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Searching for the best way to incorporate the proprietary compound GL-II -73 into the nanoemulsion carrier for prospective parenteral application
(International Association of Physical Chemists, 2023)
Searching for the best way to incorporate the proprietary compound GL-II -73 into the nanoemulsion carrier for prospective parenteral application
Jelena Đoković1, Bojan Marković2, Dishary Sharmin3, James M Cook3, Miroslav ...
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
(International Association of Physical Chemists, 2023)
Design of tailor-made biocompatible nanocarrier for novel pyrazoloquinolinone ligand (CW-02-79) based on comprehensive evaluation of critical physicochemical descriptors
Tijana Stanković1, Tanja Ilić1, Ivana Pantelić1, ...
Study of ionization of montelukast in differently charged micellar solutions as biomembrane mimetic systems
(International Association of Physical Chemists, 2023)
Montelukast is a leukotriene receptor antagonist indicated for asthma prophylaxis in adults
as well as in pediatric patients 6 months of age and older. Because it is associated with
numerous side effects, including ...
Neuro pharmacokinetics: the secret life of - old and novel - psychopharmacological drugs
(International Association of Physical Chemists, 2023)
In the 21st century, the pace of development of new pharmacological treatments for general medical and psychiatric disorders is remarkably different. While successes for the former are frequent, new drugs for mental, ...
Elucidation of molecular mechanisms of activity of Echinacea spp. constituents for possible treatment of COVID 19 by computer-aided methods
(International Association of Physical Chemists, 2023)
Echinacea spp. have long history of use, dating from American natives. Among ten, three species (Echinacea purpurea (L.), Echinacea pallida (Nutt.) and Echinacea angustifolia (DC.)), are the most used, alone or in mixes, ...
Investigation of molecular mechanism of action of Satureja Montana essential oil constituents related to effects on viremias
(International Association of Physical Chemists, 2023)
The effects of Satureja Montana (SM) on retroviruses such as HIV-1 and SARS-CoV2, have been recorded in literature. Water-soluble phenols are confered as associated with inhibition of reverse transcriptases, whilst the ...
Computational study of interactions of Cannabis Sativa constituents with potential epigenetic targets involved in processes of multiple sclerosis
(International Association of Physical Chemists, 2023)
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease, which treatment requires better understanding of underlying pathological processes. Epigenetic alterations as to some extent ...
Highlight on the benefits of PBPK modeling: A link between drug properties and its in vivo performance
(International Association of Physical Chemists, 2023)
Physiologically based pharmacokinetic (PBPK) modeling or more recently also known as physiologically based biopharmaceutics modeling (PBBM) is a computer-aided (in silico) biopharmaceutical tool, designed to mechanistically ...
Navigating towards improved cytotoxicity assessment in nanomedicine development: Shifting from colorimetric to fluorescence-based assays
(International Association of Physical Chemists, 2023)
It is well known that the characterization of nanomedicines can pursue different levels of complexity, both in the development stage and in the quality control process [1]. In line with physicochemical aspects, even more ...
Bridging science & regulation: quality by design in patient- focused formulation development
(International Association of Physical Chemists, 2023)
Patient acceptance and usability play a crucial role in achieving successful therapeutic outcomes. Consequently, there is an imperative to incorporate patient-focused formulation design into the pharmaceutical development ...