TY  - JOUR
AU  - Tasić, Gordana
AU  - Mitrović, Nikola
AU  - Simić, Milena
AU  - Koravović, Mladen
AU  - Jovanović, Predrag
AU  - Petković, Miloš
AU  - Jovanović, Miloš
AU  - Ivković, Branka
AU  - Savić, Vladimir
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5556
AB  - Hydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%).
PB  - Wiley Periodicals LLC.
T2  - Journal Heterocyclic Chemistry
T1  - Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent
DO  - 10.1002/jhet.4802
ER  - 

@article{
author = "Tasić, Gordana and Mitrović, Nikola and Simić, Milena and Koravović, Mladen and Jovanović, Predrag and Petković, Miloš and Jovanović, Miloš and Ivković, Branka and Savić, Vladimir",
year = "2024",
abstract = "Hydantoin derivatives are versatile structural motifs found in natural products
and various compounds with different biological or other properties. Due to
their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology
utilizing N-Boc protected amino acid amides for their preparation has been
described. The cyclisation process was accomplished using solid supported
PPh3 and CBr 4 as reagents affording substituted hydantoins in moderate to
good yields (40%–77%).",
publisher = "Wiley Periodicals LLC.",
journal = "Journal Heterocyclic Chemistry",
title = "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent",
doi = "10.1002/jhet.4802"
}

Tasić, G., Mitrović, N., Simić, M., Koravović, M., Jovanović, P., Petković, M., Jovanović, M., Ivković, B.,& Savić, V.. (2024). Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry
Wiley Periodicals LLC...
https://doi.org/10.1002/jhet.4802

Tasić G, Mitrović N, Simić M, Koravović M, Jovanović P, Petković M, Jovanović M, Ivković B, Savić V. Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent. in Journal Heterocyclic Chemistry. 2024;.
doi:10.1002/jhet.4802 .

Tasić, Gordana, Mitrović, Nikola, Simić, Milena, Koravović, Mladen, Jovanović, Predrag, Petković, Miloš, Jovanović, Miloš, Ivković, Branka, Savić, Vladimir, "Synthesis of hydantoins from N-Boc protected aminoacid derived amides using polymer-supported PPh3/CBr4as a reagent" in Journal Heterocyclic Chemistry (2024),
https://doi.org/10.1002/jhet.4802 . .

TY  - JOUR
AU  - Koravović, Mladen
AU  - Mayasundari, Anand
AU  - Tasić, Gordana
AU  - Keramatnia, F.
AU  - Stachowski, Timothy R.
AU  - Cui, Huarui
AU  - Chai, Sergio C.
AU  - Jonchere, Barbara
AU  - Yang, Lei
AU  - Li, Yong
AU  - Fu, Xiang
AU  - Hiltenbrand, Ryan
AU  - Paul, Leena
AU  - Mishra, Vibhor
AU  - Klco, Jeffery M.
AU  - Roussel, Martine F.
AU  - Pomerantz, William CK.
AU  - Fischer, Marcus
AU  - Ranković, Zoran
AU  - Savić, Vladimir
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4513
AB  - An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying overall improved profiles when compared to JQ1 and birabresib. A thiadiazole derived 1q (SJ1461) displayed excellent BRD4 and BRD2 affinity and high potency in the panel of acute leukaemia and medulloblastoma cell lines. A structure of 1q co-crystalised with BRD4-BD1 revealed polar interactions with the AZ/BC loops, in particular with Asn140 and Tyr139, rationalising the observed affinity improvements. In addition, exploration of pharmacokinetic properties of this class of compounds suggest that the heterocyclic amide moiety improves drug-like features. Our study led to the discovery of potent and orally bioavailable BET inhibitor 1q (SJ1461) as a promising candidate for further development.
PB  - Elsevier
T2  - European Journal of Medicinal Chemistry
T1  - From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
VL  - 251
DO  - 10.1016/j.ejmech.2023.115246
ER  - 

@article{
author = "Koravović, Mladen and Mayasundari, Anand and Tasić, Gordana and Keramatnia, F. and Stachowski, Timothy R. and Cui, Huarui and Chai, Sergio C. and Jonchere, Barbara and Yang, Lei and Li, Yong and Fu, Xiang and Hiltenbrand, Ryan and Paul, Leena and Mishra, Vibhor and Klco, Jeffery M. and Roussel, Martine F. and Pomerantz, William CK. and Fischer, Marcus and Ranković, Zoran and Savić, Vladimir",
year = "2023",
abstract = "An X-ray structure of a CLICK chemistry-based BET PROTAC bound to BRD2(BD2) inspired synthesis of JQ1 derived heterocyclic amides. This effort led to the discovery of potent BET inhibitors displaying overall improved profiles when compared to JQ1 and birabresib. A thiadiazole derived 1q (SJ1461) displayed excellent BRD4 and BRD2 affinity and high potency in the panel of acute leukaemia and medulloblastoma cell lines. A structure of 1q co-crystalised with BRD4-BD1 revealed polar interactions with the AZ/BC loops, in particular with Asn140 and Tyr139, rationalising the observed affinity improvements. In addition, exploration of pharmacokinetic properties of this class of compounds suggest that the heterocyclic amide moiety improves drug-like features. Our study led to the discovery of potent and orally bioavailable BET inhibitor 1q (SJ1461) as a promising candidate for further development.",
publisher = "Elsevier",
journal = "European Journal of Medicinal Chemistry",
title = "From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors",
volume = "251",
doi = "10.1016/j.ejmech.2023.115246"
}

Koravović, M., Mayasundari, A., Tasić, G., Keramatnia, F., Stachowski, T. R., Cui, H., Chai, S. C., Jonchere, B., Yang, L., Li, Y., Fu, X., Hiltenbrand, R., Paul, L., Mishra, V., Klco, J. M., Roussel, M. F., Pomerantz, W. CK., Fischer, M., Ranković, Z.,& Savić, V.. (2023). From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. in European Journal of Medicinal Chemistry
Elsevier., 251.
https://doi.org/10.1016/j.ejmech.2023.115246

Koravović M, Mayasundari A, Tasić G, Keramatnia F, Stachowski TR, Cui H, Chai SC, Jonchere B, Yang L, Li Y, Fu X, Hiltenbrand R, Paul L, Mishra V, Klco JM, Roussel MF, Pomerantz WC, Fischer M, Ranković Z, Savić V. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. in European Journal of Medicinal Chemistry. 2023;251.
doi:10.1016/j.ejmech.2023.115246 .

Koravović, Mladen, Mayasundari, Anand, Tasić, Gordana, Keramatnia, F., Stachowski, Timothy R., Cui, Huarui, Chai, Sergio C., Jonchere, Barbara, Yang, Lei, Li, Yong, Fu, Xiang, Hiltenbrand, Ryan, Paul, Leena, Mishra, Vibhor, Klco, Jeffery M., Roussel, Martine F., Pomerantz, William CK., Fischer, Marcus, Ranković, Zoran, Savić, Vladimir, "From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors" in European Journal of Medicinal Chemistry, 251 (2023),
https://doi.org/10.1016/j.ejmech.2023.115246 . .

TY  - JOUR
AU  - Koravović, Mladen
AU  - Marković, Bojan
AU  - Kovačević, Milena
AU  - Rmandić, Milena
AU  - Tasić, Gordana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4296
AB  - The traditional concept of drug discovery is based on the occupancydriven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins that do not have such binding sites are generally considered as pharmacologically intractable. Furthermore, drugs that act in this way must be administered in dosage regimens that often result in high systemic drug exposures in order to maintain sufficient protein inhibition. Thus, there is a risk of the onset of off-target binding and side effects. The landscape of drug discovery has been markedly changed since proteolysis targeting chimera (PROTAC) molecules emerged twenty years ago as a part of the event-driven pharmacology model. These are bifunctional molecules that harness the ubiquitin-proteasome system, and are composed of a ligand that binds the protein of interest (POI), a ligand that recruits E3 ubiquitin ligase (E3UL) and a linker that connects these two parts. Pharmacologically, PROTACs bring POI and E3UL into close proximity, which triggers the formation of a functional ternary complex POI-PROTAC-E3UL. This event drives polyubiquitination and subsequent POI degradation by the 26S proteasome. The development and exceptional properties of PROTAC molecules that brought them to clinical studies will be discussed in this paper. © 2022 Serbian Chemical Society. All rights reserved.
AB  - Традиционални концепт открића лекова базиран је на фармаколошком моделу заснованом на окупираности циљних протеина. То подразумева развој инхибитора који окупирају везујућа места директно повезана са функцијама протеина. Стога, протеини који немају таква везујућа места се генерално сматрају фармаколошки недодирљивим. Осим тога, лекови који делују на овакав начин морају се примењивати у режимима дозирања који често доводе до претеране системске изложености леку ради одржања довољне инхибиције протеина. Дакле, постоји ризик од појаве везивања лека ван свог примарног места дејства и нежељених ефеката. Окосница развоја лекова је значајно измењена откако су се појавили PROTAC (енг. proteolysis targeting chimera) молекули пре двадесет година као део фармаколошког модела заснованог на покретању догађаја који доводе до разградње циљних протеина. Ово су бифункционални молекули који користе убиквитин-протеазом систем, а састоје се од лиганда који се везује за протеин од инте- реса (POI), лиганда који регрутује Е3 убиквитин лигазу (E3UL) и линкера који повезује ова два дела. Фармаколошки, PROTAC молекули доводе POI и Е3UL у близину, што води формирању функционалног тернарног комплекса POI–PROTAC–Е3UL. Овај догађај води полиубиквитинацији и следственој деградацији POI 26S протеазомом. Развој и изу- зетна својства PROTAC молекула која су их довела до клиничких студија дискутовани су овом раду.
PB  - Serbian Chemical Society
T2  - Journal of the Serbian Chemical Society
T1  - Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy
T1  - Деградација протеина индукована PROTAC молекулима као нова стратегија у развоју лекова
VL  - 87
IS  - 7-8
SP  - 785
EP  - 811
DO  - 10.2298/JSC211209027K
ER  - 

@article{
author = "Koravović, Mladen and Marković, Bojan and Kovačević, Milena and Rmandić, Milena and Tasić, Gordana",
year = "2022",
abstract = "The traditional concept of drug discovery is based on the occupancydriven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins that do not have such binding sites are generally considered as pharmacologically intractable. Furthermore, drugs that act in this way must be administered in dosage regimens that often result in high systemic drug exposures in order to maintain sufficient protein inhibition. Thus, there is a risk of the onset of off-target binding and side effects. The landscape of drug discovery has been markedly changed since proteolysis targeting chimera (PROTAC) molecules emerged twenty years ago as a part of the event-driven pharmacology model. These are bifunctional molecules that harness the ubiquitin-proteasome system, and are composed of a ligand that binds the protein of interest (POI), a ligand that recruits E3 ubiquitin ligase (E3UL) and a linker that connects these two parts. Pharmacologically, PROTACs bring POI and E3UL into close proximity, which triggers the formation of a functional ternary complex POI-PROTAC-E3UL. This event drives polyubiquitination and subsequent POI degradation by the 26S proteasome. The development and exceptional properties of PROTAC molecules that brought them to clinical studies will be discussed in this paper. © 2022 Serbian Chemical Society. All rights reserved., Традиционални концепт открића лекова базиран је на фармаколошком моделу заснованом на окупираности циљних протеина. То подразумева развој инхибитора који окупирају везујућа места директно повезана са функцијама протеина. Стога, протеини који немају таква везујућа места се генерално сматрају фармаколошки недодирљивим. Осим тога, лекови који делују на овакав начин морају се примењивати у режимима дозирања који често доводе до претеране системске изложености леку ради одржања довољне инхибиције протеина. Дакле, постоји ризик од појаве везивања лека ван свог примарног места дејства и нежељених ефеката. Окосница развоја лекова је значајно измењена откако су се појавили PROTAC (енг. proteolysis targeting chimera) молекули пре двадесет година као део фармаколошког модела заснованог на покретању догађаја који доводе до разградње циљних протеина. Ово су бифункционални молекули који користе убиквитин-протеазом систем, а састоје се од лиганда који се везује за протеин од инте- реса (POI), лиганда који регрутује Е3 убиквитин лигазу (E3UL) и линкера који повезује ова два дела. Фармаколошки, PROTAC молекули доводе POI и Е3UL у близину, што води формирању функционалног тернарног комплекса POI–PROTAC–Е3UL. Овај догађај води полиубиквитинацији и следственој деградацији POI 26S протеазомом. Развој и изу- зетна својства PROTAC молекула која су их довела до клиничких студија дискутовани су овом раду.",
publisher = "Serbian Chemical Society",
journal = "Journal of the Serbian Chemical Society",
title = "Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy, Деградација протеина индукована PROTAC молекулима као нова стратегија у развоју лекова",
volume = "87",
number = "7-8",
pages = "785-811",
doi = "10.2298/JSC211209027K"
}

Koravović, M., Marković, B., Kovačević, M., Rmandić, M.,& Tasić, G.. (2022). Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy. in Journal of the Serbian Chemical Society
Serbian Chemical Society., 87(7-8), 785-811.
https://doi.org/10.2298/JSC211209027K

Koravović M, Marković B, Kovačević M, Rmandić M, Tasić G. Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy. in Journal of the Serbian Chemical Society. 2022;87(7-8):785-811.
doi:10.2298/JSC211209027K .

Koravović, Mladen, Marković, Bojan, Kovačević, Milena, Rmandić, Milena, Tasić, Gordana, "Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy" in Journal of the Serbian Chemical Society, 87, no. 7-8 (2022):785-811,
https://doi.org/10.2298/JSC211209027K . .

TY  - CONF
AU  - Koravović, Mladen
AU  - Tasić, Gordana
AU  - Mayasundari, Anand
AU  - Keramatnia, Fatemeh
AU  - Fischer, Marcus
AU  - Ranković, Zoran
AU  - Savić, Vladimir
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5385
AB  - BET proteini su epigenetski biološki targeti koji regulišu ekspresiju gena i uključeni su u
patogenezu kancera. Jedan od inhibitora ovih proteina koji je opisan u literaturi je derivat
tienotriazolodiazepina (+)-JQ1. Cilj ovog rada bio je dalje unapređenje osobina (+)-JQ1
derivatizacijom estarske grupe (Shema 1). U toku ovog istraživanja sintetisano je više amidnih
analoga od koji je jedan pokazao 16 puta veću aktivnost u TR-FRET testu u odnosu na (+)-JQ1.
AB  - BET proteins are epigenetic biological targets that regulate gene expression and are involved in
cancer pathogenesis. One of BET inhibitors described in the literature is thienotriazolodiazepine
derivative (+)-JQ1. The aim of this research was to further improve the properties of (+)-JQ1 by
ester group derivatization (Scheme 1). During the research several amide analogs were synthesized
and one of them had 16 fold greater activity in TR-FRET assay compared to (+)-JQ1.
PB  - Srpsko hemijsko društvo, Beograd
C3  - 57. Savetovanje Srpskog hemijskog društva.  Kratki izvodi, Juni 18 i 19, 2021, Kragujevac, Srbija
T1  - Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora
T1  - Synthesis and biological profiling of (+)-JQ1 amides as BET inhibitors
SP  - 86
EP  - 86
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5385
ER  - 

@conference{
author = "Koravović, Mladen and Tasić, Gordana and Mayasundari, Anand and Keramatnia, Fatemeh and Fischer, Marcus and Ranković, Zoran and Savić, Vladimir",
year = "2021",
abstract = "BET proteini su epigenetski biološki targeti koji regulišu ekspresiju gena i uključeni su u
patogenezu kancera. Jedan od inhibitora ovih proteina koji je opisan u literaturi je derivat
tienotriazolodiazepina (+)-JQ1. Cilj ovog rada bio je dalje unapređenje osobina (+)-JQ1
derivatizacijom estarske grupe (Shema 1). U toku ovog istraživanja sintetisano je više amidnih
analoga od koji je jedan pokazao 16 puta veću aktivnost u TR-FRET testu u odnosu na (+)-JQ1., BET proteins are epigenetic biological targets that regulate gene expression and are involved in
cancer pathogenesis. One of BET inhibitors described in the literature is thienotriazolodiazepine
derivative (+)-JQ1. The aim of this research was to further improve the properties of (+)-JQ1 by
ester group derivatization (Scheme 1). During the research several amide analogs were synthesized
and one of them had 16 fold greater activity in TR-FRET assay compared to (+)-JQ1.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "57. Savetovanje Srpskog hemijskog društva.  Kratki izvodi, Juni 18 i 19, 2021, Kragujevac, Srbija",
title = "Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora, Synthesis and biological profiling of (+)-JQ1 amides as BET inhibitors",
pages = "86-86",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5385"
}

Koravović, M., Tasić, G., Mayasundari, A., Keramatnia, F., Fischer, M., Ranković, Z.,& Savić, V.. (2021). Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora. in 57. Savetovanje Srpskog hemijskog društva.  Kratki izvodi, Juni 18 i 19, 2021, Kragujevac, Srbija
Srpsko hemijsko društvo, Beograd., 86-86.
https://hdl.handle.net/21.15107/rcub_farfar_5385

Koravović M, Tasić G, Mayasundari A, Keramatnia F, Fischer M, Ranković Z, Savić V. Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora. in 57. Savetovanje Srpskog hemijskog društva.  Kratki izvodi, Juni 18 i 19, 2021, Kragujevac, Srbija. 2021;:86-86.
https://hdl.handle.net/21.15107/rcub_farfar_5385 .

Koravović, Mladen, Tasić, Gordana, Mayasundari, Anand, Keramatnia, Fatemeh, Fischer, Marcus, Ranković, Zoran, Savić, Vladimir, "Sinteza i biološko profilisanje (+)-JQ1 amida kao BET inhibitora" in 57. Savetovanje Srpskog hemijskog društva.  Kratki izvodi, Juni 18 i 19, 2021, Kragujevac, Srbija (2021):86-86,
https://hdl.handle.net/21.15107/rcub_farfar_5385 .

TY  - CONF
AU  - Koravović, Mladen
AU  - Tasić, Gordana
AU  - Mayasundari, Anand
AU  - Keramatnia, Fatemeh
AU  - Stachowski, Tim
AU  - Fischer, Marcus
AU  - Ranković, Zoran
AU  - Savić, Vladimir
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4010
AB  - Histoni su bazni proteini koji interakcijom preko baznih ostataka lizina sa fosfatnim grupama DNK omogućavaju upakivanje DNK molekula i formiranje nukleozoma i hromatina. Jedan od glavnih mehanizama aktivacije hromatina uključuje prepoznavanje Nε-acetilovanih L-lizina na N-terminalnim krajevima histona od strane proteina BET (eng. Bromodomain and Extra-Terminal domain) familije. Opisano je četiri BET proteina označenih kao BRD2, BRD3, BRD4 i BRDT. Strukturu ovih proteina čine dva bromodomena (BD1 i BD2), kao i ekstraterminalni (ET) i C-terminalni domen (CTD). Bromodomeni su, zapravo, hidrofobni regioni sačinjeni od četiri α-heliksa (Z, A, B, C) i dve petlje (ZA i BC) koji prepoznaju Nε-acetilovane L-lizine u histonima i drugim proteinima. Članovi BET familije proteina su epigenetski čitači koji regulišu ekspresiju gena. Uključeni su u brojne fiziološke i patofiziološke procese, pri čemu je markantna njihova uloga u razvoju kancera. Različite klase BET inhibitora su opisane u literaturi. Među prvima je prijavljen (+)-JQ1 molekul koji, farmakološki posmatrano, predstavlja kompetitivni inhibitor BET proteina i danas se veoma često koristi kao alat u proučavanju biologije BET proteina. Međutim, estarska funkcionalna grupa koja uslovljava njegov kratak poluživot je onemogućila sprovođenje širih kliničkih ispitivanja ovog molekula. Suprotno tome, amidni analog (+)-JQ1 molekula, birabresib, ušao je u kliničke studije i pokazao povoljan bezbednosni profil i aktivnost u NMC (eng. NUT Midline Carcinoma). Interesovanje za BET proteine je pokrenulo ovu studiju o amidnim derivatima (+)-JQ1 koji bi imali unapređene fizičko-hemijske i farmakološke profile.
C3  - Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija
T1  - Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4010
ER  - 

@conference{
author = "Koravović, Mladen and Tasić, Gordana and Mayasundari, Anand and Keramatnia, Fatemeh and Stachowski, Tim and Fischer, Marcus and Ranković, Zoran and Savić, Vladimir",
year = "2021",
abstract = "Histoni su bazni proteini koji interakcijom preko baznih ostataka lizina sa fosfatnim grupama DNK omogućavaju upakivanje DNK molekula i formiranje nukleozoma i hromatina. Jedan od glavnih mehanizama aktivacije hromatina uključuje prepoznavanje Nε-acetilovanih L-lizina na N-terminalnim krajevima histona od strane proteina BET (eng. Bromodomain and Extra-Terminal domain) familije. Opisano je četiri BET proteina označenih kao BRD2, BRD3, BRD4 i BRDT. Strukturu ovih proteina čine dva bromodomena (BD1 i BD2), kao i ekstraterminalni (ET) i C-terminalni domen (CTD). Bromodomeni su, zapravo, hidrofobni regioni sačinjeni od četiri α-heliksa (Z, A, B, C) i dve petlje (ZA i BC) koji prepoznaju Nε-acetilovane L-lizine u histonima i drugim proteinima. Članovi BET familije proteina su epigenetski čitači koji regulišu ekspresiju gena. Uključeni su u brojne fiziološke i patofiziološke procese, pri čemu je markantna njihova uloga u razvoju kancera. Različite klase BET inhibitora su opisane u literaturi. Među prvima je prijavljen (+)-JQ1 molekul koji, farmakološki posmatrano, predstavlja kompetitivni inhibitor BET proteina i danas se veoma često koristi kao alat u proučavanju biologije BET proteina. Međutim, estarska funkcionalna grupa koja uslovljava njegov kratak poluživot je onemogućila sprovođenje širih kliničkih ispitivanja ovog molekula. Suprotno tome, amidni analog (+)-JQ1 molekula, birabresib, ušao je u kliničke studije i pokazao povoljan bezbednosni profil i aktivnost u NMC (eng. NUT Midline Carcinoma). Interesovanje za BET proteine je pokrenulo ovu studiju o amidnim derivatima (+)-JQ1 koji bi imali unapređene fizičko-hemijske i farmakološke profile.",
journal = "Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija",
title = "Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4010"
}

Koravović, M., Tasić, G., Mayasundari, A., Keramatnia, F., Stachowski, T., Fischer, M., Ranković, Z.,& Savić, V.. (2021). Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula. in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija.
https://hdl.handle.net/21.15107/rcub_farfar_4010

Koravović M, Tasić G, Mayasundari A, Keramatnia F, Stachowski T, Fischer M, Ranković Z, Savić V. Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula. in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_4010 .

Koravović, Mladen, Tasić, Gordana, Mayasundari, Anand, Keramatnia, Fatemeh, Stachowski, Tim, Fischer, Marcus, Ranković, Zoran, Savić, Vladimir, "Nove protein-ligand interakcije amidnih BET inhibitora otkrivene derivatizacijom (+)-JQ1 molekula" in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija (2021),
https://hdl.handle.net/21.15107/rcub_farfar_4010 .

TY  - JOUR
AU  - Koravović, Mladen
AU  - Tasić, Gordana
AU  - Rmandić, Milena
AU  - Marković, Bojan
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3918
AB  - Traditional drug discovery strategies are usually focused on occupancy of binding sites that directly affect functions of proteins. Hence, proteins that lack such binding sites are generally considered pharmacologically intractable. Modulators of protein activity, especially inhibitors, must be applied in appropriate dosage regimens that often lead to high systemic drug exposures in  order  to  maintain  sufficient  protein  inhibition in  vivo.  Consequently,  there  is  a  risk  of undesirable off-target drug binding and side effects. Recently, PROteolysis TArgeting Chimera (PROTAC) technology has emerged as a new pharmacological modality that exploits PROTAC molecules for induced protein degradation. PROTAC molecule is a heterobifunctional structure consisting of a ligand that binds a protein of interest (POI), a ligand for recruiting an E3 ubiquitin ligase (an enzyme involved in the POI ubiquitination) and a linker that connects these two. After POI-PROTAC-E3 ubiquitin ligase ternary complex formation, the POI undergoes ubiquitination (an enzymatic post-translational modification in which ubiquitin is attached to the POI) and degradation.  By  merging  the  principles  of  photopharmacology  and  PROTAC  technology, photocontrollable PROTACs for spatiotemporal control of induced protein degradation have recently emerged. The main advantage of photocontrollable over conventional PROTACs is the possible prevention of off-target toxicity thanks to local photoactivation.
AB  - Tradicionalne strategije razvoja lekova su obično osvrnute na okupiranje vezujućih mesta koja direktno utiču na funkcije proteina. Stoga se proteini koji nemaju takva vezujuća mesta generalno smatraju farmakološki nedodirljivim. Modulatori aktivnosti proteina, naročito inhibitori, koriste se u režimima doziranja koji često dovode do preterane sistemske izloženosti leku, a sve u cilju održavanja dovoljne inhibicije proteina in vivo. Posledično, postoji rizik od neželjenog vezivanja leka van svog primarnog mesta dejstva i neželjenih efekata. Nedavno je predstavljena tehnologija dirigovane proteolize (PROteolysis TArgeting Chimera, PROTAC) kao novi farmakološki modalitet koji koristi PROTAC molekule za indukovanu degradaciju proteina. PROTAC molekuli su heterobifunkcionalne strukture sačinjene od liganda koji se vezuje za protein od interesa (POI), liganda za regrutovanje E3 ubikvitin ligaze (enzima uključenog u ubikvitinaciju POI) i linkera koji ih povezuje. Nakon formiranja ternarnog kompleksa POI-PROTAC-E3 ubikvitin ligaza, POI podleže ubikvitinaciji (enzimskoj post-translacionoj modifikaciji u kojoj se ubikvitin vezuje za POI) i degradaciji. Integrisanjem principa fotofarmakologije i PROTAC tehnologije, nedavno su nastali su fotokontrolisani PROTAC molekuli za prostorno-vremensku kontrolu indukovane degradacije proteina. Zahvaljujući lokalnoj fotoaktivaciji, glavna prednost fotokontrolisanih nad konvencionalnim PROTAC molekulima je moguća prevencija toksičnosti koja nastaje usled dejstva van primarnog biološkog targeta.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Photocontrollable PROTAC molecules – structure and mechanism of action
T1  - Fotokontrolisani PROTAC molekuli - struktura i mehanizam dejstva
VL  - 71
IS  - 3
SP  - 161
EP  - 176
DO  - 10.5937/arhfarm71‐30785
ER  - 

@article{
author = "Koravović, Mladen and Tasić, Gordana and Rmandić, Milena and Marković, Bojan",
year = "2021",
abstract = "Traditional drug discovery strategies are usually focused on occupancy of binding sites that directly affect functions of proteins. Hence, proteins that lack such binding sites are generally considered pharmacologically intractable. Modulators of protein activity, especially inhibitors, must be applied in appropriate dosage regimens that often lead to high systemic drug exposures in  order  to  maintain  sufficient  protein  inhibition in  vivo.  Consequently,  there  is  a  risk  of undesirable off-target drug binding and side effects. Recently, PROteolysis TArgeting Chimera (PROTAC) technology has emerged as a new pharmacological modality that exploits PROTAC molecules for induced protein degradation. PROTAC molecule is a heterobifunctional structure consisting of a ligand that binds a protein of interest (POI), a ligand for recruiting an E3 ubiquitin ligase (an enzyme involved in the POI ubiquitination) and a linker that connects these two. After POI-PROTAC-E3 ubiquitin ligase ternary complex formation, the POI undergoes ubiquitination (an enzymatic post-translational modification in which ubiquitin is attached to the POI) and degradation.  By  merging  the  principles  of  photopharmacology  and  PROTAC  technology, photocontrollable PROTACs for spatiotemporal control of induced protein degradation have recently emerged. The main advantage of photocontrollable over conventional PROTACs is the possible prevention of off-target toxicity thanks to local photoactivation., Tradicionalne strategije razvoja lekova su obično osvrnute na okupiranje vezujućih mesta koja direktno utiču na funkcije proteina. Stoga se proteini koji nemaju takva vezujuća mesta generalno smatraju farmakološki nedodirljivim. Modulatori aktivnosti proteina, naročito inhibitori, koriste se u režimima doziranja koji često dovode do preterane sistemske izloženosti leku, a sve u cilju održavanja dovoljne inhibicije proteina in vivo. Posledično, postoji rizik od neželjenog vezivanja leka van svog primarnog mesta dejstva i neželjenih efekata. Nedavno je predstavljena tehnologija dirigovane proteolize (PROteolysis TArgeting Chimera, PROTAC) kao novi farmakološki modalitet koji koristi PROTAC molekule za indukovanu degradaciju proteina. PROTAC molekuli su heterobifunkcionalne strukture sačinjene od liganda koji se vezuje za protein od interesa (POI), liganda za regrutovanje E3 ubikvitin ligaze (enzima uključenog u ubikvitinaciju POI) i linkera koji ih povezuje. Nakon formiranja ternarnog kompleksa POI-PROTAC-E3 ubikvitin ligaza, POI podleže ubikvitinaciji (enzimskoj post-translacionoj modifikaciji u kojoj se ubikvitin vezuje za POI) i degradaciji. Integrisanjem principa fotofarmakologije i PROTAC tehnologije, nedavno su nastali su fotokontrolisani PROTAC molekuli za prostorno-vremensku kontrolu indukovane degradacije proteina. Zahvaljujući lokalnoj fotoaktivaciji, glavna prednost fotokontrolisanih nad konvencionalnim PROTAC molekulima je moguća prevencija toksičnosti koja nastaje usled dejstva van primarnog biološkog targeta.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Photocontrollable PROTAC molecules – structure and mechanism of action, Fotokontrolisani PROTAC molekuli - struktura i mehanizam dejstva",
volume = "71",
number = "3",
pages = "161-176",
doi = "10.5937/arhfarm71‐30785"
}

Koravović, M., Tasić, G., Rmandić, M.,& Marković, B.. (2021). Photocontrollable PROTAC molecules – structure and mechanism of action. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(3), 161-176.
https://doi.org/10.5937/arhfarm71‐30785

Koravović M, Tasić G, Rmandić M, Marković B. Photocontrollable PROTAC molecules – structure and mechanism of action. in Arhiv za farmaciju. 2021;71(3):161-176.
doi:10.5937/arhfarm71‐30785 .

Koravović, Mladen, Tasić, Gordana, Rmandić, Milena, Marković, Bojan, "Photocontrollable PROTAC molecules – structure and mechanism of action" in Arhiv za farmaciju, 71, no. 3 (2021):161-176,
https://doi.org/10.5937/arhfarm71‐30785 . .

TY  - CONF
AU  - Koravović, Mladen
AU  - Tasić, Gordana
AU  - Mayasundari, Anand
AU  - Min, Jaeki
AU  - Keramatnia, Fatemeh
AU  - Fischer, Marcus
AU  - Ranković, Zoran
AU  - Savić, Vladimir
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4011
AB  - Hsp90 (Heat Shock Protein 90) is a chaperon protein which plays role in protein folding and maintaining protein structures. It is overexpressed in cancer and stabilizes many oncoproteins and as such represents a good target for developing anticancer drugs. The majority of approved drugs today operate by occupancy-driven pharmacology. The PROTAC approach as a strategy in creating novel drugs utilizes event-driven pharmacology in which target proteins are degraded. In recent years it emerged as very attractive and conceptually novel approach in drug discovery and development. PROTACs are molecules with two warheads connected with a linker with general structure: Ligand(protein of interest)-Linker-Ligand(E3 ligase). One warhead binds the protein of interest (POI) and the other one binds E3 ligase, while the linker brings these two parts in close proximity permitting ubiquitination and subsequent degradation of the protein. Two classes of compounds were studied: pyrrolopyrimidine and thienopyrimidine derivatives. Both classes of compounds were reported in the literature and their structure is modified in order to investigate whether linker introduction deteriorate binding of those molecules to Hsp90.
C3  - Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija
T1  - Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4011
ER  - 

@conference{
author = "Koravović, Mladen and Tasić, Gordana and Mayasundari, Anand and Min, Jaeki and Keramatnia, Fatemeh and Fischer, Marcus and Ranković, Zoran and Savić, Vladimir",
year = "2019",
abstract = "Hsp90 (Heat Shock Protein 90) is a chaperon protein which plays role in protein folding and maintaining protein structures. It is overexpressed in cancer and stabilizes many oncoproteins and as such represents a good target for developing anticancer drugs. The majority of approved drugs today operate by occupancy-driven pharmacology. The PROTAC approach as a strategy in creating novel drugs utilizes event-driven pharmacology in which target proteins are degraded. In recent years it emerged as very attractive and conceptually novel approach in drug discovery and development. PROTACs are molecules with two warheads connected with a linker with general structure: Ligand(protein of interest)-Linker-Ligand(E3 ligase). One warhead binds the protein of interest (POI) and the other one binds E3 ligase, while the linker brings these two parts in close proximity permitting ubiquitination and subsequent degradation of the protein. Two classes of compounds were studied: pyrrolopyrimidine and thienopyrimidine derivatives. Both classes of compounds were reported in the literature and their structure is modified in order to investigate whether linker introduction deteriorate binding of those molecules to Hsp90.",
journal = "Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija",
title = "Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4011"
}

Koravović, M., Tasić, G., Mayasundari, A., Min, J., Keramatnia, F., Fischer, M., Ranković, Z.,& Savić, V.. (2019). Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents. in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija.
https://hdl.handle.net/21.15107/rcub_farfar_4011

Koravović M, Tasić G, Mayasundari A, Min J, Keramatnia F, Fischer M, Ranković Z, Savić V. Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents. in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija. 2019;.
https://hdl.handle.net/21.15107/rcub_farfar_4011 .

Koravović, Mladen, Tasić, Gordana, Mayasundari, Anand, Min, Jaeki, Keramatnia, Fatemeh, Fischer, Marcus, Ranković, Zoran, Savić, Vladimir, "Design and synthesis of Hsp90 PROTAC degraders as potential anticancer agents" in Konkurs za izbor najboljih naučno-istraživačkih radova studenata doktorskih akademskih studija (2019),
https://hdl.handle.net/21.15107/rcub_farfar_4011 .

TY  - JOUR
AU  - Savčić, Gordana
AU  - Paravina, Mirjana
AU  - Koravović, Mladen
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2947
AB  - Brooke-Spiegler syndrome is a rare autosomal dominant hereditary disease with variable penetration. The syndrome is manifested by the appearance of three types of tumors: multiple cylindromas, trichoepitheliomas and spiradenomas. Tumors can cover the entire scalp in the form of turban, so Turban tumor is usually a synonym for this disease. We presented a patient with a typical clinical picture of Brooke-Spiegler syndrome, who has a positive family history (mother, two sisters, brother and niece). Recommended therapy for this syndrome is surgical treatment. She did not accept surgical treatment, because she was afraid of losing her hair.
AB  - Brooke-Spiegler sindrom je retko autozomno dominantno nasledno oboljenje s varijabilnom penetracijom gena. Sindrom se manifestuje pojavom tri tipa tumora: multipli cilindromi, trihoepiteliomi i spiradenomi. Tumori mogu da prekriju čitavu poglavinu u vidu turbana, tako da se kao sinonim za ovu bolest koristi i naziv Turban tumor. U radu je iznet prikaz slučaja bolesnice, starosti 48 godina, s tipičnom kliničkom slikom Brook-Spiegler sindroma, koja ima pozitivnu porodičnu anamnezu. Brook-Spiegler sindrom ispoljio se kod majke, dve sestre, brata i sestričine naše bolesnice. Kao terapija ovog sindroma preporučuje se hirurško lečenje, koje je naša bolesnica odbila iz ličnih razloga zbog straha od gubitka kose.
PB  - Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac
T2  - Medicinski časopis
T1  - A case report of a female patient with Brooke-Spiegler syndrome
T1  - Prikaz slučaja bolesnice sa Brooke-Spiegler sindromom
VL  - 51
IS  - 2
SP  - 59
EP  - 62
DO  - 10.5937/mckg51-14558
ER  - 

@article{
author = "Savčić, Gordana and Paravina, Mirjana and Koravović, Mladen",
year = "2017",
abstract = "Brooke-Spiegler syndrome is a rare autosomal dominant hereditary disease with variable penetration. The syndrome is manifested by the appearance of three types of tumors: multiple cylindromas, trichoepitheliomas and spiradenomas. Tumors can cover the entire scalp in the form of turban, so Turban tumor is usually a synonym for this disease. We presented a patient with a typical clinical picture of Brooke-Spiegler syndrome, who has a positive family history (mother, two sisters, brother and niece). Recommended therapy for this syndrome is surgical treatment. She did not accept surgical treatment, because she was afraid of losing her hair., Brooke-Spiegler sindrom je retko autozomno dominantno nasledno oboljenje s varijabilnom penetracijom gena. Sindrom se manifestuje pojavom tri tipa tumora: multipli cilindromi, trihoepiteliomi i spiradenomi. Tumori mogu da prekriju čitavu poglavinu u vidu turbana, tako da se kao sinonim za ovu bolest koristi i naziv Turban tumor. U radu je iznet prikaz slučaja bolesnice, starosti 48 godina, s tipičnom kliničkom slikom Brook-Spiegler sindroma, koja ima pozitivnu porodičnu anamnezu. Brook-Spiegler sindrom ispoljio se kod majke, dve sestre, brata i sestričine naše bolesnice. Kao terapija ovog sindroma preporučuje se hirurško lečenje, koje je naša bolesnica odbila iz ličnih razloga zbog straha od gubitka kose.",
publisher = "Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac",
journal = "Medicinski časopis",
title = "A case report of a female patient with Brooke-Spiegler syndrome, Prikaz slučaja bolesnice sa Brooke-Spiegler sindromom",
volume = "51",
number = "2",
pages = "59-62",
doi = "10.5937/mckg51-14558"
}

Savčić, G., Paravina, M.,& Koravović, M.. (2017). A case report of a female patient with Brooke-Spiegler syndrome. in Medicinski časopis
Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac., 51(2), 59-62.
https://doi.org/10.5937/mckg51-14558

Savčić G, Paravina M, Koravović M. A case report of a female patient with Brooke-Spiegler syndrome. in Medicinski časopis. 2017;51(2):59-62.
doi:10.5937/mckg51-14558 .

Savčić, Gordana, Paravina, Mirjana, Koravović, Mladen, "A case report of a female patient with Brooke-Spiegler syndrome" in Medicinski časopis, 51, no. 2 (2017):59-62,
https://doi.org/10.5937/mckg51-14558 . .

TY  - JOUR
AU  - Veličković, Vesna
AU  - Simović, Slađana
AU  - Živanović, Sandra
AU  - Stojanović, Jasmina
AU  - Koravović, Mladen
AU  - Mihailović, Nataša
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2937
AB  - Objective. The aim of the present study was to investigate the frequency of allergic rhinitis in dysphonic professional voice users and to assess the correlation between allergic rhinitis and demographic characteristics (sex, ages and years in occupation) and presence of laryngopharyngeal reflux, as comorbidity health condition. Methods. A total of 104 male and female dysphonic patients who came to the Department of Otorhinolaryngology, Health Centre Kragujevac, Serbia because of the presence of dysphonia symptoms and who used their voice more than 4 hours per day at job were included in the study. The patients underwent rigid or transnasal fiberoptic laryngoscopy with videostroboscopy to assess the causes of dysphonia. Descriptive analysis, Pearson Chi-Square Tests and Binary Logistic regression were carried out using the SPSS 19.0 statistical software package. Results. Frequency of allergic rhinitis in dysphonic professional voice users was 44.2%. The patients were 1.1 times more likely to have allergic rhinitis with each passing year of life. Allergic rhinitis is with each year in occupation 0.89 times less frequent and 0.035 times less often in patients with laryngopharyngeal reflux. Conclusion. In dysphonic professional voice users, it has been found that allergic rhinitis occurs rarely with each year in occupation, which means that allergic rhinitis is not a predisposing factor for developing dysphonia, but year in occupation are a protective factor when it comes to the appearance of allergic rhinitis in the examined population.
AB  - Cilj. Cilj ovog rada bio je da se analizira učestalost alergijskog rinitisa kod profesionalnih korisnika glasa sa disfonijom, kao i povezanost između alergijskog rinitisa, demografskih karakteristika (pol, starost i dužina radnog staža) i laringofaringealnog refluksa u ispitivanoj populaciji. Metode. U studiju su uključena ukupno 104 ispitanika muškog i ženskog pola, koji su upućeni u Odeljenje za otorinolaringologiju Doma zdravlja Kragujevac, Srbija, zbog prisustva simptoma disfonije, a zaposleni su na poslovima koji zahtevaju upotrebu glasa više od četiri sata dnevno. Kod ispitanika je primenjena rigidna endovideostroboskopija ili transnazalna fibrooptička laringoskopija da bi se utvrdio uzrok disfonija. Statistička obrada podataka učinjena je primenom deskriptivne metode, Pirsonovog x2 testa i binarne logističke regresije, korišćenjem standardnog statističkog softverskog paketa SPSS 13.0. Rezultati. U ispitivanoj populaciji alergijski rinitis, identifikovan je kod 44,2% profesionalnih korisnika glasa sa disfonijom. U populaciji obuhvaćenoj istraživanjem alergijski rinitis se sa svakom godinom života 1,1 puta češće ispoljava, dok se sa svakom godinom radnog staža 0,89 puta ređe dijagnostikuje. Kod ispitivanih disfoničnih profesionalnih korisnika glasa, kod kojih je ustanovljen laringofaringealni refluks, alergijski rinitis je 0,035 puta ređe prisutan. Zaključak. Kod disfoničnih profesionalnih korisnika glasa, ustanovljeno je da se alergijski rinitis ređe javlja sa svakom godinom radnog staža, što znači da alergijski rinitis nije predisponirajući faktor za nastanak disfonije, već su godine radnog staža protektivni faktor kada je u pitanju pojava alergijskog rinitisa u ispitivanoj populaciji.
PB  - Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac
T2  - Medicinski časopis
T1  - The factors associated with allergic rhinitis in the dysphonic professional voice users
T1  - Faktori povezani s alergijskim rinitisom kod disfoničnih profesionalnih korisnika glasa
VL  - 51
IS  - 3
SP  - 73
EP  - 78
DO  - 10.5937/mckg51-16098
ER  - 

@article{
author = "Veličković, Vesna and Simović, Slađana and Živanović, Sandra and Stojanović, Jasmina and Koravović, Mladen and Mihailović, Nataša",
year = "2017",
abstract = "Objective. The aim of the present study was to investigate the frequency of allergic rhinitis in dysphonic professional voice users and to assess the correlation between allergic rhinitis and demographic characteristics (sex, ages and years in occupation) and presence of laryngopharyngeal reflux, as comorbidity health condition. Methods. A total of 104 male and female dysphonic patients who came to the Department of Otorhinolaryngology, Health Centre Kragujevac, Serbia because of the presence of dysphonia symptoms and who used their voice more than 4 hours per day at job were included in the study. The patients underwent rigid or transnasal fiberoptic laryngoscopy with videostroboscopy to assess the causes of dysphonia. Descriptive analysis, Pearson Chi-Square Tests and Binary Logistic regression were carried out using the SPSS 19.0 statistical software package. Results. Frequency of allergic rhinitis in dysphonic professional voice users was 44.2%. The patients were 1.1 times more likely to have allergic rhinitis with each passing year of life. Allergic rhinitis is with each year in occupation 0.89 times less frequent and 0.035 times less often in patients with laryngopharyngeal reflux. Conclusion. In dysphonic professional voice users, it has been found that allergic rhinitis occurs rarely with each year in occupation, which means that allergic rhinitis is not a predisposing factor for developing dysphonia, but year in occupation are a protective factor when it comes to the appearance of allergic rhinitis in the examined population., Cilj. Cilj ovog rada bio je da se analizira učestalost alergijskog rinitisa kod profesionalnih korisnika glasa sa disfonijom, kao i povezanost između alergijskog rinitisa, demografskih karakteristika (pol, starost i dužina radnog staža) i laringofaringealnog refluksa u ispitivanoj populaciji. Metode. U studiju su uključena ukupno 104 ispitanika muškog i ženskog pola, koji su upućeni u Odeljenje za otorinolaringologiju Doma zdravlja Kragujevac, Srbija, zbog prisustva simptoma disfonije, a zaposleni su na poslovima koji zahtevaju upotrebu glasa više od četiri sata dnevno. Kod ispitanika je primenjena rigidna endovideostroboskopija ili transnazalna fibrooptička laringoskopija da bi se utvrdio uzrok disfonija. Statistička obrada podataka učinjena je primenom deskriptivne metode, Pirsonovog x2 testa i binarne logističke regresije, korišćenjem standardnog statističkog softverskog paketa SPSS 13.0. Rezultati. U ispitivanoj populaciji alergijski rinitis, identifikovan je kod 44,2% profesionalnih korisnika glasa sa disfonijom. U populaciji obuhvaćenoj istraživanjem alergijski rinitis se sa svakom godinom života 1,1 puta češće ispoljava, dok se sa svakom godinom radnog staža 0,89 puta ređe dijagnostikuje. Kod ispitivanih disfoničnih profesionalnih korisnika glasa, kod kojih je ustanovljen laringofaringealni refluks, alergijski rinitis je 0,035 puta ređe prisutan. Zaključak. Kod disfoničnih profesionalnih korisnika glasa, ustanovljeno je da se alergijski rinitis ređe javlja sa svakom godinom radnog staža, što znači da alergijski rinitis nije predisponirajući faktor za nastanak disfonije, već su godine radnog staža protektivni faktor kada je u pitanju pojava alergijskog rinitisa u ispitivanoj populaciji.",
publisher = "Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac",
journal = "Medicinski časopis",
title = "The factors associated with allergic rhinitis in the dysphonic professional voice users, Faktori povezani s alergijskim rinitisom kod disfoničnih profesionalnih korisnika glasa",
volume = "51",
number = "3",
pages = "73-78",
doi = "10.5937/mckg51-16098"
}

Veličković, V., Simović, S., Živanović, S., Stojanović, J., Koravović, M.,& Mihailović, N.. (2017). The factors associated with allergic rhinitis in the dysphonic professional voice users. in Medicinski časopis
Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac., 51(3), 73-78.
https://doi.org/10.5937/mckg51-16098

Veličković V, Simović S, Živanović S, Stojanović J, Koravović M, Mihailović N. The factors associated with allergic rhinitis in the dysphonic professional voice users. in Medicinski časopis. 2017;51(3):73-78.
doi:10.5937/mckg51-16098 .

Veličković, Vesna, Simović, Slađana, Živanović, Sandra, Stojanović, Jasmina, Koravović, Mladen, Mihailović, Nataša, "The factors associated with allergic rhinitis in the dysphonic professional voice users" in Medicinski časopis, 51, no. 3 (2017):73-78,
https://doi.org/10.5937/mckg51-16098 . .

TY  - JOUR
AU  - Simović, Slađana
AU  - Šarenac-Vulović, Tatjana
AU  - Stojanović, Jasmina
AU  - Živanović, Sandra
AU  - Koravović, Mladen
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2782
AB  - The aim of this case report is to present the laryngeal granuloma in 23 year old female patient. Case outline: Te 23 year old female was admitted for examination, because of long lasting, progressive hoarseness. In anamnesis, we found that she has undergone general anesthesia for 8 times, in the early childhood. We performing direct laryngoscopy with complete otorhinolaryngologic examination, rigid endovideostroboscopy and the large granuloma of the larynx was found. Conclusions: Laryngeal granuloma of vocal cords affected mainly men, except for cases associated with laryngeal intubation. We should keep in mind that postintubation laryngeal granuloma might develop after tracheal intubation, so care must be taken to avoid the potential complication.
AB  - Cilj ovog rada je da prikažemo slučaj granuloma larinksa kod bolesnice ženskog pola. Prikaz bolesnika: Bolesnica starosti 23 godine, javila se zbog dugotrajne, promuklosti. U anamnezi ove bolesnice dobijamo podatak da je kod nje, tokom ranog detinjstva 8 puta bila primenjena endotrahealna intubacija. Tokom dijagnostičke evaluacije primenjena je direktna laringoskopija, kompletan otorinolaringološki pregled i rigidnu endovideolaringostroboskopija i uočen je laringealni granulom. Zaključak: Laringealni granulom je benigni izraštaj koji je češći kod osoba muškog pola, osim u slučajevima kod kojih je primenjivana endotrahealna intubacija. Trebalo bi imati u vidu da bi laringealni granulom mogao da se razvije posle primene endotrahealne intubacije, pa treba preduzeti sve mere da bi se izbegla ova potencijalna komplikacija.
PB  - Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac
T2  - Serbian Journal of Experimental and Clinical Research
T1  - A case report of female patient with laryngeal granuloma
T1  - Prikaz slučaja bolesnice sa laringealnim granulomom
VL  - 18
IS  - 2
SP  - 175
EP  - 177
DO  - 10.1515/sjecr-2017-0017
ER  - 

@article{
author = "Simović, Slađana and Šarenac-Vulović, Tatjana and Stojanović, Jasmina and Živanović, Sandra and Koravović, Mladen",
year = "2017",
abstract = "The aim of this case report is to present the laryngeal granuloma in 23 year old female patient. Case outline: Te 23 year old female was admitted for examination, because of long lasting, progressive hoarseness. In anamnesis, we found that she has undergone general anesthesia for 8 times, in the early childhood. We performing direct laryngoscopy with complete otorhinolaryngologic examination, rigid endovideostroboscopy and the large granuloma of the larynx was found. Conclusions: Laryngeal granuloma of vocal cords affected mainly men, except for cases associated with laryngeal intubation. We should keep in mind that postintubation laryngeal granuloma might develop after tracheal intubation, so care must be taken to avoid the potential complication., Cilj ovog rada je da prikažemo slučaj granuloma larinksa kod bolesnice ženskog pola. Prikaz bolesnika: Bolesnica starosti 23 godine, javila se zbog dugotrajne, promuklosti. U anamnezi ove bolesnice dobijamo podatak da je kod nje, tokom ranog detinjstva 8 puta bila primenjena endotrahealna intubacija. Tokom dijagnostičke evaluacije primenjena je direktna laringoskopija, kompletan otorinolaringološki pregled i rigidnu endovideolaringostroboskopija i uočen je laringealni granulom. Zaključak: Laringealni granulom je benigni izraštaj koji je češći kod osoba muškog pola, osim u slučajevima kod kojih je primenjivana endotrahealna intubacija. Trebalo bi imati u vidu da bi laringealni granulom mogao da se razvije posle primene endotrahealne intubacije, pa treba preduzeti sve mere da bi se izbegla ova potencijalna komplikacija.",
publisher = "Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac",
journal = "Serbian Journal of Experimental and Clinical Research",
title = "A case report of female patient with laryngeal granuloma, Prikaz slučaja bolesnice sa laringealnim granulomom",
volume = "18",
number = "2",
pages = "175-177",
doi = "10.1515/sjecr-2017-0017"
}

Simović, S., Šarenac-Vulović, T., Stojanović, J., Živanović, S.,& Koravović, M.. (2017). A case report of female patient with laryngeal granuloma. in Serbian Journal of Experimental and Clinical Research
Univerzitet u Kragujevcu - Fakultet medicinskih nauka, Kragujevac., 18(2), 175-177.
https://doi.org/10.1515/sjecr-2017-0017

Simović S, Šarenac-Vulović T, Stojanović J, Živanović S, Koravović M. A case report of female patient with laryngeal granuloma. in Serbian Journal of Experimental and Clinical Research. 2017;18(2):175-177.
doi:10.1515/sjecr-2017-0017 .

Simović, Slađana, Šarenac-Vulović, Tatjana, Stojanović, Jasmina, Živanović, Sandra, Koravović, Mladen, "A case report of female patient with laryngeal granuloma" in Serbian Journal of Experimental and Clinical Research, 18, no. 2 (2017):175-177,
https://doi.org/10.1515/sjecr-2017-0017 . .

TY  - JOUR
AU  - Simović, Slađana
AU  - Živanović, Sandra
AU  - Đurović, Slavica
AU  - Veličković, Vesna
AU  - Koravović, Mladen
AU  - Kocić, Sanja
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2742
AB  - Objective. The purpose of this study was to determine diabetes mellitus tip 2 influence on the incidence and severity of sensorineural hearing loss. Methods. The prospective case control study was done during 2013 among 132 patients, whose age range was 21-84 years, who were admitted to ENT department of the Health Center Kragujevac for evaluation of hearing loss. We performed detailed history, complete otorhinolaryngological examination including otoscopy, tympanometry and tonal liminal audiometry. All subjects were divided into two groups. The study group consisted of 67 patients with diabetes mellitus type 2 and the control group included age and gender matched subjects. We used tonal liminar audiometry for evaluation of the existence and the degree of hearing loss. The mean value obtained by tonal liminar audiometry at frequencies of 500, 1000, 2000 and 4000 Hz, greater than 25 dB was considered as a hearing loss. Data was statistically analyzed by using descriptive statistical methods, t-test and x2-test using standard statistical software package (SPSS for Windows, version 19.0). Results. There was sensorineural hearing loss in all patients with diabetes mellitus type 2. The frequency and degree of sensorineural hearing loss were statistically significantly higher in the group with diabetes mellitus patient compared to the control group (p  lt  0.05). Conclusion. The results indicate that diabetes mellitus type 2 patients often have significant hearing loss, which is very easy to establish by using tonal liminar audiometry, suggesting that these patients should be referred to the assessment of the impairment.
AB  - Cilj. Cilj stidije bio je da se utvrdi uticaj dijabetesa melitusa tip 2 na ispoljavanje i težinu senzorineuralnog oštećenja sluha kod obolelih u poređenju s kontrolnom grupom, jednakom po polu i uzrastu. Metode. Opservaciona prospektivna studija slučajeva i kontrola sprovedene su tokom 2013. godine na 132 ispitanika, uzrasta 21-84 godine, koji su zbog gubitka sluha pregledani na ORL odeljenju specijalističko-konsultativne službe Doma zdravlja Kragujevac. Kod ispitanika su primenjeni: detaljna anamneza, kompletan otorinolaringološki pregled, uključujući i otoskopiju, timpanometriju i tonalnu liminalnu audiometriju. Svi ispitanicipodeljeni su u dve grupe. Prvu grupu činilo je 67 ispitanika sa dijagnostikovanim dijabetesom melitusom tip 2, dok je u drugoj grupi, adekvatnoj po starosnoj i polnoj zastupljenosti, bilo 65 ispitanika, i ona je predstavljala kontrolnu grupu. Primenom tonalne liminalne audiometrije utvrđeni su postojanje i stepen oštećenja sluha. Srednja vrednost dobijenih rezultata, na frekvencijama 500, 1.000, 2.000 i 4.000 Hz, veća od 25 dB smatrana je oštećenjem sluha. Podaci su statistički obrađeni primenom deskriptivnog metoda, t-testa i x2-testa standardnim statističkim paketom (SPSS za Windows, verzija 19.0). Rezultati. Kod svih ispitanika obolelih od dijabetesa melitusa tip 2 postoji senzorineuralno oštećenje sluha. Uočeno je da kod obolelih od dijabetesa melitusa tip 2 postoji statističtí značajno povišena učestalost i težina senzorineuralnog ostećenja sluha (p  lt  0,05) u odnosu na pripadnike kontrolne grupe. Zaključak. Dobijeni rezultati ukazuju na to da oboleli od dijabetesa melitusa tip 2 često imaju znatno oštećenje sluha koje je veoma jednostavno utvrditi tonalnom liminarnom audiometrijom i sugerišu da ove bolesnika treba upućivati na procenu stanja sluha.
PB  - Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac
T2  - Medicinski časopis
T1  - Assessment of hearing loss severity in patients with type 2 diabetes mellitus
T1  - Procena težine oštećenja sluha kod obolelih od dijabetesa melitusa tip 2
VL  - 50
IS  - 4
SP  - 133
EP  - 138
DO  - 10.5937/mckg50-11735
ER  - 

@article{
author = "Simović, Slađana and Živanović, Sandra and Đurović, Slavica and Veličković, Vesna and Koravović, Mladen and Kocić, Sanja",
year = "2016",
abstract = "Objective. The purpose of this study was to determine diabetes mellitus tip 2 influence on the incidence and severity of sensorineural hearing loss. Methods. The prospective case control study was done during 2013 among 132 patients, whose age range was 21-84 years, who were admitted to ENT department of the Health Center Kragujevac for evaluation of hearing loss. We performed detailed history, complete otorhinolaryngological examination including otoscopy, tympanometry and tonal liminal audiometry. All subjects were divided into two groups. The study group consisted of 67 patients with diabetes mellitus type 2 and the control group included age and gender matched subjects. We used tonal liminar audiometry for evaluation of the existence and the degree of hearing loss. The mean value obtained by tonal liminar audiometry at frequencies of 500, 1000, 2000 and 4000 Hz, greater than 25 dB was considered as a hearing loss. Data was statistically analyzed by using descriptive statistical methods, t-test and x2-test using standard statistical software package (SPSS for Windows, version 19.0). Results. There was sensorineural hearing loss in all patients with diabetes mellitus type 2. The frequency and degree of sensorineural hearing loss were statistically significantly higher in the group with diabetes mellitus patient compared to the control group (p  lt  0.05). Conclusion. The results indicate that diabetes mellitus type 2 patients often have significant hearing loss, which is very easy to establish by using tonal liminar audiometry, suggesting that these patients should be referred to the assessment of the impairment., Cilj. Cilj stidije bio je da se utvrdi uticaj dijabetesa melitusa tip 2 na ispoljavanje i težinu senzorineuralnog oštećenja sluha kod obolelih u poređenju s kontrolnom grupom, jednakom po polu i uzrastu. Metode. Opservaciona prospektivna studija slučajeva i kontrola sprovedene su tokom 2013. godine na 132 ispitanika, uzrasta 21-84 godine, koji su zbog gubitka sluha pregledani na ORL odeljenju specijalističko-konsultativne službe Doma zdravlja Kragujevac. Kod ispitanika su primenjeni: detaljna anamneza, kompletan otorinolaringološki pregled, uključujući i otoskopiju, timpanometriju i tonalnu liminalnu audiometriju. Svi ispitanicipodeljeni su u dve grupe. Prvu grupu činilo je 67 ispitanika sa dijagnostikovanim dijabetesom melitusom tip 2, dok je u drugoj grupi, adekvatnoj po starosnoj i polnoj zastupljenosti, bilo 65 ispitanika, i ona je predstavljala kontrolnu grupu. Primenom tonalne liminalne audiometrije utvrđeni su postojanje i stepen oštećenja sluha. Srednja vrednost dobijenih rezultata, na frekvencijama 500, 1.000, 2.000 i 4.000 Hz, veća od 25 dB smatrana je oštećenjem sluha. Podaci su statistički obrađeni primenom deskriptivnog metoda, t-testa i x2-testa standardnim statističkim paketom (SPSS za Windows, verzija 19.0). Rezultati. Kod svih ispitanika obolelih od dijabetesa melitusa tip 2 postoji senzorineuralno oštećenje sluha. Uočeno je da kod obolelih od dijabetesa melitusa tip 2 postoji statističtí značajno povišena učestalost i težina senzorineuralnog ostećenja sluha (p  lt  0,05) u odnosu na pripadnike kontrolne grupe. Zaključak. Dobijeni rezultati ukazuju na to da oboleli od dijabetesa melitusa tip 2 često imaju znatno oštećenje sluha koje je veoma jednostavno utvrditi tonalnom liminarnom audiometrijom i sugerišu da ove bolesnika treba upućivati na procenu stanja sluha.",
publisher = "Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac",
journal = "Medicinski časopis",
title = "Assessment of hearing loss severity in patients with type 2 diabetes mellitus, Procena težine oštećenja sluha kod obolelih od dijabetesa melitusa tip 2",
volume = "50",
number = "4",
pages = "133-138",
doi = "10.5937/mckg50-11735"
}

Simović, S., Živanović, S., Đurović, S., Veličković, V., Koravović, M.,& Kocić, S.. (2016). Assessment of hearing loss severity in patients with type 2 diabetes mellitus. in Medicinski časopis
Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac., 50(4), 133-138.
https://doi.org/10.5937/mckg50-11735

Simović S, Živanović S, Đurović S, Veličković V, Koravović M, Kocić S. Assessment of hearing loss severity in patients with type 2 diabetes mellitus. in Medicinski časopis. 2016;50(4):133-138.
doi:10.5937/mckg50-11735 .

Simović, Slađana, Živanović, Sandra, Đurović, Slavica, Veličković, Vesna, Koravović, Mladen, Kocić, Sanja, "Assessment of hearing loss severity in patients with type 2 diabetes mellitus" in Medicinski časopis, 50, no. 4 (2016):133-138,
https://doi.org/10.5937/mckg50-11735 . .

TY  - JOUR
AU  - Simović, Slađana
AU  - Živanović, Sandra
AU  - Šarenac-Vulović, Tatjana
AU  - Veličković, Vesna
AU  - Mihailović, Nataša
AU  - Koravović, Mladen
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2743
AB  - Objective. To examine the characteristics of patients with allergic rhinitis and assess the severity of symptoms by using a visual analog scale. Methods. A prospective study was carried out among allergic rhinitis patients, who were referred by the primary care physician to the ENT Department of Health Centre Kragujevac. The assessment of severity of symptoms was performed using visual analog scale (overall influence of all nasal or nasal and ocular symptoms, VAS score of 0 'nasal or nasal and ocular symptoms do not bother' to 10 'nasal or nasal and ocular symptoms are extremely bothered') during the first examination. Data was statistically analysed with descriptive statistical methods, t-test, x2 test and logistic regression using by standard statistical software package (SPSS for Windows, version 19.0). Results. Among our respondents there were 34.3% (37/108) males and 65.7% (71/108) females. Average age of all patients was 29 ± 15,1. Average duration of disease in the sample studied was 7,2 ± 16,2 years. The majority of our participants were classified as having moderate to severe persistent allergic rhinitis. Severity of disease has a greater impact on the VAS score of disease duration. Average VAS score of all participants were 6,9±4,2. It was found that the severity of the disease and the presence of ocular symptoms in patients with allergic rhinitis have an impact on the VAS score (p lt 0,0001) while the use of therapy and sensitization to inhalant allergens did not have such impact. Conclusion. Visual analog scale is a simple quantitative method to assess the severity of allergic rhinitis.
AB  - Cilj. Proceniti težinu simptoma metodom vizuelne analogne skale kod obolelih od alergijskog rinitisa. Metode: Sprovedena je prospektivna studija u kojoj su analizirani oboleli od alergijskog rinitisa, koje su izabrani lekari upućivali na ORL odeljenje specijalističko-konsultativne službe Doma zdravlja 'Kragujevac'. Težina simptoma procenjena je vizuelnom analognom skalom (ukupan uticaj svih nazalnih ili nazalnih i okularnih simptoma, VAS skor od nula - 'nazalni ili nazalni i okularni simptomi uopšte ne smetaju', do 10 - 'nazalni ili nazalni i okularni simptomi izuzetno smetaju') prilikom prvog pregleda. Statistički značajnim smatrane su vrednosti za p  lt  0,05. Podaci su statistički obrađeni primenom deskriptivnog metoda, t-testa, X2-testa i logističke regresije standardnim statističkim paketom (SPSS za Windows, verzija 19.0). Rezultati. Među našim ispitanicima bilo je 34,3% (37/108) osoba muškog pola, dok je osoba ženskog pola bilo 65,7% (71/108). Starost svih ispitanika bila je 29 ± 15,1. Prosečna dužina trajanja bolesti u ispitivanom uzorku bila je 7,2 ± 16,2 godine. Najviše ispitanika imalo je umereno do težak perzistentan oblik bolesti. Prosečna vrednost VAS skora za sve ispitanike bila je 6,9 ± 4,2. Primenom logističke regresije ustanovljeno je da težina bolesti ima veći uticaj na VAS skor od trajanja bolesti. Utvrđeno je da težina bolesti i prisustvo okularnih simptoma kod obolelih od alergijskog rinitisa ima veći uticaj na VAS skor (p  lt  0,0001), dok primena terapije i senzibilizacija na inhalatorne alergene nema. Zaključak. Vizuelna analogna skala je jednostavan kvantitativan metod za procenu težine alergijskog rinitisa.
PB  - Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac
T2  - Medicinski časopis
T1  - Assessment of allergic rhinitis severity symptoms using visual analog scale
T1  - Procena težine simptoma alergijskog rinitisa vizuelnom analognom skalom
VL  - 50
IS  - 2
SP  - 49
EP  - 53
DO  - 10.5937/mckg50-11749
ER  - 

@article{
author = "Simović, Slađana and Živanović, Sandra and Šarenac-Vulović, Tatjana and Veličković, Vesna and Mihailović, Nataša and Koravović, Mladen",
year = "2016",
abstract = "Objective. To examine the characteristics of patients with allergic rhinitis and assess the severity of symptoms by using a visual analog scale. Methods. A prospective study was carried out among allergic rhinitis patients, who were referred by the primary care physician to the ENT Department of Health Centre Kragujevac. The assessment of severity of symptoms was performed using visual analog scale (overall influence of all nasal or nasal and ocular symptoms, VAS score of 0 'nasal or nasal and ocular symptoms do not bother' to 10 'nasal or nasal and ocular symptoms are extremely bothered') during the first examination. Data was statistically analysed with descriptive statistical methods, t-test, x2 test and logistic regression using by standard statistical software package (SPSS for Windows, version 19.0). Results. Among our respondents there were 34.3% (37/108) males and 65.7% (71/108) females. Average age of all patients was 29 ± 15,1. Average duration of disease in the sample studied was 7,2 ± 16,2 years. The majority of our participants were classified as having moderate to severe persistent allergic rhinitis. Severity of disease has a greater impact on the VAS score of disease duration. Average VAS score of all participants were 6,9±4,2. It was found that the severity of the disease and the presence of ocular symptoms in patients with allergic rhinitis have an impact on the VAS score (p lt 0,0001) while the use of therapy and sensitization to inhalant allergens did not have such impact. Conclusion. Visual analog scale is a simple quantitative method to assess the severity of allergic rhinitis., Cilj. Proceniti težinu simptoma metodom vizuelne analogne skale kod obolelih od alergijskog rinitisa. Metode: Sprovedena je prospektivna studija u kojoj su analizirani oboleli od alergijskog rinitisa, koje su izabrani lekari upućivali na ORL odeljenje specijalističko-konsultativne službe Doma zdravlja 'Kragujevac'. Težina simptoma procenjena je vizuelnom analognom skalom (ukupan uticaj svih nazalnih ili nazalnih i okularnih simptoma, VAS skor od nula - 'nazalni ili nazalni i okularni simptomi uopšte ne smetaju', do 10 - 'nazalni ili nazalni i okularni simptomi izuzetno smetaju') prilikom prvog pregleda. Statistički značajnim smatrane su vrednosti za p  lt  0,05. Podaci su statistički obrađeni primenom deskriptivnog metoda, t-testa, X2-testa i logističke regresije standardnim statističkim paketom (SPSS za Windows, verzija 19.0). Rezultati. Među našim ispitanicima bilo je 34,3% (37/108) osoba muškog pola, dok je osoba ženskog pola bilo 65,7% (71/108). Starost svih ispitanika bila je 29 ± 15,1. Prosečna dužina trajanja bolesti u ispitivanom uzorku bila je 7,2 ± 16,2 godine. Najviše ispitanika imalo je umereno do težak perzistentan oblik bolesti. Prosečna vrednost VAS skora za sve ispitanike bila je 6,9 ± 4,2. Primenom logističke regresije ustanovljeno je da težina bolesti ima veći uticaj na VAS skor od trajanja bolesti. Utvrđeno je da težina bolesti i prisustvo okularnih simptoma kod obolelih od alergijskog rinitisa ima veći uticaj na VAS skor (p  lt  0,0001), dok primena terapije i senzibilizacija na inhalatorne alergene nema. Zaključak. Vizuelna analogna skala je jednostavan kvantitativan metod za procenu težine alergijskog rinitisa.",
publisher = "Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac",
journal = "Medicinski časopis",
title = "Assessment of allergic rhinitis severity symptoms using visual analog scale, Procena težine simptoma alergijskog rinitisa vizuelnom analognom skalom",
volume = "50",
number = "2",
pages = "49-53",
doi = "10.5937/mckg50-11749"
}

Simović, S., Živanović, S., Šarenac-Vulović, T., Veličković, V., Mihailović, N.,& Koravović, M.. (2016). Assessment of allergic rhinitis severity symptoms using visual analog scale. in Medicinski časopis
Srpsko lekarsko društvo - Okružna podružnica Kragujevac, Kragujevac., 50(2), 49-53.
https://doi.org/10.5937/mckg50-11749

Simović S, Živanović S, Šarenac-Vulović T, Veličković V, Mihailović N, Koravović M. Assessment of allergic rhinitis severity symptoms using visual analog scale. in Medicinski časopis. 2016;50(2):49-53.
doi:10.5937/mckg50-11749 .

Simović, Slađana, Živanović, Sandra, Šarenac-Vulović, Tatjana, Veličković, Vesna, Mihailović, Nataša, Koravović, Mladen, "Assessment of allergic rhinitis severity symptoms using visual analog scale" in Medicinski časopis, 50, no. 2 (2016):49-53,
https://doi.org/10.5937/mckg50-11749 . .