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The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling
(Elsevier Science BV, Amsterdam, 2009)
Monitoring valproic acid (VPA) concentrations is especially challenging due to its highly variable pharmacokinetics (PK) and complex interactions with other antiepileptic drugs. We used sparse routine therapeutic drug ...
Study of forced degradation behavior of Eletriptan hydrobromide by LC and LC-MS and development of stability-indicating method
(Elsevier Science BV, Amsterdam, 2009)
The objective of the present study was to report the stability profile of novel antimigrain drug Eletriptan hydrobromide based on the information obtained from forced degradation studies. The drug was subjected to acid ...
Statistical Optimization of Reverse Phase High Performance Liquid Chromatography for the Analysis of Caffeine Paracetamol and its Degradation Product p-aminophenol
(Slovensko Kemijsko Drustvo, Ljubljana, 2008)
Paracetamol, analgoantipyretic and anti-inflammatory drug, is available in numerous pharmaceutical formulations in common combination with caffeine and some other drug substances. p-aminophenol is paracatamol's process-related ...
Determination of S-carboxymethyl-L-cysteine, methylparaben and their degradation products in syrup preparations
(Springer Heidelberg, Heidelberg, 2004)
An HPLC method was developed for the determination of S-carboxymethyl-L-cysteine, methylparaben and related compounds in cough syrup preparations. The HPLC operating conditions used were acetonitrile-methanol-water ...
Sectroscopic study of stability and molecular species of 12-tungstophosphoric acid in aqueous solution
(Canadian Science Publishing, Nrc Research Press, Ottawa, 2008)
The various molecular species of 12-tungstophosporic acid (WPA) in aqueous solutions of different pH values (from 1 to 11.5) were investigated by UV, IR, and NMR spectroscopy. The dependence of the attained equilibrium ...
Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay
(Walter de Gruyter Gmbh, Berlin, 2006)
Increased C-reactive protein (CRP) concentration within the reference interval ( lt 10.0 mg/L) is a strong predictor of cardiovascular disease (CVD) in apparently healthy adults. Cutoff points for use of CRP in estimating ...
Morphometrical characteristics of age-associated changes in the thymus of old male wistar rats
(Wiley, Hoboken, 2006)
In order to provide a morphometrical description of the changes in the aged rat thymus and to relate them to apoptotic and proliferative activity of thymocytes, the thymuses from 3- and 18-month-old male Wistar rats and ...
Combined Effects of Small Apolipoprotein (a) Isoforms and Small, Dense LDL on Coronary Artery Disease Risk
(Elsevier Science Inc, New York, 2009)
Background and Aims. Lipoprotein (a) [Lp(a)] consists of low-density lipoprotein (LDL) and apolipoprotein (a) [apo(a)]. Both Lp(a) constituents are well-recognized risk factors for coronary artery disease (CAD). This study ...
Composition and antimicrobial activity of essential oil of Stachys plumosa Griseb.
(Wiley, Hoboken, 2006)
The essential oil of Balkan endemic Stachys plumosa Griseb. obtained by steam distillation was analysed by GC and GC-MS. Essential oil yield was 0.15% (v/w) and 45 components were identified (86.9% of the total amount). ...
Evaluation of Hypericum perforatum Oil Extracts for an Antiinflammatory and Gastroprotective Activity in Rats
(John Wiley & Sons Ltd, Chichester, 2009)
Oil extracts of Hypericum perforatum L. (Oleum Hyperici) were prepared in three different ways according to the prescriptions from traditional medicine. Variability of constituents and biological activity were evaluated ...