TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Stanojković, Tatjana
AU  - Srdić-Rajić, Tatjana
AU  - Dilber, Sanda
AU  - Đorđević, Brižita
AU  - Stanković, Ivan
AU  - Juranić, Zorica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2671
AB  - Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention. Biologically active compounds of different Brassicaceae species with antitumor potential are isothiocyanates, present in the form of their precursors - glucosinolates. The aim of this study was to determine the selectivity of antiproliferative action of dietary isothiocyanates for malignant versus normal cells. Methods. Antiproliferative activity of three isothiocyanates abundant in human diet: sulforaphane, benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate, on human cervix carcinoma cell line - HeLa, melanoma cell line - Fem-x, and colon cancer cell line - LS 174, and on peripheral blood mononuclear cells (PBMC), with or without mitogen, were determined by MTT colorimetric assay 72 h after their continuous action. Results. All investigated isothiocyanates inhibited the proliferation of HeLa, Fem-x and LS 174 cells. On all cell lines treated, BITC was the most potent inhibitor of cell proliferation with half-maximum inhibitory concentration (IC50) values of 5.04 mmoL m-3 on HeLa cells, 2.76 mmol m-3 on Fem-x, and 14.30 mmol m-3 on LS 174 cells. Antiproliferative effects on human PBMC were with higher IC50 than on malignant cells. Indexes of selectivity, calculated as a ratio between IC50 values obtained on PBMC and malignant cells, were between 1.12 and 16.57, with the highest values obtained for the action of BITC on melanoma Fem-x cells. Conclusion. Based on its antiproliferative effects on malignant cells, as well as the selectivity of the action to malignant vs normal cells, benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. In general, the safety of investigated compounds, in addition to their antitumor potential, should be considered as an important criterion in cancer chemoprevention. Screening of selectivity is a plausible approach to the evaluation of safety of both natural isothiocyanates and synthesised analogues of these bioactive compounds.
AB  - Uvod/Cilj. Brojne epidemiološke studije pokazale su povoljne efekte konzumiranja povrća iz familije kupusnjača (Brassicaceae) u hemioprevenciji karcinoma. Osnovni biološki aktivni sastojci ovog povrća su izotiocijanati, prisutni u obliku prekursora - glukozinolata. Cilj ovog rada bio je određivanje selektivnosti antiproliferativnog delovanja dijetetskih izotiocijanata na maligne ćelije u odnosu na normalne ćelije. Metode. Antiproliferativna aktivnost tri izotiocijanata zastupljena u ljudskoj ishrani: sulforafana (SFN), benzil-izotiocijanata (BITC) i feniletil-izotiocijanata (FEITC) na humane maligne ćelijske linije, HeLa, ćelijsku liniju karcinoma grlića materice, Fem-x, ćelijsku liniju melanoma, i LS 174, ćelijsku liniju karcinoma kolona, kao i na mononuklearne ćelije periferne krvi (MNĆPK), sa ili bez delovanja mitogena, određivana je MTT kalorimetrijskim testom, 72 h nakon kontinuiranog delovanja agenasa. Rezultati. Svi ispitivani izotiocijanati inhibirali su proliferaciju HeLa, Fem-x i LS 174 ćelija. Na svim ćelijskim linijama BITC je pokazao najizraženije delovanje sa vrednostima polumaksimalne inhibitorne koncentracije (IC50) od 5.04 mmol m-3 na HeLa ćelijama, 2,76 mmoL m-3 na Fem-x i 14,30 mmol m-3 na LS 174 ćelijama. Svi ispitivani izotiocijanati pokazali su citotoksično delovanje na MNĆPK, ali sa višim IC50 vrednostima u odnosu na maligne ćelije. Indeksi selektivnosti antitumorkog delovanja, izraženi kao odnos IC50 vrednosti dobijenih na MNĆPK i malignim ćelijama, bili su između 1,12 i 16,57, sa najvišom vrednosti pri delovanju BITC na Fem-x ćelije. Zaključak. Na osnovu antiproliferativne aktivnosti na maligne ćelije i selektivnosti antiproliferativnog delovanja na maligne u odnosu na normalne ćelije, benzil izotiocijanat se ističe kao perspektivni agens u hemioprevenciji karcinoma. Generalno, pored antitumorskog delovanja, bezbednost primene ovih jedinjenja treba da predstavlja važan kriterijum u izboru odgovarajućih izotiocijanata za primenu u primarnoj, sekundarnoj i tercijarnoj hemioprevenciji kancera. Ispitivanje selektivnosti predstavlja pogodan pristup oceni bezbednosti i prirodnih izotiocijanata i sintetskih analoga.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells
T1  - In vitro ispitivanje selektivnosti antiproliferativnog dejstva dijetetskih izotiocijanata na tumorske u odnosu na normalne humane ćelije
VL  - 73
IS  - 7
SP  - 636
EP  - 642
DO  - 10.2298/VSP141103066K
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Stanojković, Tatjana and Srdić-Rajić, Tatjana and Dilber, Sanda and Đorđević, Brižita and Stanković, Ivan and Juranić, Zorica",
year = "2016",
abstract = "Background/Aim. Numerous epidemiological studies have shown beneficial effects of cruciferous vegetables consumption in cancer chemoprevention. Biologically active compounds of different Brassicaceae species with antitumor potential are isothiocyanates, present in the form of their precursors - glucosinolates. The aim of this study was to determine the selectivity of antiproliferative action of dietary isothiocyanates for malignant versus normal cells. Methods. Antiproliferative activity of three isothiocyanates abundant in human diet: sulforaphane, benzyl isothiocyanate (BITC) and phenylethyl isothiocyanate, on human cervix carcinoma cell line - HeLa, melanoma cell line - Fem-x, and colon cancer cell line - LS 174, and on peripheral blood mononuclear cells (PBMC), with or without mitogen, were determined by MTT colorimetric assay 72 h after their continuous action. Results. All investigated isothiocyanates inhibited the proliferation of HeLa, Fem-x and LS 174 cells. On all cell lines treated, BITC was the most potent inhibitor of cell proliferation with half-maximum inhibitory concentration (IC50) values of 5.04 mmoL m-3 on HeLa cells, 2.76 mmol m-3 on Fem-x, and 14.30 mmol m-3 on LS 174 cells. Antiproliferative effects on human PBMC were with higher IC50 than on malignant cells. Indexes of selectivity, calculated as a ratio between IC50 values obtained on PBMC and malignant cells, were between 1.12 and 16.57, with the highest values obtained for the action of BITC on melanoma Fem-x cells. Conclusion. Based on its antiproliferative effects on malignant cells, as well as the selectivity of the action to malignant vs normal cells, benzyl isothiocyanate can be considered as a promising candidate in cancer chemoprevention. In general, the safety of investigated compounds, in addition to their antitumor potential, should be considered as an important criterion in cancer chemoprevention. Screening of selectivity is a plausible approach to the evaluation of safety of both natural isothiocyanates and synthesised analogues of these bioactive compounds., Uvod/Cilj. Brojne epidemiološke studije pokazale su povoljne efekte konzumiranja povrća iz familije kupusnjača (Brassicaceae) u hemioprevenciji karcinoma. Osnovni biološki aktivni sastojci ovog povrća su izotiocijanati, prisutni u obliku prekursora - glukozinolata. Cilj ovog rada bio je određivanje selektivnosti antiproliferativnog delovanja dijetetskih izotiocijanata na maligne ćelije u odnosu na normalne ćelije. Metode. Antiproliferativna aktivnost tri izotiocijanata zastupljena u ljudskoj ishrani: sulforafana (SFN), benzil-izotiocijanata (BITC) i feniletil-izotiocijanata (FEITC) na humane maligne ćelijske linije, HeLa, ćelijsku liniju karcinoma grlića materice, Fem-x, ćelijsku liniju melanoma, i LS 174, ćelijsku liniju karcinoma kolona, kao i na mononuklearne ćelije periferne krvi (MNĆPK), sa ili bez delovanja mitogena, određivana je MTT kalorimetrijskim testom, 72 h nakon kontinuiranog delovanja agenasa. Rezultati. Svi ispitivani izotiocijanati inhibirali su proliferaciju HeLa, Fem-x i LS 174 ćelija. Na svim ćelijskim linijama BITC je pokazao najizraženije delovanje sa vrednostima polumaksimalne inhibitorne koncentracije (IC50) od 5.04 mmol m-3 na HeLa ćelijama, 2,76 mmoL m-3 na Fem-x i 14,30 mmol m-3 na LS 174 ćelijama. Svi ispitivani izotiocijanati pokazali su citotoksično delovanje na MNĆPK, ali sa višim IC50 vrednostima u odnosu na maligne ćelije. Indeksi selektivnosti antitumorkog delovanja, izraženi kao odnos IC50 vrednosti dobijenih na MNĆPK i malignim ćelijama, bili su između 1,12 i 16,57, sa najvišom vrednosti pri delovanju BITC na Fem-x ćelije. Zaključak. Na osnovu antiproliferativne aktivnosti na maligne ćelije i selektivnosti antiproliferativnog delovanja na maligne u odnosu na normalne ćelije, benzil izotiocijanat se ističe kao perspektivni agens u hemioprevenciji karcinoma. Generalno, pored antitumorskog delovanja, bezbednost primene ovih jedinjenja treba da predstavlja važan kriterijum u izboru odgovarajućih izotiocijanata za primenu u primarnoj, sekundarnoj i tercijarnoj hemioprevenciji kancera. Ispitivanje selektivnosti predstavlja pogodan pristup oceni bezbednosti i prirodnih izotiocijanata i sintetskih analoga.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells, In vitro ispitivanje selektivnosti antiproliferativnog dejstva dijetetskih izotiocijanata na tumorske u odnosu na normalne humane ćelije",
volume = "73",
number = "7",
pages = "636-642",
doi = "10.2298/VSP141103066K"
}

Konić-Ristić, A., Stanojković, T., Srdić-Rajić, T., Dilber, S., Đorđević, B., Stanković, I.,& Juranić, Z.. (2016). In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(7), 636-642.
https://doi.org/10.2298/VSP141103066K

Konić-Ristić A, Stanojković T, Srdić-Rajić T, Dilber S, Đorđević B, Stanković I, Juranić Z. In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells. in Vojnosanitetski pregled. 2016;73(7):636-642.
doi:10.2298/VSP141103066K .

Konić-Ristić, Aleksandra, Stanojković, Tatjana, Srdić-Rajić, Tatjana, Dilber, Sanda, Đorđević, Brižita, Stanković, Ivan, Juranić, Zorica, "In vitro assessment of antiproliferative action selectivity of dietary isothiocyanates for tumor versus normal human cells" in Vojnosanitetski pregled, 73, no. 7 (2016):636-642,
https://doi.org/10.2298/VSP141103066K . .

TY  - JOUR
AU  - Damjanović, Ana B.
AU  - Matić, Ivana Z.
AU  - Dordić, Marija
AU  - Nikolić-Durović, Marina
AU  - Nikolić, Srdan
AU  - Roki, Ksenija
AU  - Milovanović, Zorka
AU  - Antić-Stanković, Jelena
AU  - Dzodić, Radan
AU  - Damjanović, Svetozar S.
AU  - Kanjer, Ksenija
AU  - Abu Rabi, Zaki
AU  - Juranić, Zorica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2457
AB  - The aim of research was to determine the effects of maximally therapeutically achievable concentrations of metformin on malignant cells and healthy peripheral blood mononuclear cells (PBMC). Eight patients with T2D or hyperglycemia and nine healthy volunteers were included in the study. For determination of the influence of metformin on the phenotype of breast carcinoma, 1,410 patients with surgically removed tumors were included. From this group 37 breast cancer patients had DM type 2 or hyperglycemia and were pretreated with metformin alone or sometimes in combination with other antidiabetic drugs. Our results proved that metformin at low concentrations induced mild decrease in survival of malignant cells and PBMC stimulated for proliferation, but it didn't affect survival of resting PBMC. The effects of plasma of hyperglycemic patients who were under metformin therapy on autologous PBMC-induced decrease in survival of MDA-MB-361 cells, was noticeable in some patients. Metformin pretreatment for 24 h of HER2+ MDA-MB-361 cells, which were subsequently treated for 48 h with Herceptin, induced additional decline in cell survival. The analysis of influence of metformin on phenotype of breast cancer cells revealed significantly lower number of diabetic cancer patients treated with metformin with overexpressed HER2+ tumors (p  lt  0.013), while the number of patients with ER+PR+ tumors was not significantly changed (p  lt  0.832). In conclusion, therapeutically used concentrations of metformin exhibit mild cytotoxic action on malignant and dividing normal cells pointing to its preferred role in malignant and autoimmune diseases. The use of metformin was associated with pronounced decrease in HER2 overexpressing tumors.
PB  - Springer, Dordrecht
T2  - Pathology & Oncology Research
T1  - Metformin Effects on Malignant Cells and Healthy PBMC; The Influence of Metformin on the Phenotype of Breast Cancer Cells
VL  - 21
IS  - 3
SP  - 605
EP  - 612
DO  - 10.1007/s12253-014-9864-9
ER  - 

@article{
author = "Damjanović, Ana B. and Matić, Ivana Z. and Dordić, Marija and Nikolić-Durović, Marina and Nikolić, Srdan and Roki, Ksenija and Milovanović, Zorka and Antić-Stanković, Jelena and Dzodić, Radan and Damjanović, Svetozar S. and Kanjer, Ksenija and Abu Rabi, Zaki and Juranić, Zorica",
year = "2015",
abstract = "The aim of research was to determine the effects of maximally therapeutically achievable concentrations of metformin on malignant cells and healthy peripheral blood mononuclear cells (PBMC). Eight patients with T2D or hyperglycemia and nine healthy volunteers were included in the study. For determination of the influence of metformin on the phenotype of breast carcinoma, 1,410 patients with surgically removed tumors were included. From this group 37 breast cancer patients had DM type 2 or hyperglycemia and were pretreated with metformin alone or sometimes in combination with other antidiabetic drugs. Our results proved that metformin at low concentrations induced mild decrease in survival of malignant cells and PBMC stimulated for proliferation, but it didn't affect survival of resting PBMC. The effects of plasma of hyperglycemic patients who were under metformin therapy on autologous PBMC-induced decrease in survival of MDA-MB-361 cells, was noticeable in some patients. Metformin pretreatment for 24 h of HER2+ MDA-MB-361 cells, which were subsequently treated for 48 h with Herceptin, induced additional decline in cell survival. The analysis of influence of metformin on phenotype of breast cancer cells revealed significantly lower number of diabetic cancer patients treated with metformin with overexpressed HER2+ tumors (p  lt  0.013), while the number of patients with ER+PR+ tumors was not significantly changed (p  lt  0.832). In conclusion, therapeutically used concentrations of metformin exhibit mild cytotoxic action on malignant and dividing normal cells pointing to its preferred role in malignant and autoimmune diseases. The use of metformin was associated with pronounced decrease in HER2 overexpressing tumors.",
publisher = "Springer, Dordrecht",
journal = "Pathology & Oncology Research",
title = "Metformin Effects on Malignant Cells and Healthy PBMC; The Influence of Metformin on the Phenotype of Breast Cancer Cells",
volume = "21",
number = "3",
pages = "605-612",
doi = "10.1007/s12253-014-9864-9"
}

Damjanović, A. B., Matić, I. Z., Dordić, M., Nikolić-Durović, M., Nikolić, S., Roki, K., Milovanović, Z., Antić-Stanković, J., Dzodić, R., Damjanović, S. S., Kanjer, K., Abu Rabi, Z.,& Juranić, Z.. (2015). Metformin Effects on Malignant Cells and Healthy PBMC; The Influence of Metformin on the Phenotype of Breast Cancer Cells. in Pathology & Oncology Research
Springer, Dordrecht., 21(3), 605-612.
https://doi.org/10.1007/s12253-014-9864-9

Damjanović AB, Matić IZ, Dordić M, Nikolić-Durović M, Nikolić S, Roki K, Milovanović Z, Antić-Stanković J, Dzodić R, Damjanović SS, Kanjer K, Abu Rabi Z, Juranić Z. Metformin Effects on Malignant Cells and Healthy PBMC; The Influence of Metformin on the Phenotype of Breast Cancer Cells. in Pathology & Oncology Research. 2015;21(3):605-612.
doi:10.1007/s12253-014-9864-9 .

Damjanović, Ana B., Matić, Ivana Z., Dordić, Marija, Nikolić-Durović, Marina, Nikolić, Srdan, Roki, Ksenija, Milovanović, Zorka, Antić-Stanković, Jelena, Dzodić, Radan, Damjanović, Svetozar S., Kanjer, Ksenija, Abu Rabi, Zaki, Juranić, Zorica, "Metformin Effects on Malignant Cells and Healthy PBMC; The Influence of Metformin on the Phenotype of Breast Cancer Cells" in Pathology & Oncology Research, 21, no. 3 (2015):605-612,
https://doi.org/10.1007/s12253-014-9864-9 . .

TY  - JOUR
AU  - Sova, Matej
AU  - Žižak, Željko
AU  - Antić-Stanković, Jelena
AU  - Prijatelj, Matevz
AU  - Turk, Samo
AU  - Juranić, Zorica
AU  - Mlinarić-Rascan, Irena
AU  - Gobec, Stanislav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1962
AB  - Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Medicinal Chemistry
T1  - Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines
VL  - 9
IS  - 5
SP  - 633
EP  - 641
DO  - 10.2174/1573406411309050002
ER  - 

@article{
author = "Sova, Matej and Žižak, Željko and Antić-Stanković, Jelena and Prijatelj, Matevz and Turk, Samo and Juranić, Zorica and Mlinarić-Rascan, Irena and Gobec, Stanislav",
year = "2013",
abstract = "Cinnamic acid derivatives can be found in plant material, and they possess a remarkable variety of biological effects. In the present study, we have investigated the cytotoxic effects of representative cinnamic acid esters and amides. The cytotoxicity was determined by MTT test on human cervix adenocarcinoma (HeLa), myelogenous leukemia (K562), malignant melanoma (Fem-x), and estrogen-receptor-positive breast cancer (MCF-7) cells, versus peripheral blood mononuclear cells (PBMCs) without or with the addition of the plant lectin phytohemaglutinin (PHA). The compounds tested showed significant cytotoxicity (IC(50)s between 42 and 166 mu M) and furthermore selectivity of these cytotoxic effects on the malignant cell lines versus the PBMCs was also seen, especially when electron-withdrawing groups, such as a cyano group (compound 5), were present on the aromatic rings of the alcohol or amine parts of the cinnamic acid derivatives. The additional study on cell cycle phase distribution indicated that novel cinnamic acid derivatives inhibit cell growth by induction of cell death. Thus, cinnamic acids derivatives represent important lead compounds for further development of antineoplastic agents.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Medicinal Chemistry",
title = "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines",
volume = "9",
number = "5",
pages = "633-641",
doi = "10.2174/1573406411309050002"
}

Sova, M., Žižak, Ž., Antić-Stanković, J., Prijatelj, M., Turk, S., Juranić, Z., Mlinarić-Rascan, I.,& Gobec, S.. (2013). Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 9(5), 633-641.
https://doi.org/10.2174/1573406411309050002

Sova M, Žižak Ž, Antić-Stanković J, Prijatelj M, Turk S, Juranić Z, Mlinarić-Rascan I, Gobec S. Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines. in Medicinal Chemistry. 2013;9(5):633-641.
doi:10.2174/1573406411309050002 .

Sova, Matej, Žižak, Željko, Antić-Stanković, Jelena, Prijatelj, Matevz, Turk, Samo, Juranić, Zorica, Mlinarić-Rascan, Irena, Gobec, Stanislav, "Cinnamic Acid Derivatives Induce Cell Cycle Arrest in Carcinoma Cell Lines" in Medicinal Chemistry, 9, no. 5 (2013):633-641,
https://doi.org/10.2174/1573406411309050002 . .

TY  - JOUR
AU  - Erić, Slavica
AU  - Ke, Song
AU  - Barata, Teresa
AU  - Solmajer, Tom
AU  - Antić-Stanković, Jelena
AU  - Juranić, Zorica
AU  - Savić, Vladimir
AU  - Zloh, Mire
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1727
AB  - A set of 16 previously synthesized aryl-aminopyridine and aryl-aminoquinoline derivatives have been evaluated for cytotoxic activity against three cancer cell lines (human cervical cancer-HeLa; human chronic myeloid leukemia-K562; human melanoma-Fem-x) and two types of normal peripheral blood mononuclear cells, with and without phytohemaglutinin (PBMC - PHA; PBMC + PHA). Twelve of the studied compounds showed moderate cytotoxicity, with selectivity against K562 but not the remaining two cancer cell lines. Four compounds were not active in cytotoxicity assays, presumably due to high predicted lipophilicity and low solubility. To rationalize the observed cytotoxic effects, structure-based virtual screening was carried out against a pool of potential targets constructed using the inverse docking program Tarfisdock and bibliographical references. The putative targets were identified on the basis of the best correlation between docking scores and in vitro cytotoxicity. It is proposed that the mechanism of action of the studied aminopyridines involves the disruption of signaling pathways and cancer cell cycle through the inhibition of cyclin-dependent kinases and several tyrosine kinases, namely Bcr-Abl kinase and KIT receptor kinase. The obtained results can guide further structural modifications of the studied compounds aimed at developing selective agents targeting proteins involved in cancer cell survival and proliferation.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic & Medicinal Chemistry
T1  - Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity
VL  - 20
IS  - 17
SP  - 5220
EP  - 5228
DO  - 10.1016/j.bmc.2012.06.051
ER  - 

@article{
author = "Erić, Slavica and Ke, Song and Barata, Teresa and Solmajer, Tom and Antić-Stanković, Jelena and Juranić, Zorica and Savić, Vladimir and Zloh, Mire",
year = "2012",
abstract = "A set of 16 previously synthesized aryl-aminopyridine and aryl-aminoquinoline derivatives have been evaluated for cytotoxic activity against three cancer cell lines (human cervical cancer-HeLa; human chronic myeloid leukemia-K562; human melanoma-Fem-x) and two types of normal peripheral blood mononuclear cells, with and without phytohemaglutinin (PBMC - PHA; PBMC + PHA). Twelve of the studied compounds showed moderate cytotoxicity, with selectivity against K562 but not the remaining two cancer cell lines. Four compounds were not active in cytotoxicity assays, presumably due to high predicted lipophilicity and low solubility. To rationalize the observed cytotoxic effects, structure-based virtual screening was carried out against a pool of potential targets constructed using the inverse docking program Tarfisdock and bibliographical references. The putative targets were identified on the basis of the best correlation between docking scores and in vitro cytotoxicity. It is proposed that the mechanism of action of the studied aminopyridines involves the disruption of signaling pathways and cancer cell cycle through the inhibition of cyclin-dependent kinases and several tyrosine kinases, namely Bcr-Abl kinase and KIT receptor kinase. The obtained results can guide further structural modifications of the studied compounds aimed at developing selective agents targeting proteins involved in cancer cell survival and proliferation.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic & Medicinal Chemistry",
title = "Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity",
volume = "20",
number = "17",
pages = "5220-5228",
doi = "10.1016/j.bmc.2012.06.051"
}

Erić, S., Ke, S., Barata, T., Solmajer, T., Antić-Stanković, J., Juranić, Z., Savić, V.,& Zloh, M.. (2012). Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity. in Bioorganic & Medicinal Chemistry
Pergamon-Elsevier Science Ltd, Oxford., 20(17), 5220-5228.
https://doi.org/10.1016/j.bmc.2012.06.051

Erić S, Ke S, Barata T, Solmajer T, Antić-Stanković J, Juranić Z, Savić V, Zloh M. Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity. in Bioorganic & Medicinal Chemistry. 2012;20(17):5220-5228.
doi:10.1016/j.bmc.2012.06.051 .

Erić, Slavica, Ke, Song, Barata, Teresa, Solmajer, Tom, Antić-Stanković, Jelena, Juranić, Zorica, Savić, Vladimir, Zloh, Mire, "Target fishing and docking studies of the novel derivatives of aryl-aminopyridines with potential anticancer activity" in Bioorganic & Medicinal Chemistry, 20, no. 17 (2012):5220-5228,
https://doi.org/10.1016/j.bmc.2012.06.051 . .

TY  - JOUR
AU  - Marković, Violeta
AU  - Erić, Slavica
AU  - Juranić, Zorica
AU  - Stanojković, Tatjana
AU  - Joksović, Ljubinka
AU  - Ranković, Branislav
AU  - Kosanić, Marijana
AU  - Joksović, Milan D.
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1500
AB  - A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
VL  - 39
IS  - 1-3
SP  - 18
EP  - 27
DO  - 10.1016/j.bioorg.2010.10.003
ER  - 

@article{
author = "Marković, Violeta and Erić, Slavica and Juranić, Zorica and Stanojković, Tatjana and Joksović, Ljubinka and Ranković, Branislav and Kosanić, Marijana and Joksović, Milan D.",
year = "2011",
abstract = "A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone",
volume = "39",
number = "1-3",
pages = "18-27",
doi = "10.1016/j.bioorg.2010.10.003"
}

Marković, V., Erić, S., Juranić, Z., Stanojković, T., Joksović, L., Ranković, B., Kosanić, M.,& Joksović, M. D.. (2011). Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 39(1-3), 18-27.
https://doi.org/10.1016/j.bioorg.2010.10.003

Marković V, Erić S, Juranić Z, Stanojković T, Joksović L, Ranković B, Kosanić M, Joksović MD. Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone. in Bioorganic Chemistry. 2011;39(1-3):18-27.
doi:10.1016/j.bioorg.2010.10.003 .

Marković, Violeta, Erić, Slavica, Juranić, Zorica, Stanojković, Tatjana, Joksović, Ljubinka, Ranković, Branislav, Kosanić, Marijana, Joksović, Milan D., "Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone" in Bioorganic Chemistry, 39, no. 1-3 (2011):18-27,
https://doi.org/10.1016/j.bioorg.2010.10.003 . .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Šavikin, Katarina
AU  - Zdunić, Gordana
AU  - Janković, Teodora
AU  - Juranić, Zorica
AU  - Menković, Nebojša
AU  - Stanković, Ivan
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1497
AB  - Total phenolics total anthocyanins mineral content radical scavenging activity and antiproliferative activity against human cancer cell lines were evaluated in fresh pressed juices of five different berries Total phenolic content ranged from 133 0 to 260 3 mg of gallic acid equivalents/100 g of fresh weight for red currant and black currant respectively Bilberry Juice contained the highest amount of total anthocyanins (0 18%) Significant correlation between total phenolics content and radical scavenging activity was observed (r = -0980 p  lt  0 01) All examined juices showed antiproliferative activity in dose-dependent manner with IC50 ranging from 10 2 to 70 5 mu l/ml Black currant juice was the most effective inhibitor of proliferation in all cell lines tested (HeLa Fem X LS 174 MCF-7 and PC-3) Significant correlations of acidity and total anthocyanin content with antiproliferative activity of berry juices on HeLa cells Fem X cells and MCF-7 cells were noticed Berry juices are good sources of some minerals and contribute significantly to daily intake of these micronutrients
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Biological activity and chemical composition of different berry juices
VL  - 125
IS  - 4
SP  - 1412
EP  - 1417
DO  - 10.1016/j.foodchem.2010.10.018
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Šavikin, Katarina and Zdunić, Gordana and Janković, Teodora and Juranić, Zorica and Menković, Nebojša and Stanković, Ivan",
year = "2011",
abstract = "Total phenolics total anthocyanins mineral content radical scavenging activity and antiproliferative activity against human cancer cell lines were evaluated in fresh pressed juices of five different berries Total phenolic content ranged from 133 0 to 260 3 mg of gallic acid equivalents/100 g of fresh weight for red currant and black currant respectively Bilberry Juice contained the highest amount of total anthocyanins (0 18%) Significant correlation between total phenolics content and radical scavenging activity was observed (r = -0980 p  lt  0 01) All examined juices showed antiproliferative activity in dose-dependent manner with IC50 ranging from 10 2 to 70 5 mu l/ml Black currant juice was the most effective inhibitor of proliferation in all cell lines tested (HeLa Fem X LS 174 MCF-7 and PC-3) Significant correlations of acidity and total anthocyanin content with antiproliferative activity of berry juices on HeLa cells Fem X cells and MCF-7 cells were noticed Berry juices are good sources of some minerals and contribute significantly to daily intake of these micronutrients",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Biological activity and chemical composition of different berry juices",
volume = "125",
number = "4",
pages = "1412-1417",
doi = "10.1016/j.foodchem.2010.10.018"
}

Konić-Ristić, A., Šavikin, K., Zdunić, G., Janković, T., Juranić, Z., Menković, N.,& Stanković, I.. (2011). Biological activity and chemical composition of different berry juices. in Food Chemistry
Elsevier Sci Ltd, Oxford., 125(4), 1412-1417.
https://doi.org/10.1016/j.foodchem.2010.10.018

Konić-Ristić A, Šavikin K, Zdunić G, Janković T, Juranić Z, Menković N, Stanković I. Biological activity and chemical composition of different berry juices. in Food Chemistry. 2011;125(4):1412-1417.
doi:10.1016/j.foodchem.2010.10.018 .

Konić-Ristić, Aleksandra, Šavikin, Katarina, Zdunić, Gordana, Janković, Teodora, Juranić, Zorica, Menković, Nebojša, Stanković, Ivan, "Biological activity and chemical composition of different berry juices" in Food Chemistry, 125, no. 4 (2011):1412-1417,
https://doi.org/10.1016/j.foodchem.2010.10.018 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Milenković, Marina
AU  - Topić, Aleksandra
AU  - Stanojković, Tatjana
AU  - Juranić, Zorica
AU  - Lakušić, Branislava
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1489
AB  - Cytotoxicity and antimicrobial activity of cyclohexane, dichlormethane and methanol extracts of Teucrium scordium subspec. scordioides was studied. Cyclohexane and dichlormethane extracts of T. scordium possessed high citotoxicity against MDA-MB-361 cells (IC(50)=130.33+/-0.1 mu g/ml and IC(50)=189.89+/-3.99 mu g/ml, respectively). Dichlormethane extract was more effective against MDA-MB-453 cell line (IC(50)=130.33 +/- 0.1 mu g/ml). The methanol extract of T. scordium possessed no cytotoxicity against breast cancer cell lines, MDA-MB-361 and MDA-MB-453. Herb extracts of T. scordium have shown weak antibacterial activity on Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Bacillus subtilis with no activity against Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, and Candida albicans.
PB  - Academic Journals, Victoria Island
T2  - African Journal of Microbiology Research
T1  - Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts
VL  - 5
IS  - 19
SP  - 2950
EP  - 2954
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1489
ER  - 

@article{
author = "Kundaković, Tatjana and Milenković, Marina and Topić, Aleksandra and Stanojković, Tatjana and Juranić, Zorica and Lakušić, Branislava",
year = "2011",
abstract = "Cytotoxicity and antimicrobial activity of cyclohexane, dichlormethane and methanol extracts of Teucrium scordium subspec. scordioides was studied. Cyclohexane and dichlormethane extracts of T. scordium possessed high citotoxicity against MDA-MB-361 cells (IC(50)=130.33+/-0.1 mu g/ml and IC(50)=189.89+/-3.99 mu g/ml, respectively). Dichlormethane extract was more effective against MDA-MB-453 cell line (IC(50)=130.33 +/- 0.1 mu g/ml). The methanol extract of T. scordium possessed no cytotoxicity against breast cancer cell lines, MDA-MB-361 and MDA-MB-453. Herb extracts of T. scordium have shown weak antibacterial activity on Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Bacillus subtilis with no activity against Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, and Candida albicans.",
publisher = "Academic Journals, Victoria Island",
journal = "African Journal of Microbiology Research",
title = "Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts",
volume = "5",
number = "19",
pages = "2950-2954",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1489"
}

Kundaković, T., Milenković, M., Topić, A., Stanojković, T., Juranić, Z.,& Lakušić, B.. (2011). Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts. in African Journal of Microbiology Research
Academic Journals, Victoria Island., 5(19), 2950-2954.
https://hdl.handle.net/21.15107/rcub_farfar_1489

Kundaković T, Milenković M, Topić A, Stanojković T, Juranić Z, Lakušić B. Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts. in African Journal of Microbiology Research. 2011;5(19):2950-2954.
https://hdl.handle.net/21.15107/rcub_farfar_1489 .

Kundaković, Tatjana, Milenković, Marina, Topić, Aleksandra, Stanojković, Tatjana, Juranić, Zorica, Lakušić, Branislava, "Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts" in African Journal of Microbiology Research, 5, no. 19 (2011):2950-2954,
https://hdl.handle.net/21.15107/rcub_farfar_1489 .

TY  - CONF
AU  - Stanojković, Tatjana
AU  - Kovala-Demertzi, D.
AU  - Primikiri, A.
AU  - Demertzis, M.
AU  - Antić-Stanković, Jelena
AU  - Juranić, Zorica
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1340
PB  - Pergamon-Elsevier Science Ltd, Oxford
C3  - European Journal of Cancer Supplements
T1  - Synthesis and biological properties of some new thiosemicarbazones
VL  - 8
IS  - 5
SP  - 145
EP  - 145
DO  - 10.1016/S1359-6349(10)71369-0
ER  - 

@conference{
author = "Stanojković, Tatjana and Kovala-Demertzi, D. and Primikiri, A. and Demertzis, M. and Antić-Stanković, Jelena and Juranić, Zorica",
year = "2010",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Journal of Cancer Supplements",
title = "Synthesis and biological properties of some new thiosemicarbazones",
volume = "8",
number = "5",
pages = "145-145",
doi = "10.1016/S1359-6349(10)71369-0"
}

Stanojković, T., Kovala-Demertzi, D., Primikiri, A., Demertzis, M., Antić-Stanković, J.,& Juranić, Z.. (2010). Synthesis and biological properties of some new thiosemicarbazones. in European Journal of Cancer Supplements
Pergamon-Elsevier Science Ltd, Oxford., 8(5), 145-145.
https://doi.org/10.1016/S1359-6349(10)71369-0

Stanojković T, Kovala-Demertzi D, Primikiri A, Demertzis M, Antić-Stanković J, Juranić Z. Synthesis and biological properties of some new thiosemicarbazones. in European Journal of Cancer Supplements. 2010;8(5):145-145.
doi:10.1016/S1359-6349(10)71369-0 .

Stanojković, Tatjana, Kovala-Demertzi, D., Primikiri, A., Demertzis, M., Antić-Stanković, Jelena, Juranić, Zorica, "Synthesis and biological properties of some new thiosemicarbazones" in European Journal of Cancer Supplements, 8, no. 5 (2010):145-145,
https://doi.org/10.1016/S1359-6349(10)71369-0 . .

TY  - JOUR
AU  - Konić-Ristić, Aleksandra
AU  - Dodig, Dejan
AU  - Krstić, Radmilo
AU  - Jelić, Svetislav
AU  - Stanković, Ivan
AU  - Ninković, Aleksandra
AU  - Radić, Jelena
AU  - Besu, Irina
AU  - Bonaci-Nikolić, Branka
AU  - Jojić, Njegica
AU  - Đorđević, Milica
AU  - Popović, Dragan
AU  - Juranić, Zorica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1238
AB  - Background: Immunity to food antigens (gliadin, cow's milk proteins) is in the centre of the attention of modern medicine focused on the prevention of diseases, prevention which is based on the use of appropriate restriction diet. Detection of the enhanced levels of the immune reactions to antigen(s) present in food is from this point of view of great importance because there are reports that some of health disturbances, like celiac disease (CD) and some premalignant conditions, like monoclonal gammopathy of undetermined significance (MGUS), were vanished after the appropriate restriction diets. It is well known that gliadin is toxic to small bowel mucosa of relatively small population of genetically predisposed individuals, who under this toxic action develop celiac disease (CD). As the quantity of immunogenic gliadin could vary between different wheat species, the first aim of this work was to determine the percentage of immunogenic gliadin in ten bread wheat cultivars and in three commercially grown durum wheat cultivars. The second part of the study was initiated by results of previous publication, reporting that sera of some of multiple myeloma (MM) patients showed the presence of elevated levels of anti-gliadin IgA, without the enhanced levels of anti-gliadin IgG antibodies, determined with commercial ELISA test. It was designed to assess is it possible to reveal is there any hidden, especially anti-gliadin IgG immunoreactivity, in serum of mentioned group of patients. For this purpose we tested MM patients sera, as well as celiac disease (CD) patients sera for the immunoreaction with the native gliadin isolated from wheat species used for bread and pasta making in corresponding geographic region. Results: Gliadin was isolated from wheat flour by two step 60% ehanolic extraction. Its content was determined by commercial R5 Mendez Elisa using PWG gliadin as the standard. Results obtained showed that immunogenic gliadin content varies between 50.4 and 65.4 mg/g in bread wheat cultivars and between 20 and 25.6 mg/g in durum wheat cultivars. Anti-gliadin IgA and IgG immunoreactivity of patients' sera in (IU/ml) was firstly determined by commercial diagnostic Binding Site ELISA test, and then additionally by non-commercial ELISA tests, using standardized ethanol wheat extracts-gliadin as the antigen. In both patients groups IgA immunoreactivity to gliadin from different cultivars was almost homogenous and in correlation with results from commercial test (except for one patient with IgA(lambda) myeloma, they were more then five times higher). But, results for IgG immunoreactivity were more frequently inhomogeneous, and especially for few MM patients, they were more then five times higher and did not correlate with results obtained using Binding Site test. Conclusion: Results obtained showed different content of immunogenic gliadin epitopes in various species of wheat. They also point for new effort to elucidate is there a need to develop new standard antigen, the representative mixture of gliadin isolated from local wheat species used for bread production in corresponding geographic region for ELISA diagnostic tests.
PB  - BMC, LONDON
T2  - BMC Immunology
T1  - Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma
VL  - 10
DO  - 10.1186/1471-2172-10-32
ER  - 

@article{
author = "Konić-Ristić, Aleksandra and Dodig, Dejan and Krstić, Radmilo and Jelić, Svetislav and Stanković, Ivan and Ninković, Aleksandra and Radić, Jelena and Besu, Irina and Bonaci-Nikolić, Branka and Jojić, Njegica and Đorđević, Milica and Popović, Dragan and Juranić, Zorica",
year = "2009",
abstract = "Background: Immunity to food antigens (gliadin, cow's milk proteins) is in the centre of the attention of modern medicine focused on the prevention of diseases, prevention which is based on the use of appropriate restriction diet. Detection of the enhanced levels of the immune reactions to antigen(s) present in food is from this point of view of great importance because there are reports that some of health disturbances, like celiac disease (CD) and some premalignant conditions, like monoclonal gammopathy of undetermined significance (MGUS), were vanished after the appropriate restriction diets. It is well known that gliadin is toxic to small bowel mucosa of relatively small population of genetically predisposed individuals, who under this toxic action develop celiac disease (CD). As the quantity of immunogenic gliadin could vary between different wheat species, the first aim of this work was to determine the percentage of immunogenic gliadin in ten bread wheat cultivars and in three commercially grown durum wheat cultivars. The second part of the study was initiated by results of previous publication, reporting that sera of some of multiple myeloma (MM) patients showed the presence of elevated levels of anti-gliadin IgA, without the enhanced levels of anti-gliadin IgG antibodies, determined with commercial ELISA test. It was designed to assess is it possible to reveal is there any hidden, especially anti-gliadin IgG immunoreactivity, in serum of mentioned group of patients. For this purpose we tested MM patients sera, as well as celiac disease (CD) patients sera for the immunoreaction with the native gliadin isolated from wheat species used for bread and pasta making in corresponding geographic region. Results: Gliadin was isolated from wheat flour by two step 60% ehanolic extraction. Its content was determined by commercial R5 Mendez Elisa using PWG gliadin as the standard. Results obtained showed that immunogenic gliadin content varies between 50.4 and 65.4 mg/g in bread wheat cultivars and between 20 and 25.6 mg/g in durum wheat cultivars. Anti-gliadin IgA and IgG immunoreactivity of patients' sera in (IU/ml) was firstly determined by commercial diagnostic Binding Site ELISA test, and then additionally by non-commercial ELISA tests, using standardized ethanol wheat extracts-gliadin as the antigen. In both patients groups IgA immunoreactivity to gliadin from different cultivars was almost homogenous and in correlation with results from commercial test (except for one patient with IgA(lambda) myeloma, they were more then five times higher). But, results for IgG immunoreactivity were more frequently inhomogeneous, and especially for few MM patients, they were more then five times higher and did not correlate with results obtained using Binding Site test. Conclusion: Results obtained showed different content of immunogenic gliadin epitopes in various species of wheat. They also point for new effort to elucidate is there a need to develop new standard antigen, the representative mixture of gliadin isolated from local wheat species used for bread production in corresponding geographic region for ELISA diagnostic tests.",
publisher = "BMC, LONDON",
journal = "BMC Immunology",
title = "Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma",
volume = "10",
doi = "10.1186/1471-2172-10-32"
}

Konić-Ristić, A., Dodig, D., Krstić, R., Jelić, S., Stanković, I., Ninković, A., Radić, J., Besu, I., Bonaci-Nikolić, B., Jojić, N., Đorđević, M., Popović, D.,& Juranić, Z.. (2009). Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma. in BMC Immunology
BMC, LONDON., 10.
https://doi.org/10.1186/1471-2172-10-32

Konić-Ristić A, Dodig D, Krstić R, Jelić S, Stanković I, Ninković A, Radić J, Besu I, Bonaci-Nikolić B, Jojić N, Đorđević M, Popović D, Juranić Z. Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma. in BMC Immunology. 2009;10.
doi:10.1186/1471-2172-10-32 .

Konić-Ristić, Aleksandra, Dodig, Dejan, Krstić, Radmilo, Jelić, Svetislav, Stanković, Ivan, Ninković, Aleksandra, Radić, Jelena, Besu, Irina, Bonaci-Nikolić, Branka, Jojić, Njegica, Đorđević, Milica, Popović, Dragan, Juranić, Zorica, "Different levels of humoral immunoreactivity to different wheat cultivars gliadin are present in patients with celiac disease and in patients with multiple myeloma" in BMC Immunology, 10 (2009),
https://doi.org/10.1186/1471-2172-10-32 . .

TY  - JOUR
AU  - Topić, Aleksandra
AU  - Juranić, Zorica
AU  - Jelic, Svetislav
AU  - Golubicič-Magazinovic, Ivana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1208
AB  - Alpha-1-antitrypsin (AAT) or serine protease inhibitor A1 (SERPINA1) is an important serine protease inhibitor in humans. The main physiological role of AAT is to inhibit neutrophil elastase (NE) released from triggered neutrophils, with an additional lesser role in the defense against damage inflicted by other serine proteases, such as cathepsin G and proteinase 3. Although there is a reported association between AAT polymorphism and different types of cancer, this association with hematological malignancies (HM) is, as yet, unknown. We identified AAT phenotypes by isoelectric focusing (in the pH 4.2-4.9 range) in 151 serum samples from patients with HM (Hodgkins lymphomas, non-Hodgkins lymphomas and malignant monoclonal gammopathies). Healthy blood-donors constituted the control group (n = 272). The evaluated population of patients as well as the control group, were at Hardy-Weinberg equilibrium for the AAT gene (chi(2) = 4.42, d.f. 11, p = 0.96 and chi(2) = 4.71, d.f. 11, p = 0.97, respectively). There was no difference in the frequency of deficient AAT alleles (Pi Z and Pi S) between patients and control. However, we found a significantly higher frequency of PiM1M1 homozygote and PiM1 allele in HM patients than in control (for phenotype: f = 0.5166 and 0.4118 respectively, p = 0.037; for allele: f = 0.7020 and 0.6360 respectively, p = 0.05). In addition, PiM homozygotes in HM-patients were more numerous than in controls (59% and 48%, respectively, p = 0.044). PiM1 alleles and PiM1 homozygotes are both associated with hematological malignancies, although this is considered a functionally normal AAT variant.
PB  - Soc Brasil Genetica, Ribeirao Pret
T2  - Genetics and Molecular Biology
T1  - Polymorphism of alpha-1-antitrypsin in hematological malignancies
VL  - 32
IS  - 4
SP  - 716
EP  - 719
DO  - 10.1590/S1415-47572009005000085
ER  - 

@article{
author = "Topić, Aleksandra and Juranić, Zorica and Jelic, Svetislav and Golubicič-Magazinovic, Ivana",
year = "2009",
abstract = "Alpha-1-antitrypsin (AAT) or serine protease inhibitor A1 (SERPINA1) is an important serine protease inhibitor in humans. The main physiological role of AAT is to inhibit neutrophil elastase (NE) released from triggered neutrophils, with an additional lesser role in the defense against damage inflicted by other serine proteases, such as cathepsin G and proteinase 3. Although there is a reported association between AAT polymorphism and different types of cancer, this association with hematological malignancies (HM) is, as yet, unknown. We identified AAT phenotypes by isoelectric focusing (in the pH 4.2-4.9 range) in 151 serum samples from patients with HM (Hodgkins lymphomas, non-Hodgkins lymphomas and malignant monoclonal gammopathies). Healthy blood-donors constituted the control group (n = 272). The evaluated population of patients as well as the control group, were at Hardy-Weinberg equilibrium for the AAT gene (chi(2) = 4.42, d.f. 11, p = 0.96 and chi(2) = 4.71, d.f. 11, p = 0.97, respectively). There was no difference in the frequency of deficient AAT alleles (Pi Z and Pi S) between patients and control. However, we found a significantly higher frequency of PiM1M1 homozygote and PiM1 allele in HM patients than in control (for phenotype: f = 0.5166 and 0.4118 respectively, p = 0.037; for allele: f = 0.7020 and 0.6360 respectively, p = 0.05). In addition, PiM homozygotes in HM-patients were more numerous than in controls (59% and 48%, respectively, p = 0.044). PiM1 alleles and PiM1 homozygotes are both associated with hematological malignancies, although this is considered a functionally normal AAT variant.",
publisher = "Soc Brasil Genetica, Ribeirao Pret",
journal = "Genetics and Molecular Biology",
title = "Polymorphism of alpha-1-antitrypsin in hematological malignancies",
volume = "32",
number = "4",
pages = "716-719",
doi = "10.1590/S1415-47572009005000085"
}

Topić, A., Juranić, Z., Jelic, S.,& Golubicič-Magazinovic, I.. (2009). Polymorphism of alpha-1-antitrypsin in hematological malignancies. in Genetics and Molecular Biology
Soc Brasil Genetica, Ribeirao Pret., 32(4), 716-719.
https://doi.org/10.1590/S1415-47572009005000085

Topić A, Juranić Z, Jelic S, Golubicič-Magazinovic I. Polymorphism of alpha-1-antitrypsin in hematological malignancies. in Genetics and Molecular Biology. 2009;32(4):716-719.
doi:10.1590/S1415-47572009005000085 .

Topić, Aleksandra, Juranić, Zorica, Jelic, Svetislav, Golubicič-Magazinovic, Ivana, "Polymorphism of alpha-1-antitrypsin in hematological malignancies" in Genetics and Molecular Biology, 32, no. 4 (2009):716-719,
https://doi.org/10.1590/S1415-47572009005000085 . .

TY  - CONF
AU  - Kundaković, Tatjana
AU  - Stanojković, Tatjana
AU  - Grubin, Jasmina
AU  - Juranić, Zorica
AU  - Stevanović, B.
AU  - Kovačević, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1098
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Antioxidant and cytotoxic activity of Ampelopsis brevipedunculata and Parthenocissus tricuspidata
VL  - 74
IS  - 9
SP  - 954
EP  - 954
DO  - 10.1055/s-0028-1084060
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1098
ER  - 

@conference{
author = "Kundaković, Tatjana and Stanojković, Tatjana and Grubin, Jasmina and Juranić, Zorica and Stevanović, B. and Kovačević, Nada",
year = "2008",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antioxidant and cytotoxic activity of Ampelopsis brevipedunculata and Parthenocissus tricuspidata",
volume = "74",
number = "9",
pages = "954-954",
doi = "10.1055/s-0028-1084060",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1098"
}

Kundaković, T., Stanojković, T., Grubin, J., Juranić, Z., Stevanović, B.,& Kovačević, N.. (2008). Antioxidant and cytotoxic activity of Ampelopsis brevipedunculata and Parthenocissus tricuspidata. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 74(9), 954-954.
https://doi.org/10.1055/s-0028-1084060
https://hdl.handle.net/21.15107/rcub_farfar_1098

Kundaković T, Stanojković T, Grubin J, Juranić Z, Stevanović B, Kovačević N. Antioxidant and cytotoxic activity of Ampelopsis brevipedunculata and Parthenocissus tricuspidata. in Planta Medica. 2008;74(9):954-954.
doi:10.1055/s-0028-1084060
https://hdl.handle.net/21.15107/rcub_farfar_1098 .

Kundaković, Tatjana, Stanojković, Tatjana, Grubin, Jasmina, Juranić, Zorica, Stevanović, B., Kovačević, Nada, "Antioxidant and cytotoxic activity of Ampelopsis brevipedunculata and Parthenocissus tricuspidata" in Planta Medica, 74, no. 9 (2008):954-954,
https://doi.org/10.1055/s-0028-1084060 .,
https://hdl.handle.net/21.15107/rcub_farfar_1098 .

TY  - JOUR
AU  - Juranić, Zorica
AU  - Radić, Jelena
AU  - Konić-Ristić, Aleksandra
AU  - Jelić, Svetislav
AU  - Mihaljević, Biljana
AU  - Stanković, Ivan
AU  - Matković, Suzana
AU  - Besu, Irina
AU  - Gavrilović, Dušica
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1071
AB  - Background: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen. Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. Results: The higher serum IgA immunoreactivity to gliadin was found in 14/56 patients and in one of control people. The enhanced serum IgG immunoreactivity to gliadin was found in only two of tested patients and in two controls. The enhanced IgA immunoreactivity to tTG-2 was found in 10/49 patients' sera, while 4/45 patients had higher serum IgG immunoreactivity. The enhanced serum IgG immunoreactivity to RoSSA antigen was found in 9/47 analyzed MM patients' sera. Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P  lt  0.02) Conclusion: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease.
PB  - BMC, LONDON
T2  - BMC Immunology
T1  - Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma
VL  - 9
DO  - 10.1186/1471-2172-9-22
ER  - 

@article{
author = "Juranić, Zorica and Radić, Jelena and Konić-Ristić, Aleksandra and Jelić, Svetislav and Mihaljević, Biljana and Stanković, Ivan and Matković, Suzana and Besu, Irina and Gavrilović, Dušica",
year = "2008",
abstract = "Background: Multiple myeloma (MM) is a clonal B-cell disorder with many immunological disturbances. The aim of this work was to assess whether some of food antigens contribute to the imbalance of immune response by screening the sera of MM patients for their immunoreactivity to food constituent gliadin, to tissue transglutaminase-2 (tTG-2) and to Ro/SSA antigen. Sera from 61 patients with MM in various stages of disease, before, or after some cycles of conventional therapy were analyzed by commercial Binding Site ELISA tests. The control group consisted of 50 healthy volunteers. Statistical analysis of data obtained was performed by Mann Whitney Test. Results: The higher serum IgA immunoreactivity to gliadin was found in 14/56 patients and in one of control people. The enhanced serum IgG immunoreactivity to gliadin was found in only two of tested patients and in two controls. The enhanced IgA immunoreactivity to tTG-2 was found in 10/49 patients' sera, while 4/45 patients had higher serum IgG immunoreactivity. The enhanced serum IgG immunoreactivity to RoSSA antigen was found in 9/47 analyzed MM patients' sera. Statistical analysis of data obtained revealed that only the levels of anti-tTG-2 IgA immunoreactivity in patients with MM were significantly higher than these obtained in healthy controls (P  lt  0.02) Conclusion: Data obtained showed the existence of the enhanced serum immunoreactivity to gliadin, tTG-2 and Ro/SSA antigens in some patients with MM. These at least partially could contribute to the immunological imbalance frequently found in this disease.",
publisher = "BMC, LONDON",
journal = "BMC Immunology",
title = "Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma",
volume = "9",
doi = "10.1186/1471-2172-9-22"
}

Juranić, Z., Radić, J., Konić-Ristić, A., Jelić, S., Mihaljević, B., Stanković, I., Matković, S., Besu, I.,& Gavrilović, D.. (2008). Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma. in BMC Immunology
BMC, LONDON., 9.
https://doi.org/10.1186/1471-2172-9-22

Juranić Z, Radić J, Konić-Ristić A, Jelić S, Mihaljević B, Stanković I, Matković S, Besu I, Gavrilović D. Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma. in BMC Immunology. 2008;9.
doi:10.1186/1471-2172-9-22 .

Juranić, Zorica, Radić, Jelena, Konić-Ristić, Aleksandra, Jelić, Svetislav, Mihaljević, Biljana, Stanković, Ivan, Matković, Suzana, Besu, Irina, Gavrilović, Dušica, "Humoral immunoreactivity to gliadin and to tissue transglutaminase is present in some patients with multiple myeloma" in BMC Immunology, 9 (2008),
https://doi.org/10.1186/1471-2172-9-22 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Stanojković, Tatjana
AU  - Milenković, Marina
AU  - Grubin, Jasmina
AU  - Juranić, Zorica
AU  - Stevanović, Branka
AU  - Kovačević, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1141
AB  - Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity.
AB  - Cikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)
T1  - Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)
VL  - 60
IS  - 4
SP  - 641
EP  - 647
DO  - 10.2298/ABS0804641K
ER  - 

@article{
author = "Kundaković, Tatjana and Stanojković, Tatjana and Milenković, Marina and Grubin, Jasmina and Juranić, Zorica and Stevanović, Branka and Kovačević, Nada",
year = "2008",
abstract = "Cyclohexane and methanol extracts of leaves and inflorescences of Ampelopsis brevipedunculata and Parthenocissus tricuspidata are shown to exert significant cytotoxic action on both estrogen-dependent (MDA-MB-361) and estrogen-nondependent (MDA-MB-453) breast cancer cell lines. Methanol extracts of P. tricuspidata exhibited higher cytotoxicity for the MDA-MB-453 cell line (inflorescence: IC50 =111.45 ± 2.56 μg/ml; leaves: IC50= 56.76 ± 7.11 μg/ml) than for MDA-MB-361. Cyclohexane extracts of A. brevipedunculata leaves exhibited high cytotoxicity against MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml) and the estrogen-dependent MDA-MB-361 cell line (IC50 =97.40 ± 2.61 μg/ml). The highest DPPH-scavenging ability was exhibited by methanol extracts of P. tricuspidata inflorescences, with IC50=7.55±0.07 μg/ml. The tested extracts possessed weak antimicrobial activity., Cikloheksanski i metanolni ekstrakti listova i cvasti Ampelopsis brevipedunculata i Parthenocissus tricuspidata pokazali su značajnu citotoksičnu aktivnost na estrogen-zavisne (MDA-MB-361) i estrogen-nezavisne ćelije raka dojke (MDA-MB-453). Metanolni ekstrakt P. tricuspidata ispoljio je veću citotoksičnost na MDA-MB-453 ćelije (cvast: IC50 =111.45 ± 2.56 μg/ml; listovi: IC50= 56.76 ± 7.11 μg/ml) u odnosu na MDA-MB-361 ćelije. Cikloheksanski ekstrakt listova A. brevipedunculata pokazao je visoku citotoksičnost na MDA-MB-453 (IC50 =78.32 ± 0.1 μg/ml), kao i na estrogen-zavisne MDA-MB-361 ćelije (IC50 =97.40 ± 2.61 μg/ml). Najveću sposobnost uklanjanja DPPH radikala imao je metanolni ekstrakt cvasti P. tricuspidata čija je IC50=7.55±0.07 μg/ml. Ispitivani ekstrakti poseduju slabu antimikrobnu aktivnost.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae), Citotoksična, antioksidativna i antimikrobijalna aktivnost Ampelopsis brevipedunculata i Parthenocissus tricuspidata (Vitaceae)",
volume = "60",
number = "4",
pages = "641-647",
doi = "10.2298/ABS0804641K"
}

Kundaković, T., Stanojković, T., Milenković, M., Grubin, J., Juranić, Z., Stevanović, B.,& Kovačević, N.. (2008). Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae). in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 60(4), 641-647.
https://doi.org/10.2298/ABS0804641K

Kundaković T, Stanojković T, Milenković M, Grubin J, Juranić Z, Stevanović B, Kovačević N. Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae). in Archives of Biological Sciences. 2008;60(4):641-647.
doi:10.2298/ABS0804641K .

Kundaković, Tatjana, Stanojković, Tatjana, Milenković, Marina, Grubin, Jasmina, Juranić, Zorica, Stevanović, Branka, Kovačević, Nada, "Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae)" in Archives of Biological Sciences, 60, no. 4 (2008):641-647,
https://doi.org/10.2298/ABS0804641K . .

TY  - JOUR
AU  - Dilber, Sanda
AU  - Dobrić, Silva
AU  - Juranić, Zorica
AU  - Marković, Bojan
AU  - Vladimirov, Sote
AU  - Juranić, Ivan O.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1101
AB  - The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.
PB  - Molecular Diversity Preservation Int, Basel
T2  - Molecules
T1  - Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids
VL  - 13
IS  - 3
SP  - 603
EP  - 615
DO  - 10.3390/molecules13030603
ER  - 

@article{
author = "Dilber, Sanda and Dobrić, Silva and Juranić, Zorica and Marković, Bojan and Vladimirov, Sote and Juranić, Ivan O.",
year = "2008",
abstract = "The article describes a two-step synthesis of diastereomeric 3-hydroxy-2methyl-3-( 4-biphenylyl) butanoic acids. In the first step an intermediate alpha-bromo propanoic acid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatsky reaction in presence of Zn in tetrahydrofuran (THF) at -5 to 10 C between the previously synthesized intermediate and 4-acetylbiphenyl. Synthesis of the other studied beta-hydroxy- beta-arylpropanoic acids has already been reported. These beta-hydroxy-beta-arylpropanoic acids belong to the arylpropanoic acid class of compounds, structurally similar to the NSAIDs such as ibuprofen. The anti-inflammatory activity and gastric tolerability of the synthesized compounds were evaluated. Molecular docking experiments were carried out to identify potential COX-2 inhibitors among the beta-hydroxy- beta-aryl-alkanoic acids class. The results indicate that all compounds possess significant anti-inflammatory activity after oral administration and that the compounds 2-(9-( 9-hydroxy-fluorenyl))-2-methylpropanoic acid ( 5) and 3-hydroxy-3,3-diphenyl- propanoic acid (3) possess the strongest anti-inflammatory activity, comparable to that of ibuprofen, a standard NSAID, and that none of tested substances or ibuprofen produced any significant gastric lesions.",
publisher = "Molecular Diversity Preservation Int, Basel",
journal = "Molecules",
title = "Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids",
volume = "13",
number = "3",
pages = "603-615",
doi = "10.3390/molecules13030603"
}

Dilber, S., Dobrić, S., Juranić, Z., Marković, B., Vladimirov, S.,& Juranić, I. O.. (2008). Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules
Molecular Diversity Preservation Int, Basel., 13(3), 603-615.
https://doi.org/10.3390/molecules13030603

Dilber S, Dobrić S, Juranić Z, Marković B, Vladimirov S, Juranić IO. Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids. in Molecules. 2008;13(3):603-615.
doi:10.3390/molecules13030603 .

Dilber, Sanda, Dobrić, Silva, Juranić, Zorica, Marković, Bojan, Vladimirov, Sote, Juranić, Ivan O., "Docking studies and anti-inflammatory activity of ss-Hydroxy-ss-arylpropanoic acids" in Molecules, 13, no. 3 (2008):603-615,
https://doi.org/10.3390/molecules13030603 . .

TY  - CONF
AU  - Konić-Ristić, Aleksandra
AU  - Stanković, Ivan
AU  - Juranić, Zorica
AU  - Stanojković, Tatjana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/767
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Antiproliferative action of dietary isothiocyanates on cancer cells in vitro
T1  - Antiproliferativno delovanje dijetarnih izotiocijanata na malignim ćelijskim linijama in vitro
VL  - 56
IS  - 4
SP  - 576
EP  - 577
UR  - https://hdl.handle.net/21.15107/rcub_farfar_767
ER  - 

@conference{
author = "Konić-Ristić, Aleksandra and Stanković, Ivan and Juranić, Zorica and Stanojković, Tatjana",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Antiproliferative action of dietary isothiocyanates on cancer cells in vitro, Antiproliferativno delovanje dijetarnih izotiocijanata na malignim ćelijskim linijama in vitro",
volume = "56",
number = "4",
pages = "576-577",
url = "https://hdl.handle.net/21.15107/rcub_farfar_767"
}

Konić-Ristić, A., Stanković, I., Juranić, Z.,& Stanojković, T.. (2006). Antiproliferative action of dietary isothiocyanates on cancer cells in vitro. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 576-577.
https://hdl.handle.net/21.15107/rcub_farfar_767

Konić-Ristić A, Stanković I, Juranić Z, Stanojković T. Antiproliferative action of dietary isothiocyanates on cancer cells in vitro. in Arhiv za farmaciju. 2006;56(4):576-577.
https://hdl.handle.net/21.15107/rcub_farfar_767 .

Konić-Ristić, Aleksandra, Stanković, Ivan, Juranić, Zorica, Stanojković, Tatjana, "Antiproliferative action of dietary isothiocyanates on cancer cells in vitro" in Arhiv za farmaciju, 56, no. 4 (2006):576-577,
https://hdl.handle.net/21.15107/rcub_farfar_767 .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Stanojković, Tatjana
AU  - Juranić, Zorica
AU  - Kovačević, Nada
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/813
AB  - The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non-malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that beta-hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin. Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Phytotherapy Research
T1  - Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria
VL  - 20
IS  - 7
SP  - 602
EP  - 604
DO  - 10.1002/ptr.1899
ER  - 

@article{
author = "Kundaković, Tatjana and Stanojković, Tatjana and Juranić, Zorica and Kovačević, Nada",
year = "2006",
abstract = "The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non-malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that beta-hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin. Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Phytotherapy Research",
title = "Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria",
volume = "20",
number = "7",
pages = "602-604",
doi = "10.1002/ptr.1899"
}

Kundaković, T., Stanojković, T., Juranić, Z.,& Kovačević, N.. (2006). Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria. in Phytotherapy Research
John Wiley & Sons Ltd, Chichester., 20(7), 602-604.
https://doi.org/10.1002/ptr.1899

Kundaković T, Stanojković T, Juranić Z, Kovačević N. Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria. in Phytotherapy Research. 2006;20(7):602-604.
doi:10.1002/ptr.1899 .

Kundaković, Tatjana, Stanojković, Tatjana, Juranić, Zorica, Kovačević, Nada, "Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria" in Phytotherapy Research, 20, no. 7 (2006):602-604,
https://doi.org/10.1002/ptr.1899 . .

TY  - JOUR
AU  - Kundaković, Tatjana
AU  - Stanojković, Tatjana
AU  - Juranić, Zorica
AU  - Kovačević, Nada
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/590
AB  - The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05
PB  - Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Cytotoxic and antioxidant activity of Achillea alexandri-regis
VL  - 60
IS  - 4
SP  - 319
EP  - 320
UR  - https://hdl.handle.net/21.15107/rcub_farfar_590
ER  - 

@article{
author = "Kundaković, Tatjana and Stanojković, Tatjana and Juranić, Zorica and Kovačević, Nada",
year = "2005",
abstract = "The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 +/- 4.96 mu g/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 +/- 18.31 mu g/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 +/- 0.05",
publisher = "Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Cytotoxic and antioxidant activity of Achillea alexandri-regis",
volume = "60",
number = "4",
pages = "319-320",
url = "https://hdl.handle.net/21.15107/rcub_farfar_590"
}

Kundaković, T., Stanojković, T., Juranić, Z.,& Kovačević, N.. (2005). Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie
Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn., 60(4), 319-320.
https://hdl.handle.net/21.15107/rcub_farfar_590

Kundaković T, Stanojković T, Juranić Z, Kovačević N. Cytotoxic and antioxidant activity of Achillea alexandri-regis. in Pharmazie. 2005;60(4):319-320.
https://hdl.handle.net/21.15107/rcub_farfar_590 .

Kundaković, Tatjana, Stanojković, Tatjana, Juranić, Zorica, Kovačević, Nada, "Cytotoxic and antioxidant activity of Achillea alexandri-regis" in Pharmazie, 60, no. 4 (2005):319-320,
https://hdl.handle.net/21.15107/rcub_farfar_590 .

TY  - JOUR
AU  - Holclajtner-Antunović, Ivanka
AU  - Kuntić, Vesna
AU  - Juranić, Zorica
AU  - Filipović, Ivana M.
AU  - Mioč, Ubavka B.
AU  - Stanojković, Tatjana
AU  - Žižak, Željko
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/556
AB  - The antitumour action of three polyoxometallate compounds of Keggin's type: 12-molibdophosphoric acid (MoPA), 12-tungstophosphoric acid (WPA) and Mg salt of WPA (MgHWPA) was studied in vitro. For human cervix carcinoma (HeLa) cells survival, as well as for nonstimulated and stimulated peripheral blood mononuclear cells (PBMC), MTT test was applied and IC50 values of POMs were determinated. Index selectivity for WPA and MgHWPA are 1.9 and 1.8, calculated for nonstimulated, as well as 2.5 and 2.0, calculated for stimulated PBMS. Combination of studied POMs do not contribute to their lower IC50 values. Apoptosis detection implies mild cytotoxic effect of WPA and more cytostatical effect of MgHWPA. Combination of each of the studied POMs with caffeine decreases HeLa survival in dose dependent way. None of the studied POMs in the used concentrations (up to 100 mmol/L) damages blood cells and/or decreases their number.
AB  - Ispitivano je in vitro antitumorsko dejstvo tri jedinjenja iz grupe polioksometalata (POM-a) Keginovog tipa: 12-fosformolibdenska kiselina (MoPA), 12-fosforvolframova kiselina (WPA) i Mg so 12-fosforvolframove kiseline (MgHWPA). Primenom MTT testa na ćelije karcinoma cerviksa (HeLa ćelije), kao i na nestimulisane i stimulisane mononuklearne ćelije iz periferne krvi (PBMC), određene su IC50 vrednosti ispitivanih POM-a. Indeksi selektivnosti za WPA i MgHWPA su 1,9 i 1,8 računati za nestimulisane, odnosno 2,5 i 2,0 za stimulisane PBMC. Kombinacijom ispitivanih POMa ne postiže se smanjenje njihovih IC50 vrednosti. Detekcijom apoptoze utvrđeno je da WPA pokazuje blagi citotoksični efekat, dok MgHWPA ima blagi citotostatski efekat. U kombinaciji sa kofeinom, POM jedinjenja još više smanjuju preživljavanje HeLa ćelija. U ispitivanim koncentracijama (do 100 mmol/L), nijedno od POM jedinjenja ne utiče na broj i izgled krvnih ćelija pune krvi zdravih davalaca.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Study of some polyoxometallates of Keggin's type as potential antitumour agents
T1  - Ispitivanje nekih polioksalometalata Keginovog tipa kao potencijalnih antitumorskih agenasa
VL  - 23
IS  - 1
SP  - 25
EP  - 30
DO  - 10.2298/JMH0401025H
ER  - 

@article{
author = "Holclajtner-Antunović, Ivanka and Kuntić, Vesna and Juranić, Zorica and Filipović, Ivana M. and Mioč, Ubavka B. and Stanojković, Tatjana and Žižak, Željko",
year = "2004",
abstract = "The antitumour action of three polyoxometallate compounds of Keggin's type: 12-molibdophosphoric acid (MoPA), 12-tungstophosphoric acid (WPA) and Mg salt of WPA (MgHWPA) was studied in vitro. For human cervix carcinoma (HeLa) cells survival, as well as for nonstimulated and stimulated peripheral blood mononuclear cells (PBMC), MTT test was applied and IC50 values of POMs were determinated. Index selectivity for WPA and MgHWPA are 1.9 and 1.8, calculated for nonstimulated, as well as 2.5 and 2.0, calculated for stimulated PBMS. Combination of studied POMs do not contribute to their lower IC50 values. Apoptosis detection implies mild cytotoxic effect of WPA and more cytostatical effect of MgHWPA. Combination of each of the studied POMs with caffeine decreases HeLa survival in dose dependent way. None of the studied POMs in the used concentrations (up to 100 mmol/L) damages blood cells and/or decreases their number., Ispitivano je in vitro antitumorsko dejstvo tri jedinjenja iz grupe polioksometalata (POM-a) Keginovog tipa: 12-fosformolibdenska kiselina (MoPA), 12-fosforvolframova kiselina (WPA) i Mg so 12-fosforvolframove kiseline (MgHWPA). Primenom MTT testa na ćelije karcinoma cerviksa (HeLa ćelije), kao i na nestimulisane i stimulisane mononuklearne ćelije iz periferne krvi (PBMC), određene su IC50 vrednosti ispitivanih POM-a. Indeksi selektivnosti za WPA i MgHWPA su 1,9 i 1,8 računati za nestimulisane, odnosno 2,5 i 2,0 za stimulisane PBMC. Kombinacijom ispitivanih POMa ne postiže se smanjenje njihovih IC50 vrednosti. Detekcijom apoptoze utvrđeno je da WPA pokazuje blagi citotoksični efekat, dok MgHWPA ima blagi citotostatski efekat. U kombinaciji sa kofeinom, POM jedinjenja još više smanjuju preživljavanje HeLa ćelija. U ispitivanim koncentracijama (do 100 mmol/L), nijedno od POM jedinjenja ne utiče na broj i izgled krvnih ćelija pune krvi zdravih davalaca.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Study of some polyoxometallates of Keggin's type as potential antitumour agents, Ispitivanje nekih polioksalometalata Keginovog tipa kao potencijalnih antitumorskih agenasa",
volume = "23",
number = "1",
pages = "25-30",
doi = "10.2298/JMH0401025H"
}

Holclajtner-Antunović, I., Kuntić, V., Juranić, Z., Filipović, I. M., Mioč, U. B., Stanojković, T.,& Žižak, Ž.. (2004). Study of some polyoxometallates of Keggin's type as potential antitumour agents. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 23(1), 25-30.
https://doi.org/10.2298/JMH0401025H

Holclajtner-Antunović I, Kuntić V, Juranić Z, Filipović IM, Mioč UB, Stanojković T, Žižak Ž. Study of some polyoxometallates of Keggin's type as potential antitumour agents. in Jugoslovenska medicinska biohemija. 2004;23(1):25-30.
doi:10.2298/JMH0401025H .

Holclajtner-Antunović, Ivanka, Kuntić, Vesna, Juranić, Zorica, Filipović, Ivana M., Mioč, Ubavka B., Stanojković, Tatjana, Žižak, Željko, "Study of some polyoxometallates of Keggin's type as potential antitumour agents" in Jugoslovenska medicinska biohemija, 23, no. 1 (2004):25-30,
https://doi.org/10.2298/JMH0401025H . .