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Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies
(Newlands Press, 2022)
Post-translational modifications of histones constitute a dynamic process impacting gene expression. A well-studied modification is lysine methylation. Among the lysine histone methyltransferases, DOT1L is implicated in ...
Mechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein
(Blackwell Publishing Ltd, 2021)
Hydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S-induced relaxation in human ...
Positive modulation of α5GABAA receptors leads to dichotomous effects in rats on memory pattern and GABRA5 expression in prefrontal cortex and hippocampus
(Elsevier B.V., 2022)
Positive allosteric modulators (PAMs) of α5GABAA receptors (α5GABAARs) are emerging as potential therapeutics for a range of neuropsychiatric disorders. However, their role in memory processing of healthy animals is not ...
The Applications of New Inorganic Polymer for Adsorption Cadmium from Waste Water
(Springer Nature, 2020)
Fundamental research of inorganic polymers prepared from available aluminosilicate precursors represent an innovative class of materials characterized by low energy consumption for production. This is just one of the reasons ...
N-Terminal-pro-Brain natriuretic peptide dynamics during effort phenotypes ischemic heart failure and determines prognosis regardless of ejection fraction
(Elsevier, 2020)
Ischemic heart disease leading to heart failure (HF) portends a high overall morbidity and mortality. A higher N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP) at rest reflects HF severity and impaired cardiac output, ...
In vitro colistin susceptibility of pandrug-resistant Ac. baumannii is restored in the presence of selenium nanoparticles
(John Wiley and Sons Inc, 2022)
Aims: To investigate the synergistic activity of colistin and selenium nanoparticles (SeNPs) against pandrug-resistant (PDR) Ac. baumannii. Methods and Results: Chequerboard and time-kill assays were employed to ex- plore ...
Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River
(Springer Science and Business Media Deutschland GmbH, 2021)
Recent studies show that lanthanides (Ln) are becoming emerging pollutants due to their wide application in new technologies,but their environmental fate, transport, and possible accumulation are still relatively unknown. ...
Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus
(Verduci Editore srl, 2022)
OBJECTIVE: To our knowledge, there are no studies that investigated the relationship between diabetes mellitus type 2 (T2D) and some novel indexes, such as monocyte/granulocyte to lymphocyte ratio (M/GLR), derived neutrophil ...
Soil erodibility in european mountain beech forests
(Canadian Science Publishing, 2021)
Forests in Europe are currently not endangered by soil erosion. However, this can change with climate change or with intensified forest management practices. Using a newly established network of plots in beech forests ...
Factorial analysis of N-acetylcysteine and propolis treatment effects on symptoms, life quality and exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD): a randomized, double-blind, placebo-controlled trial
(Verduci Editore srl, 2022)
OBJECTIVE: Standard treatment for chronic obstructive pulmonary disease (COPD) includes inhalation therapy along with mucoactive drugs. The aim of this study was to assess the efficacy and safety of orally administered ...