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Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
(Pergamon-Elsevier Science Ltd, Oxford, 2015)
The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four ...
Application of the design of experiments in optimization of drug layering of pellets with an insight into drug polymer interactions
(Elsevier Science BV, Amsterdam, 2016)
This study consists of two experimental designs. Within the first one, suitable technique for application of model drug onto inactive pellets was evaluated and formulation and process parameters with greatest impact to ...
European views on patients directly obtaining their laboratory test results
(Walter de Gruyter Gmbh, Berlin, 2015)
Background: Medicine is a highly professionalized endeavour, by tradition centred on the authority of physicians. Better education and the advent of the information age cater for increased demands on society in general and ...
Quantitative structure-retention relationship of selected imidazoline derivatives on alpha(1)-acid glycoprotein column
(Elsevier Science BV, Amsterdam, 2016)
The retention behaviour of 22 selected imidazoline drugs and derivatives was investigated on alpha(1)-acid glycoprotein (AGP) column using Sorensen phosphate buffer (pH 7.0) and 2-propanol as organic modifier. Quantitative ...
Tailored porosity development in carbons via Zn2+ monodispersion: Fitting supercapacitors
(Elsevier B.V., 2022)
Here, we propose a novel, electrochemical preparation of in situ N-doped alginate-based carbon precursors with monodispersed zinc ions. Obtained carbons were evaluated by spectroscopic (FTIR, Raman and XPS), textural (N2 ...
pH-sensitive microparticles for oral drug delivery based on alginate/oligochitosan/Eudragit (R) L100-55 "sandwich" polyelectrolyte complex
(Elsevier Science BV, Amsterdam, 2013)
The primary objective of this study was to investigate the influence of the oligochitosan-Eudragit (R) L100-55 polyelectrolyte complex (OCH-EL PEC) on the pH-sensitivity of Eudragit (R) L100-55-treated alginate-oligochitosan ...
Quality by Design approach in the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol and its impurities
(Elsevier Science BV, Amsterdam, 2015)
This study presents the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol, its endo-isomer and three impurities following Quality by Design (QbD) approach. The main objective ...
Acidosis, cognitive dysfunction and motor impairments in patients with kidney disease
(Oxford University Press, 2022)
Metabolic acidosis, defined as a plasma or serum bicarbonate concentration <22 mmol/L, is a frequent consequence of chronic kidney disease (CKD) and occurs in ~10-30% of patients with advanced stages of CKD. Likewise, in ...
Simultaneous Physico-Mechanical and In Vivo Assessment towards Factual Skin Performance Profile of Topical Polymeric Film-Forming Systems
(MDPI, 2022)
Topical film-forming systems (FFS) change drastically after solvent displacement, therefore indicating their skin metamorphosis/transformation as a property of special regulatory and research interest. This paper deals ...
Xenobiotics, trace metals and genetics in the pathogenesis of tauopathies
(MDPI, 2020)
Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s ...