TY  - JOUR
AU  - Dopsaj, Milivoj
AU  - Nenasheva, A.V
AU  - Tretiakova, T.N
AU  - Syromiatnikova, Yu.A
AU  - Surina-Marysheva, E.F
AU  - Marković, S
AU  - Dopsaj, Violeta
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3322
AB  - The Aim. The aim of this paper is to define the contractile characteristics of maximal isometric handgrip force and to establish possible differences between the students of the Universities of Chelyabinsk and Belgrade. The secondary aim is to create a practically applicable initial model in order to explore the mentioned characteristics in the future. Material and methods. For the purposes of this research, the overall sample of 225 subjects was tested. 91 subjects were from Russia and 134 were from Serbia. The results were gathered using a strain gage and a standardized isometric handgrip test protocol. The contractile properties of HG muscle force were measured in relation to three different contractile dimensions: the maximal muscle force (Fmax), the maximal explosive muscle force (RFDmax), the time need for achieving maximal (tFmax) and maximal explosive (tRFDmax) muscle force. Results. This study has shown that there are no generally statistically significant differences for all observed variables of HG contractile characteristics between tested Russian and Serbian students. Based on the results of the present study, six different models of the equation for evaluation of HG contractile characteristics of female and male students, i.e. young adults, were made. All defined models are highly statistically significant, accurate and sensitive in the prediction of the general distributive position of an individual or particular group of subjects in relation to the measured contractile characteristics. Conclusions. The obtained results can generally indicate the stability of potential to exert the given contractile characteristic in relation to the population of similar evolutionary (Slavs) at different geographical background.
PB  - South Ural State University - Institute of Sport, Tourism and Service
T2  - Human Sport Medicine
T1  - Handgrip muscle force characteristics with general reference values at Chelyabinsk and Belgrade students
VL  - 19
IS  - 2
SP  - 27
EP  - 36
DO  - 10.14529/hsm190204
ER  - 

@article{
author = "Dopsaj, Milivoj and Nenasheva, A.V and Tretiakova, T.N and Syromiatnikova, Yu.A and Surina-Marysheva, E.F and Marković, S and Dopsaj, Violeta",
year = "2019",
abstract = "The Aim. The aim of this paper is to define the contractile characteristics of maximal isometric handgrip force and to establish possible differences between the students of the Universities of Chelyabinsk and Belgrade. The secondary aim is to create a practically applicable initial model in order to explore the mentioned characteristics in the future. Material and methods. For the purposes of this research, the overall sample of 225 subjects was tested. 91 subjects were from Russia and 134 were from Serbia. The results were gathered using a strain gage and a standardized isometric handgrip test protocol. The contractile properties of HG muscle force were measured in relation to three different contractile dimensions: the maximal muscle force (Fmax), the maximal explosive muscle force (RFDmax), the time need for achieving maximal (tFmax) and maximal explosive (tRFDmax) muscle force. Results. This study has shown that there are no generally statistically significant differences for all observed variables of HG contractile characteristics between tested Russian and Serbian students. Based on the results of the present study, six different models of the equation for evaluation of HG contractile characteristics of female and male students, i.e. young adults, were made. All defined models are highly statistically significant, accurate and sensitive in the prediction of the general distributive position of an individual or particular group of subjects in relation to the measured contractile characteristics. Conclusions. The obtained results can generally indicate the stability of potential to exert the given contractile characteristic in relation to the population of similar evolutionary (Slavs) at different geographical background.",
publisher = "South Ural State University - Institute of Sport, Tourism and Service",
journal = "Human Sport Medicine",
title = "Handgrip muscle force characteristics with general reference values at Chelyabinsk and Belgrade students",
volume = "19",
number = "2",
pages = "27-36",
doi = "10.14529/hsm190204"
}

Dopsaj, M., Nenasheva, A.V, Tretiakova, T.N, Syromiatnikova, Yu.A, Surina-Marysheva, E.F, Marković, S.,& Dopsaj, V.. (2019). Handgrip muscle force characteristics with general reference values at Chelyabinsk and Belgrade students. in Human Sport Medicine
South Ural State University - Institute of Sport, Tourism and Service., 19(2), 27-36.
https://doi.org/10.14529/hsm190204

Dopsaj M, Nenasheva A, Tretiakova T, Syromiatnikova Y, Surina-Marysheva E, Marković S, Dopsaj V. Handgrip muscle force characteristics with general reference values at Chelyabinsk and Belgrade students. in Human Sport Medicine. 2019;19(2):27-36.
doi:10.14529/hsm190204 .

Dopsaj, Milivoj, Nenasheva, A.V, Tretiakova, T.N, Syromiatnikova, Yu.A, Surina-Marysheva, E.F, Marković, S, Dopsaj, Violeta, "Handgrip muscle force characteristics with general reference values at Chelyabinsk and Belgrade students" in Human Sport Medicine, 19, no. 2 (2019):27-36,
https://doi.org/10.14529/hsm190204 . .

TY  - JOUR
AU  - Malenović, Anđelija
AU  - Medenica, Mirjana
AU  - Ivanović, D
AU  - Jančić, Biljana
AU  - Marković, S
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/649
AB  - The simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS 4.6 mm x 15 cm, 5 μm particle column at 40°C. The mobile phase consisted of water phase and acetonitrile (72:28:V/V), pH value of the mobile phase was adjusted to 2.0 with 85% ortophosphoric acid. Bisacodil was used as an internal standard. The flow rate was 1 ml/min and UV detection was performed at 208 nm. The proposed RP-HPLC method was validated and all the parameters for the validation of the method are given. According to the obtained results, the developed method was found to be suitable and accurate for the determination of these drugs in commercial formulations.
PB  - Elsevier Masson SAS
T2  - Farmaco
T1  - Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination
VL  - 60
IS  - 2
SP  - 157
EP  - 161
DO  - 10.1016/j.farmac.2004.11.004
ER  - 

@article{
author = "Malenović, Anđelija and Medenica, Mirjana and Ivanović, D and Jančić, Biljana and Marković, S",
year = "2005",
abstract = "The simple and rapid RP-HPLC method, for the simultaneous determination of lidocaine and cetrimonium bromide in the presence of pellet color corrigent, was developed. Separations were performed on a Beckman Ultrasphere ODS 4.6 mm x 15 cm, 5 μm particle column at 40°C. The mobile phase consisted of water phase and acetonitrile (72:28:V/V), pH value of the mobile phase was adjusted to 2.0 with 85% ortophosphoric acid. Bisacodil was used as an internal standard. The flow rate was 1 ml/min and UV detection was performed at 208 nm. The proposed RP-HPLC method was validated and all the parameters for the validation of the method are given. According to the obtained results, the developed method was found to be suitable and accurate for the determination of these drugs in commercial formulations.",
publisher = "Elsevier Masson SAS",
journal = "Farmaco",
title = "Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination",
volume = "60",
number = "2",
pages = "157-161",
doi = "10.1016/j.farmac.2004.11.004"
}

Malenović, A., Medenica, M., Ivanović, D., Jančić, B.,& Marković, S.. (2005). Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination. in Farmaco
Elsevier Masson SAS., 60(2), 157-161.
https://doi.org/10.1016/j.farmac.2004.11.004

Malenović A, Medenica M, Ivanović D, Jančić B, Marković S. Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination. in Farmaco. 2005;60(2):157-161.
doi:10.1016/j.farmac.2004.11.004 .

Malenović, Anđelija, Medenica, Mirjana, Ivanović, D, Jančić, Biljana, Marković, S, "Development and validation of RP-HPLC method for cetrimonium bromide and lidocaine determination" in Farmaco, 60, no. 2 (2005):157-161,
https://doi.org/10.1016/j.farmac.2004.11.004 . .

TY  - JOUR
AU  - Jančić, Biljana
AU  - Medenica, Mirjana
AU  - Ivanović, D
AU  - Malenović, Anđelija
AU  - Marković, S
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/609
AB  - The properties of the eluent are the essential factors governing the efficiency in the high-performance liquid chromatography (HPLC) method. A novel approach in retention modelling in the liquid chromatographic separation of fosinopril sodium and its degradation product, fosinoprilat, applying a microemulsion as the mobile phase, was used. The modifications of the mobile phase included the changes to the type of the lipophilic phase, the type and concentration of co-surfactant and surfactant, as well as the pH of the mobile phase. In this study, a full factorial 2(3) design, as the optimal method for screening of the experiment, was applied for selecting factors which had an influence on separation. Optimisation was done by a central composite design. An appropriate resolution with reasonable retention times was obtained with a microemulsion containing 0.9% w/w of cyclohexane, 2.2% w/w of sodium dodecyl sulphate (SDS), 8.0% w/w of n-butanol and 88.9% of aqueous 25 mM disodium phosphate, the pH of which was adjusted to 2.8 with 85% orthophosphoric acid. Separations were performed on an X-Terra 50-mmx4.6-mm, 3.5- mu m particle size column at 30 degrees C. UV detection was performed at 220 nm and with a flow rate of 0.3 mL min(-1). The established method was validated and applied for analysis of appropriate tablets. The proposed chromatographic procedure for the separation of fosinopril sodium and its degradation product is less expensive compared with the conventional reversed-phase HPLC method, as well as being simple and rapid. The optimised and validated method can be used for separation, identification and simultaneous determination of fosinopfil sodium and fosinoprilat in bulk drug and in pharmaceutical dose forms.
PB  - Springer Heidelberg, Heidelberg
T2  - Analytical and Bioanalytical Chemistry
T1  - Microemulsion liquid chromatographic method for characterisation of fosinopril sodium and fosinoprilat separation with chemometrical support
VL  - 383
IS  - 4
SP  - 687
EP  - 694
DO  - 10.1007/s00216-005-0074-x
ER  - 

@article{
author = "Jančić, Biljana and Medenica, Mirjana and Ivanović, D and Malenović, Anđelija and Marković, S",
year = "2005",
abstract = "The properties of the eluent are the essential factors governing the efficiency in the high-performance liquid chromatography (HPLC) method. A novel approach in retention modelling in the liquid chromatographic separation of fosinopril sodium and its degradation product, fosinoprilat, applying a microemulsion as the mobile phase, was used. The modifications of the mobile phase included the changes to the type of the lipophilic phase, the type and concentration of co-surfactant and surfactant, as well as the pH of the mobile phase. In this study, a full factorial 2(3) design, as the optimal method for screening of the experiment, was applied for selecting factors which had an influence on separation. Optimisation was done by a central composite design. An appropriate resolution with reasonable retention times was obtained with a microemulsion containing 0.9% w/w of cyclohexane, 2.2% w/w of sodium dodecyl sulphate (SDS), 8.0% w/w of n-butanol and 88.9% of aqueous 25 mM disodium phosphate, the pH of which was adjusted to 2.8 with 85% orthophosphoric acid. Separations were performed on an X-Terra 50-mmx4.6-mm, 3.5- mu m particle size column at 30 degrees C. UV detection was performed at 220 nm and with a flow rate of 0.3 mL min(-1). The established method was validated and applied for analysis of appropriate tablets. The proposed chromatographic procedure for the separation of fosinopril sodium and its degradation product is less expensive compared with the conventional reversed-phase HPLC method, as well as being simple and rapid. The optimised and validated method can be used for separation, identification and simultaneous determination of fosinopfil sodium and fosinoprilat in bulk drug and in pharmaceutical dose forms.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Analytical and Bioanalytical Chemistry",
title = "Microemulsion liquid chromatographic method for characterisation of fosinopril sodium and fosinoprilat separation with chemometrical support",
volume = "383",
number = "4",
pages = "687-694",
doi = "10.1007/s00216-005-0074-x"
}

Jančić, B., Medenica, M., Ivanović, D., Malenović, A.,& Marković, S.. (2005). Microemulsion liquid chromatographic method for characterisation of fosinopril sodium and fosinoprilat separation with chemometrical support. in Analytical and Bioanalytical Chemistry
Springer Heidelberg, Heidelberg., 383(4), 687-694.
https://doi.org/10.1007/s00216-005-0074-x

Jančić B, Medenica M, Ivanović D, Malenović A, Marković S. Microemulsion liquid chromatographic method for characterisation of fosinopril sodium and fosinoprilat separation with chemometrical support. in Analytical and Bioanalytical Chemistry. 2005;383(4):687-694.
doi:10.1007/s00216-005-0074-x .

Jančić, Biljana, Medenica, Mirjana, Ivanović, D, Malenović, Anđelija, Marković, S, "Microemulsion liquid chromatographic method for characterisation of fosinopril sodium and fosinoprilat separation with chemometrical support" in Analytical and Bioanalytical Chemistry, 383, no. 4 (2005):687-694,
https://doi.org/10.1007/s00216-005-0074-x . .

TY  - JOUR
AU  - Živanović, L
AU  - Zečević, Mira
AU  - Marković, S
AU  - Petrović, S
AU  - Ivanović, I
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/573
AB  - In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography A
T1  - Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment
VL  - 1088
IS  - 1-2
SP  - 182
EP  - 186
DO  - 10.1016/j.chroma.2005.04.049
ER  - 

@article{
author = "Živanović, L and Zečević, Mira and Marković, S and Petrović, S and Ivanović, I",
year = "2005",
abstract = "In this paper, there was developed a sensitive, precise and accurate reversed-phase liquid chromatographic (RP-HPLC) method and validated for simultaneous determination of lidocaine hydrochloride, dexamethasone acetate (DA) and calcium dobesilate (CD) in suppositories and ointment. Also there was achieved a parallel analysis of buthylhydroxyanisol, as a preservative, and hydroquinone, as a degradation product of calcium dobesilate, present in these dosage forms. The relative standard deviation (RSD) values for all five compounds indicated a good precision and accuracy of the RP-HPLC method. Method is selective, sensitive and reproducible with good recovery values and can be applied in simultaneous determination of all mentioned compounds.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography A",
title = "Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment",
volume = "1088",
number = "1-2",
pages = "182-186",
doi = "10.1016/j.chroma.2005.04.049"
}

Živanović, L., Zečević, M., Marković, S., Petrović, S.,& Ivanović, I.. (2005). Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment. in Journal of Chromatography A
Elsevier Science BV, Amsterdam., 1088(1-2), 182-186.
https://doi.org/10.1016/j.chroma.2005.04.049

Živanović L, Zečević M, Marković S, Petrović S, Ivanović I. Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment. in Journal of Chromatography A. 2005;1088(1-2):182-186.
doi:10.1016/j.chroma.2005.04.049 .

Živanović, L, Zečević, Mira, Marković, S, Petrović, S, Ivanović, I, "Validation of liquid chromatographic method for analysis of lidocaine hydrochloride, dexamethasone acetate, calcium dobesilate, buthylhydroxyanisol and degradation product hydroquinone in suppositories and ointment" in Journal of Chromatography A, 1088, no. 1-2 (2005):182-186,
https://doi.org/10.1016/j.chroma.2005.04.049 . .

TY  - JOUR
AU  - Medenica, Mirjana
AU  - Ivanović, D
AU  - Marković, S
AU  - Malenović, Anđelija
AU  - Jančić, Biljana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/487
AB  - In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.
PB  - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2  - Pharmazeutische Industrie
T1  - Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories
VL  - 66
IS  - 3
SP  - 330
EP  - 333
UR  - https://hdl.handle.net/21.15107/rcub_farfar_487
ER  - 

@article{
author = "Medenica, Mirjana and Ivanović, D and Marković, S and Malenović, Anđelija and Jančić, Biljana",
year = "2004",
abstract = "In this paper the second-derivative spectrophotometric method for the simultaneous determination of lidocaine (CAS 137-58-6) and hydrocortisone acetate (CAS 50-03-3) in suppositories is described. One suppository contains 60 mg of lidocaine and 5 mg of hydrocortisone acetate. Optimal conditions for the quantitative analysis were settled. The second-derivative spectra were recorded in the range from 210 to 380 nm against methanol. Determination of lidocaine was performed at 256.0 nm and hydrocortisone acetate at 260.5 nm, using the "zero crossing" method. The results obtained show that there was no interference of ingredients matrix under the mentioned experimental conditions. The method is simple, rapid and precise and can be used in a routine analysis of such pharmaceutical dosage forms.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Pharmazeutische Industrie",
title = "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories",
volume = "66",
number = "3",
pages = "330-333",
url = "https://hdl.handle.net/21.15107/rcub_farfar_487"
}

Medenica, M., Ivanović, D., Marković, S., Malenović, A.,& Jančić, B.. (2004). Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories. in Pharmazeutische Industrie
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 66(3), 330-333.
https://hdl.handle.net/21.15107/rcub_farfar_487

Medenica M, Ivanović D, Marković S, Malenović A, Jančić B. Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories. in Pharmazeutische Industrie. 2004;66(3):330-333.
https://hdl.handle.net/21.15107/rcub_farfar_487 .

Medenica, Mirjana, Ivanović, D, Marković, S, Malenović, Anđelija, Jančić, Biljana, "Second-derivative spectrophotometric analysis of lidocaine and hydrocortisone acetate in suppositories" in Pharmazeutische Industrie, 66, no. 3 (2004):330-333,
https://hdl.handle.net/21.15107/rcub_farfar_487 .

TY  - JOUR
AU  - Ivanović, D
AU  - Medenica, Mirjana
AU  - Jančić, Biljana
AU  - Malenović, Anđelija
AU  - Marković, S
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/509
AB  - In this paper the experimental design has been applied to define the optimum chromatographic conditions for the separation of Fosinopril sodium and its degradation product, fosinoprilat. Fosinopril is a prodrug and after being hydrolysed, it becomes an active drug fosinoprilat. For experimental screening full factorial design 2 3 was applied. Methanol content, PH of the mobile phase and column temperature were independent variables or factors to be investigated in two levels - much greater thanlowmuch less than and much greater thanhighmuch less than. Capacity and selectivity factors were chosen as dependent variables and matrix was applied to estimate coefficients of the linear model. After experimental screening, RSM (response surface methodology) was applied for optimization. Optimum conditions were: X Terra(TM) 150 mm x 4.6 mm, 5 mum particle column at 45 degreesC; methanol-water (75 : 25 v/v) at pH 3.1 as a mobile Phase, with a flow rate of 1 mL min(-1). UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril sodium and its degradation product in Monopril(R) tablets. Recovery values for fosinopril sodium were between 101.6% and 102.9% and content of degradation product fosinoprilat was lower than 5%. Applying the chemometrical approach enables a relatively limited number of experiments to define factors which affect the chromatographic behavior of investigated substances and obtain optimum conditions for their analysis.
PB  - Springer Heidelberg, Heidelberg
T2  - Chromatographia
T1  - Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis
VL  - 60
IS  - SUPPL.
DO  - 10.1365/s10337-004-0324-7
ER  - 

@article{
author = "Ivanović, D and Medenica, Mirjana and Jančić, Biljana and Malenović, Anđelija and Marković, S",
year = "2004",
abstract = "In this paper the experimental design has been applied to define the optimum chromatographic conditions for the separation of Fosinopril sodium and its degradation product, fosinoprilat. Fosinopril is a prodrug and after being hydrolysed, it becomes an active drug fosinoprilat. For experimental screening full factorial design 2 3 was applied. Methanol content, PH of the mobile phase and column temperature were independent variables or factors to be investigated in two levels - much greater thanlowmuch less than and much greater thanhighmuch less than. Capacity and selectivity factors were chosen as dependent variables and matrix was applied to estimate coefficients of the linear model. After experimental screening, RSM (response surface methodology) was applied for optimization. Optimum conditions were: X Terra(TM) 150 mm x 4.6 mm, 5 mum particle column at 45 degreesC; methanol-water (75 : 25 v/v) at pH 3.1 as a mobile Phase, with a flow rate of 1 mL min(-1). UV detection was performed at 220 nm. Propylparaben was used as an internal standard. The proposed method is rapid, accurate, selective and because of its sensitivity and reproducibility, it may be used for the quantitative analysis of fosinopril sodium and its degradation product in Monopril(R) tablets. Recovery values for fosinopril sodium were between 101.6% and 102.9% and content of degradation product fosinoprilat was lower than 5%. Applying the chemometrical approach enables a relatively limited number of experiments to define factors which affect the chromatographic behavior of investigated substances and obtain optimum conditions for their analysis.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Chromatographia",
title = "Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis",
volume = "60",
number = "SUPPL.",
doi = "10.1365/s10337-004-0324-7"
}

Ivanović, D., Medenica, M., Jančić, B., Malenović, A.,& Marković, S.. (2004). Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis. in Chromatographia
Springer Heidelberg, Heidelberg., 60(SUPPL.).
https://doi.org/10.1365/s10337-004-0324-7

Ivanović D, Medenica M, Jančić B, Malenović A, Marković S. Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis. in Chromatographia. 2004;60(SUPPL.).
doi:10.1365/s10337-004-0324-7 .

Ivanović, D, Medenica, Mirjana, Jančić, Biljana, Malenović, Anđelija, Marković, S, "Chemometrical approach in fosinopril-sodium and its degradation product fosinoprilat analysis" in Chromatographia, 60, no. SUPPL. (2004),
https://doi.org/10.1365/s10337-004-0324-7 . .

TY  - JOUR
AU  - Malenović, Anđelija
AU  - Ivanović, D
AU  - Medenica, Mirjana
AU  - Jančić, Biljana
AU  - Marković, S
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/505
AB  - A novel and unique approach was used for retention modelling in the separation of simvastatin and six impurities by liquid chromatographic using a microemulsion as mobile phase. A microemulsion is a modification of a micellar system where a lipophilic organic solvent is dissolved in the micelles; for that reason, microemulsions are usually treated as solvent-modified micellar solutions. When microemulsions are used as eluents in HPLC separations, solutes partition between the charged oil droplets and the aqueous buffer phase. The complexity of the composition of the microemulsion permits extensive manipulations to be made during method development in order to achieve acceptable resolution of such a complex mixture of substances. In order to avoid a laborious "trial and error" procedure, a 2(3) full factorial design was applied for choosing an optimal microemulsion composition to obtain good separation in a reasonable run time. Organic solvent, sodium dodecyl sulphate, and n-butanol content were varied within defined experimental domain. Optimal conditions for the separation of simvastatin and its six impurities were obtained using an X Terra(TM) 50 x 4.6 mm, 3.5 mum particle size column at 30degreesC. The mobile phase consisted of 0.9% w/w of diisopropyl ether, 2.2% w/w of sodium dodecylsulphate (SDS), 7.0% w/w of co-surfactant such as n-butanol, and 89.9% w/w of aqueous 25 mM disodium phosphate pH 7.0.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Journal of Separation Science
T1  - Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent
VL  - 27
IS  - 13
SP  - 1087
EP  - 1092
DO  - 10.1002/jssc.200401748
ER  - 

@article{
author = "Malenović, Anđelija and Ivanović, D and Medenica, Mirjana and Jančić, Biljana and Marković, S",
year = "2004",
abstract = "A novel and unique approach was used for retention modelling in the separation of simvastatin and six impurities by liquid chromatographic using a microemulsion as mobile phase. A microemulsion is a modification of a micellar system where a lipophilic organic solvent is dissolved in the micelles; for that reason, microemulsions are usually treated as solvent-modified micellar solutions. When microemulsions are used as eluents in HPLC separations, solutes partition between the charged oil droplets and the aqueous buffer phase. The complexity of the composition of the microemulsion permits extensive manipulations to be made during method development in order to achieve acceptable resolution of such a complex mixture of substances. In order to avoid a laborious "trial and error" procedure, a 2(3) full factorial design was applied for choosing an optimal microemulsion composition to obtain good separation in a reasonable run time. Organic solvent, sodium dodecyl sulphate, and n-butanol content were varied within defined experimental domain. Optimal conditions for the separation of simvastatin and its six impurities were obtained using an X Terra(TM) 50 x 4.6 mm, 3.5 mum particle size column at 30degreesC. The mobile phase consisted of 0.9% w/w of diisopropyl ether, 2.2% w/w of sodium dodecylsulphate (SDS), 7.0% w/w of co-surfactant such as n-butanol, and 89.9% w/w of aqueous 25 mM disodium phosphate pH 7.0.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Journal of Separation Science",
title = "Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent",
volume = "27",
number = "13",
pages = "1087-1092",
doi = "10.1002/jssc.200401748"
}

Malenović, A., Ivanović, D., Medenica, M., Jančić, B.,& Marković, S.. (2004). Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent. in Journal of Separation Science
Wiley-VCH Verlag GMBH, Weinheim., 27(13), 1087-1092.
https://doi.org/10.1002/jssc.200401748

Malenović A, Ivanović D, Medenica M, Jančić B, Marković S. Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent. in Journal of Separation Science. 2004;27(13):1087-1092.
doi:10.1002/jssc.200401748 .

Malenović, Anđelija, Ivanović, D, Medenica, Mirjana, Jančić, Biljana, Marković, S, "Retention modelling in liquid chromatographic separation of simvastatin and six impurities using a microemulsion as eluent" in Journal of Separation Science, 27, no. 13 (2004):1087-1092,
https://doi.org/10.1002/jssc.200401748 . .

TY  - JOUR
AU  - Medenica, Mirjana
AU  - Ivanović, D
AU  - Marković, S
AU  - Malenović, Anđelija
AU  - Misljenović, D
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/423
AB  - Optimization of important conditions for the reversed-phase high-performance liquid chromatographic method was done for the separation of the active ingredients in Marcaine(R) adrenaline injections (bupivacaine hydrochloride 2.5 mg and adrenaline 5.0 mug). Simultaneous influence of several conditions, such as the mobile phase composition, pH of the mobile phase, and temperature, on important chromatographic criteria for the separation, was investigated. The separation factor values defined the optimal conditions, which were confirmed by analysing the appropriate mathematical models. The 3-D graphs, constructed with sixty-four experimental points, were investigated, and the results showed that the optimal separation was achieved with the mobile phase of methanol-water (65: 35 v/v), by adjusting pH to 3.5 and the temperature range from 20degreesC to 30degreesC. The optimized method was validated and the obtained results were statistically evaluated.
PB  - Marcel Dekker Inc, New York
T2  - Journal of Liquid Chromatography & Related Technologies
T1  - Optimization of an RP-HPLC method for drug control analysis
VL  - 26
IS  - 20
SP  - 3401
EP  - 3412
DO  - 10.1081/JLC-120025598
ER  - 

@article{
author = "Medenica, Mirjana and Ivanović, D and Marković, S and Malenović, Anđelija and Misljenović, D",
year = "2003",
abstract = "Optimization of important conditions for the reversed-phase high-performance liquid chromatographic method was done for the separation of the active ingredients in Marcaine(R) adrenaline injections (bupivacaine hydrochloride 2.5 mg and adrenaline 5.0 mug). Simultaneous influence of several conditions, such as the mobile phase composition, pH of the mobile phase, and temperature, on important chromatographic criteria for the separation, was investigated. The separation factor values defined the optimal conditions, which were confirmed by analysing the appropriate mathematical models. The 3-D graphs, constructed with sixty-four experimental points, were investigated, and the results showed that the optimal separation was achieved with the mobile phase of methanol-water (65: 35 v/v), by adjusting pH to 3.5 and the temperature range from 20degreesC to 30degreesC. The optimized method was validated and the obtained results were statistically evaluated.",
publisher = "Marcel Dekker Inc, New York",
journal = "Journal of Liquid Chromatography & Related Technologies",
title = "Optimization of an RP-HPLC method for drug control analysis",
volume = "26",
number = "20",
pages = "3401-3412",
doi = "10.1081/JLC-120025598"
}

Medenica, M., Ivanović, D., Marković, S., Malenović, A.,& Misljenović, D.. (2003). Optimization of an RP-HPLC method for drug control analysis. in Journal of Liquid Chromatography & Related Technologies
Marcel Dekker Inc, New York., 26(20), 3401-3412.
https://doi.org/10.1081/JLC-120025598

Medenica M, Ivanović D, Marković S, Malenović A, Misljenović D. Optimization of an RP-HPLC method for drug control analysis. in Journal of Liquid Chromatography & Related Technologies. 2003;26(20):3401-3412.
doi:10.1081/JLC-120025598 .

Medenica, Mirjana, Ivanović, D, Marković, S, Malenović, Anđelija, Misljenović, D, "Optimization of an RP-HPLC method for drug control analysis" in Journal of Liquid Chromatography & Related Technologies, 26, no. 20 (2003):3401-3412,
https://doi.org/10.1081/JLC-120025598 . .

TY  - JOUR
AU  - Vladimirov, S
AU  - Marković, L
AU  - Agbaba, Danica
AU  - Živanov-Stakić, Dobrila
AU  - Brborić, Jasmina
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/166
AB  - A specific and simple HPLC procedure was developed, su table for the determination of dindamycin hydrochloride monohydrate (CLHC) and clindamycin 2-dihydrogenphosphate (CLPH) in pharmaceutical formulations. Rp-HPLC analysis was performed with a LCD-Analytical Consta Metric 3000 system, equipped with a Spectro Monitor 3100 UV/VIS detector. Lincosamides assay procedures were carried out on a Supelcosil R LC-18-DB (250 × 4,6 mm, 5 μm particles) column in an acetonitrile-potassium dihydrogenphosphate buffer (0.1 M; pH 2.50) (225:775 v/v) as mobile phase. Column effluents were monitored at 206 nm for clindamycin. The calibration curves in concentration ranges from 200 to 1800 μg/ml were established for the investigated clindamycins. The HPLC method was applied for the determination of clindamycin in pharmaceutical formulations. The obtained results and statistical parameters for both the investigated clindamycins in pharmaceutical formulations, were satisfactory and ranged from 99.99% to 104.18% (R.S.D. was ranged from 0.79% to 0.99%).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations
VL  - 62
IS  - 2
SP  - 177
EP  - 181
UR  - https://hdl.handle.net/21.15107/rcub_farfar_166
ER  - 

@article{
author = "Vladimirov, S and Marković, L and Agbaba, Danica and Živanov-Stakić, Dobrila and Brborić, Jasmina",
year = "1997",
abstract = "A specific and simple HPLC procedure was developed, su table for the determination of dindamycin hydrochloride monohydrate (CLHC) and clindamycin 2-dihydrogenphosphate (CLPH) in pharmaceutical formulations. Rp-HPLC analysis was performed with a LCD-Analytical Consta Metric 3000 system, equipped with a Spectro Monitor 3100 UV/VIS detector. Lincosamides assay procedures were carried out on a Supelcosil R LC-18-DB (250 × 4,6 mm, 5 μm particles) column in an acetonitrile-potassium dihydrogenphosphate buffer (0.1 M; pH 2.50) (225:775 v/v) as mobile phase. Column effluents were monitored at 206 nm for clindamycin. The calibration curves in concentration ranges from 200 to 1800 μg/ml were established for the investigated clindamycins. The HPLC method was applied for the determination of clindamycin in pharmaceutical formulations. The obtained results and statistical parameters for both the investigated clindamycins in pharmaceutical formulations, were satisfactory and ranged from 99.99% to 104.18% (R.S.D. was ranged from 0.79% to 0.99%).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations",
volume = "62",
number = "2",
pages = "177-181",
url = "https://hdl.handle.net/21.15107/rcub_farfar_166"
}

Vladimirov, S., Marković, L., Agbaba, D., Živanov-Stakić, D.,& Brborić, J.. (1997). High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 62(2), 177-181.
https://hdl.handle.net/21.15107/rcub_farfar_166

Vladimirov S, Marković L, Agbaba D, Živanov-Stakić D, Brborić J. High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations. in Journal of the Serbian Chemical Society. 1997;62(2):177-181.
https://hdl.handle.net/21.15107/rcub_farfar_166 .

Vladimirov, S, Marković, L, Agbaba, Danica, Živanov-Stakić, Dobrila, Brborić, Jasmina, "High performance liquid chromatographic determination of clindamycin in pharmaceutical formulations" in Journal of the Serbian Chemical Society, 62, no. 2 (1997):177-181,
https://hdl.handle.net/21.15107/rcub_farfar_166 .