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Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC
(Springer Heidelberg, Heidelberg, 2005)
A simple, precise and sensitive reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitation of bifonazole, an imidazole antifungal, simultaneously with benzyl alcohol, ...
Chromatographic behavior of fosinopril sodium and fosinoprilat using neural networks
(Springer Heidelberg, Heidelberg, 2008)
In this paper, the chromatographic characterization of fosinopril sodium and fosinoprilat is presented. The first stept was pK(a) determination for the active substance and its degradation product using RP-LC. It was ...
Chromatographic determination of dissociation constants of pramipexole and its impurities
(Vieweg, Wiesbaden, 2007)
The main goal in this investigation was monocratic HPLC determination of dissociation constant values (pK(a)) of pramipexole and its impurities, BI-II 546 CL, BI-II 751 xx and 2-aminobenzothiazole. The chromatographic ...
Application of Multicriteria Methodology in the Development of Improved RP-LC-DAD for Determination of Rizatriptan and Its Degradation Products
(Vieweg, Wiesbaden, 2008)
The aim of this study was to establish an improved isocratic RP-LC-DAD method for separation and determination of rizatriptan benzoate and its two degradation products, L-749.019 and L-783.540 in tablets. Since the ...
Chemometrically Assisted Development and Validation of LC for Simultaneous Determination of Carbamazepine and Its Impurities Iminostilbene and Iminodibenzyl in Solid Dosage Form
(Springer Heidelberg, Heidelberg, 2009)
A chemometrical approach was applied to develop a reversed-phase liquid chromatographic method for simultaneous determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form. According ...
LC determination of lercanidipine and its impurities using DryLab software and experimental design procedures
(Vieweg, Wiesbaden, 2008)
The main objective in all optimization procedures is to define the most appropriate conditions for rapid, sensitive, precise, and reproducible analysis, as economically as possible. Experimental design and DryLab optimization ...
Validation of an HPLC method for the determination of valdecoxib and its degradation product: a mixture of alpha- and beta-n-lactosyl sulfonamide anomers
(Vieweg, Wiesbaden, 2007)
An HPLC method has been developed for the separation of valdecoxib and a degradation product consisting of alpha and beta-N-lactosyl sulfonamide, i.e. alpha and beta anomers (SC-77852). Best results were achieved with a ...
Factorial Design in Optimization of Chromatographic Separation of Ramipril and Its Impurities
(Springer Heidelberg, Heidelberg, 2010)
In this paper optimization of chromatographic retention of ramipril and its five impurities employing factorial design is presented. On the basis of preliminary experiments three factors were chosen as inputs (acetonitrile ...
Evaluation of a liquid chromatographic method for analysis of Indinavir and degradation products arising from hydrolysis of its amide bond
(Springer Heidelberg, Heidelberg, 2005)
Indinavir, an antiviral drug, is a member of the novel hydroxyaminopentane amides class of HIV-1 protease inhibitors. It is the active substance in capsules which contain 400 mg indinavir as the sulfate salt and degradation ...
Avoiding the False Negative Results in LC Method Robustness Testing by Modifications of the Algorithm of Dong and Dummy Factor Effects Approach
(Springer Heidelberg, Heidelberg, 2012)
The algorithm of Dong and error estimation based on a priori declared negligible effects (dummy factor effects approach) were evaluated for testing robustness, in case they provide contradictory results. Robustness of LC ...