of developing cardiovascular disease (CVD) in women later in life, as well as complications during pregnancy. The aim of this study was to investigate the changes in lipid indexes and parameters of lipid peroxidation in non-complicated pregnancy in order to estimate their course of change and potential relationship during non-complicated pregnancy. Methods: The study included 43 healthy pregnant women and 38 non-pregnant healthy women, in appropriate ages, as the control group. Lipid parameters and oxidative stress parameters were monitored in a longitudinal study in the first, second and third trimesters, and before delivery during non-complicated pregnancy. Results: Results have shown that lipid indexes rise during pregnancy. The values were significantly increased when compared to the first trimester in all lipid indices and in comparison with the control group. Thyobarbituric acid reactive substances (TBARS) and lipid hydroperoxides (LOOH) were not changed significantly during physiological pregnancy, but LOOH showed a significantly higher value in the first trimester compared with the control group. Prooxidative-antioxidative balance (PAB) significantly increases as pregnancy progresses. Conclusions: We observed the changes in lipids, lipid indexes and parameters that indicate oxidative modification of lipids in physiological pregnancy that may lead to an atherogenic, prooxidant state.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Journal of Laboratory Medicine
T1  - Lipid indexes and parameters of lipid peroxidation during physiological pregnancy
VL  - 43
IS  - 2
SP  - 93
EP  - 99
DO  - 10.1515/labmed-2018-0026
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Ninić, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Miković, Željko",
year = "2019",
abstract = "Background: Specific metabolic changes during physiological pregnancy are characterized by hyperlipidemia and increased oxidative stress. However, these specific changes raise the question of their pro-atherogenic potential during pregnancy and their influence on the risk of developing cardiovascular disease (CVD) in women later in life, as well as complications during pregnancy. The aim of this study was to investigate the changes in lipid indexes and parameters of lipid peroxidation in non-complicated pregnancy in order to estimate their course of change and potential relationship during non-complicated pregnancy. Methods: The study included 43 healthy pregnant women and 38 non-pregnant healthy women, in appropriate ages, as the control group. Lipid parameters and oxidative stress parameters were monitored in a longitudinal study in the first, second and third trimesters, and before delivery during non-complicated pregnancy. Results: Results have shown that lipid indexes rise during pregnancy. The values were significantly increased when compared to the first trimester in all lipid indices and in comparison with the control group. Thyobarbituric acid reactive substances (TBARS) and lipid hydroperoxides (LOOH) were not changed significantly during physiological pregnancy, but LOOH showed a significantly higher value in the first trimester compared with the control group. Prooxidative-antioxidative balance (PAB) significantly increases as pregnancy progresses. Conclusions: We observed the changes in lipids, lipid indexes and parameters that indicate oxidative modification of lipids in physiological pregnancy that may lead to an atherogenic, prooxidant state.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Journal of Laboratory Medicine",
title = "Lipid indexes and parameters of lipid peroxidation during physiological pregnancy",
volume = "43",
number = "2",
pages = "93-99",
doi = "10.1515/labmed-2018-0026"
}

Ardalić, D., Stefanović, A., Kotur-Stevuljević, J., Ninić, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z.,& Miković, Ž.. (2019). Lipid indexes and parameters of lipid peroxidation during physiological pregnancy. in Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 43(2), 93-99.
https://doi.org/10.1515/labmed-2018-0026

Ardalić D, Stefanović A, Kotur-Stevuljević J, Ninić A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Miković Ž. Lipid indexes and parameters of lipid peroxidation during physiological pregnancy. in Journal of Laboratory Medicine. 2019;43(2):93-99.
doi:10.1515/labmed-2018-0026 .

Ardalić, Daniela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Ninić, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Miković, Željko, "Lipid indexes and parameters of lipid peroxidation during physiological pregnancy" in Journal of Laboratory Medicine, 43, no. 2 (2019):93-99,
https://doi.org/10.1515/labmed-2018-0026 . .

TY  - JOUR
AU  - Stefanović, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3560
AB  - Type  2  diabetes  mellitus  is  a  chronic  high-prevalence  metabolic  disease,  which  is characterized by hyperglycaemia, but also with lipid and protein metabolism disorders. Patients with  type  2  diabetes  have  a  high  risk  for  cardiovascular  disease  (CVD)  development  and dyslipidemia is considered as a key marker of this increased risk. Hypertriglyceridemia, reduced high  density  lipoprotein  cholesterol  (HDL-c)  concentrations,  and  a  shift  in  low-density lipoprotein  particles  (LDL)  distribution  toward  the  small,  triglycerides-rich  particles,  are  the most important changes in the lipid profile in diabetes.Type 2 diabetes is a metabolic disorder associated with low grade inflammation and oxidative stress, so in this condition high density lipoprotein  particles  (HDL)  also  undergo  structural  and  functional  changes  and,  as  a consequence, lose their atheroprotective role. Dyslipidemia treatment in type 2 diabetes patients younger than 40 and without any other risk factor for CVD development starts with changes in a lifestyle, but in patients older than 40 years, first line medications are statins.Glycemic and lipid control in type 2 diabetes patients significantly reduces CVD risk.
AB  - Dijabetes melitus tip 2 je hronično oboljenje sa visokom prevalencom, koje se karakteriše hiperglikemijom,  ali  i  poremećajima  u  metabolizmu  lipida  i  proteina.  Pacijenti  sa  tipom  2 dijabetesa imaju visok rizik za razvoj kardiovaskularnih bolesti (KVB) i upravo se dislipidemija smatra  ključnim  uzročnikom  ovog  povećanog  rizika.  Hipertrigliceridemija,  snižena koncentracija  holesterola  u  lipoproteinskim  česticama  visoke  gustine  (HDL-h)  i  promena  u raspodeli  lipoproteinskih  čestica  niske  gustine  (LDL)  u  smeru  većeg  udela  malih  čestica, bogatih  trigliceridima,  predstavljaju  najvažnije  promene  lipidnog  profila  koje  se  odnose  na dislipidemiju  u  dijabetesu.  Kako je  dijabetes  stanje  kontinuirane  blage  inflamacije  niskog stepena  i  stalne  produkcije  slobodnih  radikala,  HDL  lipoproteinske  čestice  takođe  podležu strukturnim  i  funkcionalnim  promenama,  usled  čega  gube  svoje  ateroprotektivne  osobine. Terapija dislipidemije kod pacijenata mlađih od 40 godina bez prisutnih drugih faktora rizika za razvoj KVB počinje promenom životnog stila, a kod pacijenata starijih od 40 godina lekovi izbora u terapiji su statini. Glikemijska i lipidna kontrola kod pacijenata sa tipom 2 dijabetesa značajno umanjuje rizik od nastanka KVB.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Dyslipidemia in type 2 diabetes mellitus
T1  - Dislipidemija u dijabetes melitusu tip 2
VL  - 69
IS  - 5
SP  - 338
EP  - 348
DO  - 10.5937/arhfarm1905338S
ER  - 

@article{
author = "Stefanović, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2019",
abstract = "Type  2  diabetes  mellitus  is  a  chronic  high-prevalence  metabolic  disease,  which  is characterized by hyperglycaemia, but also with lipid and protein metabolism disorders. Patients with  type  2  diabetes  have  a  high  risk  for  cardiovascular  disease  (CVD)  development  and dyslipidemia is considered as a key marker of this increased risk. Hypertriglyceridemia, reduced high  density  lipoprotein  cholesterol  (HDL-c)  concentrations,  and  a  shift  in  low-density lipoprotein  particles  (LDL)  distribution  toward  the  small,  triglycerides-rich  particles,  are  the most important changes in the lipid profile in diabetes.Type 2 diabetes is a metabolic disorder associated with low grade inflammation and oxidative stress, so in this condition high density lipoprotein  particles  (HDL)  also  undergo  structural  and  functional  changes  and,  as  a consequence, lose their atheroprotective role. Dyslipidemia treatment in type 2 diabetes patients younger than 40 and without any other risk factor for CVD development starts with changes in a lifestyle, but in patients older than 40 years, first line medications are statins.Glycemic and lipid control in type 2 diabetes patients significantly reduces CVD risk., Dijabetes melitus tip 2 je hronično oboljenje sa visokom prevalencom, koje se karakteriše hiperglikemijom,  ali  i  poremećajima  u  metabolizmu  lipida  i  proteina.  Pacijenti  sa  tipom  2 dijabetesa imaju visok rizik za razvoj kardiovaskularnih bolesti (KVB) i upravo se dislipidemija smatra  ključnim  uzročnikom  ovog  povećanog  rizika.  Hipertrigliceridemija,  snižena koncentracija  holesterola  u  lipoproteinskim  česticama  visoke  gustine  (HDL-h)  i  promena  u raspodeli  lipoproteinskih  čestica  niske  gustine  (LDL)  u  smeru  većeg  udela  malih  čestica, bogatih  trigliceridima,  predstavljaju  najvažnije  promene  lipidnog  profila  koje  se  odnose  na dislipidemiju  u  dijabetesu.  Kako je  dijabetes  stanje  kontinuirane  blage  inflamacije  niskog stepena  i  stalne  produkcije  slobodnih  radikala,  HDL  lipoproteinske  čestice  takođe  podležu strukturnim  i  funkcionalnim  promenama,  usled  čega  gube  svoje  ateroprotektivne  osobine. Terapija dislipidemije kod pacijenata mlađih od 40 godina bez prisutnih drugih faktora rizika za razvoj KVB počinje promenom životnog stila, a kod pacijenata starijih od 40 godina lekovi izbora u terapiji su statini. Glikemijska i lipidna kontrola kod pacijenata sa tipom 2 dijabetesa značajno umanjuje rizik od nastanka KVB.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Dyslipidemia in type 2 diabetes mellitus, Dislipidemija u dijabetes melitusu tip 2",
volume = "69",
number = "5",
pages = "338-348",
doi = "10.5937/arhfarm1905338S"
}

Stefanović, A., Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z.,& Spasić, S.. (2019). Dyslipidemia in type 2 diabetes mellitus. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(5), 338-348.
https://doi.org/10.5937/arhfarm1905338S

Stefanović A, Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Spasić S. Dyslipidemia in type 2 diabetes mellitus. in Arhiv za farmaciju. 2019;69(5):338-348.
doi:10.5937/arhfarm1905338S .

Stefanović, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Spasić, Slavica, "Dyslipidemia in type 2 diabetes mellitus" in Arhiv za farmaciju, 69, no. 5 (2019):338-348,
https://doi.org/10.5937/arhfarm1905338S . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Crevar-Sakač, Milkica
AU  - Milenković, Marina
AU  - Vujić, Zorica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3054
AB  - Paraoxonases isoenzymes, PON1, PON2 and PON3, have important antioxidative and anti-inflammatory properties in blood and cells. They prevent oxidation of low and high density lipoprotein particles, foam cells formation and development of atherosclerosis. The authors investigated effects of high fat diet and atorvastatin therapy on paraoxonases gene expression levels and distribution in different rat organs. Liver, white adipose tissue (WAT) and aorta were taken from young male Wistar rats that were fed with normal diet (ND), atherogenic diet (AD) and atherogenic diet with 1.14 mg of atorvastatin per kg (ADA). Messenger RNA (mRNA) relative levels of paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3) were measured in rat organs using real-time polymerase chain reaction (PCR). PON1 mRNA expression levels were down-regulated in ADA compared to AD group. ND group had significantly lower PON2 mRNA expression than AD group. PON1 mRNA expression levels were higher in liver than in aorta in group of rats on ND, AD and ADA. PON2 mRNA expression was higher in WAT than in aorta only in ADA group of rats. PON2 and PON3 were significantly higher than PON1 in aorta of rats on each ND, AD or ADA.
PB  - Natl Inst Science Communication-Niscair, New Delhi
T2  - Indian Journal of Biotechnology
T1  - Paraoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapy
VL  - 17
IS  - 2
SP  - 217
EP  - 223
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3054
ER  - 

@article{
author = "Ninić, Ana and Spasojević-Kalimanovska, Vesna and Sopić, Miron and Munjas, Jelena and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Kotur-Stevuljević, Jelena and Spasić, Slavica and Crevar-Sakač, Milkica and Milenković, Marina and Vujić, Zorica",
year = "2018",
abstract = "Paraoxonases isoenzymes, PON1, PON2 and PON3, have important antioxidative and anti-inflammatory properties in blood and cells. They prevent oxidation of low and high density lipoprotein particles, foam cells formation and development of atherosclerosis. The authors investigated effects of high fat diet and atorvastatin therapy on paraoxonases gene expression levels and distribution in different rat organs. Liver, white adipose tissue (WAT) and aorta were taken from young male Wistar rats that were fed with normal diet (ND), atherogenic diet (AD) and atherogenic diet with 1.14 mg of atorvastatin per kg (ADA). Messenger RNA (mRNA) relative levels of paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3) were measured in rat organs using real-time polymerase chain reaction (PCR). PON1 mRNA expression levels were down-regulated in ADA compared to AD group. ND group had significantly lower PON2 mRNA expression than AD group. PON1 mRNA expression levels were higher in liver than in aorta in group of rats on ND, AD and ADA. PON2 mRNA expression was higher in WAT than in aorta only in ADA group of rats. PON2 and PON3 were significantly higher than PON1 in aorta of rats on each ND, AD or ADA.",
publisher = "Natl Inst Science Communication-Niscair, New Delhi",
journal = "Indian Journal of Biotechnology",
title = "Paraoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapy",
volume = "17",
number = "2",
pages = "217-223",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3054"
}

Ninić, A., Spasojević-Kalimanovska, V., Sopić, M., Munjas, J., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Kotur-Stevuljević, J., Spasić, S., Crevar-Sakač, M., Milenković, M.,& Vujić, Z.. (2018). Paraoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapy. in Indian Journal of Biotechnology
Natl Inst Science Communication-Niscair, New Delhi., 17(2), 217-223.
https://hdl.handle.net/21.15107/rcub_farfar_3054

Ninić A, Spasojević-Kalimanovska V, Sopić M, Munjas J, Bogavac-Stanojević N, Jelić-Ivanović Z, Kotur-Stevuljević J, Spasić S, Crevar-Sakač M, Milenković M, Vujić Z. Paraoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapy. in Indian Journal of Biotechnology. 2018;17(2):217-223.
https://hdl.handle.net/21.15107/rcub_farfar_3054 .

Ninić, Ana, Spasojević-Kalimanovska, Vesna, Sopić, Miron, Munjas, Jelena, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Kotur-Stevuljević, Jelena, Spasić, Slavica, Crevar-Sakač, Milkica, Milenković, Marina, Vujić, Zorica, "Paraoxonases gene expression and distribution in rats organs treated with atherogenic diet and atorvastatin therapy" in Indian Journal of Biotechnology, 17, no. 2 (2018):217-223,
https://hdl.handle.net/21.15107/rcub_farfar_3054 .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, Slavica
AU  - Vučinić-Mihailović, Violeta
AU  - Videnović-Ivanov, Jelica
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3078
AB  - Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.
PB  - Mattioli 1885, Fidenza
T2  - Sarcoidosis Vasculitis and Diffuse Lung Diseases
T1  - Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis
VL  - 35
IS  - 3
SP  - 198
EP  - 205
DO  - 10.36141/svdld.v35i3.6573
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3078
ER  - 

@article{
author = "Ivanišević, Jasmina and Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P lt 0.05) and more LDL II, LDL III, LDL IVA particles (P lt 0.01), but lower HDL size, SH groups (P lt 0.001), PON1 activity and less LDL I subclasses (P lt 0.05) than controls. In isolated pulmonary disease, HDL-cholesterol (P lt 0.01) was significantly lower whereas proportions of HDL 3a and PAB were significantly higher (P lt 0.05) when compared with the control group. PON1 was significantly higher in pulmonary than in combined pulmonary-extrapulmonary disease (P lt 0.05). In pulmonary sarcoidosis, TOS and PON1 correlated significantly with small-sized HDL particles (P lt 0.05). Conclusions: Both patient groups were characterized by adverse lipoprotein profile and elevated oxidative stress. In isolated pulmonary group significant associations of oxidative stress and HDL particles distribution was demonstrated. Pulmonary sarcoidosis was associated with higher PON1 activity and rearrangement of LDL particles did not depend on disease localization.",
publisher = "Mattioli 1885, Fidenza",
journal = "Sarcoidosis Vasculitis and Diffuse Lung Diseases",
title = "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis",
volume = "35",
number = "3",
pages = "198-205",
doi = "10.36141/svdld.v35i3.6573",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3078"
}

Ivanišević, J., Vekić, J., Zeljković, A., Stefanović, A., Kotur-Stevuljević, J., Spasojević-Kalimanovska, V., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z.. (2018). Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases
Mattioli 1885, Fidenza., 35(3), 198-205.
https://doi.org/10.36141/svdld.v35i3.6573
https://hdl.handle.net/21.15107/rcub_farfar_3078

Ivanišević J, Vekić J, Zeljković A, Stefanović A, Kotur-Stevuljević J, Spasojević-Kalimanovska V, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis. in Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2018;35(3):198-205.
doi:10.36141/svdld.v35i3.6573
https://hdl.handle.net/21.15107/rcub_farfar_3078 .

Ivanišević, Jasmina, Vekić, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, Spasić, Slavica, Vučinić-Mihailović, Violeta, Videnović-Ivanov, Jelica, Jelić-Ivanović, Zorana, "Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis" in Sarcoidosis Vasculitis and Diffuse Lung Diseases, 35, no. 3 (2018):198-205,
https://doi.org/10.36141/svdld.v35i3.6573 .,
https://hdl.handle.net/21.15107/rcub_farfar_3078 .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
AU  - Videnović-Ivanov, Jelica
AU  - Mihailović-Vučinić, Violeta
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2942
AB  - Matrix metaloproteinases (MMPs) and their specific inhibitors - tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P lt 0.05), hsCRP, SAA and TIMP-1 (P lt 0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P lt 0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP- 9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P lt 0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.
AB  - Matriks metaloproteinaze (MMP) i tkivni inhibitori matriks metaloproteinaza (TIMP) imaju značajnu ulogu u destrukciji plućnog ekstracelularnog matriksa. Sarkoidoza je inflamatorno oboljenje koje zahvata različite organe. Utvrđeno je da su koncentracije MMP-9 i TIMP-1 povećane u bronhoalveolarnom lavatu i sputumu pacijenata sa sarkoidozom. Cilj naše studije je bio da se odrede koncentracije MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa, MMP- 9/TIMP-1 odnosa u sarkoidozi, njihova povezanost sa parametrima inflamacije, kao i njihov potencijal za predviđanje postojanja bolesti. Ispitivanjem su obuhvaćeni 101 pacijent sa sarkoidozom i 50 zdravih ispitanika. Analizirani su uzorci seruma. Pored rutinskih biohemijskih parametara, merene su koncentracije visoko-osetljivog C-reaktivnog proteina (hsCRP), serumskog amiloida A (SAA), MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa. MMP-9 (P lt 0,05), hsCRP, SAA i TIMP-1 (P lt 0,001) su bili značajno veći kod pacijenata dok je koncentracija MMP-9/TIMP-1 kompleksa bila veća, ali sa graničnom značajnošću. U sarkoidozi, TIMP-1 je značajno pozitivno korelirao sa inflamatornim parametrima (P lt 0,05). Uni-varijantna analiza je pokazala da su MMP-9, TIMP-1, hsCRP i SAA imali značajan potencijal za predviđanje postojanja bolesti. U modelu koji je sadržao MMP-9, TIMP-1, hsCRP i SAA, samo SAA je ostao značajan u ovom predviđanju (P lt 0,01). Rezultati pokazuju značaj MMP-9 i TIMP-1 u sarkoidozi.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients
T1  - Matriks metaloproteinaze-9 i tkivni inhibitori matriks metaloproteinaza-1 kod pacijenata sa sarkoidozom
VL  - 67
IS  - 1
SP  - 1
EP  - 13
DO  - 10.5937/arhfarm1701001I
ER  - 

@article{
author = "Ivanišević, Jasmina and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana and Spasić, Slavica and Videnović-Ivanov, Jelica and Mihailović-Vučinić, Violeta",
year = "2017",
abstract = "Matrix metaloproteinases (MMPs) and their specific inhibitors - tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P lt 0.05), hsCRP, SAA and TIMP-1 (P lt 0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P lt 0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP- 9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P lt 0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis., Matriks metaloproteinaze (MMP) i tkivni inhibitori matriks metaloproteinaza (TIMP) imaju značajnu ulogu u destrukciji plućnog ekstracelularnog matriksa. Sarkoidoza je inflamatorno oboljenje koje zahvata različite organe. Utvrđeno je da su koncentracije MMP-9 i TIMP-1 povećane u bronhoalveolarnom lavatu i sputumu pacijenata sa sarkoidozom. Cilj naše studije je bio da se odrede koncentracije MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa, MMP- 9/TIMP-1 odnosa u sarkoidozi, njihova povezanost sa parametrima inflamacije, kao i njihov potencijal za predviđanje postojanja bolesti. Ispitivanjem su obuhvaćeni 101 pacijent sa sarkoidozom i 50 zdravih ispitanika. Analizirani su uzorci seruma. Pored rutinskih biohemijskih parametara, merene su koncentracije visoko-osetljivog C-reaktivnog proteina (hsCRP), serumskog amiloida A (SAA), MMP-9, TIMP-1 i MMP-9/TIMP-1 kompleksa. MMP-9 (P lt 0,05), hsCRP, SAA i TIMP-1 (P lt 0,001) su bili značajno veći kod pacijenata dok je koncentracija MMP-9/TIMP-1 kompleksa bila veća, ali sa graničnom značajnošću. U sarkoidozi, TIMP-1 je značajno pozitivno korelirao sa inflamatornim parametrima (P lt 0,05). Uni-varijantna analiza je pokazala da su MMP-9, TIMP-1, hsCRP i SAA imali značajan potencijal za predviđanje postojanja bolesti. U modelu koji je sadržao MMP-9, TIMP-1, hsCRP i SAA, samo SAA je ostao značajan u ovom predviđanju (P lt 0,01). Rezultati pokazuju značaj MMP-9 i TIMP-1 u sarkoidozi.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients, Matriks metaloproteinaze-9 i tkivni inhibitori matriks metaloproteinaza-1 kod pacijenata sa sarkoidozom",
volume = "67",
number = "1",
pages = "1-13",
doi = "10.5937/arhfarm1701001I"
}

Ivanišević, J., Stefanović, A., Kotur-Stevuljević, J., Jelić-Ivanović, Z., Spasić, S., Videnović-Ivanov, J.,& Mihailović-Vučinić, V.. (2017). Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(1), 1-13.
https://doi.org/10.5937/arhfarm1701001I

Ivanišević J, Stefanović A, Kotur-Stevuljević J, Jelić-Ivanović Z, Spasić S, Videnović-Ivanov J, Mihailović-Vučinić V. Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients. in Arhiv za farmaciju. 2017;67(1):1-13.
doi:10.5937/arhfarm1701001I .

Ivanišević, Jasmina, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, Spasić, Slavica, Videnović-Ivanov, Jelica, Mihailović-Vučinić, Violeta, "Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients" in Arhiv za farmaciju, 67, no. 1 (2017):1-13,
https://doi.org/10.5937/arhfarm1701001I . .

TY  - JOUR
AU  - Pijanović, Marina
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Marić-Krejović, Snežana
AU  - Spasić, Slavica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2986
AB  - Background: Leptin and adiponectin play an important role during normal gestation; they are implicated in energy metabolism, glucose utilization and inflammation. Osteocalcin is released into circulation during bone formation; it also affects glucose metabolism by regulating insulin secretion and sensitivity, possibly mediated by adiponectin. The aim of this study was to explore the longitudinal changes of leptin and adiponectin in pregnancy, and their associations with lipid profile, insulin and bone formation parameters in late pregnancy. Methods: Leptin, adiponectin, lipid status parameters, C-reactive protein (CRP), insulin, 25-hydroxyvitamin D, osteocalcin and procollagen type 1 aminoterminal propeptide (P1NP) were measured in the sera of 38 healthy pregnant women. The samples were obtained in the 1st , 2nd, early and late 3rd, trimester, and post-partum. Results: Leptin was significantly increased in the 3rd trimester. The decrease of adiponectin was significant only in postpartum. Osteocalcin and P1NP increased in the late 3rd trimester and postpartum. Leptin was significantly positively correlated with body mass index (BMI), uric acid, insulin, osteocalcin, P1NP and CRP in the 3rd trimester; adiponectin was positively correlated with highdensity lipoprotein (HDL) cholesterol, and negatively with BMI, glucose, osteocalcin, triglycerides and insulin. Multiple regression analysis showed that only HDL is independently associated with adiponectin. Conclusions: The results of our study suggest complex interactions of leptin and adiponectin with glucose, lipid and bone metabolism during pregnancy. Adiponectin might be part of the protective systems that counterbalance a transient proatherogenic state observed in pregnancy mainly by improving the HDL levels. The exact mechanisms and potential implications in pathological states of pregnancy remain unexplained and require further investigation.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Laboratoriumsmedizin-Journal of Laboratory Medicine
T1  - Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy
VL  - 41
IS  - 3
SP  - 129
EP  - 136
DO  - 10.1515/labmed-2017-0052
ER  - 

@article{
author = "Pijanović, Marina and Stefanović, Aleksandra and Miljković, Milica and Marić-Krejović, Snežana and Spasić, Slavica",
year = "2017",
abstract = "Background: Leptin and adiponectin play an important role during normal gestation; they are implicated in energy metabolism, glucose utilization and inflammation. Osteocalcin is released into circulation during bone formation; it also affects glucose metabolism by regulating insulin secretion and sensitivity, possibly mediated by adiponectin. The aim of this study was to explore the longitudinal changes of leptin and adiponectin in pregnancy, and their associations with lipid profile, insulin and bone formation parameters in late pregnancy. Methods: Leptin, adiponectin, lipid status parameters, C-reactive protein (CRP), insulin, 25-hydroxyvitamin D, osteocalcin and procollagen type 1 aminoterminal propeptide (P1NP) were measured in the sera of 38 healthy pregnant women. The samples were obtained in the 1st , 2nd, early and late 3rd, trimester, and post-partum. Results: Leptin was significantly increased in the 3rd trimester. The decrease of adiponectin was significant only in postpartum. Osteocalcin and P1NP increased in the late 3rd trimester and postpartum. Leptin was significantly positively correlated with body mass index (BMI), uric acid, insulin, osteocalcin, P1NP and CRP in the 3rd trimester; adiponectin was positively correlated with highdensity lipoprotein (HDL) cholesterol, and negatively with BMI, glucose, osteocalcin, triglycerides and insulin. Multiple regression analysis showed that only HDL is independently associated with adiponectin. Conclusions: The results of our study suggest complex interactions of leptin and adiponectin with glucose, lipid and bone metabolism during pregnancy. Adiponectin might be part of the protective systems that counterbalance a transient proatherogenic state observed in pregnancy mainly by improving the HDL levels. The exact mechanisms and potential implications in pathological states of pregnancy remain unexplained and require further investigation.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Laboratoriumsmedizin-Journal of Laboratory Medicine",
title = "Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy",
volume = "41",
number = "3",
pages = "129-136",
doi = "10.1515/labmed-2017-0052"
}

Pijanović, M., Stefanović, A., Miljković, M., Marić-Krejović, S.,& Spasić, S.. (2017). Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 41(3), 129-136.
https://doi.org/10.1515/labmed-2017-0052

Pijanović M, Stefanović A, Miljković M, Marić-Krejović S, Spasić S. Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine. 2017;41(3):129-136.
doi:10.1515/labmed-2017-0052 .

Pijanović, Marina, Stefanović, Aleksandra, Miljković, Milica, Marić-Krejović, Snežana, Spasić, Slavica, "Longitudinal changes in leptin and adiponectin concentrations through uncomplicated pregnancy" in Laboratoriumsmedizin-Journal of Laboratory Medicine, 41, no. 3 (2017):129-136,
https://doi.org/10.1515/labmed-2017-0052 . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2699
AB  - Specifically altered lipid profile and physiological hyperlipidemia during pregnancy are considered essential for the normal course of pregnancy and fetal development. This specific alteration of the lipid profile raises the questions about potential proaterogenic effect of these altered lipid parameters during pregnancy and its influence on the development of cardiovascular disease in women later in life. Research topic was also the association of altered lipid profile during pregnancy with the development of complications in pregnancy, especially gestational diabetes, hypertension and preeclampsia. Through the mediation of cholesterol ester transfer protein (CETP), the activity of which grows in mid-gestation, there are exchanges of the triglycerides between VLDL and LDL or HDL particle, which leads to increased accumulation of triglycerides in these particles, causes them to become smaller and denser with much greater atherogenic potential. These changes in lipid profile point out that a large number of pregnancies increase risk of development of cardiovascular diseases later in life. In order to optimize the predictive capacity of the lipid profile during pregnancy, it is recommended to determine the indexes of lipid.
AB  - Specifično izmenjen lipidni profil i fiziološka hiperlipidemija tokom trudnoće smatraju se esencijalnim za normalan ishod trudnoće i razvoj fetusa, a upravo ova specifičnost promena parametara lipidnog profila otvara pitanja njihove potencijalne proaterogenosti tokom trudnoće i uticaja na rizik za razvoj kardiovaskularne bolesti u kasnijem životu žene. Takođe se ispituje i povezanost izmenjenog lipidnog profila tokom trudnoće sa razvojem komplikacija u trudnoći, pre svega sa razvojem gestacijskog dijabetesa, hipertenzije i preeklampsije. Posredovanjem holesterol estar transportnog proteina (CETP), čija aktivnost raste sredinom trudnoće, dolazi do izmene triglicerida i holesterola između lipoproteinskih čestica vrlo niske gustine (VLDL) i lipoproteinskih čestica male gustine (LDL) ili lipoproteinskih čestica velike gustine (HDL), tako da dolazi do povećanog nakupljanja triglicerida u LDL i HDL česticama, pri čemu one postaju manje i gušće, i kao takve imaju veći proaterogeni potencijal, što sve ukazuje i na proaterogeni potencijal trudnoće, posebno ukoliko se ona ponavlja više puta tokom života. Da bi se optimizirao prediktivni kapacitet lipidnog profila tokom trudnoće preporučuje se određivanje lipidnih indeksa.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Lipid status in phyisiological non-complicated pregnancy
T1  - Lipidni status fiziološke nekomplikovane trudnoće
VL  - 66
IS  - 5
SP  - 191
EP  - 206
DO  - 10.5937/arhfarm1605191A
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Spasić, Slavica and Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2016",
abstract = "Specifically altered lipid profile and physiological hyperlipidemia during pregnancy are considered essential for the normal course of pregnancy and fetal development. This specific alteration of the lipid profile raises the questions about potential proaterogenic effect of these altered lipid parameters during pregnancy and its influence on the development of cardiovascular disease in women later in life. Research topic was also the association of altered lipid profile during pregnancy with the development of complications in pregnancy, especially gestational diabetes, hypertension and preeclampsia. Through the mediation of cholesterol ester transfer protein (CETP), the activity of which grows in mid-gestation, there are exchanges of the triglycerides between VLDL and LDL or HDL particle, which leads to increased accumulation of triglycerides in these particles, causes them to become smaller and denser with much greater atherogenic potential. These changes in lipid profile point out that a large number of pregnancies increase risk of development of cardiovascular diseases later in life. In order to optimize the predictive capacity of the lipid profile during pregnancy, it is recommended to determine the indexes of lipid., Specifično izmenjen lipidni profil i fiziološka hiperlipidemija tokom trudnoće smatraju se esencijalnim za normalan ishod trudnoće i razvoj fetusa, a upravo ova specifičnost promena parametara lipidnog profila otvara pitanja njihove potencijalne proaterogenosti tokom trudnoće i uticaja na rizik za razvoj kardiovaskularne bolesti u kasnijem životu žene. Takođe se ispituje i povezanost izmenjenog lipidnog profila tokom trudnoće sa razvojem komplikacija u trudnoći, pre svega sa razvojem gestacijskog dijabetesa, hipertenzije i preeklampsije. Posredovanjem holesterol estar transportnog proteina (CETP), čija aktivnost raste sredinom trudnoće, dolazi do izmene triglicerida i holesterola između lipoproteinskih čestica vrlo niske gustine (VLDL) i lipoproteinskih čestica male gustine (LDL) ili lipoproteinskih čestica velike gustine (HDL), tako da dolazi do povećanog nakupljanja triglicerida u LDL i HDL česticama, pri čemu one postaju manje i gušće, i kao takve imaju veći proaterogeni potencijal, što sve ukazuje i na proaterogeni potencijal trudnoće, posebno ukoliko se ona ponavlja više puta tokom života. Da bi se optimizirao prediktivni kapacitet lipidnog profila tokom trudnoće preporučuje se određivanje lipidnih indeksa.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Lipid status in phyisiological non-complicated pregnancy, Lipidni status fiziološke nekomplikovane trudnoće",
volume = "66",
number = "5",
pages = "191-206",
doi = "10.5937/arhfarm1605191A"
}

Ardalić, D., Stefanović, A., Spasić, S., Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2016). Lipid status in phyisiological non-complicated pregnancy. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 66(5), 191-206.
https://doi.org/10.5937/arhfarm1605191A

Ardalić D, Stefanović A, Spasić S, Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. Lipid status in phyisiological non-complicated pregnancy. in Arhiv za farmaciju. 2016;66(5):191-206.
doi:10.5937/arhfarm1605191A .

Ardalić, Daniela, Stefanović, Aleksandra, Spasić, Slavica, Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "Lipid status in phyisiological non-complicated pregnancy" in Arhiv za farmaciju, 66, no. 5 (2016):191-206,
https://doi.org/10.5937/arhfarm1605191A . .

TY  - JOUR
AU  - Pijanović, Marina
AU  - Stefanović, Aleksandra
AU  - Miljković, Milica
AU  - Marić-Krejović, Snežana
AU  - Spasić, Slavica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2717
AB  - Background: The aim of this study was to explore longitudinal changes of serum osteocalcin during normal, uncomplicated pregnancy and after delivery, and its correlations with parameters of glucose homeostasis, lipid status, and oxidative status in late pregnancy. Methods: Osteocalcin, glucose, insulin, lipid status parameters, total oxidative status (TOS), and total antioxidant capacity (TAC) were measured in sera of 38 healthy pregnant women. The sera were collected at the midpoint of the 1st, in the 2nd and 3rd trimester, and after delivery. Homeostatic model assessment (HOMA) indices were calculated and used as surrogate markers of insulin resistance. Results: Repeated measures analysis of variance showed a progressive increase in total cholesterol, triglycerides, and low density lipoprotein (LDL)-cholesterol, with a postpartum decrease. High density lipoprotein (HDL)-cholesterol increased in the 2nd trimester and decreased after delivery. Total oxidative status (TOS) increased significantly in the 3rd trimester (p  lt  0.001). TAC showed a significant increase after delivery (p  lt  0.05). Insulin showed a significant increase in the 3rd trimester (p  lt  0.05). Homeostatic model assessment (HOMA)-%B increased significantly in the 3rd trimester (p  lt  0.001). Osteocalcin showed a decrease in the 2nd trimester, and a marked increase in the 3rd - trimester and postpartum (p  lt  0.001). Osteocalcin was significantly positively correlated with BMI, insulin, HOMA of insulin resistance (HOMA-IR), HOMA-%B, TAC (p  lt  0.05), triglycerides and uric acid (p  lt  0.001). Multiple regression analysis showed that TAC is independently associated with osteocalcin level during 3rd trimester (p  lt  0.05). Conclusions: We observed the changes in pregnancy that may lead towards atherogenic, prooxidant and insulin resistant state, which are possibly counterbalanced by various protective systems, one of which might be osteocalcin.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Laboratoriumsmedizin-Journal of Laboratory Medicine
T1  - Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy
VL  - 40
IS  - 4
SP  - 247
EP  - 253
DO  - 10.1515/labmed-2016-0024
ER  - 

@article{
author = "Pijanović, Marina and Stefanović, Aleksandra and Miljković, Milica and Marić-Krejović, Snežana and Spasić, Slavica",
year = "2016",
abstract = "Background: The aim of this study was to explore longitudinal changes of serum osteocalcin during normal, uncomplicated pregnancy and after delivery, and its correlations with parameters of glucose homeostasis, lipid status, and oxidative status in late pregnancy. Methods: Osteocalcin, glucose, insulin, lipid status parameters, total oxidative status (TOS), and total antioxidant capacity (TAC) were measured in sera of 38 healthy pregnant women. The sera were collected at the midpoint of the 1st, in the 2nd and 3rd trimester, and after delivery. Homeostatic model assessment (HOMA) indices were calculated and used as surrogate markers of insulin resistance. Results: Repeated measures analysis of variance showed a progressive increase in total cholesterol, triglycerides, and low density lipoprotein (LDL)-cholesterol, with a postpartum decrease. High density lipoprotein (HDL)-cholesterol increased in the 2nd trimester and decreased after delivery. Total oxidative status (TOS) increased significantly in the 3rd trimester (p  lt  0.001). TAC showed a significant increase after delivery (p  lt  0.05). Insulin showed a significant increase in the 3rd trimester (p  lt  0.05). Homeostatic model assessment (HOMA)-%B increased significantly in the 3rd trimester (p  lt  0.001). Osteocalcin showed a decrease in the 2nd trimester, and a marked increase in the 3rd - trimester and postpartum (p  lt  0.001). Osteocalcin was significantly positively correlated with BMI, insulin, HOMA of insulin resistance (HOMA-IR), HOMA-%B, TAC (p  lt  0.05), triglycerides and uric acid (p  lt  0.001). Multiple regression analysis showed that TAC is independently associated with osteocalcin level during 3rd trimester (p  lt  0.05). Conclusions: We observed the changes in pregnancy that may lead towards atherogenic, prooxidant and insulin resistant state, which are possibly counterbalanced by various protective systems, one of which might be osteocalcin.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Laboratoriumsmedizin-Journal of Laboratory Medicine",
title = "Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy",
volume = "40",
number = "4",
pages = "247-253",
doi = "10.1515/labmed-2016-0024"
}

Pijanović, M., Stefanović, A., Miljković, M., Marić-Krejović, S.,& Spasić, S.. (2016). Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 40(4), 247-253.
https://doi.org/10.1515/labmed-2016-0024

Pijanović M, Stefanović A, Miljković M, Marić-Krejović S, Spasić S. Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy. in Laboratoriumsmedizin-Journal of Laboratory Medicine. 2016;40(4):247-253.
doi:10.1515/labmed-2016-0024 .

Pijanović, Marina, Stefanović, Aleksandra, Miljković, Milica, Marić-Krejović, Snežana, Spasić, Slavica, "Association of osteocalcin, insulin resistance and oxidative stress during noncomplicated pregnancy" in Laboratoriumsmedizin-Journal of Laboratory Medicine, 40, no. 4 (2016):247-253,
https://doi.org/10.1515/labmed-2016-0024 . .

TY  - JOUR
AU  - Ivanišević, Jasmina
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Vučinić-Mihailović, Violeta
AU  - Videnović-Ivanov, Jelica
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2594
AB  - Background It has been reported that high-density lipoprotein (HDL) particles have anti-inflammatory and antioxidant roles thanks to different enzymes such as paraoxonase 1 (PON1). Under inflammatory and oxidative stress conditions, HDL particles may lose their protective properties. Sarcoidosis is an inflammatory disease characterized by excessive oxidative stress. Serum amyloid A (SAA) is produced in liver and in granulomas, and its concentration increases in inflammatory conditions contributing to increased catabolism of HDL particles. The aim of our study was to determine PON1 activity, SAA concentration and their associations in patients with sarcoidosis. Materials and methods Inflammatory [high-sensitive C-reactive protein (hsCRP), angiotensin-converting enzyme (ACE), SAA], lipid [total cholesterol (TC), HDL-cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG)] oxidative stress status parameters [total oxidant status (TOS), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), sulfhydryl (SH) groups] and PON1 activities were determined in serum of 72 patients with sarcoidosis and 62 healthy subjects. Results HsCRP (P  lt  0.05), TC, LDL-c, TG, SAA, TOS, MDA and PAB (P  lt  0.001) were significantly higher, whereas HDL-c, SH groups and PON1 activity (P  lt  0.001) were significantly lower in patients with sarcoidosis when compared with controls. PON1 showed significant association with SAA, MDA and PAB. It was shown that 71% of decrease in PON1 activity may be explained by increase in TOS, PAB and SAA concentration. Conclusions We found decreased PON1 activity and increased SAA concentration in patients with sarcoidosis. Inflammatory condition presented by high SAA was implicated in impaired HDL functionality evident through dysregulated PON1 activity. Excessive oxidative stress was also involved in dysregulation of PON1 activity.
PB  - Wiley-Blackwell, Hoboken
T2  - European Journal of Clinical Investigation
T1  - Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients
VL  - 46
IS  - 5
SP  - 418
EP  - 424
DO  - 10.1111/eci.12610
ER  - 

@article{
author = "Ivanišević, Jasmina and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Spasić, Slavica and Vučinić-Mihailović, Violeta and Videnović-Ivanov, Jelica and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background It has been reported that high-density lipoprotein (HDL) particles have anti-inflammatory and antioxidant roles thanks to different enzymes such as paraoxonase 1 (PON1). Under inflammatory and oxidative stress conditions, HDL particles may lose their protective properties. Sarcoidosis is an inflammatory disease characterized by excessive oxidative stress. Serum amyloid A (SAA) is produced in liver and in granulomas, and its concentration increases in inflammatory conditions contributing to increased catabolism of HDL particles. The aim of our study was to determine PON1 activity, SAA concentration and their associations in patients with sarcoidosis. Materials and methods Inflammatory [high-sensitive C-reactive protein (hsCRP), angiotensin-converting enzyme (ACE), SAA], lipid [total cholesterol (TC), HDL-cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG)] oxidative stress status parameters [total oxidant status (TOS), malondialdehyde (MDA), pro-oxidant-antioxidant balance (PAB), sulfhydryl (SH) groups] and PON1 activities were determined in serum of 72 patients with sarcoidosis and 62 healthy subjects. Results HsCRP (P  lt  0.05), TC, LDL-c, TG, SAA, TOS, MDA and PAB (P  lt  0.001) were significantly higher, whereas HDL-c, SH groups and PON1 activity (P  lt  0.001) were significantly lower in patients with sarcoidosis when compared with controls. PON1 showed significant association with SAA, MDA and PAB. It was shown that 71% of decrease in PON1 activity may be explained by increase in TOS, PAB and SAA concentration. Conclusions We found decreased PON1 activity and increased SAA concentration in patients with sarcoidosis. Inflammatory condition presented by high SAA was implicated in impaired HDL functionality evident through dysregulated PON1 activity. Excessive oxidative stress was also involved in dysregulation of PON1 activity.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "European Journal of Clinical Investigation",
title = "Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients",
volume = "46",
number = "5",
pages = "418-424",
doi = "10.1111/eci.12610"
}

Ivanišević, J., Kotur-Stevuljević, J., Stefanović, A., Spasić, S., Vučinić-Mihailović, V., Videnović-Ivanov, J.,& Jelić-Ivanović, Z.. (2016). Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients. in European Journal of Clinical Investigation
Wiley-Blackwell, Hoboken., 46(5), 418-424.
https://doi.org/10.1111/eci.12610

Ivanišević J, Kotur-Stevuljević J, Stefanović A, Spasić S, Vučinić-Mihailović V, Videnović-Ivanov J, Jelić-Ivanović Z. Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients. in European Journal of Clinical Investigation. 2016;46(5):418-424.
doi:10.1111/eci.12610 .

Ivanišević, Jasmina, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Spasić, Slavica, Vučinić-Mihailović, Violeta, Videnović-Ivanov, Jelica, Jelić-Ivanović, Zorana, "Association of serum amyloid A and oxidative stress with paraoxonase 1 in sarcoidosis patients" in European Journal of Clinical Investigation, 46, no. 5 (2016):418-424,
https://doi.org/10.1111/eci.12610 . .

TY  - JOUR
AU  - Miljković, Milica
AU  - Đuričić, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Šobajić, Slađana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kerkez, Mirko
AU  - Đorđević, Vladimir
AU  - Đurasić, Ljubomir
AU  - Spasić, Slavica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2312
AB  - Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.
PB  - Vup Food Research Inst, Bratislava
T2  - Journal of Food and Nutrition Research
T1  - Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity
VL  - 54
IS  - 4
SP  - 314
EP  - 322
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2312
ER  - 

@article{
author = "Miljković, Milica and Đuričić, Ivana and Kotur-Stevuljević, Jelena and Šobajić, Slađana and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kerkez, Mirko and Đorđević, Vladimir and Đurasić, Ljubomir and Spasić, Slavica",
year = "2015",
abstract = "Paraoxonase-1 activity (PON1) and expression modulation using different pharmacological, nutritional and life-style approaches are current scientific foci. We have assessed the influence of omega-3 fatty acids from different dietary sources on PON1 activity and total oxidative status (TOS) in middle-aged dyslipidemic subjects. The study group consisted of 35 subjects, assigned to use commercial fish oil capsules or 150 g of smoked salmon two times per week during 8 weeks with 6 months of wash-out period. After the wash-out period, the same participants were invited again for the second part of the study, and the study was repeated with reversed interventions. PON1 activity and TOS were measured four times, before and after each supplementation period. Consumption of salmon and fish oil capsules both increased PON1 activity (p  lt  0.001). Pro-oxidative effect (TOS) during the first supplementation period was decreased at the end of supplementation (p  lt  0.001). The present study showed that omega-3 fatty acids, regardless of the dietary source, increased the activity of PON1 in patients with dyslipidaemia. This is possibly a consequence of an enzymatic response to the initially pro-oxidant effect of omega-3 fatty acids, which led to a reduction in oxidative stress after complete supplementation.",
publisher = "Vup Food Research Inst, Bratislava",
journal = "Journal of Food and Nutrition Research",
title = "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity",
volume = "54",
number = "4",
pages = "314-322",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2312"
}

Miljković, M., Đuričić, I., Kotur-Stevuljević, J., Šobajić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kerkez, M., Đorđević, V., Đurasić, L.,& Spasić, S.. (2015). Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research
Vup Food Research Inst, Bratislava., 54(4), 314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312

Miljković M, Đuričić I, Kotur-Stevuljević J, Šobajić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kerkez M, Đorđević V, Đurasić L, Spasić S. Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity. in Journal of Food and Nutrition Research. 2015;54(4):314-322.
https://hdl.handle.net/21.15107/rcub_farfar_2312 .

Miljković, Milica, Đuričić, Ivana, Kotur-Stevuljević, Jelena, Šobajić, Slađana, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kerkez, Mirko, Đorđević, Vladimir, Đurasić, Ljubomir, Spasić, Slavica, "Omega-3 fatty acids supplementation effects on paraoxonase-1 enzymatic activity" in Journal of Food and Nutrition Research, 54, no. 4 (2015):314-322,
https://hdl.handle.net/21.15107/rcub_farfar_2312 .

TY  - JOUR
AU  - Vuković-Dejanović, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Topalović, Mirko
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2324
AB  - Background: We compared factors of inflammation high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity. Methods: The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels. Results: We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770, p lt 0.001). Conclusion: PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography
VL  - 34
IS  - 4
SP  - 440
EP  - 449
DO  - 10.2478/jomb-2014-0061
ER  - 

@article{
author = "Vuković-Dejanović, Vesna and Bogavac-Stanojević, Nataša and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Topalović, Mirko and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Background: We compared factors of inflammation high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity. Methods: The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels. Results: We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770, p lt 0.001). Conclusion: PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography",
volume = "34",
number = "4",
pages = "440-449",
doi = "10.2478/jomb-2014-0061"
}

Vuković-Dejanović, V., Bogavac-Stanojević, N., Spasić, S., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Topalović, M.,& Jelić-Ivanović, Z.. (2015). Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(4), 440-449.
https://doi.org/10.2478/jomb-2014-0061

Vuković-Dejanović V, Bogavac-Stanojević N, Spasić S, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Topalović M, Jelić-Ivanović Z. Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography. in Journal of Medical Biochemistry. 2015;34(4):440-449.
doi:10.2478/jomb-2014-0061 .

Vuković-Dejanović, Vesna, Bogavac-Stanojević, Nataša, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Topalović, Mirko, Jelić-Ivanović, Zorana, "Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography" in Journal of Medical Biochemistry, 34, no. 4 (2015):440-449,
https://doi.org/10.2478/jomb-2014-0061 . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Kornić-Ristovski, Danijela
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Deanović, Marija
AU  - Babka, Sofika
AU  - Aleksić, Bosiljka
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2382
AB  - Aim: The purpose of this study was to investigate the relationship between anthropometric parameters and serum lipid concentrations in both preadolescent and adolescent girls and boys. Materials & Methods: Basic lipid status parameters were determined in fasting venous blood from 186 preadolescents and adolescents. Atherogenic indices were calculated. Results: Two-way analysis of variance showed significant interactions between age and BMI subgroups in girls at the level of HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), non-HDL-C, total cholesterol/HDL-C and LDL-C/HDL-C. Ordinal regression analysis showed that increasing age in both genders reduced the probability of higher HDL-C concentrations. Conclusion: Age was an independent predictor for lower HDL-C concentration in both genders. BMI was the most significant independent predictor for most lipid parameters in girls.
PB  - Future Medicine Ltd, London
T2  - Clinical Lipidology
T1  - Associations between anthropometric parameters and serum lipids in preadolescent and adolescent girls and boys
VL  - 10
IS  - 2
SP  - 119
EP  - 128
DO  - 10.2217/CLP.15.2
ER  - 

@article{
author = "Ninić, Ana and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Kornić-Ristovski, Danijela and Stefanović, Aleksandra and Spasić, Slavica and Deanović, Marija and Babka, Sofika and Aleksić, Bosiljka and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Aim: The purpose of this study was to investigate the relationship between anthropometric parameters and serum lipid concentrations in both preadolescent and adolescent girls and boys. Materials & Methods: Basic lipid status parameters were determined in fasting venous blood from 186 preadolescents and adolescents. Atherogenic indices were calculated. Results: Two-way analysis of variance showed significant interactions between age and BMI subgroups in girls at the level of HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), non-HDL-C, total cholesterol/HDL-C and LDL-C/HDL-C. Ordinal regression analysis showed that increasing age in both genders reduced the probability of higher HDL-C concentrations. Conclusion: Age was an independent predictor for lower HDL-C concentration in both genders. BMI was the most significant independent predictor for most lipid parameters in girls.",
publisher = "Future Medicine Ltd, London",
journal = "Clinical Lipidology",
title = "Associations between anthropometric parameters and serum lipids in preadolescent and adolescent girls and boys",
volume = "10",
number = "2",
pages = "119-128",
doi = "10.2217/CLP.15.2"
}

Ninić, A., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Kornić-Ristovski, D., Stefanović, A., Spasić, S., Deanović, M., Babka, S., Aleksić, B.,& Jelić-Ivanović, Z.. (2015). Associations between anthropometric parameters and serum lipids in preadolescent and adolescent girls and boys. in Clinical Lipidology
Future Medicine Ltd, London., 10(2), 119-128.
https://doi.org/10.2217/CLP.15.2

Ninić A, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Kornić-Ristovski D, Stefanović A, Spasić S, Deanović M, Babka S, Aleksić B, Jelić-Ivanović Z. Associations between anthropometric parameters and serum lipids in preadolescent and adolescent girls and boys. in Clinical Lipidology. 2015;10(2):119-128.
doi:10.2217/CLP.15.2 .

Ninić, Ana, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Kornić-Ristovski, Danijela, Stefanović, Aleksandra, Spasić, Slavica, Deanović, Marija, Babka, Sofika, Aleksić, Bosiljka, Jelić-Ivanović, Zorana, "Associations between anthropometric parameters and serum lipids in preadolescent and adolescent girls and boys" in Clinical Lipidology, 10, no. 2 (2015):119-128,
https://doi.org/10.2217/CLP.15.2 . .

TY  - JOUR
AU  - Ardalić, Daniela
AU  - Stefanović, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Vujović, Ana
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Mandić-Marković, Vesna
AU  - Miković, Željko
AU  - Cerović, Nikola
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2143
AB  - Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p  lt  0.05) and PON1 activity was significantly lower (p  lt  0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.
PB  - Wroclaw Medical Univ, Wroclaw
T2  - Advances in Clinical and Experimental Medicine
T1  - The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy
VL  - 23
IS  - 4
SP  - 575
EP  - 583
DO  - 10.17219/acem/37226
ER  - 

@article{
author = "Ardalić, Daniela and Stefanović, Aleksandra and Kotur-Stevuljević, Jelena and Vujović, Ana and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Mandić-Marković, Vesna and Miković, Željko and Cerović, Nikola",
year = "2014",
abstract = "Background. As a physiological condition closely linked with increased susceptibility to oxidative stress, pregnancy can be further compromised by cigarette smoking. Inadequate nutrition and reduced intake of antioxidants can also disrupt the prooxidant/antioxidant relationship and contribute to oxidative stress. Increased oxidative stress during pregnancy may be involved in several complications of pregnancy, such as preterm labor, fetal growth restriction, preeclampsia and Miscarriage. Objectives. The aim of this study was to investigate the influence of maternal smoking habits before pregnancy on the parameters of oxidative stress and the antioxidative defense system, lipid profile parameters and paraoxonase-1 (PON1) activity during the third trimester of uncomplicated pregnancies. Material and Methods. Healthy pregnant women (n = 86) were divided into non-smoking and smoking groups, and into groups taking vitamin supplements and not taking them. Oxidative damage was measured through the levels of thiobarbituric acid-reacting substances (TBARS) and plasma antioxidant status was evaluated by measuring total antioxidant capacity (TAC). Results. TBARS concetration was significantly higher (p  lt  0.05) and PON1 activity was significantly lower (p  lt  0.05) in the smokers' group. No significant differences were found in the investigated parameters in relation to vitamin supplement intake. Conclusions. Habitual smoking before pregnancy is associated with increased oxidative stress. Vitamin supplementation has no effect on the oxidative stress status of healthy pregnant women.",
publisher = "Wroclaw Medical Univ, Wroclaw",
journal = "Advances in Clinical and Experimental Medicine",
title = "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy",
volume = "23",
number = "4",
pages = "575-583",
doi = "10.17219/acem/37226"
}

Ardalić, D., Stefanović, A., Kotur-Stevuljević, J., Vujović, A., Spasić, S., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Mandić-Marković, V., Miković, Ž.,& Cerović, N.. (2014). The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine
Wroclaw Medical Univ, Wroclaw., 23(4), 575-583.
https://doi.org/10.17219/acem/37226

Ardalić D, Stefanović A, Kotur-Stevuljević J, Vujović A, Spasić S, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Mandić-Marković V, Miković Ž, Cerović N. The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy. in Advances in Clinical and Experimental Medicine. 2014;23(4):575-583.
doi:10.17219/acem/37226 .

Ardalić, Daniela, Stefanović, Aleksandra, Kotur-Stevuljević, Jelena, Vujović, Ana, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Mandić-Marković, Vesna, Miković, Željko, Cerović, Nikola, "The Influence of Maternal Smoking Habits Before Pregnancy and Antioxidative Supplementation During Pregnancy on Oxidative Stress Status in a Non-Complicated Pregnancy" in Advances in Clinical and Experimental Medicine, 23, no. 4 (2014):575-583,
https://doi.org/10.17219/acem/37226 . .

TY  - JOUR
AU  - Kardum, Nevena
AU  - Konić-Ristić, Aleksandra
AU  - Šavikin, Katarina
AU  - Spasić, Slavica
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2100
AB  - Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P  lt  .001) and pro-oxidant-antioxidant balance (PAB; P  lt  .05), as well as increase in paroxonase-1 activity toward diazoxon (P  lt  .01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects
VL  - 17
IS  - 8
SP  - 869
EP  - 874
DO  - 10.1089/jmf.2013.0135
ER  - 

@article{
author = "Kardum, Nevena and Konić-Ristić, Aleksandra and Šavikin, Katarina and Spasić, Slavica and Stefanović, Aleksandra and Ivanišević, Jasmina and Miljković, Milica",
year = "2014",
abstract = "Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25-49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P  lt  .001) and pro-oxidant-antioxidant balance (PAB; P  lt  .05), as well as increase in paroxonase-1 activity toward diazoxon (P  lt  .01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects",
volume = "17",
number = "8",
pages = "869-874",
doi = "10.1089/jmf.2013.0135"
}

Kardum, N., Konić-Ristić, A., Šavikin, K., Spasić, S., Stefanović, A., Ivanišević, J.,& Miljković, M.. (2014). Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects. in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 17(8), 869-874.
https://doi.org/10.1089/jmf.2013.0135

Kardum N, Konić-Ristić A, Šavikin K, Spasić S, Stefanović A, Ivanišević J, Miljković M. Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects. in Journal of Medicinal Food. 2014;17(8):869-874.
doi:10.1089/jmf.2013.0135 .

Kardum, Nevena, Konić-Ristić, Aleksandra, Šavikin, Katarina, Spasić, Slavica, Stefanović, Aleksandra, Ivanišević, Jasmina, Miljković, Milica, "Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects" in Journal of Medicinal Food, 17, no. 8 (2014):869-874,
https://doi.org/10.1089/jmf.2013.0135 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milovanović, Srđan
AU  - Đorđević, Brižita
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Spasić, Slavica
AU  - Stojanović, Dragana
AU  - Pantović, Maja
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2095
AB  - Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia. Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O-2(center dot-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)]. Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days. Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.
PB  - Medicinska Naklada, Zagreb
T2  - Psychiatria Danubina
T1  - Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia
VL  - 26
IS  - 3
SP  - 205
EP  - 213
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2095
ER  - 

@article{
author = "Vidović, Bojana and Milovanović, Srđan and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Ivanišević, Jasmina and Miljković, Milica and Spasić, Slavica and Stojanović, Dragana and Pantović, Maja",
year = "2014",
abstract = "Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia. Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O-2(center dot-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)]. Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days. Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.",
publisher = "Medicinska Naklada, Zagreb",
journal = "Psychiatria Danubina",
title = "Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia",
volume = "26",
number = "3",
pages = "205-213",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2095"
}

Vidović, B., Milovanović, S., Đorđević, B., Kotur-Stevuljević, J., Stefanović, A., Ivanišević, J., Miljković, M., Spasić, S., Stojanović, D.,& Pantović, M.. (2014). Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. in Psychiatria Danubina
Medicinska Naklada, Zagreb., 26(3), 205-213.
https://hdl.handle.net/21.15107/rcub_farfar_2095

Vidović B, Milovanović S, Đorđević B, Kotur-Stevuljević J, Stefanović A, Ivanišević J, Miljković M, Spasić S, Stojanović D, Pantović M. Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia. in Psychiatria Danubina. 2014;26(3):205-213.
https://hdl.handle.net/21.15107/rcub_farfar_2095 .

Vidović, Bojana, Milovanović, Srđan, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Ivanišević, Jasmina, Miljković, Milica, Spasić, Slavica, Stojanović, Dragana, Pantović, Maja, "Effect of alpha-lipoic acid supplementation on oxidative stress markers and antioxidative defense in patients with schizophrenia" in Psychiatria Danubina, 26, no. 3 (2014):205-213,
https://hdl.handle.net/21.15107/rcub_farfar_2095 .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Stefanović, Aleksandra
AU  - Milovanović, Srđan
AU  - Đorđević, Brižita
AU  - Kotur-Stevuljević, Jelena
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2230
AB  - Background. The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination. Methods. Fasting glucose, lipid profi le and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects. Results. Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients. Conclusion. Increased oxidative stress and changed lipid profi le parameters are associated in schizophrenic patients and may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia
VL  - 74
IS  - 3
SP  - 184
EP  - 191
DO  - 10.3109/00365513.2013.873947
ER  - 

@article{
author = "Vidović, Bojana and Stefanović, Aleksandra and Milovanović, Srđan and Đorđević, Brižita and Kotur-Stevuljević, Jelena and Ivanišević, Jasmina and Miljković, Milica and Spasić, Slavica",
year = "2014",
abstract = "Background. The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination. Methods. Fasting glucose, lipid profi le and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects. Results. Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients. Conclusion. Increased oxidative stress and changed lipid profi le parameters are associated in schizophrenic patients and may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia",
volume = "74",
number = "3",
pages = "184-191",
doi = "10.3109/00365513.2013.873947"
}

Vidović, B., Stefanović, A., Milovanović, S., Đorđević, B., Kotur-Stevuljević, J., Ivanišević, J., Miljković, M.,& Spasić, S.. (2014). Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(3), 184-191.
https://doi.org/10.3109/00365513.2013.873947

Vidović B, Stefanović A, Milovanović S, Đorđević B, Kotur-Stevuljević J, Ivanišević J, Miljković M, Spasić S. Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(3):184-191.
doi:10.3109/00365513.2013.873947 .

Vidović, Bojana, Stefanović, Aleksandra, Milovanović, Srđan, Đorđević, Brižita, Kotur-Stevuljević, Jelena, Ivanišević, Jasmina, Miljković, Milica, Spasić, Slavica, "Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 3 (2014):184-191,
https://doi.org/10.3109/00365513.2013.873947 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Bogavac-Stanojević, Nataša
AU  - Topić, Aleksandra
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2164
AB  - Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with
PB  - Sage Publications Inc, Thousand Oaks
T2  - Annals of Clinical Biochemistry
T1  - Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients
VL  - 51
IS  - 3
SP  - 412
EP  - 415
DO  - 10.1177/0004563213499908
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Bogavac-Stanojević, Nataša and Topić, Aleksandra and Spasić, Slavica",
year = "2014",
abstract = "Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Annals of Clinical Biochemistry",
title = "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients",
volume = "51",
number = "3",
pages = "412-415",
doi = "10.1177/0004563213499908"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kalimanovska-Oštrić, D., Memon, L., Bogavac-Stanojević, N., Topić, A.,& Spasić, S.. (2014). Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry
Sage Publications Inc, Thousand Oaks., 51(3), 412-415.
https://doi.org/10.1177/0004563213499908

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kalimanovska-Oštrić D, Memon L, Bogavac-Stanojević N, Topić A, Spasić S. Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry. 2014;51(3):412-415.
doi:10.1177/0004563213499908 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Bogavac-Stanojević, Nataša, Topić, Aleksandra, Spasić, Slavica, "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients" in Annals of Clinical Biochemistry, 51, no. 3 (2014):412-415,
https://doi.org/10.1177/0004563213499908 . .

TY  - JOUR
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Spasić, Slavica
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2236
AB  - Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Factor analysis of risk variables associated with iron status in patients with coronary artery disease
VL  - 47
IS  - 7-8
SP  - 564
EP  - 569
DO  - 10.1016/j.clinbiochem.2014.03.014
ER  - 

@article{
author = "Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Spasić, Slavica and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Factor analysis of risk variables associated with iron status in patients with coronary artery disease",
volume = "47",
number = "7-8",
pages = "564-569",
doi = "10.1016/j.clinbiochem.2014.03.014"
}

Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Memon, L., Spasić, S., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2014). Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 47(7-8), 564-569.
https://doi.org/10.1016/j.clinbiochem.2014.03.014

Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Memon L, Spasić S, Kotur-Stevuljević J, Jelić-Ivanović Z. Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry. 2014;47(7-8):564-569.
doi:10.1016/j.clinbiochem.2014.03.014 .

Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Spasić, Slavica, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Factor analysis of risk variables associated with iron status in patients with coronary artery disease" in Clinical Biochemistry, 47, no. 7-8 (2014):564-569,
https://doi.org/10.1016/j.clinbiochem.2014.03.014 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Damjanović, Tatjana
AU  - Šuvakov, Sonja
AU  - Matić, Marija
AU  - Savić-Radojević, Ana
AU  - Simić, Tatjana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Spasić, Slavica
AU  - Dimković, Nada
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2157
AB  - Objectives: End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD. Design and methods: GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods. Results: GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P  lt  0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P  lt  0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P  lt  0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P  lt  0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P  lt  0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P  lt  0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions. Conclusions: Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients
VL  - 47
IS  - 6
SP  - 398
EP  - 403
DO  - 10.1016/j.clinbiochem.2013.11.011
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Damjanović, Tatjana and Šuvakov, Sonja and Matić, Marija and Savić-Radojević, Ana and Simić, Tatjana and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Spasić, Slavica and Dimković, Nada",
year = "2014",
abstract = "Objectives: End-stage renal disease (ESRD) is characterized by profound dyslipidemia and enhanced oxidative stress. The patients also show evidence of exhausted and/or deficient anti-oxidative defense enzymes, one of them being glutathione-S-transferase (GST). This study investigates relationship between GST gene polymorphism and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses in ESRD. Design and methods: GSTM1, T1, and P1 genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism in 160 patients undergoing hemodialysis. LDL and HDL subclasses were separated by gradient gel electrophoresis and biochemical parameters were measured by routine laboratory methods. Results: GSTM1-positive patients had higher proportion of small, dense LDL III particles than those with GSTM1-null genotype (P  lt  0.05). Similarly, GSTP1-Ile/Ile patients had higher proportion of LDL III (P  lt  0.05), but more HDL 2b and less HDL 3a particles than GSTP1-Ile/Val and Val/Val carriers (P  lt  0.05). LDL subclass distribution in smokers with GSTM1-null genotype was shifted towards smaller particles, as compared to GSTM1-positive and GSTM1-null non-smokers. Smokers with GSTP1-Ile/Val and Val/Val genotypes had smaller LDL size than their non-smoking counterparts (P  lt  0.05). Both smokers and non-smokers with GSTP1 Ile/Ile genotype had more LDL III particles than non-smokers carrying Val allele. Non-smokers with GSTP1 Ile/Ile genotype had more HDL 2b subclasses than non-smokers with GSTP1-Ile/Val and Val/Val (P  lt  0.05), but less HDL 3a particles than smokers with GSTP1-Ile/Val and Val/Val genotypes (P  lt  0.05). GSTT1 gene polymorphism had no effect on lipoprotein subclass distributions. Conclusions: Our results demonstrate significant associations between low activity GST genotypes and proatherogenic lipoprotein particles in hemodialysis patients which might further increase their cardiovascular disease risk.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients",
volume = "47",
number = "6",
pages = "398-403",
doi = "10.1016/j.clinbiochem.2013.11.011"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Damjanović, T., Šuvakov, S., Matić, M., Savić-Radojević, A., Simić, T., Spasojević-Kalimanovska, V., Gojković, T., Spasić, S.,& Dimković, N.. (2014). Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 47(6), 398-403.
https://doi.org/10.1016/j.clinbiochem.2013.11.011

Vekić J, Zeljković A, Jelić-Ivanović Z, Damjanović T, Šuvakov S, Matić M, Savić-Radojević A, Simić T, Spasojević-Kalimanovska V, Gojković T, Spasić S, Dimković N. Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients. in Clinical Biochemistry. 2014;47(6):398-403.
doi:10.1016/j.clinbiochem.2013.11.011 .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Damjanović, Tatjana, Šuvakov, Sonja, Matić, Marija, Savić-Radojević, Ana, Simić, Tatjana, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Spasić, Slavica, Dimković, Nada, "Association of glutathione-S-transferase gene polymorphism and lipoprotein subclasses in hemodialysis patients" in Clinical Biochemistry, 47, no. 6 (2014):398-403,
https://doi.org/10.1016/j.clinbiochem.2013.11.011 . .

TY  - JOUR
AU  - Savić, Jasna
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Stošović, Milan
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Gojković, Tamara
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2126
AB  - Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.
PB  - Informa Healthcare, London
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease
VL  - 74
IS  - 7
SP  - 637
EP  - 643
DO  - 10.3109/00365513.2014.928944
ER  - 

@article{
author = "Savić, Jasna and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Stošović, Milan and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Gojković, Tamara and Spasić, Slavica",
year = "2014",
abstract = "Background. Dyslipidemia is a common feature of chronic kidney disease (CKD). Although it has been observed that the pattern of lipid abnormalities can vary according to the stage of CKD, there is lack of data concerning the distribution of lipoprotein subclasses at various stages of the disease. In addition, association of proatherogenic small, dense low-density lipoprotein (sdLDL) subclasses with markers of inflammation, such is galectin-3, is not sufficiently explored. The aim of this study was to analyze concentrations and relative proportions of sdLDL-cholesterol (sdLDL-C) and galectin-3 in patients with CKD, with respect to the stage of the disease. Also, we sought possible independent associations of galectin-3 and sdLDL-C. Methods. The study involved 100 hemodialysis (HD) and 50 pre-dialysis patients, together with 94 healthy individuals. SdLDL-C was measured by heparin-magnesium precipitation method. Galectin-3 was measured by ELISA technique. Results. Galectin-3 levels were higher in pre-dialysis and HD patients than in the control group (p  lt  0.01). The concentration of sdLDL-C was highest in the pre-dialysis group and lowest in HD patients (p  lt  0.01). CKD patients with increased galectin-3 concentrations had significantly higher relative proportions of cholesterol in sdLDL (% sdLDL-C) than their counterparts with lower galectin-3 levels (p  lt  0.05). Relative proportion of sdLDL-C was shown to be an independent determinant of galectin-3 concentration. Conclusions. Our results demonstrated alterations in concentrations and proportions of sdLDL-C according to the stages of CKD. The observed independent associations of % sdLDL-C and galectin-3 provide further insight into their complex interaction during the progression of atherosclerosis in CKD.",
publisher = "Informa Healthcare, London",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease",
volume = "74",
number = "7",
pages = "637-643",
doi = "10.3109/00365513.2014.928944"
}

Savić, J., Zeljković, A., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M., Stošović, M., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Gojković, T.,& Spasić, S.. (2014). Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation
Informa Healthcare, London., 74(7), 637-643.
https://doi.org/10.3109/00365513.2014.928944

Savić J, Zeljković A, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Stošović M, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Gojković T, Spasić S. Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease. in Scandinavian Journal of Clinical and Laboratory Investigation. 2014;74(7):637-643.
doi:10.3109/00365513.2014.928944 .

Savić, Jasna, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Stošović, Milan, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Gojković, Tamara, Spasić, Slavica, "Association of small, dense low-density lipoprotein cholesterol and galectin-3 in patients with chronic kidney disease" in Scandinavian Journal of Clinical and Laboratory Investigation, 74, no. 7 (2014):637-643,
https://doi.org/10.3109/00365513.2014.928944 . .

TY  - JOUR
AU  - Baralić, Ivana
AU  - Đorđević, Brižita
AU  - Dikić, Nenad
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Radivojević, Nenad
AU  - Anđelković, Marija
AU  - Pejić, Snežana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1871
AB  - The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright
PB  - Wiley-Blackwell, Hoboken
T2  - Phytotherapy Research
T1  - Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players
VL  - 27
IS  - 10
SP  - 1536
EP  - 1542
DO  - 10.1002/ptr.4898
ER  - 

@article{
author = "Baralić, Ivana and Đorđević, Brižita and Dikić, Nenad and Kotur-Stevuljević, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Radivojević, Nenad and Anđelković, Marija and Pejić, Snežana",
year = "2013",
abstract = "The purpose of the study was to examine the effects of astaxanthin (Asx) on paraoxonase (PON1) activities and oxidative stress status in soccer players. Forty soccer players were randomly assigned in a double-blind fashion to Asx and placebo (P) group. Blood samples were obtained before, 45 and 90days after supplementation. PON1 activity was assessed by using two substrates: paraoxon and diazoxon. The oxidative stress biomarkers were also examined: total sulphydryl group content (-SH groups), thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products and redox balance. The significant interaction effect of supplementation and training (p lt 0.05) on PON1 activity toward paraoxon was observed. The PON1 activity toward diazoxon increased in Asx group after 90days (p lt 0.01), while there was no significant difference in P group. SH groups content rose from pre- to post-supplementation period only in Asx group (supplementation and training, p lt 0.05; training, p lt 0.01). TBARS levels decreased after 45days and increased after 90days of regular soccer training in both groups (training, p lt 0.001). Redox balance decreased significantly in response to the regular training, regardless of treatment group (training, p lt 0.001). Asx supplementation might increase total SH groups content and improve PON1 activity through protection of free thiol groups against oxidative modification. Copyright",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Phytotherapy Research",
title = "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players",
volume = "27",
number = "10",
pages = "1536-1542",
doi = "10.1002/ptr.4898"
}

Baralić, I., Đorđević, B., Dikić, N., Kotur-Stevuljević, J., Spasić, S., Jelić-Ivanović, Z., Radivojević, N., Anđelković, M.,& Pejić, S.. (2013). Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research
Wiley-Blackwell, Hoboken., 27(10), 1536-1542.
https://doi.org/10.1002/ptr.4898

Baralić I, Đorđević B, Dikić N, Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Radivojević N, Anđelković M, Pejić S. Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players. in Phytotherapy Research. 2013;27(10):1536-1542.
doi:10.1002/ptr.4898 .

Baralić, Ivana, Đorđević, Brižita, Dikić, Nenad, Kotur-Stevuljević, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Radivojević, Nenad, Anđelković, Marija, Pejić, Snežana, "Effect of Astaxanthin Supplementation on Paraoxonase 1 Activities and Oxidative Stress Status in Young Soccer Players" in Phytotherapy Research, 27, no. 10 (2013):1536-1542,
https://doi.org/10.1002/ptr.4898 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1897
AB  - BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Laboratory Analysis
T1  - Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?
VL  - 27
IS  - 6
SP  - 461
EP  - 470
DO  - 10.1002/jcla.21628
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Laboratory Analysis",
title = "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?",
volume = "27",
number = "6",
pages = "461-470",
doi = "10.1002/jcla.21628"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis
Wiley, Hoboken., 27(6), 461-470.
https://doi.org/10.1002/jcla.21628

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis. 2013;27(6):461-470.
doi:10.1002/jcla.21628 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?" in Journal of Clinical Laboratory Analysis, 27, no. 6 (2013):461-470,
https://doi.org/10.1002/jcla.21628 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1859
AB  - Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients
SP  - 173
EP  - 180
DO  - 10.1155/2013/306908
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients",
pages = "173-180",
doi = "10.1155/2013/306908"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers
Hindawi Ltd, London., 173-180.
https://doi.org/10.1155/2013/306908

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers. 2013;:173-180.
doi:10.1155/2013/306908 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients" in Disease Markers (2013):173-180,
https://doi.org/10.1155/2013/306908 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Ardalić, Daniela
AU  - Mandić-Marković, Vesna
AU  - Cerović, Nikola
AU  - Miković, Željko
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1918
AB  - Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P  lt  0.001), due to reduction in relative proportion of LDL I (P  lt  0.01) and increase of LDL II (P  lt  0.001) and IIIA (P  lt  0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P  lt  0.001), with concomitant increase of HDL 3b and 3c subclasses (P  lt  0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.
PB  - Springer/Plenum Publishers, New York
T2  - Maternal and Child Health Journal
T1  - Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference
VL  - 17
IS  - 3
SP  - 556
EP  - 565
DO  - 10.1007/s10995-012-1031-x
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Ardalić, Daniela and Mandić-Marković, Vesna and Cerović, Nikola and Miković, Željko",
year = "2013",
abstract = "Pregnancy is associated with alterations in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, but the exact pattern of these variations remains controversial. This study investigates longitudinal changes of plasma LDL and HDL particles distributions during the course of normal pregnancy, as well as associations of maternal LDL and HDL subclasses distributions before delivery with parameters of newborn size. Blood samples were collected from 41 healthy pregnant women throughout entire pregnancy, before delivery and 7 weeks postpartum. LDL and HDL subclasses were determined by gradient gel electrophoresis, while other biochemical parameters were measured by standard laboratory methods. During gestation LDL size significantly decreased (P  lt  0.001), due to reduction in relative proportion of LDL I (P  lt  0.01) and increase of LDL II (P  lt  0.001) and IIIA (P  lt  0.05) subclasses. In the same time, HDL size and proportions of HDL 2a particles significantly decreased (P  lt  0.001), with concomitant increase of HDL 3b and 3c subclasses (P  lt  0.05). Observed alterations were associated with changes in serum triglyceride levels. Rearrangement in LDL subclasses distribution during gestation was transient, while postpartum HDL subclasses distribution remained shifted toward smaller particles. Higher proportion of LDL IVB in maternal plasma before delivery was an independent predictor of smaller birth weights and lengths, while higher proportions of LDL IVB and HDL 2a subclasses were independent determinants of newborns' smaller head circumferences. Routine gestational and prenatal care in otherwise normal pregnancy could be complemented with evaluation of LDL and HDL particles distribution in order to ensure an adequate size of the newborn.",
publisher = "Springer/Plenum Publishers, New York",
journal = "Maternal and Child Health Journal",
title = "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference",
volume = "17",
number = "3",
pages = "556-565",
doi = "10.1007/s10995-012-1031-x"
}

Zeljković, A., Vekić, J., Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Gojković, T., Ardalić, D., Mandić-Marković, V., Cerović, N.,& Miković, Ž.. (2013). Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal
Springer/Plenum Publishers, New York., 17(3), 556-565.
https://doi.org/10.1007/s10995-012-1031-x

Zeljković A, Vekić J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Gojković T, Ardalić D, Mandić-Marković V, Cerović N, Miković Ž. Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference. in Maternal and Child Health Journal. 2013;17(3):556-565.
doi:10.1007/s10995-012-1031-x .

Zeljković, Aleksandra, Vekić, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Ardalić, Daniela, Mandić-Marković, Vesna, Cerović, Nikola, Miković, Željko, "Changes in LDL and HDL Subclasses in Normal Pregnancy and Associations with Birth Weight, Birth Length and Head Circumference" in Maternal and Child Health Journal, 17, no. 3 (2013):556-565,
https://doi.org/10.1007/s10995-012-1031-x . .