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The association between lecithin–cholesterol acyltransferase activity and fatty liver index
(Sage Publications Ltd, 2019)
Background: Non-alcoholic fatty liver disease is a frequent ailment with known complications, including those within the cardiovascular system. Associations between several indicators of high-density lipoprotein metabolism ...
Comparison of AQbD and grid point search methodology in the development of micellar HPLC method for the analysis of cilazapril and hydrochlorothiazide dosage form stability
(Elsevier Science BV, Amsterdam, 2019)
The development of stability-indicating method with isocratic elution mode based on micellar liquid chromatography for the analysis of cilazapril, hydrochlorothiazide and their degradation products was the primary aim of ...
A novel method for classification of wine based on organic acids
(Elsevier Sci Ltd, Oxford, 2019)
Bio-electronic tongue was linked to artificial intelligence processing unit and used for classification of wines based on carboxylic acids levels, which were indirectly related to malolactic fermentation. The system employed ...
Dyslipidemia in type 2 diabetes mellitus / Dislipidemija u dijabetes melitusu tip 2
(Beograd : Savez farmaceutskih udruženja Srbije, 2019)
Type 2 diabetes mellitus is a chronic high-prevalence metabolic disease, which is characterized by hyperglycaemia, but also with lipid and protein metabolism disorders. Patients with type 2 diabetes have a ...
Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients
(Wiley, Hoboken, 2019)
Aims CYP2D6*9, CYP2D6*10 and CYP2D6*41 are the most frequent reduced-function CYP2D6 alleles in Caucasians. Despite lacking in vivo evidence, they are collectively classified with an enzyme activity score of 0.5. Thus, the ...
Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches
(Wiley-VCH Verlag GMBH, Weinheim, 2019)
Life relies on a myriad of carefully orchestrated processes, in which proteins and their direct interplay ultimately determine cellular function and disease. Modulation of this complex crosstalk has recently attracted ...
Wild mint (Mentha longifolia) extracts in the production of non-alcoholic beverages
(Mattioli 1885, Fidenza, 2019)
Isolates of medicinal and aromatic herbs are used as additives in non-alcoholic drinks to improve the sensory characteristics and antioxidant potential. The method of drying the plant material, among other factors, has a ...
Changes in lecithin: cholesterol acyltransferase, cholesteryl ester transfer protein and paraoxonase-1 activities in patients with colorectal cancer
(Pergamon-Elsevier Science Ltd, Oxford, 2019)
Background: Previous studies revealed decreased level of high-density lipoprotein cholesterol (HDL-C) as important factor for development of colorectal cancer (CRC). Quantity and structure of HDL particles depend on ...
Application of data mining approach to identify drug subclasses based on solubility and permeability
(Wiley, Hoboken, 2019)
Solubility and permeability are recognized as key parameters governing drug intestinal absorption and represent the basis for biopharmaceutics drug classification. The Biopharmaceutics Classification System (BCS) is widely ...
Machine Learning Modeling of Wet Granulation Scale-up Using Particle Size Distribution Characterization Parameters
(Springer New York LLC, 2019)
Purpose: Optimal particle size distribution (PSD) is an important factor in wet granulation in order to achieve appropriate powder flow, compactibility, and content uniformity. Parameters like D50 and surface area (SA) are ...